Transcription/Replication Conflicts in Tumorigenesis and Their Potential Role as Novel Therapeutic Targets in Multiple Myeloma

Ribonucleotide incorporation into DNA during DNA replication and its consequences

(2021) Zhi-Xiong Zhou et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

BRCA2 promotes R‐loop resolution by DDX5 helicase at DNA breaks to facilitate their repair by homologous recombination

(2021) Gaetana Sessa et al.   EMBO JOURNAL

Noncoding RNA processing by DIS3 regulates chromosomal architecture and somatic hypermutation in B cells

(2021) Brice Laffleur et al.   NATURE GENETICS

Human Rev1 relies on insert-2 to promote selective binding and accurate replication of stabilized G-quadruplex motifs

(2021) Amit Ketkar et al.   NUCLEIC ACIDS RESEARCH

NF-κB–induced R-loop accumulation and DNA damage select for nucleotide excision repair deficiencies in adult T cell leukemia

(2021) Yunlong He et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

DIS3 mutations in multiple myeloma impact the transcriptional signature and clinical outcome

(2021) Katia Todoerti et al.   HAEMATOLOGICA

RNA-sequencing data-driven dissection of human plasma cell differentiation reveals new potential transcription regulators

(2021) Alboukadel Kassambara et al.   LEUKEMIA

Comprehensive CRISPR-Cas9 screens identify genetic determinants of drug responsiveness in multiple myeloma

(2021) Stephan R. Bohl et al.   Blood Advances

BRAF and DIS3 Mutations Associate with Adverse Outcome in a Long-term Follow-up of Patients with Multiple Myeloma

(2020) Eileen M Boyle et al.   CLINICAL CANCER RESEARCH

Regulatory R-loops as facilitators of gene expression and genome stability

(2020) Christof Niehrs et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Silencing of SENP2 in Multiple Myeloma Induces Bortezomib Resistance by Activating NF-κB Through the Modulation of IκBα Sumoylation

(2020) Hongyi Xie et al.   Scientific Reports

Manipulating Adult Neural Stem and Progenitor Cells with G-Quadruplex Ligands

(2020) David C. Goldberg et al.   ACS Chemical Neuroscience

UAP56/DDX39B is a major cotranscriptional RNA–DNA helicase that unwinds harmful R loops genome-wide

(2020) Carmen Pérez-Calero et al.   GENES & DEVELOPMENT

Human POT1 unfolds G-quadruplexes by conformational selection

(2020) Jonathan B Chaires et al.   NUCLEIC ACIDS RESEARCH

EXO1 resection at G-quadruplex structures facilitates resolution and replication

(2020) Susanna Stroik et al.   NUCLEIC ACIDS RESEARCH

Timing the initiation of multiple myeloma

(2020) Even H. Rustad et al.   Nature Communications

Impact of mitochondrial DNA mutations in multiple myeloma

(2020) Phuc H. Hoang et al.   Blood Cancer Journal

A Genetic Map of the Response to DNA Damage in Human Cells

(2020) Michele Olivieri et al.   CELL

Replication protein A binds RNA and promotes R-loop formation

(2020) Olga M Mazina et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Knockdown of THOC1 reduces the proliferation of hepatocellular carcinoma and increases the sensitivity to cisplatin

(2020) Shijiao Cai et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Topoisomerase 1 prevents replication stress at R-loop-enriched transcription termination sites

(2020) Alexy Promonet et al.   Nature Communications

Cancer-associated mutations in the iron-sulfur domain of FANCJ affect G-quadruplex metabolism

(2020) Diana C. Odermatt et al.   PLoS Genetics

RECQ1 Helicase in Genomic Stability and Cancer

(2020) Subrata Debnath et al.   Genes

XRN2 Links RNA:DNA Hybrid Resolution to Double Strand Break Repair Pathway Choice

(2020) Tuyen T. Dang et al.   Cancers

Genome-wide R-loop analysis defines unique roles for DDX5, XRN2, and PRMT5 in DNA/RNA hybrid resolution

(2020) Oscar D Villarreal et al.   Life Science Alliance

The dangers of déjà vu: Memory B-cells as the cell-of-origin of ABC-DLBCLs

(2020) Leandro Venturutti et al.   BLOOD

A Small Molecule Stabilizer of the MYC G4-Quadruplex Induces Endoplasmic Reticulum Stress, Senescence and Pyroptosis in Multiple Myeloma

