Type 1 diabetes mellitus as a disease of the β-cell (do not blame the immune system?)

Beta-Cell Stress Shapes CTL Immune Recognition of Preproinsulin Signal Peptide by Post-Transcriptional Regulation of Endoplasmic Reticulum Aminopeptidase 1

(2020) Sofia Thomaidou et al.   DIABETES

Oral butyrate does not affect innate immunity and islet autoimmunity in individuals with longstanding type 1 diabetes: a randomised controlled trial

(2020) Pieter F. de Groot et al.   DIABETOLOGIA

Studies of insulin and proinsulin in pancreas and serum support the existence of aetiopathological endotypes of type 1 diabetes associated with age at diagnosis

(2020) Pia Leete et al.   DIABETOLOGIA

Safety and feasibility of intradermal injection with tolerogenic dendritic cells pulsed with proinsulin peptide—for type 1 diabetes

(2020) Tatjana Nikolic et al.   Lancet Diabetes & Endocrinology

Presumption of innocence for beta cells: why are they vulnerable autoimmune targets in type 1 diabetes?

(2020) Roberto Mallone et al.   DIABETOLOGIA

Association of Rotavirus Vaccination With the Incidence of Type 1 Diabetes in Children

(2019) Kirsten P. Perrett et al.   JAMA Pediatrics

Beta cells in type 1 diabetes: mass and function; sleeping or dead?

(2019) Richard A. Oram et al.   DIABETOLOGIA

A Map of Human Type 1 Diabetes Progression by Imaging Mass Cytometry

(2019) Nicolas Damond et al.   Cell Metabolism

Multiplexed In Situ Imaging Mass Cytometry Analysis of the Human Endocrine Pancreas and Immune System in Type 1 Diabetes

(2019) Yue J. Wang et al.   Cell Metabolism

Targeted Elimination of Senescent Beta Cells Prevents Type 1 Diabetes

(2019) Peter J. Thompson et al.   Cell Metabolism

Immune checkpoint inhibitors and type 1 diabetes mellitus: a case report and systematic review

(2019) Jeroen M.k. de Filette et al.   EUROPEAN JOURNAL OF ENDOCRINOLOGY

Checkpoint inhibitor associated autoimmune diabetes (CIADM) is distinct from type 1 diabetes

(2019) Venessa H M Tsang et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Genetic and Environmental Interaction in Type 1 Diabetes: a Relationship Between Genetic Risk Alleles and Molecular Traits of Enterovirus Infection?

(2019) Marfa Blanter et al.   Current Diabetes Reports

Alterations in Beta Cell Identity in Type 1 and Type 2 Diabetes

(2019) Abu Saleh Md Moin et al.   Current Diabetes Reports

Aging and stress induced β cell senescence and its implication in diabetes development

(2019) Na Li et al.   Aging-US

Introducing the Endotype Concept to Address the Challenge of Disease Heterogeneity in Type 1 Diabetes

(2019) Manuela Battaglia et al.   DIABETES CARE

Clinical and genetic correlates of islet-autoimmune signatures in juvenile-onset type 1 diabetes

(2019) Laura A. Claessens et al.   DIABETOLOGIA

The impact of proinflammatory cytokines on the β-cell regulatory landscape provides insights into the genetics of type 1 diabetes

(2019) Mireia Ramos-Rodríguez et al.   NATURE GENETICS

A viral link for type 1 diabetes

(2019) Bart O. Roep   NATURE MEDICINE

Prospective virome analyses in young children at increased genetic risk for type 1 diabetes

(2019) Kendra Vehik et al.   NATURE MEDICINE

Gut Microbiota-Stimulated Innate Lymphoid Cells Support β-Defensin 14 Expression in Pancreatic Endocrine Cells, Preventing Autoimmune Diabetes

(2018) Michela Miani et al.   Cell Metabolism

Loss of IDO1 Expression From Human Pancreatic β-Cells Precedes Their Destruction During the Development of Type 1 Diabetes

