Article
Biochemistry & Molecular Biology
Olga M. Koper-Lenkiewicz, Kinga Sutkowska, Natalia Wawrusiewicz-Kurylonek, Ewa Kowalewska, Joanna Matowicka-Karna
Summary: Studies have shown that the relationship between SNPs in proinflammatory cytokines genes and susceptibility to developing RA is inconclusive and varies among different ethnic populations. These polymorphisms also have an impact on clinicopathological features of RA and patients' response to treatment. Further research on larger cohorts and diverse populations is needed to elucidate the role of these SNPs in RA patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Nizar J. Bahlis, Caitlin L. Costello, Noopur S. Raje, Moshe Y. Levy, Bhagirathbhai Dholaria, Melhem Solh, Michael H. Tomasson, Michael A. Damore, Sibo Jiang, Cynthia Basu, Athanasia Skoura, Edward M. Chan, Suzanne Trudel, Andrzej Jakubowiak, Cristina Gasparetto, Michael P. Chu, Andrew Dalovisio, Michael Sebag, Alexander M. Lesokhin
Summary: In the first-in-human trial of elranatamab, patients with refractory or relapsed multiple myeloma who received the bispecific antibody against BCMA and CD3 experienced no dose-limiting toxicities during dose escalation, and the agent showed promising clinical efficacy.
Article
Biochemistry & Molecular Biology
Bing Wen, Dan-Xia Deng, Lian-Di Liao, Zhi-Da Zhang, Ya-Qi Zheng, Ke Dong, Li-Yan Xu, En-Min Li
Summary: In this study, CHAF1A and PCNA were identified as key cell cycle-related proteins leading to the malignant progression of esophageal cancer. These proteins could serve as important prognostic biomarkers and targets for esophageal cancer.
Article
Multidisciplinary Sciences
Naito Ishimoto, Jae-Hyun Park, Kouki Kawakami, Michiko Tajiri, Kenji Mizutani, Satoko Akashi, Jeremy R. H. Tame, Asuka Inoue, Sam-Yong Park
Summary: Neutrophil granulocytes play key roles in innate immunity and shaping adaptive immune responses. The chemokine CXCL8 and its receptors CXCR1 and CXCR2 are crucial in this process and the development of cancers. By solving the structure of CXCR1 complexed with CXCL8 and G-proteins using cryo-EM, the authors reveal the detailed interactions and ligand preferences of this receptor. This study provides valuable insights for structure-based drug design targeting specific CXC chemokine receptor subtypes.
NATURE COMMUNICATIONS
(2023)
Article
Hematology
Ilseyar Akhmetzyanova, Tonya Aaron, Phillip Galbo, Anastasia Tikhonova, Igor Dolgalev, Masato Tanaka, Iannis Aifantis, Deyou Zheng, Xingxing Zang, David Fooksman
Summary: The dissemination and progression of multiple myeloma is associated with an increased inflammatory signature in bone marrow MPs, with CD169(+) MPs playing a critical role in the early spread of myeloma.
Article
Microbiology
Fuchun Zhang, Lingling Sun, Mark K. Lafferty, Joseph B. Margolick, Alfredo Garzino-Demo
Summary: HIV infection leads to the inhibition of CCR6 chemokine MIP-3 alpha, resulting in the loss of immune function and the progression of AIDS.
Article
Biochemistry & Molecular Biology
Aurelien Philippe, Mathilde Puel, Celine Narjoz, Nicolas Gendron, Marie Agnes Durey-Dragon, Benoit Vedie, Malika Balduyck, Richard Chocron, Caroline Hauw-Berlemont, Olivier Sanchez, Tristan Mirault, Jean-Luc Diehl, David M. Smadja, Marie Anne Loriot
Summary: This study examines the ability of alpha-1-antitrypsin (AAT) to predict thrombosis and in-hospital mortality during COVID-19. The results show that patients with higher levels of AAT are more prone to thrombosis and have a higher survival rate. There is no significant correlation between abnormal AAT variants and thrombosis.