(2020) Snehal M. Gaikwad et al.   Cancers

Recent Update on Targeting c-MYC G-Quadruplexes by Small Molecules for Anticancer Therapeutics

(2020) Ritapa Chaudhuri et al.   JOURNAL OF MEDICINAL CHEMISTRY

G-Quadruplex loops regulate PARP-1 enzymatic activation

(2020) Andrea D Edwards et al.   NUCLEIC ACIDS RESEARCH

Prognosis value of RBBP8 expression in plasma cell myeloma

(2019) Weilong Zhang et al.   CANCER GENE THERAPY

Binding of FANCI-FANCD2 Complex to RNA and R-Loops Stimulates Robust FANCD2 Monoubiquitination

(2019) Zhuobin Liang et al.   Cell Reports

Development and Validation of a 9-Gene Prognostic Signature in Patients With Multiple Myeloma

(2019) Xiao-Ping Liu et al.   Frontiers in Oncology

EZH2 is overexpressed in transitional preplasmablasts and is involved in human plasma cell differentiation

(2019) Laurie Herviou et al.   LEUKEMIA

Transcription-mediated replication hindrance: a major driver of genome instability

(2019) Belén Gómez-González et al.   GENES & DEVELOPMENT

Exome sequencing identifies germline variants in DIS3 in familial multiple myeloma

(2019) Maroulio Pertesi et al.   LEUKEMIA

Depletion of the RNA binding protein HNRNPD impairs homologous recombination by inhibiting DNA-end resection and inducing R-loop accumulation

(2019) Luigi Alfano et al.   NUCLEIC ACIDS RESEARCH

Drugging the R-loop interactome: RNA-DNA hybrid binding proteins as targets for cancer therapy

(2019) Beáta Boros-Oláh et al.   DNA REPAIR

RNases H: Structure and mechanism

(2019) Malwina Hyjek et al.   DNA REPAIR

Arginine methylation of the DDX 5 helicase RGG / RG motif by PRMT 5 regulates resolution of RNA:DNA hybrids

(2019) Sofiane Y Mersaoui et al.   EMBO JOURNAL

Complementary roles of Pif1 helicase and single stranded DNA binding proteins in stimulating DNA replication through G-quadruplexes

(2019) Melanie A Sparks et al.   NUCLEIC ACIDS RESEARCH

EXOSC10 is required for RPA assembly and controlled DNA end resection at DNA double-strand breaks

(2019) Judit Domingo-Prim et al.   Nature Communications

Involvement of G-quadruplex regions in mammalian replication origin activity

(2019) Paulina Prorok et al.   Nature Communications

Current insights into the mechanism of mammalian immunoglobulin class switch recombination

(2019) Kefei Yu et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

Quantifying the impact of small molecule ligands on G-quadruplex stability against Bloom helicase

(2019) Parastoo Maleki et al.   NUCLEIC ACIDS RESEARCH

HNRNPH1-dependent splicing of a fusion oncogene reveals a targetable RNA G-quadruplex interaction

(2019) Carla Neckles et al.   RNA

Mutational processes contributing to the development of multiple myeloma

(2019) Phuc H. Hoang et al.   Blood Cancer Journal

Dual Processing of R-Loops and Topoisomerase I Induces Transcription-Dependent DNA Double-Strand Breaks

(2019) Agnese Cristini et al.   Cell Reports

MRE11-RAD50-NBS1 promotes Fanconi Anemia R-loop suppression at transcription–replication conflicts

(2019) Emily Yun-Chia Chang et al.   Nature Communications

HERC2 regulates RPA2 by mediating ATR-induced Ser33 phosphorylation and ubiquitin-dependent degradation

(2019) Yongqiang Lai et al.   Scientific Reports

Assembly of a G-Quadruplex Repair Complex by the FANCJ DNA Helicase and the REV1 Polymerase

(2019) Kaitlin Lowran et al.   Genes

Spliceosomal components protect embryonic neurons from R-loop-mediated DNA damage and apoptosis

