Targeting Autophagy in Cancer: Update on Clinical Trials and Novel Inhibitors

Recent progress in autophagic lysosome reformation

(2017) Yang Chen et al.   TRAFFIC

Research progress of hydroxychloroquine and autophagy inhibitors on cancer

(2016) Ting-Ting Shi et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Disruption of Autophagic Degradation with ROC-325 Antagonizes Renal Cell Carcinoma Pathogenesis

(2016) Jennifer S. Carew et al.   CLINICAL CANCER RESEARCH

Autophagy provides metabolic substrates to maintain energy charge and nucleotide pools in Ras-driven lung cancer cells

(2016) Jessie Yanxiang Guo et al.   GENES & DEVELOPMENT

Gemcitabine-Induced Autophagy Protects Human Lung Cancer Cells from Apoptotic Death

(2016) Hui-Mei Wu et al.   LUNG

SAR405, a PIK3C3/Vps34 inhibitor that prevents autophagy and synergizes with MTOR inhibition in tumor cells

(2015) Benoit Pasquier   Autophagy

mTOR: a pharmacologic target for autophagy regulation

(2015) Young Chul Kim et al.   JOURNAL OF CLINICAL INVESTIGATION

Small Molecule Inhibition of the Autophagy Kinase ULK1 and Identification of ULK1 Substrates

(2015) Daniel F. Egan et al.   MOLECULAR CELL

Hydroxychloroquine and Chloroquine Retinopathy

(2015) Adrian C. Tsang et al.   OPHTHALMOLOGY

Targeting autophagy in cancer management – strategies and developments

(2015) Bulent Ozpolat et al.   Cancer Management and Research

Autophagy Activation Is Involved in 3,4-Methylenedioxymethamphetamine (‘Ecstasy’)—Induced Neurotoxicity in Cultured Cortical Neurons

(2015) I-Hsun Li et al.   PLoS One

Hydroxychloroquine Destabilizes Phospho-S6 in Human Renal Carcinoma Cells

(2015) Hyung-Ok Lee et al.   PLoS One

Phase I clinical trial and pharmacodynamic evaluation of combination hydroxychloroquine and doxorubicin treatment in pet dogs treated for spontaneously occurring lymphoma

(2014) Rebecca A Barnard et al.   Autophagy

Combined autophagy and HDAC inhibition

(2014) Devalingam Mahalingam et al.   Autophagy

Phase I trial of hydroxychloroquine with dose-intense temozolomide in patients with advanced solid tumors and melanoma

(2014) Reshma Rangwala et al.   Autophagy

Combined MTOR and autophagy inhibition

(2014) Reshma Rangwala et al.   Autophagy

A novel ATG4B antagonist inhibits autophagy and has a negative impact on osteosarcoma tumors

(2014) Debra Akin et al.   Autophagy

Posttranslational modification of autophagy-related proteins in macroautophagy

(2014) Yangchun Xie et al.   Autophagy

Acidic extracellular pH neutralizes the autophagy-inhibiting activity of chloroquine

(2014) Paola Pellegrini et al.   Autophagy

Combined autophagy and proteasome inhibition

(2014) Dan T Vogl et al.   Autophagy

A phase I/II trial of hydroxychloroquine in conjunction with radiation therapy and concurrent and adjuvant temozolomide in patients with newly diagnosed glioblastoma multiforme

(2014) Myrna R Rosenfeld et al.   Autophagy

Chloroquine Inhibits Autophagy to Potentiate Antiestrogen Responsiveness in ER+ Breast Cancer

(2014) K. L. Cook et al.   CLINICAL CANCER RESEARCH

Phosphoinositide 3-kinase inhibitors in lymphoma

(2014) Emily Curran et al.   CURRENT OPINION IN ONCOLOGY

Spautin-1, a novel autophagy inhibitor, enhances imatinib-induced apoptosis in chronic myeloid leukemia

(2014) SHAN SHAO et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Selective VPS34 inhibitor blocks autophagy and uncovers a role for NCOA4 in ferritin degradation and iron homeostasis in vivo

(2014) William E. Dowdle et al.   NATURE CELL BIOLOGY

A highly potent and selective Vps34 inhibitor alters vesicle trafficking and autophagy

