Article
Medicine, Research & Experimental
Caiqi Ma, Zhijian Huang, Zhikun Wu, Chunguang Di, Xueping Lin, Mao Huang, Honghai Hong, Haofan Yin
Summary: FUBP1 mRNA transcription and protein expression levels were significantly increased in cervical carcinoma tissues. Elevated FUBP1 expression was positively correlated with age, T classification, N classification, tumor recurrence, Ki67 expression, and poor prognosis in cervical carcinoma patients. Overexpression of FUBP1 significantly promoted cervical carcinoma cell proliferation and inhibited cell apoptosis in vitro.
Article
Immunology
Lin Xiang, Longhuan Piao, Dong Wang, Li-Feng-Rong Qi
Summary: Disorders of polyamine metabolism may contribute to the development of hepatocellular carcinoma (HCC). The overexpression of spermine synthase (SMS), an enzyme involved in polyamine biosynthesis, is associated with poor prognosis and low survival rate in HCC patients. However, SMS overexpression limits the therapeutic effect of immune checkpoint blockade (ICB). Functional enrichment analysis shows that SMS may be linked to the occurrence and development of HCC by affecting various immune-related pathways.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Ziying Zhang, Peng Chen, Hui Xie, Peiguo Cao
Summary: This study identified that GINS4 is significantly overexpressed in hepatocellular carcinoma (HCC) and is associated with poor prognosis in HCC patients. Overexpression of GINS4 is significantly correlated with adverse prognosis in HCC patients, especially in those over 60 years old, with histological grade 1, HBV infection-negative, and in the relapse subgroup. A nomogram combining GINS4 level and TNM stage showed satisfactory predictive accuracy and clinical utility in predicting HCC prognosis.
FRONTIERS IN ONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Ye Li, Qing Yi, Xiaoli Liao, Chenglong Han, Li Zheng, Hui Li, Qian Yu, Xuexin Yan, Xinyu Chen, Huawei Zhu, Bi Zhao, Qiulu Lin, Li Liang, Li Wang, Fanghui Qin, Weimin Xie, Yongqiang Li, Wenfeng Huang
Summary: HJURP is identified as a crucial oncogene promoting HCC progression, with its high expression significantly associated with patient survival. HJURP enhances tumorigenesis through reducing cell arrest and increasing invasiveness in HCC.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Cell Biology
Wenhui Bai, Li Cheng, Liangkun Xiong, Maoming Wang, Hao Liu, Kaihuan Yu, Weixing Wang
Summary: The study investigated the effect of succinylation modification of lysine on hepatocellular carcinoma, finding that high succinyllysine levels may be associated with a worse prognosis for patients. Model construction using 20 genes related to succinylation modification showed reliable predictive ability for prognosis in HCC.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2022)
Article
Oncology
Xiaowu Ma, Hongkai Zhuang, Qingbin Wang, Lei Yang, Zhiqin Xie, Wenliang Tan, Chenwei Tang, Yajin Chen, Changzhen Shang
Summary: SLC39A1 overexpression was found in hepatocellular carcinoma (HCC) and correlated with poor prognosis, advanced TNM stage, and higher histological grade. Additionally, SLC39A1 may play a role in HCC by regulating tumor-related pathways such as cell cycle and Wnt signaling. Knockdown of SLC39A1 suppressed HCC cell proliferation, invasion, and migration, and decreased the expression of tumor progression-related proteins. Furthermore, SLC39A1 overexpression may be associated with impaired tumor immunity in HCC.
JOURNAL OF HEPATOCELLULAR CARCINOMA
(2022)
Article
Multidisciplinary Sciences
Vrutant V. Shah, Aundrietta D. Duncan, Shiming Jiang, Sabrina A. Stratton, Kendra L. Allton, Clinton Yam, Abhinav Jain, Patrick M. Krause, Yue Lu, Shirong Cai, Yizheng Tu, Xinhui Zhou, Xiaomei Zhang, Yan Jiang, Christopher L. Carroll, Zhijun Kang, Bin Liu, Jianjun Shen, Mihai Gagea, Sebastian M. Manu, Lei Huo, Michael Gilcrease, Reid T. Powell, Lei Guo, Clifford Stephan, Peter J. Davies, Jan Parker-Thornburg, Guillermina Lozano, Richard R. Behringer, Helen Piwnica-Worms, Jeffrey T. Chang, Stacy L. Moulder, Michelle Craig Barton
Summary: Overexpression of histone reader TRIM24 in mouse mammary epithelia can drive the development of mammary carcinosarcoma tumors with similarities to human MpBC tumors. The direct oncogenic target of TRIM24 is Met, leading to aberrant PI3K/mTOR activation, and targeting these pathways may have therapeutic potential in TRIM24-expressing TNBC.