(2018) Shelly Sorrells et al.   Disease Models & Mechanisms

The Augmented R-Loop Is a Unifying Mechanism for Myelodysplastic Syndromes Induced by High-Risk Splicing Factor Mutations

(2018) Liang Chen et al.   MOLECULAR CELL

RNA Helicase DDX1 Converts RNA G-Quadruplex Structures into R-Loops to Promote IgH Class Switch Recombination

(2018) Claudia Ribeiro de Almeida et al.   MOLECULAR CELL

Toward predictive R-loop computational biology: genome-scale prediction of R-loops reveals their association with complex promoter structures, G-quadruplexes and transcriptionally active enhancers

(2018) Vladimir A Kuznetsov et al.   NUCLEIC ACIDS RESEARCH

SUMO2 conjugation of PCNA facilitates chromatin remodeling to resolve transcription-replication conflicts

(2018) Min Li et al.   Nature Communications

BLM helicase suppresses recombination at G-quadruplex motifs in transcribed genes

(2018) Niek van Wietmarschen et al.   Nature Communications

RNA/DNA Hybrid Interactome Identifies DXH9 as a Molecular Player in Transcriptional Termination and R-Loop-Associated DNA Damage

(2018) Agnese Cristini et al.   Cell Reports

Human Rad52 Promotes XPG-Mediated R-loop Processing to Initiate Transcription-Associated Homologous Recombination Repair

(2018) Takaaki Yasuhara et al.   CELL

Human proteins that interact with RNA/DNA hybrids

(2018) Isabel X. Wang et al.   GENOME RESEARCH

Novel splicing in IGFN1 intron 15 and role of stable G-quadruplex in the regulation of splicing in renal cell carcinoma

(2018) Shiv Prakash Verma et al.   PLoS One

HERC2 Facilitates BLM and WRN Helicase Complex Interaction with RPA to Suppress G-Quadruplex DNA

(2018) Wenwen Wu et al.   CANCER RESEARCH

FANCD2 protects genome stability by recruiting RNA processing enzymes to resolve R-loops during mild replication stress

(2018) Yusuke Okamoto et al.   FEBS Journal

The antitumor drugs trabectedin and lurbinectedin induce transcription-dependent replication stress and genome instability

(2018) Emanuela Tumini et al.   MOLECULAR CANCER RESEARCH

Pif1 is essential for efficient replisome progression through lagging strand G-quadruplex DNA secondary structures

(2018) Danielle Dahan et al.   NUCLEIC ACIDS RESEARCH

DNA damage and genome instability by G-quadruplex ligands are mediated by R loops in human cancer cells

(2018) Alessio De Magis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

DHX9 helicase promotes R-loop formation in cells with impaired RNA splicing

(2018) Prasun Chakraborty et al.   Nature Communications

Sae2/CtIP prevents R-loop accumulation in eukaryotic cells

(2018) Nodar Makharashvili et al.   eLife

Human ribonuclease H1 resolves R-loops and thereby enables progression of the DNA replication fork

(2017) Shankar Parajuli et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

RECQ-like helicases Sgs1 and BLM regulate R-loop–associated genome instability

(2017) Emily Yun-Chia Chang et al.   JOURNAL OF CELL BIOLOGY

RECQ1 helicase is involved in replication stress survival and drug resistance in multiple myeloma

(2017) E Viziteu et al.   LEUKEMIA

Protein arginine methyltransferase 5 has prognostic relevance and is a druggable target in multiple myeloma

(2017) A Gullà et al.   LEUKEMIA

Functions of Replication Protein A as a Sensor of R Loops and a Regulator of RNaseH1

(2017) Hai Dang Nguyen et al.   MOLECULAR CELL

ATM, ATR, and DNA-PK: The Trinity at the Heart of the DNA Damage Response

(2017) Andrew N. Blackford et al.   MOLECULAR CELL

cGAS surveillance of micronuclei links genome instability to innate immunity

(2017) Karen J. Mackenzie et al.   NATURE

Control of structure-specific endonucleases to maintain genome stability

(2017) Pierre-Marie Dehé et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

DNA G-quadruplexes in the human genome: detection, functions and therapeutic potential

(2017) Robert Hänsel-Hertsch et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Characterization of the mammalian DEAD-box protein DDX5 reveals functional conservation with S. cerevisiae ortholog Dbp2 in transcriptional control and glucose metabolism

