Unique integrated stress response sensors regulate cancer cell susceptibility when Hsp70 activity is compromised
出版年份 2021 全文链接
标题
Unique integrated stress response sensors regulate cancer cell susceptibility when Hsp70 activity is compromised
作者
关键词
-
出版物
eLife
Volume 10, Issue -, Pages -
出版商
eLife Sciences Publications, Ltd
发表日期
2021-06-28
DOI
10.7554/elife.64977
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- Autophagy and Protein Secretion
- (2020) Giulio Cavalli et al. JOURNAL OF MOLECULAR BIOLOGY
- Mitochondrial stress is relayed to the cytosol by an OMA1–DELE1–HRI pathway
- (2020) Xiaoyan Guo et al. NATURE
- Potential benefit of manipulating protein quality control systems in neurodegenerative diseases
- (2020) Laura M Luh et al. CURRENT OPINION IN NEUROBIOLOGY
- Mechanisms, regulation and functions of the unfolded protein response
- (2020) Claudio Hetz et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Autophagy Regulation by the Translation Machinery and Its Implications in Cancer
- (2020) Pilar Sarah Acevo-Rodríguez et al. Frontiers in Oncology
- Salubrinal in Combination With 4E1RCat Synergistically Impairs Melanoma Development by Disrupting the Protein Synthetic Machinery
- (2020) Gregory R. Kardos et al. Frontiers in Oncology
- Autophagy as a therapeutic target in pancreatic cancer
- (2020) Max Piffoux et al. BRITISH JOURNAL OF CANCER
- Small molecule strategies to harness the unfolded protein response: where do we go from here?
- (2020) Julia M.D. Grandjean et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Direct involvement of Hsp70 ATP hydrolysis in Ubr1-dependent quality control
- (2020) Amanjot Singh et al. MOLECULAR BIOLOGY OF THE CELL
- Research progress of mTOR inhibitors
- (2020) Yifan Chen et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Functional Modules of the Proteostasis Network
- (2019) Gopal G. Jayaraj et al. Cold Spring Harbor Perspectives in Biology
- Activation of GCN2 by the ribosomal P-stalk
- (2019) Alison J. Inglis et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Small molecule ISRIB suppresses the integrated stress response within a defined window of activation
- (2019) Huib H. Rabouw et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The kinase PERK and the transcription factor ATF4 play distinct and essential roles in autophagy resulting from tunicamycin-induced ER stress
- (2019) Morten Luhr et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- HRI coordinates translation necessary for protein homeostasis and mitochondrial function in erythropoiesis
- (2019) Shuping Zhang et al. eLife
- EIF2A promotes cell survival during paclitaxel treatment in vitro and in vivo
- (2019) Lin Chen et al. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
- The Hsp70 chaperone network
- (2019) Rina Rosenzweig et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- An integrated stress response via PKR suppresses HER2+ cancers and improves trastuzumab therapy
- (2019) Cedric Darini et al. Nature Communications
- Role of PKR in the Inhibition of Proliferation and Translation by Polycystin-1
- (2019) Yan Tang et al. Biomed Research International
- GCN2 suppression attenuates cerebral ischemia in mice by reducing apoptosis and endoplasmic reticulum (ER) stress through the blockage of FoxO3a-regulated ROS production
- (2019) Wen-Zhen Shi et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Therapeutic targeting of the PI4K2A/PKR lysosome network is critical for misfolded protein clearance and survival in cancer cells
- (2019) Apar Pataer et al. ONCOGENE
- Cancer and ER stress: Mutual crosstalk between autophagy, oxidative stress and inflammatory response
- (2019) Yuning Lin et al. BIOMEDICINE & PHARMACOTHERAPY
- HO-1 drives autophagy as a mechanism of resistance against HER2-targeted therapies
- (2019) Natasha Tracey et al. BREAST CANCER RESEARCH AND TREATMENT
- Activation of the ISR mediates the behavioral and neurophysiological abnormalities in Down syndrome
- (2019) Ping Jun Zhu et al. SCIENCE
