XRN2 Links Transcription Termination to DNA Damage and Replication Stress

Repair Pathway Choices and Consequences at the Double-Strand Break

(2016) Raphael Ceccaldi et al.   TRENDS IN CELL BIOLOGY

RRP6/EXOSC10 is required for the repair of DNA double-strand breaks by homologous recombination

(2015) C. Marin-Vicente et al.   JOURNAL OF CELL SCIENCE

Effects of Transcription Elongation Rate and Xrn2 Exonuclease Activity on RNA Polymerase II Termination Suggest Widespread Kinetic Competition

(2015) Nova Fong et al.   MOLECULAR CELL

BRCA1 Recruitment to Transcriptional Pause Sites Is Required for R-Loop-Driven DNA Damage Repair

(2015) Elodie Hatchi et al.   MOLECULAR CELL

The core spliceosome as target and effector of non-canonical ATM signalling

(2015) Maria Tresini et al.   NATURE

Senataxin suppresses the antiviral transcriptional response and controls viral biogenesis

(2015) Matthew S Miller et al.   NATURE IMMUNOLOGY

Systematic screening reveals a role for BRCA1 in the response to transcription-associated DNA damage

(2014) Sarah J. Hill et al.   GENES & DEVELOPMENT

Transcription-Coupled Nucleotide Excision Repair Factors Promote R-Loop-Induced Genome Instability

(2014) Julie Sollier et al.   MOLECULAR CELL

R-loops induce repressive chromatin marks over mammalian gene terminators

(2014) Konstantina Skourti-Stathaki et al.   NATURE

BRCA2 prevents R-loop accumulation and associates with TREX-2 mRNA export factor PCID2

(2014) Vaibhav Bhatia et al.   NATURE

Kub5-Hera, the human Rtt103 homolog, plays dual functional roles in transcription termination and DNA repair

(2014) Julio C. Morales et al.   NUCLEIC ACIDS RESEARCH

Human single-stranded DNA binding protein 1 (hSSB1/NABP2) is required for the stability and repair of stalled replication forks

(2014) Emma Bolderson et al.   NUCLEIC ACIDS RESEARCH

The causes of replication stress and their consequences on genome stability and cell fate

(2014) Indiana Magdalou et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Causes of Genome Instability

(2013) Andrés Aguilera et al.   Annual Review of Genetics

DNA repair mechanisms in dividing and non-dividing cells

(2013) Teruaki Iyama et al.   DNA REPAIR

GC skew at the 5' and 3' ends of human genes links R-loop formation to epigenetic regulation and transcription termination

(2013) P. A. Ginno et al.   GENOME RESEARCH

A Cell Cycle-Dependent Regulatory Circuit Composed of 53BP1-RIF1 and BRCA1-CtIP Controls DNA Repair Pathway Choice

(2013) Cristina Escribano-Díaz et al.   MOLECULAR CELL

The RNA exosome and proteasome: common principles of degradation control

(2013) Debora L. Makino et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Transcription-replication encounters, consequences and genomic instability

(2013) Anne Helmrich et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Senataxin Plays an Essential Role with DNA Damage Response Proteins in Meiotic Recombination and Gene Silencing

(2013) Olivier J. Becherel et al.   PLoS Genetics

Kinase-dead ATM protein causes genomic instability and early embryonic lethality in mice

(2012) Kenta Yamamoto et al.   JOURNAL OF CELL BIOLOGY

Senataxin, Defective in the Neurodegenerative Disorder Ataxia with Oculomotor Apraxia 2, Lies at the Interface of Transcription and the DNA Damage Response

(2012) O. Yuce et al.   MOLECULAR AND CELLULAR BIOLOGY

R Loops: From Transcription Byproducts to Threats to Genome Stability

(2012) Andrés Aguilera et al.   MOLECULAR CELL

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Involvement of Matrin 3 and SFPQ/NONO in the DNA damage response

(2011) Maayan Salton et al.   CELL CYCLE

Ending the message: poly(A) signals then and now

(2011) N. J. Proudfoot   GENES & DEVELOPMENT

Collisions between Replication and Transcription Complexes Cause Common Fragile Site Instability at the Longest Human Genes

(2011) Anne Helmrich et al.   MOLECULAR CELL

RNase H and Multiple RNA Biogenesis Factors Cooperate to Prevent RNA:DNA Hybrids from Generating Genome Instability

(2011) Lamia Wahba et al.   MOLECULAR CELL

Human Senataxin Resolves RNA/DNA Hybrids Formed at Transcriptional Pause Sites to Promote Xrn2-Dependent Termination

(2011) Konstantina Skourti-Stathaki et al.   MOLECULAR CELL

Loss of Topoisomerase I leads to R-loop-mediated transcriptional blocks during ribosomal RNA synthesis

(2010) A. El Hage et al.   GENES & DEVELOPMENT

Ku Regulates the Non-Homologous End Joining Pathway Choice of DNA Double-Strand Break Repair in Human Somatic Cells

(2010) Farjana Fattah et al.   PLoS Genetics

Transcription termination by nuclear RNA polymerases

(2009) P. Richard et al.   GENES & DEVELOPMENT

Human PSF binds to RAD51 and modulates its homologous-pairing and strand-exchange activities

(2009) Y. Morozumi et al.   NUCLEIC ACIDS RESEARCH

Involvement of p54(nrb), a PSF partner protein, in DNA double-strand break repair and radioresistance

(2009) Shuyi Li et al.   NUCLEIC ACIDS RESEARCH