(2017) Zheng Xing et al.   RNA

PIF1 family DNA helicases suppress R-loop mediated genome instability at tRNA genes

(2017) Phong Lan Thao Tran et al.   Nature Communications

CX-5461 is a DNA G-quadruplex stabilizer with selective lethality in BRCA1/2 deficient tumours

(2017) Hong Xu et al.   Nature Communications

Attenuation of RNA polymerase II pausing mitigates BRCA1-associated R-loop accumulation and tumorigenesis

(2017) Xiaowen Zhang et al.   Nature Communications

RECQ1 expression is upregulated in response to DNA damage and in a p53-dependent manner

(2017) Swetha Parvathaneni et al.   Oncotarget

Transcription Dynamics Prevent RNA-Mediated Genomic Instability through SRPK2-Dependent DDX23 Phosphorylation

(2017) Sreerama Chaitanya Sridhara et al.   Cell Reports

Inhibition of DNA2 nuclease as a therapeutic strategy targeting replication stress in cancer cells

(2017) S Kumar et al.   Oncogenesis

The Interplay between G-quadruplex and Transcription

(2017) Nayun Kim   CURRENT MEDICINAL CHEMISTRY

Conflict Resolution in the Genome: How Transcription and Replication Make It Work

(2016) Stephan Hamperl et al.   CELL

Exonuclease 1 and its versatile roles in DNA repair

(2016) Guido Keijzers et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

Mechanism and regulation of DNA end resection in eukaryotes

(2016) Lorraine S. Symington   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

Yeast Helicase Pif1 Unwinds RNA:DNA Hybrids with Higher Processivity than DNA:DNA Duplexes

(2016) Shubeena Chib et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

5′ to 3′ Unfolding Directionality of DNA Secondary Structures by Replication Protein A

(2016) Layal Safa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Transcriptome guided identification of novel functions of RECQ1 helicase

(2016) Xing Lu et al.   METHODS

DEAD Box 1 Facilitates Removal of RNA and Homologous Recombination at DNA Double-Strand Breaks

(2016) Lei Li et al.   MOLECULAR AND CELLULAR BIOLOGY

Targeting BRCA1 and BRCA2 Deficiencies with G-Quadruplex-Interacting Compounds

(2016) Jutta Zimmer et al.   MOLECULAR CELL

FANCD2 Facilitates Replication through Common Fragile Sites

(2016) Advaitha Madireddy et al.   MOLECULAR CELL

Genomic complexity of multiple myeloma and its clinical implications

(2016) Salomon Manier et al.   Nature Reviews Clinical Oncology

Transcription–replication conflicts: how they occur and how they are resolved

(2016) Tatiana García-Muse et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The Fanconi anaemia pathway: new players and new functions

(2016) Raphael Ceccaldi et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

ViableRNaseH1knockout mice show RNaseH1 is essential for R loop processing, mitochondrial and liver function

(2016) Walt F. Lima et al.   NUCLEIC ACIDS RESEARCH

G-quadruplex recognition and remodeling by the FANCJ helicase

(2016) Colin G. Wu et al.   NUCLEIC ACIDS RESEARCH

XRN2 Links Transcription Termination to DNA Damage and Replication Stress

(2016) Julio C. Morales et al.   PLoS Genetics

Dynamic Effects of Topoisomerase I Inhibition on R-Loops and Short Transcripts at Active Promoters

(2016) Jessica Marinello et al.   PLoS One

Molecular mechanism of G-quadruplex unwinding helicase: sequential and repetitive unfolding of G-quadruplex by Pif1 helicase

(2015) Xi-Miao Hou et al.   BIOCHEMICAL JOURNAL

DEAD-box RNA helicase DDX23 modulates glioma malignancy via elevating miR-21 biogenesis

(2015) Jinlong Yin et al.   BRAIN

SnapShot: Multiple Myeloma

(2015) Esteban Braggio et al.   CANCER CELL

Celastrol induces proteasomal degradation of FANCD2 to sensitize lung cancer cells to DNA crosslinking agents

(2015) Gui-Zhen Wang et al.   CANCER SCIENCE

Fanconi anemia: a model disease for studies on human genetics and advanced therapeutics