NATURE COMMUNICATIONS
(2021)
Article
Multidisciplinary Sciences
Seiga Komiyama, Takahiro Yamada, Nobuyuki Takemura, Norihiro Kokudo, Koji Hase, Yuki Kawamura
Summary: Liver cancer is the fourth leading cause of cancer-related death, with patients exhibiting distinct tumor microbiota composition that may play a role in the pathogenesis of HCC.
SCIENTIFIC REPORTS
(2021)
Review
Oncology
Xue-Qin Gong, Yun-Yun Tao, Yao-Kun Wu, Ning Liu, Xi Yu, Ran Wang, Jing Zheng, Nian Liu, Xiao-Hua Huang, Jing-Dong Li, Gang Yang, Xiao-Qin Wei, Lin Yang, Xiao-Ming Zhang
Summary: Radiomics is a promising new imaging method that extracts high-throughput imaging data to predict clinical outcomes noninvasively before surgery. MRI radiomics can be used as biomarkers to determine the diagnosis, histological grade, microvascular invasion status, gene expression status, therapeutic responses, and prognosis of HCC patients.
FRONTIERS IN ONCOLOGY
(2021)
Article
Cell Biology
Dafeng Xu, Yu Wang, Jincai Wu, Zhensheng Zhang, Jiacheng Chen, Mingwei Xie, Rong Tang, Cheng Chen, Liang Chen, Shixun Lin, Xiangxiang Luo, Jinfang Zheng
Summary: This study identified a new candidate diagnostic and prognostic biomarker (ECT2) for HCC, and revealed its role in promoting the polarization of M2 macrophages.
CELL DEATH & DISEASE
(2021)
Article
Oncology
Renumathy Dhanasekaran, Aida S. Hansen, Jangho Park, Lea Lemaitre, Ian Lai, Nia Adeniji, Sibu Kuruvilla, Akanksha Suresh, Josephine Zhang, Varsha Swamy, Dean W. Felsher
Summary: MYC oncogene suppresses innate immune surveillance and drives resistance to immunotherapy. Overexpression of MYC increases immune-checkpoint expression, predicts nonresponsiveness to immune-checkpoint blockade, and is associated with Th2-like immune profile and reduced CD8 T-cell infiltration. MYC transcriptionally suppresses innate immunity and MHCI-mediated antigen presentation, impeding T-cell response. Combined blockade of PDL1 and CTLA4 can reverse MYC-driven immune suppression by recruiting proinflammatory antigen-presenting macrophages. Depletion of macrophages abrogates the antineoplastic effects of PDL1 and CTLA4 blockade in MYC-driven hepatocellular carcinoma.
Article
Oncology
Guosheng Tan, Binhui Xie, Na Yu, Jianwen Huang, Bing Zhang, Fangzeng Lin, Heping Li
Summary: The study showed that TRIM37 expression was significantly increased in HCC cells and tissues, especially in Sorafenib-resistant HCC tissues. High TRIM37 expression was correlated with poor prognosis in HCC patients. TRIM37 overexpression conferred Sorafenib resistance on HCC cells, while inhibition of TRIM37 sensitized HCC cells to Sorafenib cytotoxicity. Additionally, TRIM37 upregulated AKT activity and phosphorylated AKT levels, thereby activating canonical AKT signaling.
INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Chien-Chang Kao, Yin-Lun Chang, Hui-Ying Liu, Sheng-Tang Wu, En Meng, Tai-Lung Cha, Guang-Huan Sun, Dah-Shyong Yu, Hao-Lun Luo
Summary: Urothelial carcinoma, a type of malignant tumor commonly found in the upper urinary tract and bladder, is associated with high recurrence and poor prognosis. This study identified INHBA as a potential diagnostic biomarker for urothelial carcinoma, showing its role in carcinogenesis and metastasis. INHBA was found to be hypomethylated and overexpressed in clinical samples of urothelial carcinoma. Further experiments demonstrated that INHBA depletion reduced cell growth and migration, potentially through the SMAD pathway. These findings provide insights into the molecular mechanisms of urothelial carcinoma and suggest a potential target for early detection and treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Rong-Quan He, Jian-Di Li, Xiu-Fang Du, Yi-Wu Dang, Lin-Jie Yang, Zhi-Guang Huang, Li-Min Liu, Liu-Feng Liao, Hong Yang, Gang Chen
Summary: This study revealed that increased LPCAT1 expression correlated with poor prognosis in HCC patients and promoted HCC progression by enhancing cellular growth, migration, and metastasis. The cell cycle and chemical carcinogenesis were identified as the most enriched signaling pathways.
CANCER CELL INTERNATIONAL
(2021)
Article
Medicine, General & Internal
Hao-Wen Chuang, Kan-Tai Hsia, Jia-Bin Liao, Chih-Ching Yeh, Wei-Ting Kuo, Yi-Fang Yang
Summary: Recent studies have suggested that high SERPINE2 expression is associated with poor prognosis and adverse pathologic parameters in patients with urinary bladder urothelial carcinoma (UBUC). This indicates that SERPINE2 could potentially serve as a prognostic biomarker for UC.