(2018) Florence Anquetil et al.   DIABETES

Collateral Damage: Insulin-Dependent Diabetes Induced With Checkpoint Inhibitors

(2018) Angeliki M. Stamatouli et al.   DIABETES

C-Peptide Decline in Type 1 Diabetes Has Two Phases: An Initial Exponential Fall and a Subsequent Stable Phase

(2018) Beverley M. Shields et al.   DIABETES CARE

Gut Microbiota and Type 1 Diabetes

(2018) Hui Han et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

IAPP and type 1 diabetes: implications for immunity, metabolism and islet transplants

(2018) Heather C Denroche et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

Verapamil and beta cell function in adults with recent-onset type 1 diabetes

(2018) Fernando Ovalle et al.   NATURE MEDICINE

T cells specific for post-translational modifications escape intrathymic tolerance induction

(2018) Bruno Raposo et al.   Nature Communications

Increased RNA Editing May Provide a Source for Autoantigens in Systemic Lupus Erythematosus

(2018) Shalom Hillel Roth et al.   Cell Reports

Pancreatic Beta Cell Death: Novel Potential Mechanisms in Diabetes Therapy

(2018) Joselyn Rojas et al.   Journal of Diabetes Research

Conventional and Neo-Antigenic Peptides Presented by β Cells Are Targeted by Circulating Naïve CD8+ T Cells in Type 1 Diabetic and Healthy Donors

(2018) Sergio Gonzalez-Duque et al.   Cell Metabolism

Short chain fatty acids stimulate insulin secretion and reduce apoptosis in mouse and human islets in vitro: role of FFAR2

(2018) A. Pingitore et al.   DIABETES OBESITY & METABOLISM

Islet stress, degradation and autoimmunity

(2018) Sofia Thomaidou et al.   DIABETES OBESITY & METABOLISM

When one becomes many-Alternative splicing in β-cell function and failure

(2018) Maria Inês Alvelos et al.   DIABETES OBESITY & METABOLISM

Fifty years of pancreatic islet pathology in human type 1 diabetes: insights gained and progress made

(2018) Noel G. Morgan et al.   DIABETOLOGIA

Unexpected subcellular distribution of a specific isoform of the Coxsackie and adenovirus receptor, CAR-SIV, in human pancreatic beta cells

(2018) Eseoghene Ifie et al.   DIABETOLOGIA

Pancreatic islets communicate with lymphoid tissues via exocytosis of insulin peptides

(2018) Xiaoxiao Wan et al.   NATURE

RNA editing derived epitopes function as cancer antigens to elicit immune responses

(2018) Minying Zhang et al.   Nature Communications

Association between maternal gluten intake and type 1 diabetes in offspring: national prospective cohort study in Denmark

(2018) Julie C Antvorskov et al.   BMJ-British Medical Journal

PDL1 is expressed in the islets of people with type 1 diabetes and is up-regulated by interferons-α and-γ via IRF1 induction

(2018) Maikel L. Colli et al.   EBioMedicine

Histone deacetylase inhibitor MGCD0103 protects the pancreas from streptozotocin-induced oxidative stress and β-cell death

(2018) Hae-Ahm Lee et al.   BIOMEDICINE & PHARMACOTHERAPY

Disease-specific oligodendrocyte lineage cells arise in multiple sclerosis

(2018) Ana Mendanha Falcão et al.   NATURE MEDICINE

A low-gluten diet induces changes in the intestinal microbiome of healthy Danish adults

(2018) Lea B. S. Hansen et al.   Nature Communications

The challenge of modulating β-cell autoimmunity in type 1 diabetes

(2018) Mark A Atkinson et al.   Lancet Diabetes & Endocrinology

Antigen-based immune modulation therapy for type 1 diabetes: the era of precision medicine

(2018) Bart O Roep et al.   Lancet Diabetes & Endocrinology

Antibody Neutralization of CXCL10in VivoIs Dependent on Binding to Free and Not Endothelial-bound Chemokine