(2015) Massimo Bogliolo et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

RPA prevents G-rich structure formation at lagging-strand telomeres to allow maintenance of chromosome ends

(2015) J. Audry et al.   EMBO JOURNAL

A Parallel Quadruplex DNA Is Bound Tightly but Unfolded Slowly by Pif1 Helicase

(2015) Alicia K. Byrd et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Fanconi Anemia Pathway Maintains Genome Stability by Coordinating Replication and Transcription

(2015) Rebekka A. Schwab et al.   MOLECULAR CELL

BRCA1 Recruitment to Transcriptional Pause Sites Is Required for R-Loop-Driven DNA Damage Repair

(2015) Elodie Hatchi et al.   MOLECULAR CELL

A fluorescence-based helicase assay: application to the screening of G-quadruplex ligands

(2015) O. Mendoza et al.   NUCLEIC ACIDS RESEARCH

BLM unfolds G-quadruplexes in different structural environments through different mechanisms

(2015) Wen-Qiang Wu et al.   NUCLEIC ACIDS RESEARCH

G-quadruplexes and their regulatory roles in biology

(2015) Daniela Rhodes et al.   NUCLEIC ACIDS RESEARCH

Breaking bad: R-loops and genome integrity

(2015) Julie Sollier et al.   TRENDS IN CELL BIOLOGY

RECQ5-dependent SUMOylation of DNA topoisomerase I prevents transcription-associated genome instability

(2015) Min Li et al.   Nature Communications

YK-4-279 effectively antagonizes EWS-FLI1 induced leukemia in a transgenic mouse model

(2015) Tsion Zewdu Minas et al.   Oncotarget

GenomicScape: An Easy-to-Use Web Tool for Gene Expression Data Analysis. Application to Investigate the Molecular Events in the Differentiation of B Cells into Plasma Cells

(2015) Alboukadel Kassambara et al.   PLoS Computational Biology

The Fanconi Anemia Pathway Protects Genome Integrity from R-loops

(2015) María L. García-Rubio et al.   PLoS Genetics

Differential Expression of Non-Shelterin Genes Associated with High Telomerase Levels and Telomere Shortening in Plasma Cell Disorders

(2015) Julieta Panero et al.   PLoS One

A critical role for the NFkB pathway in multiple myeloma

(2015)   Oncotarget

Widespread Genetic Heterogeneity in Multiple Myeloma: Implications for Targeted Therapy

(2014) Jens G. Lohr et al.   CANCER CELL

RPA Inhibition Increases Replication Stress and Suppresses Tumor Growth

(2014) J. G. Glanzer et al.   CANCER RESEARCH

BRCA1 Deficiency Exacerbates Estrogen-Induced DNA Damage and Genomic Instability

(2014) K. I. Savage et al.   CANCER RESEARCH

Identification of RECQ1-regulated transcriptome uncovers a role of RECQ1 in regulation of cancer cell migration and invasion

(2014) Xiao Ling Li et al.   CELL CYCLE

The contribution of co-transcriptional RNA:DNA hybrid structures to DNA damage and genome instability

(2014) Stephan Hamperl et al.   DNA REPAIR

FANCJ promotes DNA synthesis through G-quadruplex structures

(2014) P. Castillo Bosch et al.   EMBO JOURNAL

Systematic screening reveals a role for BRCA1 in the response to transcription-associated DNA damage

(2014) Sarah J. Hill et al.   GENES & DEVELOPMENT

IgH Chain Class Switch Recombination: Mechanism and Regulation

(2014) Janet Stavnezer et al.   JOURNAL OF IMMUNOLOGY

IL-6 supports the generation of human long-lived plasma cells in combination with either APRIL or stromal cell-soluble factors

(2014) M Jourdan et al.   LEUKEMIA

Transcription-Coupled Nucleotide Excision Repair Factors Promote R-Loop-Induced Genome Instability

(2014) Julie Sollier et al.   MOLECULAR CELL

Caught in the Act: R-Loops Are Cleaved by Structure-Specific Endonucleases to Generate DSBs

(2014) Yea-Lih Lin et al.   MOLECULAR CELL

Catalytic and Noncatalytic Roles of the CtIP Endonuclease in Double-Strand Break End Resection