- The ribosomal P-stalk couples amino acid starvation to GCN2 activation in mammalian cells
- (2019) Heather P Harding et al. eLife
- Proteostasis In The Endoplasmic Reticulum: Road to Cure
- (2019) Nam et al. Cancers
- Unravelling triple-negative breast cancer molecular heterogeneity using an integrative multiomic analysis
- (2018) Y Bareche et al. ANNALS OF ONCOLOGY
- Proteasome inhibition promotes autophagy and protects from endoplasmic reticulum stress in rat alveolar macrophages exposed to hypoxia-reoxygenation injury
- (2018) Tao Fan et al. JOURNAL OF CELLULAR PHYSIOLOGY
- HRI-mediated translational repression reduces proteotoxicity and sensitivity to bortezomib in human pancreatic cancer cells
- (2018) Matthew C. White et al. ONCOGENE
- Binding of ISRIB reveals a regulatory site in the nucleotide exchange factor eIF2B
- (2018) Alisa F. Zyryanova et al. SCIENCE
- Development of a stress response therapy targeting aggressive prostate cancer
- (2018) Hao G. Nguyen et al. Science Translational Medicine
- Role of eIF2α Kinases in Translational Control and Adaptation to Cellular Stress
- (2018) Ronald C. Wek Cold Spring Harbor Perspectives in Biology
- Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries
- (2018) Freddie Bray et al. CA-A CANCER JOURNAL FOR CLINICIANS
- Target-Based Discovery of an Inhibitor of the Regulatory Phosphatase PPP1R15B
- (2018) Agnieszka Krzyzosiak et al. CELL
- Inhibitors and chemical probes for molecular chaperone networks
- (2018) Jason E. Gestwicki et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Compensatory increases of select proteostasis networks after Hsp70 inhibition in cancer cells
- (2018) Sara Sannino et al. JOURNAL OF CELL SCIENCE
- Inhibition of GCN2 sensitizes ASNS-low cancer cells to asparaginase by disrupting the amino acid response
- (2018) Akito Nakamura et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- PPT1 promotes tumor growth and is the molecular target of chloroquine derivatives in cancer.
- (2018) Vito W Rebecca et al. Cancer Discovery
- The exponential growth of autophagy-related research: from the humble yeast to the Nobel Prize
- (2017) Noboru Mizushima FEBS LETTERS
- Targeting Autophagy in Cancer: Update on Clinical Trials and Novel Inhibitors
- (2017) et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- AMPK: Mechanisms of Cellular Energy Sensing and Restoration of Metabolic Balance
- (2017) Daniel Garcia et al. MOLECULAR CELL
- N -Acetyl-l-Cysteine Protects Astrocytes against Proteotoxicity without Recourse to Glutathione
- (2017) Amanda M. Gleixner et al. MOLECULAR PHARMACOLOGY
- Salmon provides fast and bias-aware quantification of transcript expression
- (2017) Rob Patro et al. NATURE METHODS
- The HSP90 chaperone machinery
- (2017) Florian H. Schopf et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Knockdown of IRE1α inhibits colonic tumorigenesis through decreasing β-catenin and IRE1α targeting suppresses colon cancer cells
- (2017) X-X Li et al. ONCOGENE
- Targeting the unfolded protein response in cancer
- (2017) Rani Ojha et al. PHARMACOLOGICAL RESEARCH
- Understanding the role of PD-L1/PD1 pathway blockade and autophagy in cancer therapy
- (2017) Marianela Robainas et al. OncoTargets and Therapy
- Phosphorylated eIF2α predicts disease-free survival in triple-negative breast cancer patients
- (2017) Liang Guo et al. Scientific Reports
- Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)
- (2016) Daniel J Klionsky et al. Autophagy
- Compounds Triggering ER Stress Exert Anti-Melanoma Effects and Overcome BRAF Inhibitor Resistance
- (2016) Michaël Cerezo et al. CANCER CELL
- Research progress of hydroxychloroquine and autophagy inhibitors on cancer
- (2016) Ting-Ting Shi et al. CANCER CHEMOTHERAPY AND PHARMACOLOGY
- Functional Genomic Landscape of Human Breast Cancer Drivers, Vulnerabilities, and Resistance
- (2016) Richard Marcotte et al. CELL
- The integrated stress response
- (2016) Karolina Pakos‐Zebrucka et al. EMBO REPORTS
- Recent insights into the function of autophagy in cancer: Table 1.