(2017) Pauline Bonvin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Autoimmunity against a defective ribosomal insulin gene product in type 1 diabetes

(2017) Maria J L Kracht et al.   NATURE MEDICINE

Long-term survival in paraneoplastic Lambert-Eaton myasthenic syndrome

(2017) Paul Maddison et al.   NEUROLOGY

Type 1 diabetes induction in humanized mice

(2017) Shulian Tan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Resident macrophages of pancreatic islets have a seminal role in the initiation of autoimmune diabetes of NOD mice

(2017) Javier A. Carrero et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Metabolic and immune effects of immunotherapy with proinsulin peptide in human new-onset type 1 diabetes

(2017) Mohammad Alhadj Ali et al.   Science Translational Medicine

Butyrate and propionate inhibit antigen-specific CD8+ T cell activation by suppressing IL-12 production by antigen-presenting cells

(2017) Claudia Nastasi et al.   Scientific Reports

Immunological Balance Is Associated with Clinical Outcome after Autologous Hematopoietic Stem Cell Transplantation in Type 1 Diabetes

(2017) Kelen C. R. Malmegrim et al.   Frontiers in Immunology

Human beta cell mass and function in diabetes: Recent advances in knowledge and technologies to understand disease pathogenesis

(2017) Chunguang Chen et al.   Molecular Metabolism

Human islets and dendritic cells generate post-translationally modified islet autoantigens

(2016) R. J. McLaughlin et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

A roadmap of the generation of neoantigens as targets of the immune system in type 1 diabetes

(2016) Bart O Roep et al.   CURRENT OPINION IN IMMUNOLOGY

Differential Insulitic Profiles Determine the Extent of β-Cell Destruction and the Age at Onset of Type 1 Diabetes

(2016) Pia Leete et al.   DIABETES

Islet-Derived CD4 T Cells Targeting Proinsulin in Human Autoimmune Diabetes

(2016) Aaron W. Michels et al.   DIABETES

Methylation of insulin DNA in response to proinflammatory cytokines during the progression of autoimmune diabetes in NOD mice

(2016) Jinxiu Rui et al.   DIABETOLOGIA

Short-Chain Fatty Acids Regulate Cytokines and Th17/Treg Cells in Human Peripheral Blood Mononuclear Cellsin vitro

(2016) M. Asarat et al.   IMMUNOLOGICAL INVESTIGATIONS

Increased Hormone-Negative Endocrine Cells in the Pancreas in Type 1 Diabetes

(2016) Abu Saleh Md Moin et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Dendritic Cells Guide Islet Autoimmunity through a Restricted and Uniquely Processed Peptidome Presented by High-Risk HLA-DR

(2016) Menno van Lummel et al.   JOURNAL OF IMMUNOLOGY

Endoplasmic reticulum stress and the unfolded protein response in pancreatic islet inflammation

(2016) Kira Meyerovich et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

Analysis of self-antigen specificity of islet-infiltrating T cells from human donors with type 1 diabetes

(2016) Jenny Aurielle B Babon et al.   NATURE MEDICINE

Type 1 diabetes cadaveric human pancreata exhibit a unique exocrine tissue proteomic profile

(2016) Chih-Wei Liu et al.   PROTEOMICS

Pathogenic CD4 T cells in type 1 diabetes recognize epitopes formed by peptide fusion

(2016) T. Delong et al.   SCIENCE

A Single-Cell Transcriptome Atlas of the Human Pancreas

(2016) Mauro J. Muraro et al.   Cell Systems

Proinsulin multi-peptide immunotherapy induces antigen-specific regulatory T cells and limits autoimmunity in a humanized model

(2015) V. B. Gibson et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Insulitis and β-Cell Mass in the Natural History of Type 1 Diabetes

(2015) Martha Campbell-Thompson et al.   DIABETES

Discovery of a Selective Islet Peptidome Presented by the Highest-Risk HLA-DQ8transMolecule

(2015) Menno van Lummel et al.   DIABETES

Pancreatic β-Cells Limit Autoimmune Diabetes via an Immunoregulatory Antimicrobial Peptide Expressed under the Influence of the Gut Microbiota