(2014) Nodar Makharashvili et al.   MOLECULAR CELL

BRCA2 prevents R-loop accumulation and associates with TREX-2 mRNA export factor PCID2

(2014) Vaibhav Bhatia et al.   NATURE

A genome-wide function of THSC/TREX-2 at active genes prevents transcription–replication collisions

(2014) José M. Santos-Pereira et al.   NUCLEIC ACIDS RESEARCH

Multifaceted role of the Topo IIIα–RMI1-RMI2 complex and DNA2 in the BLM-dependent pathway of DNA break end resection

(2014) James M. Daley et al.   NUCLEIC ACIDS RESEARCH

DNA damage triggers SAF-A and RNA biogenesis factors exclusion from chromatin coupled to R-loops removal

(2014) Sébastien Britton et al.   NUCLEIC ACIDS RESEARCH

Regulation of gene expression by the BLM helicase correlates with the presence of G-quadruplex DNA motifs

(2014) Giang Huong Nguyen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

G-quadruplex formation in telomeres enhances POT1/TPP1 protection against RPA binding

(2014) S. Ray et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Quality control of mRNP biogenesis: Networking at the transcription site

(2014) Andrea B. Eberle et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

PAR-CLIP analysis uncovers AUF1 impact on target RNA fate and genome integrity

(2014) Je-Hyun Yoon et al.   Nature Communications

Periodic DNA patrolling underlies diverse functions of Pif1 on R-loops and G-rich DNA

(2014) Ruobo Zhou et al.   eLife

Expression profile of shelterin components in plasma cell disorders. Clinical significance of POT1 overexpression

(2013) Julieta Panero et al.   BLOOD CELLS MOLECULES AND DISEASES

Xbp1s-Negative Tumor B Cells and Pre-Plasmablasts Mediate Therapeutic Proteasome Inhibitor Resistance in Multiple Myeloma

(2013) Chungyee Leung-Hagesteijn et al.   CANCER CELL

A Small Molecule Inhibitor of the BLM Helicase Modulates Chromosome Stability in Human Cells

(2013) Giang Huong Nguyen et al.   CHEMISTRY & BIOLOGY

Mammalian DNA2 helicase/nuclease cleaves G-quadruplex DNA and is required for telomere integrity

(2013) Weiqiang Lin et al.   EMBO JOURNAL

A SUMO-dependent interaction between Senataxin and the exosome, disrupted in the neurodegenerative disease AOA2, targets the exosome to sites of transcription-induced DNA damage

(2013) P. Richard et al.   GENES & DEVELOPMENT

G-Quadruplex DNA as a Molecular Target for Induced Synthetic Lethality in Cancer Cells

(2013) Keith I. E. McLuckie et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Replication stress induces specific enrichment of RECQ1 at common fragile sites FRA3B and FRA16D

(2013) Xing Lu et al.   Molecular Cancer

DNA Double-Strand Break Repair Pathway Choice Is Directed by Distinct MRE11 Nuclease Activities

(2013) Atsushi Shibata et al.   MOLECULAR CELL

Pif1 family helicases suppress genome instability at G-quadruplex motifs

(2013) Katrin Paeschke et al.   NATURE

Causes and consequences of replication stress

(2013) Michelle K. Zeman et al.   NATURE CELL BIOLOGY

Regulation of PCNA–protein interactions for genome stability

(2013) Niels Mailand et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Human Rev1 polymerase disrupts G-quadruplex DNA

(2013) S. Eddy et al.   NUCLEIC ACIDS RESEARCH

Targeting Proliferating Cell Nuclear Antigen and Its Protein Interactions Induces Apoptosis in Multiple Myeloma Cells

(2013) Rebekka Müller et al.   PLoS One

Selective RNA Versus DNA G-Quadruplex Targeting by In Situ Click Chemistry

(2012) Marco Di Antonio et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Inhibition of RNA Polymerase I as a Therapeutic Strategy to Promote Cancer-Specific Activation of p53

(2012) Megan J. Bywater et al.   CANCER CELL

Human Nuclease/Helicase DNA2 Alleviates Replication Stress by Promoting DNA End Resection

(2012) G. Peng et al.   CANCER RESEARCH

RECQ1 is required for cellular resistance to replication stress and catalyzes strand exchange on stalled replication fork structures

