Rare MTNR1B variants impairing melatonin receptor 1B function contribute to type 2 diabetes

New evidence for a role of melatonin in glucose regulation

(2010) Elmar Peschke et al.   BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM

MTNR1B G24E Variant Associates With BMI and Fasting Plasma Glucose in the General Population in Studies of 22,142 Europeans

(2010) E. A. Andersson et al.   DIABETES

Disruption of the clock components CLOCK and BMAL1 leads to hypoinsulinaemia and diabetes

(2010) Biliana Marcheva et al.   NATURE

Excess of rare variants in genes identified by genome-wide association study of hypertriglyceridemia

(2010) Christopher T Johansen et al.   NATURE GENETICS

Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis

(2010) Benjamin F Voight et al.   NATURE GENETICS

A method and server for predicting damaging missense mutations

(2010) Ivan A Adzhubei et al.   NATURE METHODS

International Union of Basic and Clinical Pharmacology. LXXV. Nomenclature, Classification, and Pharmacology of G Protein-Coupled Melatonin Receptors

(2010) M. L. Dubocovich et al.   PHARMACOLOGICAL REVIEWS

Reduced Expression of IFIH1 Is Protective for Type 1 Diabetes

(2010) Kate Downes et al.   PLoS One

Circadian Integration of Metabolism and Energetics

(2010) J. Bass et al.   SCIENCE

Deep resequencing reveals excess rare recent variants consistent with explosive population growth

(2010) Alex Coventry et al.   Nature Communications

A Novel Adaptive Method for the Analysis of Next-Generation Sequencing Data to Detect Complex Trait Associations with Rare Variants Due to Gene Main Effects and Interactions

(2010) Dajiang J. Liu et al.   PLoS Genetics

Common vs. rare allele hypotheses for complex diseases

(2009) Nicholas J Schork et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Agomelatine, a melatonin agonist with antidepressant properties

(2009) Steven L Dubovsky et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Finding the missing heritability of complex diseases

(2009) Teri A. Manolio et al.   NATURE

Rare Variants of IFIH1, a Gene Implicated in Antiviral Responses, Protect Against Type 1 Diabetes

(2009) S. Nejentsev et al.   SCIENCE

Ligand binding and micro-switches in 7TM receptor structures

(2009) Rie Nygaard et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Melatonin receptors, heterodimerization, signal transduction and binding sites: what's new?

(2008) R Jockers et al.   BRITISH JOURNAL OF PHARMACOLOGY

Prognostic Value of the Insertion/Deletion Polymorphism of the ACE Gene in Type 2 Diabetic Subjects: Results from the Non-Insulin-Dependent Diabetes, Hypertension, Microalbuminuria or Proteinuria, Cardiovascular Events, and Ramipril (DIABHYCAR), Diabete de type 2, Nephropathie et Genetique (DIAB2NEPHROGENE), and Survie, Diabete de type 2 et Genetique (SURDIAGENE) studies

(2008) S. Hadjadj et al.   DIABETES CARE

Common variant in MTNR1B associated with increased risk of type 2 diabetes and impaired early insulin secretion

(2008) Valeriya Lyssenko et al.   NATURE GENETICS

Variants in MTNR1B influence fasting glucose levels

(2008) Inga Prokopenko et al.   NATURE GENETICS

A variant near MTNR1B is associated with increased fasting plasma glucose levels and type 2 diabetes risk

(2008) Nabila Bouatia-Naji et al.   NATURE GENETICS