(2015) Jia Sun et al.   IMMUNITY

T cell receptor reversed polarity recognition of a self-antigen major histocompatibility complex

(2015) Dennis X Beringer et al.   NATURE IMMUNOLOGY

Pancreatic α Cells are Resistant to Metabolic Stress-induced Apoptosis in Type 2 Diabetes

(2015) Laura Marroqui et al.   EBioMedicine

Detection of a Low-Grade Enteroviral Infection in the Islets of Langerhans of Living Patients Newly Diagnosed With Type 1 Diabetes

(2014) Lars Krogvold et al.   DIABETES

Pancreatic biopsy by minimal tail resection in live adult patients at the onset of type 1 diabetes: experiences from the DiViD study

(2014) Lars Krogvold et al.   DIABETOLOGIA

Temporal profiling of cytokine-induced genes in pancreatic β-cells by meta-analysis and network inference

(2014) Miguel Lopes et al.   GENOMICS

The Effector T Cells of Diabetic Subjects Are Resistant to Regulation via CD4+FOXP3+ Regulatory T Cells

(2014) A. Schneider et al.   JOURNAL OF IMMUNOLOGY

Checkpoint blockade cancer immunotherapy targets tumour-specific mutant antigens

(2014) Matthew M. Gubin et al.   NATURE

Acceleration of the Loss of the First-Phase Insulin Response During the Progression to Type 1 Diabetes in Diabetes Prevention Trial-Type 1 Participants

(2013) J. M. Sosenko et al.   DIABETES

Posttranslational Modification of HLA-DQ Binding Islet Autoantigens in Type 1 Diabetes

(2013) M. van Lummel et al.   DIABETES

Do post-translational beta cell protein modifications trigger type 1 diabetes?

(2013) Joachim Størling et al.   DIABETOLOGIA

Plasmid-Encoded Proinsulin Preserves C-Peptide While Specifically Reducing Proinsulin-Specific CD8+ T Cells in Type 1 Diabetes

(2013) B. O. Roep et al.   Science Translational Medicine

Revisiting the notion of type 1 diabetes being a T-cell-mediated autoimmune disease

(2013) Oskar Skog et al.   Current Opinion in Endocrinology Diabetes and Obesity

Targeting of memory T cells with alefacept in new-onset type 1 diabetes (T1DAL study): 12 month results of a randomised, double-blind, placebo-controlled phase 2 trial

(2013) Mark R Rigby et al.   Lancet Diabetes & Endocrinology

CD8 T cell autoreactivity to preproinsulin epitopes with very low human leucocyte antigen class I binding affinity

(2012) J. R. F. Abreu et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Expression of endoplasmic reticulum stress markers in the islets of patients with type 1 diabetes

(2012) I. Marhfour et al.   DIABETOLOGIA

Post-transcriptional control of candidate risk genes for type 1 diabetes by rare genetic variants

(2012) V M de Jong et al.   GENES AND IMMUNITY

Pancreas Organ Weight in Individuals With Disease-Associated Autoantibodies at Risk for Type 1 Diabetes

(2012) Martha Campbell-Thompson et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Demonstration of islet-autoreactive CD8 T cells in insulitic lesions from recent onset and long-term type 1 diabetes patients

(2012) Ken T. Coppieters et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Self-reactive human CD4 T cell clones form unusual immunological synapses

(2012) David A. Schubert et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Structural basis for the killing of human beta cells by CD8+ T cells in type 1 diabetes

(2012) Anna M Bulek et al.   NATURE IMMUNOLOGY

The Human Pancreatic Islet Transcriptome: Expression of Candidate Genes for Type 1 Diabetes and the Impact of Pro-Inflammatory Cytokines

(2012) Décio L. Eizirik et al.   PLoS Genetics

Discovery of low-affinity preproinsulin epitopes and detection of autoreactive CD8 T-cells using combinatorial MHC multimers