(2012) Venkateswarlu Popuri et al.   CELL CYCLE

DNA2 and EXO1 in replication-coupled, homology-directed repair and in the interplay between HDR and the FA/BRCA network

(2012) Kenneth K. Karanja et al.   CELL CYCLE

Development of Gene Expression-Based Score to Predict Sensitivity of Multiple Myeloma Cells to DNA Methylation Inhibitors

(2012) J. Moreaux et al.   MOLECULAR CANCER THERAPEUTICS

Nuclear Matrix Factor hnRNP U/SAF-A Exerts a Global Control of Alternative Splicing by Regulating U2 snRNP Maturation

(2012) Rui Xiao et al.   MOLECULAR CELL

Collaborating functions of BLM and DNA topoisomerase I in regulating human rDNA transcription

(2012) Patrick M. Grierson et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

Small-molecule–induced DNA damage identifies alternative DNA structures in human genes

(2012) Raphaël Rodriguez et al.   Nature Chemical Biology

Role of SUMO modification of human PCNA at stalled replication fork

(2012) Himabindu Gali et al.   NUCLEIC ACIDS RESEARCH

Involvement of DNA ligase III and ribonuclease H1 in mitochondrial DNA replication in cultured human cells

(2011) Heini Ruhanen et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

DNA Replication through G-Quadruplex Motifs Is Promoted by the Saccharomyces cerevisiae Pif1 DNA Helicase

(2011) Katrin Paeschke et al.   CELL

The RNA Exosome Targets the AID Cytidine Deaminase to Both Strands of Transcribed Duplex DNA Substrates

(2011) Uttiya Basu et al.   CELL

Genome-wide function of THO/TREX in active genes prevents R-loop-dependent replication obstacles

(2011) Belén Gómez-González et al.   EMBO JOURNAL

Assessment of proliferating cell nuclear antigen and its relationship with proinflammatory cytokines and parameters of disease activity in multiple myeloma patients

(2011) G. Tsirakis et al.   EUROPEAN JOURNAL OF HISTOCHEMISTRY

R-loop-mediated genomic instability is caused by impairment of replication fork progression

(2011) W. Gan et al.   GENES & DEVELOPMENT

Characterization of a Transitional Preplasmablast Population in the Process of Human B Cell to Plasma Cell Differentiation

(2011) Michel Jourdan et al.   JOURNAL OF IMMUNOLOGY

Human Senataxin Resolves RNA/DNA Hybrids Formed at Transcriptional Pause Sites to Promote Xrn2-Dependent Termination

(2011) Konstantina Skourti-Stathaki et al.   MOLECULAR CELL

Inhibition of Homologous Recombination by the PCNA-Interacting Protein PARI

(2011) George-Lucian Moldovan et al.   MOLECULAR CELL

Initial genome sequencing and analysis of multiple myeloma

(2011) Michael A. Chapman et al.   NATURE

A single-molecule platform for investigation of interactions between G-quadruplexes and small-molecule ligands

(2011) Deepak Koirala et al.   Nature Chemistry

NF-κB regulates DNA double-strand break repair in conjunction with BRCA1–CtIP complexes

(2011) Meta Volcic et al.   NUCLEIC ACIDS RESEARCH

Genome Instability and Transcription Elongation Impairment in Human Cells Depleted of THO/TREX

(2011) María S. Domínguez-Sánchez et al.   PLoS Genetics

DEAD box 1: a novel and independent prognostic marker for early recurrence in breast cancer

(2010) Devon R. Germain et al.   BREAST CANCER RESEARCH AND TREATMENT

Targeted Inhibition of Replication Protein A Reveals Cytotoxic Activity, Synergy with Chemotherapeutic DNA-Damaging Agents, and Insight into Cellular Function

(2010) S. C. Shuck et al.   CANCER RESEARCH

Targeting RNA Polymerase I with an Oral Small Molecule CX-5461 Inhibits Ribosomal RNA Synthesis and Solid Tumor Growth