(2014) Baptiste Ronan et al.   Nature Chemical Biology

Imaging the intracellular distribution of tyrosine kinase inhibitors in living cells with quantitative hyperspectral stimulated Raman scattering

(2014) Dan Fu et al.   Nature Chemistry

Dynamic regulation of macroautophagy by distinctive ubiquitin-like proteins

(2014) Daniel J Klionsky et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Phase II and Pharmacodynamic Study of Autophagy Inhibition Using Hydroxychloroquine in Patients With Metastatic Pancreatic Adenocarcinoma

(2014) B. M. Wolpin et al.   ONCOLOGIST

Autophagy regulation by nutrient signaling

(2013) Ryan C Russell et al.   CELL RESEARCH

Autophagy and chemotherapy resistance: a promising therapeutic target for cancer treatment

(2013) X Sui et al.   Cell Death & Disease

The Autophagy Inhibitor Verteporfin Moderately Enhances the Antitumor Activity of Gemcitabine in a Pancreatic Ductal Adenocarcinoma Model

(2013) Elizabeth Donohue et al.   Journal of Cancer

The Interplay between NLRs and Autophagy in Immunity and Inflammation

(2013) Leticia A. M. Carneiro et al.   Frontiers in Immunology

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(2012) Ravi K. Amaravadi et al.   Autophagy

Binding of the Atg1/ULK1 kinase to the ubiquitin-like protein Atg8 regulates autophagy

(2012) Claudine Kraft et al.   EMBO JOURNAL

A Phase I Study of Erlotinib and Hydroxychloroquine in Advanced Non–Small-Cell Lung Cancer

(2012) Sarah B. Goldberg et al.   Journal of Thoracic Oncology

Clathrin and phosphatidylinositol-4,5-bisphosphate regulate autophagic lysosome reformation

(2012) Yueguang Rong et al.   NATURE CELL BIOLOGY

Autophagy modulation as a potential therapeutic target for diverse diseases

(2012) David C. Rubinsztein et al.   NATURE REVIEWS DRUG DISCOVERY

Chloroquine enhances the cytotoxicity of topotecan by inhibiting autophagy in lung cancer cells

(2012) Yao Wang et al.   Chinese Journal of Cancer

The Phosphatidylinositol 3-kinase (PI3K) inhibitor LY294002 modulates cytokine expression in macrophages via p50 nuclear factor kappa B inhibition, in a PI3K-independent mechanism

(2011) Dorit Avni et al.   BIOCHEMICAL PHARMACOLOGY

Beclin1 Controls the Levels of p53 by Regulating the Deubiquitination Activity of USP10 and USP13

(2011) Junli Liu et al.   CELL

The Beclin 1 network regulates autophagy and apoptosis

(2011) R Kang et al.   CELL DEATH AND DIFFERENTIATION

Principles and Current Strategies for Targeting Autophagy for Cancer Treatment

(2011) R. K. Amaravadi et al.   CLINICAL CANCER RESEARCH

Small-molecule inhibitors of the PI3K signaling network

(2011) Colleen R McNamara et al.   Future Medicinal Chemistry

Deubiquitinating p53

(2011) Amy Donner   Nature Chemical Biology

Methods in Mammalian Autophagy Research

(2010) Noboru Mizushima et al.   CELL

Inhibition of Autophagosome Formation by the Benzoporphyrin Derivative Verteporfin

(2010) Elizabeth Donohue et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dual Role of 3-Methyladenine in Modulation of Autophagy via Different Temporal Patterns of Inhibition on Class I and III Phosphoinositide 3-Kinase

(2010) You-Tong Wu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of the autophagy protein LC3 by phosphorylation

(2010) Salvatore J. Cherra et al.   JOURNAL OF CELL BIOLOGY

Chloroquine and its analogs: A new promise of an old drug for effective and safe cancer therapies

(2009) V. Raja Solomon et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

pH-dependent antitumor activity of proton pump inhibitors against human melanoma is mediated by inhibition of tumor acidity

(2009) Angelo De Milito et al.   INTERNATIONAL JOURNAL OF CANCER