Article
Medicine, General & Internal
Weronika Pawlik, Jakub Pawlik, Mateusz Kozlowski, Karolina Luczkowska, Sebastian Kwiatkowski, Ewa Kwiatkowska, Boguslaw Machalinski, Aneta Cymbaluk-Ploska
Summary: This study found that serum levels of IL-8 and TNF-alpha were significantly higher in ovarian cancer patients compared to patients with benign ovarian cysts, and they can be used as new useful markers for predicting ovarian cancer. IL-8 and TNF-alpha have a sensitivity and specificity of 70% and 96%, and 85.7% and 79.3% respectively, indicating their utility in predicting the malignant nature of ovarian lesions.
Article
Biochemistry & Molecular Biology
Sham Mailankody, Jeffrey V. Matous, Saurabh Chhabra, Michaela Liedtke, Surbhi Sidana, Olalekan O. Oluwole, Shahbaz Malik, Rajneesh Nath, Faiz Anwer, Jose Carlos Cruz, Myo Htut, Erin E. Karski, Wade Lovelace, Myles Dillon, Eric Butz, Wendy Ying, Arun Balakumaran, Shaji K. Kumar
Summary: In an interim phase 1 trial analysis, escalating doses of off-the-shelf allogeneic anti-BCMA CAR T cells, in combination with an anti-CD52 antibody-containing lymphodepletion regimen, were shown to be feasible and safe for the treatment of relapsed or refractory multiple myeloma.
Article
Oncology
Paula Roberta Aguiar Pastrez, Ana Margarida Barbosa, Vania Sammartino Mariano, Rhafaela Lima Causin, Antonio Gil Castro, Egidio Torrado, Adhemar Longatto-Filho
Summary: Esophageal squamous cell carcinoma (ESCC) is a rapidly progressing cancer with high mortality rates. In this study, we investigated the levels of inflammatory cytokines in ESCC patients and healthy individuals. We found increased levels of IL-1 beta, IL-6, IL-8, and IL-10 in ESCC patients. Among these cytokines, IL-8 was identified as an independent prognostic factor for ESCC. Additionally, patients with low IL-6, IL-8, TNM I/II, or those who underwent surgery had a higher overall survival rate. Our findings suggest IL-8 as a potential biomarker for ESCC.
Article
Cell Biology
Yasukazu Saitoh, Nene Yonekura, Daigo Matsuoka, Akira Matsumoto
Summary: The study demonstrates that molecular hydrogen (H-2) significantly inhibits the secretion of inflammatory factors IL-1α and IL-6 induced by Porphyromonas gingivalis lipopolysaccharide (Pg LPS), providing a new approach for the treatment of periodontitis.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Charlotte Rose Lemech, Ganessan Kichenadasse, Jens-Peter Marschner, Konstantinos Alevizopoulos, Marit Otterlei, Michael Millward
Summary: Proliferating Cell Nuclear Antigen (PCNA) is a highly conserved protein essential for DNA replication, repair and scaffold functions in the cytosol. Inhibition of PCNA in cancer cells with ATX-101 has been shown to have anti-cancer activity and enhance the effectiveness of anti-cancer therapies.
Article
Medicine, Research & Experimental
Ying Zhang, Qinghui Zhuang, Fang Wang, Can Zhang, Chang Xu, Aiqin Gu, William H. Zhong, Yi Hu, Xiaosong Zhong
Summary: In this study, we successfully constructed CD19 specific armored CAR-T cells overexpressing IL-15 and IL-15 receptor alpha (IL-15Ra). CAR-T cells overexpressing IL-15 alone showed enhanced viability and superior tumor-inhibitory effects, but also resulted in serious liver injuries in tumor-free mice. However, CAR-T cells overexpressing IL-15 combined with IL-15Ra had reduced adverse effects and improved mouse survival.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Review
Oncology
Li-Juan Liu, Jian-Ming Liao, Fan Zhu
Summary: GI cancers are a leading cause of death globally due to their poor prognosis, making it urgent to investigate potential molecular targets for prediction, diagnosis, prognosis, and therapy. PCLAF, a key factor in cell proliferation and apoptosis, plays a significant role in GI cancers by contributing to various malignant properties. It is also implicated in other cancers and autoimmune diseases through dysregulation of multiple signaling pathways. Suppression of PCLAF/PCNA interaction or PCLAF expression may be a promising therapeutic strategy for GI cancers.