- (2016) Ravi Amaravadi et al. GENES & DEVELOPMENT
- Transcriptional regulation of mammalian autophagy at a glance
- (2016) Jens Füllgrabe et al. JOURNAL OF CELL SCIENCE
- Combined chemical–genetic approach identifies cytosolic HSP70 dependence in rhabdomyosarcoma
- (2016) Amit J. Sabnis et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- In vivo aspects of protein folding and quality control
- (2016) D. Balchin et al. SCIENCE
- Heat Shock Proteins Promote Cancer: It's a Protection Racket
- (2016) Stuart K. Calderwood et al. TRENDS IN BIOCHEMICAL SCIENCES
- Emerging tale of UPR and cancer: an essentiality for malignancy
- (2016) Younis Mohammad Hazari et al. TUMOR BIOLOGY
- Autophagy Promotes Focal Adhesion Disassembly and Cell Motility of Metastatic Tumor Cells through the Direct Interaction of Paxillin with LC3
- (2016) Marina N. Sharifi et al. Cell Reports
- Therapeutic Targeting of Autophagy
- (2016) Christina G. Towers et al. EBioMedicine
- Toward rapamycin analog (rapalog)-based precision cancer therapy
- (2015) Ling-hua Meng et al. ACTA PHARMACOLOGICA SINICA
- A plastic SQSTM1/p62-dependent autophagic reserve maintains proteostasis and determines proteasome inhibitor susceptibility in multiple myeloma cells
- (2015) Enrico Milan et al. Autophagy
- Roles of the translation initiation factor eIF2α serine 51 phosphorylation in cancer formation and treatment
- (2015) Antonis E. Koromilas Biochimica et Biophysica Acta-Gene Regulatory Mechanisms
- GCN2 sustains mTORC1 suppression upon amino acid deprivation by inducing Sestrin2
- (2015) Jiangbin Ye et al. GENES & DEVELOPMENT
- Taxol-induced unfolded protein response activation in breast cancer cells exposed to hypoxia: ATF4 activation regulates autophagy and inhibits apoptosis
- (2015) Annick Notte et al. INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
- Discovery of a First-in-Class, Potent, Selective, and Orally Bioavailable Inhibitor of the p97 AAA ATPase (CB-5083)
- (2015) Han-Jie Zhou et al. JOURNAL OF MEDICINAL CHEMISTRY
- Annual Report to the Nation on the Status of Cancer, 1975-2011, Featuring Incidence of Breast Cancer Subtypes by Race/Ethnicity, Poverty, and State
- (2015) Betsy A. Kohler et al. JNCI-Journal of the National Cancer Institute
- HER2-mTOR signaling–driven breast cancer cells require ER-associated degradation to survive
- (2015) Navneet Singh et al. Science Signaling
- Endoplasmic reticulum quality control in cancer: Friend or foe
- (2015) Hana Kim et al. SEMINARS IN CANCER BIOLOGY
- The Opposing Actions of Target of Rapamycin and AMP-Activated Protein Kinase in Cell Growth Control
- (2015) Sravanth K. Hindupur et al. Cold Spring Harbor Perspectives in Biology
- Partial restoration of protein synthesis rates by the small molecule ISRIB prevents neurodegeneration without pancreatic toxicity
- (2015) M Halliday et al. Cell Death & Disease
- Interplay between unfolded protein response and autophagy promotes tumor drug resistance
- (2015) MING-MING YAN et al. Oncology Letters
- The small molecule ISRIB reverses the effects of eIF2α phosphorylation on translation and stress granule assembly
- (2015) Carmela Sidrauski et al. eLife
- Annual Report to the Nation on the Status of Cancer, 1975-2011, Featuring Incidence of Breast Cancer Subtypes by Race/Ethnicity, Poverty, and State
- (2015) Betsy A. Kohler et al. JNCI-Journal of the National Cancer Institute
- HER2-mTOR signaling–driven breast cancer cells require ER-associated degradation to survive
- (2015) Navneet Singh et al. Science Signaling
- Mode of cell death induced by the HSP90 inhibitor 17-AAG (tanespimycin) is dependent on the expression of pro-apoptotic BAX
- (2015) Marissa V Powers et al. Oncotarget
- Proteotoxic crisis, the ubiquitin-proteasome system, and cancer therapy
- (2014) Raymond J Deshaies BMC BIOLOGY
- Crosstalk between autophagy and proteasome protein degradation systems: possible implications for cancer therapy
- (2014) Slawomir Wojcik FOLIA HISTOCHEMICA ET CYTOBIOLOGICA
- Targeting ER stress–induced autophagy overcomes BRAF inhibitor resistance in melanoma