(2011) Wendy W. Unger et al.   JOURNAL OF AUTOIMMUNITY

Clinical Dutch-English Lambert-Eaton Myasthenic Syndrome (LEMS) Tumor Association Prediction Score Accurately Predicts Small-Cell Lung Cancer in the LEMS

(2011) Maarten J. Titulaer et al.   JOURNAL OF CLINICAL ONCOLOGY

Co-stimulation modulation with abatacept in patients with recent-onset type 1 diabetes: a randomised, double-blind, placebo-controlled trial

(2011) Tihamer Orban et al.   LANCET

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(2011) Dan Christensen et al.   MOLECULAR MEDICINE

Immunological efficacy of heat shock protein 60 peptide DiaPep277TM therapy in clinical type I diabetes

(2010) V. A. L. Huurman et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Islet inflammation and CXCL10 in recent-onset type 1 diabetes

(2010) B. O. Roep et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Cytokine-Induced Dicing and Splicing in the  -Cell and the Immune Response in Type 1 Diabetes

(2010) J. C. Hutton et al.   DIABETES

Recurrence of Type 1 Diabetes After Simultaneous Pancreas-Kidney Transplantation, Despite Immunosuppression, Is Associated With Autoantibodies and Pathogenic Autoreactive CD4 T-Cells

(2010) F. Vendrame et al.   DIABETES

Simultaneous Detection of Circulating Autoreactive CD8+ T-Cells Specific for Different Islet Cell-Associated Epitopes Using Combinatorial MHC Multimers

(2010) J. H. Velthuis et al.   DIABETES

Naturally Arising Human CD4 T-Cells That Recognize Islet Autoantigens and Secrete Interleukin-10 Regulate Proinflammatory T-Cell Responses via Linked Suppression

(2010) T. I. M. Tree et al.   DIABETES

Insulin gene VNTR genotype associates with frequency and phenotype of the autoimmune response to proinsulin

(2010) I Durinovic-Belló et al.   GENES AND IMMUNITY

STAT1 Is a Master Regulator of Pancreatic β-Cell Apoptosis and Islet Inflammation

(2010) Fabrice Moore et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Defects in IL-2R Signaling Contribute to Diminished Maintenance of FOXP3 Expression in CD4+CD25+ Regulatory T-Cells of Type 1 Diabetic Subjects

(2009) S. A. Long et al.   DIABETES

Differences in Baseline Lymphocyte Counts and Autoreactivity Are Associated With Differences in Outcome of Islet Cell Transplantation in Type 1 Diabetic Patients

(2009) R. Hilbrands et al.   DIABETES

Progression to Diabetes in Relatives of Type 1 Diabetic Patients: Mechanisms and Mode of Onset

(2009) E. Ferrannini et al.   DIABETES

Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes

(2009) Jeffrey C Barrett et al.   NATURE GENETICS

The role of inflammation in insulitis and β-cell loss in type 1 diabetes

(2009) Décio L. Eizirik et al.   Nature Reviews Endocrinology

Cytokine signalling in the β-cell: a dual role for IFNγ: Figure 1

(2008) Conny Gysemans et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Proinsulin peptide immunotherapy in type 1 diabetes: report of a first-in-man Phase I safety study

(2008) S. L. Thrower et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Analysis of islet inflammation in human type 1 diabetes

(2008) A. Willcox et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

 -Cell Mass and Type 1 Diabetes: Going, Going, Gone?

(2008) E. Akirav et al.   DIABETES

Accumulation of autoreactive effector T cells and allo-specific regulatory T cells in the pancreas allograft of a type 1 diabetic recipient

(2008) J. H. Velthuis et al.   DIABETOLOGIA

GAD Treatment and Insulin Secretion in Recent-Onset Type 1 Diabetes

(2008) Johnny Ludvigsson et al.   NEW ENGLAND JOURNAL OF MEDICINE

Cellular Islet Autoimmunity Associates with Clinical Outcome of Islet Cell Transplantation

(2008) Volkert A. L. Huurman et al.   PLoS One