WORLD JOURNAL OF GASTROINTESTINAL ONCOLOGY
(2021)
Review
Immunology
Wei-Jie Xu, Qiong Wu, Wen-Ni He, Shang Wang, Ya-Lin Zhao, Jun-Xia Huang, Xue-Shen Yan, Rong Jiang
Summary: Pulmonary hypertension is a complex pulmonary vascular disease with high morbidity and mortality. Inflammatory factors, particularly interleukin-6 (IL-6), play a crucial role in its pathogenesis. This review discusses the potential role of IL-6 in accelerating the progression of pulmonary hypertension, as well as the specific mechanisms and signaling pathways involved. Current drugs targeting inflammatory pathways are also summarized, providing a theoretical basis for future targeted treatment in patients with pulmonary hypertension.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Medicine, Research & Experimental
Seyed Sajjad Babaeimarzangou, Himasadat Zaker, Ehsan Soleimannezhadbari, Naeimeh Shamsi Gamchi, Masoud Kazeminia, Shima Tarighi, Homayon Seyedian, Aristidis Tsatsakis, Demetrios A. Spandidos, Denisa Margina
Summary: Zoonotic viral diseases have become a major threat to global public health and economies in recent times. The lack of vaccines and effective antiviral drugs against most of these viruses increases the risk of new outbreaks. This review provides an update on the progress of vaccine development in clinical trials for various zoonotic viruses.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2023)
Article
Medicine, General & Internal
Ismail Topal, Mustafa Yasar Ozdamar, Tulin Catakli, Ismail Malkoc, Ahmet Hacimuftuoglu, Charalampos Mamoulakis, Aristidis Tsatsakis, Konstantinos Tsarouhas, Christina Tsitsimpikou, Ali Taghizadehghalehjoughi
Summary: This study aimed to evaluate the renoprotective effects of taxifolin (TXF) in a paracetamol (PAR)-induced nephrotoxicity rat model. The results showed that the levels of blood urea nitrogen, creatinine and malondialdehyde were significantly increased in the PAR group, while the levels of glutathione peroxidase, glutathione reductase and total glutathione were significantly higher in the TXF group. Histopathological examination revealed severe tubular epithelium damage in the PAR group, while the TXF group showed mild dilated/congested blood vessels. These findings suggest that TXF has potential renoprotective effects against PAR-induced nephrotoxicity through its antioxidant activity and should be further investigated.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Pharmacology & Pharmacy
Sidika Genc, Ali Taghizadehghalehjoughi, Yesim Yeni, Abbas Jafarizad, Ahmet Hacimuftuoglu, Dragana Nikitovic, Anca Oana Docea, Yaroslav Mezhuev, Aristidis Tsatsakis
Summary: In this study, the combination of Fe3O4 NPs and 5-FU showed a synergistic cytotoxic effect on Caco-2 cells at concentrations below the active drug threshold levels.
Article
Environmental Sciences
K. Yu Maksimovich, R. Yu Dudko, E. I. Shatalova, A. K. Tsakalof, A. M. Tsatsakis, K. S. Golokhvast, E. A. Novikov
Summary: The detrimental environmental consequences caused by intensification of crop cultivation can be prevented through monitoring of specific biological indicators. This study focused on the impact of crop type and cultivation intensity on the community of ground beetles in the forest-steppe of Western Siberia. The ground beetles' community showed a high evenness of species distribution across the agroecosystems. Differences in ground beetle distribution were observed between wheat and corn crops. The use of bioindicators allowed for assessing the environmental sustainability of the agricultural environment and provided insights for ecologically directed correction of agrotechnological operations in agroecosystem management.
ENVIRONMENTAL RESEARCH
(2023)
Article
Pharmacology & Pharmacy
Daniela-Madalina Ciuca Anghel, Ana-Maria Vlasceanu, Gheorghe Tudor, Anne-Marie Ciobanu, Miriana Stan, Gabriela Viorela Nitescu, Dimitra Florou, Aristidis M. Tsatsakis, Daniela Luiza Baconi
Summary: The aim of our study was to evaluate the differences among different groups of drug users, focusing on hematological, biochemical, urinary, and cardiological aspects. A retrospective study was conducted on 2572 hospitalized patients in Bucharest, Romania from 2015 to 2021. The study group was characterized based on demographic data, personal history/co-morbidities, consumption history, and substitution treatment. The analysis of medical records revealed correlations between GGT levels and alcohol intake as well as contagious diseases, a decrease in MCH and MCHC levels across the entire study group, and correlations between specific cardiological events and certain substance groups. The study provides important information on different types of drug users and supports future research on the chemical structures of consumed compounds.