- (2014) Xiao-Hong Ma et al. JOURNAL OF CLINICAL INVESTIGATION
- The HSP70 Modulator MAL3-101 Inhibits Merkel Cell Carcinoma
- (2014) Christian Adam et al. PLoS One
- How early studies on secreted and membrane protein quality control gave rise to the ER associated degradation (ERAD) pathway: The early history of ERAD
- (2013) Patrick G. Needham et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
- The Unfolded Protein Response Transducer ATF6 Represents a Novel Transmembrane-type Endoplasmic Reticulum-associated Degradation Substrate Requiring Both Mannose Trimming and SEL1L Protein
- (2013) Satoshi Horimoto et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Paralog-selective Hsp90 inhibitors define tumor-specific regulation of HER2
- (2013) Pallav D Patel et al. Nature Chemical Biology
- The eIF2α/ATF4 pathway is essential for stress-induced autophagy gene expression
- (2013) Wafa B’chir et al. NUCLEIC ACIDS RESEARCH
- Functional Contribution of the Transcription Factor ATF4 to the Pathogenesis of Amyotrophic Lateral Sclerosis
- (2013) Soledad Matus et al. PLoS One
- Autophagy and chemotherapy resistance: a promising therapeutic target for cancer treatment
- (2013) X Sui et al. Cell Death & Disease
- Inhibition of HSP70: A challenging anti-cancer strategy
- (2012) Anastasia R. Goloudina et al. CANCER LETTERS
- Translation Regulation as a Therapeutic Target in Cancer: Figure 1.
- (2012) Michal Grzmil et al. CANCER RESEARCH
- Discovery of 7-Methyl-5-(1-{[3-(trifluoromethyl)phenyl]acetyl}-2,3-dihydro-1H-indol-5-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine (GSK2606414), a Potent and Selective First-in-Class Inhibitor of Protein Kinase R (PKR)-like Endoplasmic Reticulum Kinase (PERK)
- (2012) Jeffrey M. Axten et al. JOURNAL OF MEDICINAL CHEMISTRY
- The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity
- (2012) Jordi Barretina et al. NATURE
- Comprehensive molecular portraits of human breast tumours
- (2012) Daniel C. Koboldt et al. NATURE
- clusterProfiler: an R Package for Comparing Biological Themes Among Gene Clusters
- (2012) Guangchuang Yu et al. OMICS-A JOURNAL OF INTEGRATIVE BIOLOGY
- The Role of Atg Proteins in Autophagosome Formation
- (2011) Noboru Mizushima et al. Annual Review of Cell and Developmental Biology
- Structure based design of heat shock protein 90 inhibitors acting as anticancer agents
- (2011) Munikumar Reddy Doddareddy et al. BIOORGANIC & MEDICINAL CHEMISTRY
- Targeting HSP70: The second potentially druggable heat shock protein and molecular chaperone?
- (2011) Marissa V. Powers et al. CELL CYCLE
- Punctate LC3B Expression Is a Common Feature of Solid Tumors and Associated with Proliferation, Metastasis, and Poor Outcome
- (2011) R. Lazova et al. CLINICAL CANCER RESEARCH
- Principles and Current Strategies for Targeting Autophagy for Cancer Treatment
- (2011) R. K. Amaravadi et al. CLINICAL CANCER RESEARCH
- Bortezomib as the First Proteasome Inhibitor Anticancer Drug: Current Status and Future Perspectives
- (2011) D. Chen et al. CURRENT CANCER DRUG TARGETS
- Phosphorylation of eIF2 Facilitates Ribosomal Bypass of an Inhibitory Upstream ORF to EnhanceCHOPTranslation
- (2011) Lakshmi Reddy Palam et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1
- (2011) Joungmok Kim et al. NATURE CELL BIOLOGY
- The biological and therapeutic relevance of mRNA translation in cancer
- (2011) Sarah P. Blagden et al. Nature Reviews Clinical Oncology
- Chemical methodology as a source of small-molecule checkpoint inhibitors and heat shock protein 70 (Hsp70) modulators
- (2011) D. M. Huryn et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Road to Ruin: Targeting Proteins for Degradation in the Endoplasmic Reticulum
- (2011) M. H. Smith et al. SCIENCE
- The Unfolded Protein Response: From Stress Pathway to Homeostatic Regulation
- (2011) P. Walter et al. SCIENCE
- mTOR Signaling
- (2011) M. Laplante et al. Cold Spring Harbor Perspectives in Biology
- Ubiquitylation in ERAD: Reversing to Go Forward?