(2010) Denis Drygin et al.   CANCER RESEARCH

Unwinding the functions of the Pif1 family helicases

(2010) Matthew L. Bochman et al.   DNA REPAIR

Small-molecule-mediated G-quadruplex isolation from human cells

(2010) Sebastian Müller et al.   Nature Chemistry

Abundant ribonucleotide incorporation into DNA by yeast replicative polymerases

(2010) S. A. Nick McElhinny et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An in vitro model of differentiation of memory B cells into plasmablasts and plasma cells including detailed phenotypic and molecular characterization

(2009) M. Jourdan et al.   BLOOD

Targeting the Fanconi Anemia/BRCA Pathway Circumvents Drug Resistance in Multiple Myeloma

(2009) D. N. Yarde et al.   CANCER RESEARCH

Ribonuclease H: the enzymes in eukaryotes

(2009) Susana M. Cerritelli et al.   FEBS Journal

Sem1 is a functional component of the nuclear pore complex–associated messenger RNA export machinery

(2009) Marius Boulos Faza et al.   JOURNAL OF CELL BIOLOGY

The S-Phase Checkpoint Is Required To Respond to R-Loops Accumulated in THO Mutants

(2009) B. Gomez-Gonzalez et al.   MOLECULAR AND CELLULAR BIOLOGY

Genomics screen in transformed stem cells reveals RNASEH2A, PPAP2C, and ADARB1 as putative anticancer drug targets

(2009) J. M. Flanagan et al.   MOLECULAR CANCER THERAPEUTICS

The Yeast Pif1 Helicase Prevents Genomic Instability Caused by G-Quadruplex-Forming CEB1 Sequences In Vivo

(2009) Cyril Ribeyre et al.   PLoS Genetics

How Shelterin Protects Mammalian Telomeres

(2008) Wilhelm Palm et al.   Annual Review of Genetics

Recognition of the unique structure of DNA:RNA hybrids

(2008) Nicholas N. Shaw et al.   BIOCHIMIE

Structures, folding patterns, and functions of intramolecular DNA G-quadruplexes found in eukaryotic promoter regions

(2008) Yong Qin et al.   BIOCHIMIE

Luteolin, a Flavonoid with Potential for Cancer Prevention and Therapy

(2008) Yong Lin et al.   CURRENT CANCER DRUG TARGETS

A novel cell-free screen identifies a potent inhibitor of the Fanconi anemia pathway

(2008) Igor Landais et al.   INTERNATIONAL JOURNAL OF CANCER

Processing of G4 DNA by Dna2 Helicase/Nuclease and Replication Protein A (RPA) Provides Insights into the Mechanism of Dna2/RPA Substrate Recognition

(2008) Taro Masuda-Sasa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

FANCJ Is a Structure-specific DNA Helicase Associated with the Maintenance of Genomic G/C Tracts

(2008) Timothy B. C. London et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Human RecQ Helicases, BLM and RECQ1, Display Distinct DNA Substrate Specificities

(2008) Venkateswarlu Popuri et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Novel Small Molecule That Alters Shelterin Integrity and Triggers a DNA-Damage Response at Telomeres

(2008) Raphaël Rodriguez et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The Histone Acetyltransferase PCAF Associates with Actin and hnRNP U for RNA Polymerase II Transcription

(2008) A. Obrdlik et al.   MOLECULAR AND CELLULAR BIOLOGY

FANCJ Helicase Defective in Fanconia Anemia and Breast Cancer Unwinds G-Quadruplex DNA To Defend Genomic Stability

(2008) Y. Wu et al.   MOLECULAR AND CELLULAR BIOLOGY

A Role for DEAD Box 1 at DNA Double-Strand Breaks

(2008) L. Li et al.   MOLECULAR AND CELLULAR BIOLOGY

A Genetic Interaction Map of RNA-Processing Factors Reveals Links between Sem1/Dss1-Containing Complexes and mRNA Export and Splicing

(2008) Gwendolyn M. Wilmes et al.   MOLECULAR CELL

A forward chemical genetic screen reveals an inhibitor of the Mre11–Rad50–Nbs1 complex

(2008) Aude Dupré et al.   Nature Chemical Biology

Phosphorylation of human PRP28 by SRPK2 is required for integration of the U4/U6-U5 tri-snRNP into the spliceosome

(2008) Rebecca Mathew et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The exosome: a multipurpose RNA-decay machine

(2008) Manfred Schmid et al.   TRENDS IN BIOCHEMICAL SCIENCES