Review
Medicine, Research & Experimental
Michael Aschner, Anatoly V. Skalny, Viktor A. Gritsenko, Olga L. Kartashova, Abel Santamaria, Joao B. T. Rocha, Demetrios A. Spandidos, Irina P. Zaitseva, Aristidis Tsatsakis, Alexey A. Tinkov
Summary: The aim of this study was to summarize the potential interactive effects between the gut microbiota and advanced glycation end-product (AGE) accumulation and toxicity in the host, and to reveal the mediating effects of the gut microbiota on AGE-related health effects. Existing data demonstrates that dietary AGEs can significantly impact the richness and diversity of the gut microbiota, with specific effects depending on species type and exposure dose. Additionally, the gut microbiota may metabolize dietary AGEs. The characteristics of the gut microbiota, including richness and relative abundance of certain taxa, are closely associated with AGE accumulation in the host organism. In turn, the interplay between AGE toxicity and modulation of the gut microbiota may contribute to aging and diabetes-associated diseases. Bacterial endotoxin lipopolysaccharide appears to mediate the interactions between the gut microbiota and AGE toxicity, specifically through modulation of the receptor for AGE signaling. Therefore, modulation of the gut microbiota using probiotics or other dietary interventions may significantly impact AGE-induced glycative stress and systemic inflammation.
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Vasiliki Karzi, Eren Ozcagli, Manolis N. Tzatzarakis, Elena Vakonaki, Irene Fragkiadoulaki, Aikaterini Kalliantasi, Christina Chalkiadaki, Athanasios Alegakis, Polychronis Stivaktakis, Aikaterini Karzi, Antonios Makrigiannakis, Anca Oana Docea, Daniela Calina, Aristidis Tsatsakis
Summary: Exposure to combined endocrine disruptors can cause DNA damage, as observed in this study using comet and micronuclei assays. The highest level of damage was found in the group exposed to a high-dose mixture of substances, particularly glyphosate. The micronuclei assay results were moderately correlated with exposure period, and all exposure groups showed an increasing trend in micronuclei counts over time.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Oncology
Aristidis Tsatsakis, Tatiana Oikonomopoulou, Taxiarchis Konstantinos Nikolouzakis, Elena Vakonaki, Manolis Tzatzarakis, Matthaios Flamourakis, Elisavet Renieri, Persefoni Fragkiadaki, Evaggelia Iliaki, Maria Bachlitzanaki, Vasiliki Karzi, Ioanna Katsikantami, Fotios Kakridonis, Eleftheria Hatzidaki, Maria Tolia, Andrey A. Svistunov, Demetrios A. Spandidos, Dragana Nikitovic, John Tsiaoussis, Aikaterini Berdiaki
Summary: Cancer is a major issue in clinical, social, and economic aspects, ranking highest in terms of cause-specific disability-adjusted life years among all human pathologies. The trigger of cancer involves various factors, including genetic predisposition and telomere status, which are DNA structures at the end of chromosomes. However, there is no universal trend in the association between telomere length and cancer, as both short and long telomeres have been linked to high cancer incidence risks. This review aims to present the complex relationship between telomere length and cancer comprehensively.
INTERNATIONAL JOURNAL OF ONCOLOGY
(2023)
Review
Toxicology
Yuliya V. Ryabova, Marina P. Sutunkova, Ilzira A. Minigalieva, Lada V. Shabardina, Tommaso Filippini, Aristides Tsatsakis
Summary: This paper provides a comprehensive summary of the toxicological studies conducted on selenium nanoparticles (NPs) using laboratory animals. In vivo studies have shown adverse effects of selenium NPs on laboratory animals, including reductions in body mass, changes in hepatotoxicity indices, and possible impairment of metabolic processes. However, no specific toxic action solely attributable to selenium has been identified. The LOAEL and NOAEL values are contradictory, and the relationship between the adverse effects of selenium NPs and exposure dose is controversial and diverse.