- (2011) Yien Che Tsai et al. PLOS BIOLOGY
- Antimyeloma Effects of the Heat Shock Protein 70 Molecular Chaperone Inhibitor MAL3-101
- (2011) Marc J. Braunstein et al. Journal of Oncology
- Binding of a Small Molecule at a Protein–Protein Interface Regulates the Chaperone Activity of Hsp70–Hsp40
- (2010) Susanne Wisén et al. ACS Chemical Biology
- Protein dislocation from the ER
- (2010) Katrin Bagola et al. BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
- Inhibition of MCL-1 enhances Lapatinib toxicity and overcomes lapatinib resistance via BAK-dependent autophagy
- (2010) Aditi Pandya Martin et al. CANCER BIOLOGY & THERAPY
- Death by chaperone: HSP90, HSP70 or both?
- (2010) Marissa V. Powers et al. CELL CYCLE
- The GCN2-ATF4 pathway is critical for tumour cell survival and proliferation in response to nutrient deprivation
- (2010) Jiangbin Ye et al. EMBO JOURNAL
- Heat Shock Protein 70 (Hsp70) as an Emerging Drug Target
- (2010) Christopher G. Evans et al. JOURNAL OF MEDICINAL CHEMISTRY
- Neuronal Apoptosis Induced by Endoplasmic Reticulum Stress Is Regulated by ATF4-CHOP-Mediated Induction of the Bcl-2 Homology 3-Only Member PUMA
- (2010) Z. Galehdar et al. JOURNAL OF NEUROSCIENCE
- Autophagy: assays and artifacts
- (2010) Sandra Barth et al. JOURNAL OF PATHOLOGY
- Autophagy and the Integrated Stress Response
- (2010) Guido Kroemer et al. MOLECULAR CELL
- Regulation Mechanisms and Signaling Pathways of Autophagy
- (2009) Congcong He et al. Annual Review of Genetics
- Autophagy facilitates the progression of ERα-positive breast cancer cells to antiestrogen resistance
- (2009) Patricia V. Schoenlein et al. Autophagy
- Post-translational import of protein into the endoplasmic reticulum of a trypanosome: anin vitrosystem for discovery of anti-trypanosomal chemical entities
- (2009) Bhargavi Patham et al. BIOCHEMICAL JOURNAL
- Aneuploidy: Cancer's Fatal Flaw?
- (2009) Bret R. Williams et al. CANCER RESEARCH
- Beclin 1 and LC3 autophagic gene expression in cutaneous melanocytic lesions
- (2009) Clelia Miracco et al. HUMAN PATHOLOGY
- The unfolded protein response protects human tumor cells during hypoxia through regulation of the autophagy genes MAP1LC3B and ATG5
- (2009) Kasper M.A. Rouschop et al. JOURNAL OF CLINICAL INVESTIGATION
- Autophagic Elimination of Misfolded Procollagen Aggregates in the Endoplasmic Reticulum as a Means of Cell Protection
- (2009) Yoshihito Ishida et al. MOLECULAR BIOLOGY OF THE CELL
- Autophagy Facilitates the Development of Breast Cancer Resistance to the Anti-HER2 Monoclonal Antibody Trastuzumab
- (2009) Alejandro Vazquez-Martin et al. PLoS One
- Discovery and development of heat shock protein 90 inhibitors
- (2008) Tony Taldone et al. BIOORGANIC & MEDICINAL CHEMISTRY
- Chemical and Biological Approaches Synergize to Ameliorate Protein-Folding Diseases
- (2008) Ting-Wei Mu et al. CELL
- Autophagy in the Pathogenesis of Disease
- (2008) Beth Levine et al. CELL
- Identification of Metastasis-Related Proteins and Their Clinical Relevance to Triple-Negative Human Breast Cancer
- (2008) B. Sun et al. CLINICAL CANCER RESEARCH
- A role for macroautophagy in protection against 4-hydroxytamoxifen-induced cell death and the development of antiestrogen resistance
- (2008) J. S. Samaddar et al. MOLECULAR CANCER THERAPEUTICS
- Autophagy fights disease through cellular self-digestion
- (2008) Noboru Mizushima et al. NATURE
- Adapting Proteostasis for Disease Intervention
- (2008) William E. Balch et al. SCIENCE
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreBecome a Peeref-certified reviewer
The Peeref Institute provides free reviewer training that teaches the core competencies of the academic peer review process.
Get Started