JOURNAL OF APPLIED TOXICOLOGY
(2023)
Article
Oncology
Ozgur Celebi, Ali Taghizadehghalehjoughi, Demet Celebi, Robin Mesnage, Kirill Sergeevich Golokhvast, Andreea Letitia Arsene, Demetrios A. Spandidos, Aristidis Tsatsakis
Summary: The gut microbiota is important for maintaining health and regulating immune response. Probiotics and vitamins can improve microbial population and prevent tight junction protein breakdown. The study evaluated the effects of vitamins and probiotics on Escherichia coli and Staphylococcus aureus.
MOLECULAR MEDICINE REPORTS
(2023)
Article
Biochemistry & Molecular Biology
Betul Danisman, Betul Cicek, Serkan Yildirim, Ismail Bolat, Deniz Kantar, Kirill S. Golokhvast, Dragana Nikitovic, Aristidis Tsatsakis, Ali Taghizadehghalehjoughi
Summary: This study aimed to investigate the impact of carnosic acid (CA) on indomethacin (IND)-induced gastric ulceration. The results showed that CA pretreatment attenuated both gross morphological lesions and histopathological alterations induced by IND, and it achieved gastroprotective effects by reducing oxidative stress and suppressing inflammation.
Article
Health Care Sciences & Services
Betul Cicek, Ahmet Hacimuftuoglu, Yesim Yeni, Betul Danisman, Mustafa Ozkaraca, Behzad Mokhtare, Mecit Kantarci, Marios Spanakis, Dragana Nikitovic, Georgios Lazopoulos, Konstantinos Tsarouhas, Aristidis Tsatsakis, Ali Taghizadehghalehjoughi
Summary: This research evaluated the cardioprotective properties of chlorogenic acid (CGA) in doxorubicin (DOX)-induced cardiotoxicity and identified one of the possible mechanisms for its protective effects. The study found that CGA ameliorated oxidative stress and cardiomyocyte apoptosis by upregulating the Nrf2/HO-1-dependent pathway and downregulating dityrosine (DT) expression. These findings suggest that CGA may be cardioprotective, particularly in patients receiving DOX-based chemotherapy.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Environmental Sciences
Cigdem Sevim, Erol Akpinar, Emrah Hicazi Aksu, Ali Dogan Omur, Serkan Yildirim, Mehtap Kara, Ismail Bolat, Aristides Tsatsakis, Robin Mesnage, Kirill S. S. Golokhvast, Sevgi Karabulut Uzuncakmak, Rabia Nilufer Ersoylu
Summary: The study aimed to investigate the positive effects of probiotic Saccharomyces boulardii on the male reproductive system under low dose neonicotinoid pesticide exposure conditions. Acetamiprid and imidacloprid caused degeneration and necrosis of spermatocytes, severe edema of the intertubular region, and hyperemia. This was accompanied by increased oxidative stress and apoptosis. Saccharomyces boulardii supplementation mitigated these toxic effects.
Article
Biochemistry & Molecular Biology
Betul Cicek, Betul Danisman, Serkan Yildirim, Neslihan Yuce, Dragana Nikitovic, Ismail Bolat, Mehmet Kuzucu, Ertugrul Ceyran, Ebru Bardas, Kirill S. Golokhvast, Aristidis Tsatsakis, Ali Taghizadehghalehjoughi
Summary: SN berry extract has protective effects against IND-induced gastric ulcers in rats by reducing oxidative damage and inflammation in the gastric mucosa.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Environmental Sciences
Yuliya V. Ryabova, Ilzira A. Minigalieva, Marina P. Sutunkova, Svetlana V. Klinova, Alexandra K. Tsaplina, Irene E. Valamina, Ekaterina M. Petrunina, Aristides M. Tsatsakis, Charalampos Mamoulakis, Kostas Stylianou, Sergey V. Kuzmin, Larisa I. Privalova, Boris A. Katsnelson
Summary: This study found that chronic diseases of the urogenital tract can develop under the effects of chemical hazards in the working environment, particularly from nanosized particles generated in industrial processes. The researchers studied the nephrotoxicity of element oxide nanoparticles through animal experiments, and found that these nanoparticles had a toxic effect on the kidneys and caused changes in kidney function and histological structure. The results of this study are important for the early diagnosis of occupational and nonoccupational nephropathies.