Research progress of hydroxychloroquine and autophagy inhibitors on cancer

Recommendations on Screening for Chloroquine and Hydroxychloroquine Retinopathy (2016 Revision)

(2016) Michael F. Marmor et al.   OPHTHALMOLOGY

Rapid Onset of Retinal Toxicity From High-Dose Hydroxychloroquine Given for Cancer Therapy

(2015) Loh-Shan B. Leung et al.   AMERICAN JOURNAL OF OPHTHALMOLOGY

SAR405, a PIK3C3/Vps34 inhibitor that prevents autophagy and synergizes with MTOR inhibition in tumor cells

(2015) Benoit Pasquier   Autophagy

Hydroxychloroquine Destabilizes Phospho-S6 in Human Renal Carcinoma Cells

(2015) Hyung-Ok Lee et al.   PLoS One

Development of potent autophagy inhibitors that sensitize oncogenic BRAF V600E mutant melanoma tumor cells to vemurafenib

(2014) Megan L Goodall et al.   Autophagy

Outcome of early clinical trials of the combination of hydroxychloroquine with chemotherapy in cancer

(2014) Andrew Poklepovic et al.   Autophagy

Phase I clinical trial and pharmacodynamic evaluation of combination hydroxychloroquine and doxorubicin treatment in pet dogs treated for spontaneously occurring lymphoma

(2014) Rebecca A Barnard et al.   Autophagy

Autophagy in non-small cell lung carcinogenesis

(2014) Shuan Rao et al.   Autophagy

Inhibition of autophagy attenuates pancreatic cancer growth independent ofTP53/TRP53status

(2014) Annan Yang et al.   Autophagy

Combined autophagy and HDAC inhibition

(2014) Devalingam Mahalingam et al.   Autophagy

Phase I trial of hydroxychloroquine with dose-intense temozolomide in patients with advanced solid tumors and melanoma

(2014) Reshma Rangwala et al.   Autophagy

Combined MTOR and autophagy inhibition

(2014) Reshma Rangwala et al.   Autophagy

Acidic extracellular pH neutralizes the autophagy-inhibiting activity of chloroquine

(2014) Paola Pellegrini et al.   Autophagy

Combined autophagy and proteasome inhibition

(2014) Dan T Vogl et al.   Autophagy

A phase I/II trial of hydroxychloroquine in conjunction with radiation therapy and concurrent and adjuvant temozolomide in patients with newly diagnosed glioblastoma multiforme

(2014) Myrna R Rosenfeld et al.   Autophagy

Chloroquine Inhibits Autophagy to Potentiate Antiestrogen Responsiveness in ER+ Breast Cancer

(2014) K. L. Cook et al.   CLINICAL CANCER RESEARCH

Targeting ER stress–induced autophagy overcomes BRAF inhibitor resistance in melanoma

(2014) Xiao-Hong Ma et al.   JOURNAL OF CLINICAL INVESTIGATION

A highly potent and selective Vps34 inhibitor alters vesicle trafficking and autophagy

(2014) Baptiste Ronan et al.   Nature Chemical Biology

Essential role for autophagy in the maintenance of immunological memory against influenza infection

(2014) Min Chen et al.   NATURE MEDICINE

Phase II and Pharmacodynamic Study of Autophagy Inhibition Using Hydroxychloroquine in Patients With Metastatic Pancreatic Adenocarcinoma

(2014) B. M. Wolpin et al.   ONCOLOGIST

Autophagy protects C. elegans against necrosis during Pseudomonas aeruginosa infection

(2014) C.-G. Zou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Optineurin is an autophagy receptor for damaged mitochondria in parkin-mediated mitophagy that is disrupted by an ALS-linked mutation

(2014) Yvette C. Wong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tubulin hyperacetylation is adaptive in cardiac proteotoxicity by promoting autophagy

(2014) Patrick M. McLendon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Autophagic Response to Radiation: Relevance for Radiation Sensitization in Cancer Therapy

(2014) David A. Gewirtz   RADIATION RESEARCH

Autophagy in Tuberculosis

(2014) V. Deretic   Cold Spring Harbor Perspectives in Medicine

Regular Examinations for Toxic Maculopathy in Long-term Chloroquine or Hydroxychloroquine Users

(2014) Melisa Nika et al.   JAMA Ophthalmology

The Risk of Toxic Retinopathy in Patients on Long-term Hydroxychloroquine Therapy

(2014) Ronald B. Melles et al.   JAMA Ophthalmology

Preventing the autophagic survival response by inhibition of calpain enhances the cytotoxic activity of bortezomib in vitro and in vivo

(2013) Aluvia M. Escalante et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Autophagy promotes hepatocellular carcinoma cell invasion through activation of epithelial–mesenchymal transition

(2013) Jun Li et al.   CARCINOGENESIS

Autophagy in Chronic Myeloid Leukaemia: Stem Cell Survival and Implication in Therapy

(2013) Gudmundur Helgason et al.   CURRENT CANCER DRUG TARGETS

Coordinate Autophagy and mTOR Pathway Inhibition Enhances Cell Death in Melanoma

(2013) Xiaoqi Xie et al.   PLoS One

Induction of Autophagy Is an Early Response to Gefitinib and a Potential Therapeutic Target in Breast Cancer

(2013) Wieslawa H. Dragowska et al.   PLoS One

The Autophagy Inhibitor Verteporfin Moderately Enhances the Antitumor Activity of Gemcitabine in a Pancreatic Ductal Adenocarcinoma Model

(2013) Elizabeth Donohue et al.   Journal of Cancer

Lys05

(2012) Ravi K. Amaravadi et al.   Autophagy

Inhibition of autophagy and induction of breast cancer cell death by mefloquine, an antimalarial agent

(2012) Natasha Sharma et al.   CANCER LETTERS

Autophagy inhibition in cancer therapy: metabolic considerations for antitumor immunity

(2012) Katelin N. Townsend et al.   IMMUNOLOGICAL REVIEWS

Autophagy modulation as a potential therapeutic target for diverse diseases

(2012) David C. Rubinsztein et al.   NATURE REVIEWS DRUG DISCOVERY

Autophagy Suppresses RIP Kinase-Dependent Necrosis Enabling Survival to mTOR Inhibition

(2012) Kevin Bray et al.   PLoS One

Autophagy inhibitor Lys05 has single-agent antitumor activity and reproduces the phenotype of a genetic autophagy deficiency

(2012) Q. McAfee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Comparison of Screening Procedures in Hydroxychloroquine Toxicity

(2011) Michael F. Marmor   ARCHIVES OF OPHTHALMOLOGY

Autophagy: Renovation of Cells and Tissues

(2011) Noboru Mizushima et al.   CELL

Beclin1 Controls the Levels of p53 by Regulating the Deubiquitination Activity of USP10 and USP13

(2011) Junli Liu et al.   CELL

Targeting Autophagy Augments In Vitro and In Vivo Antimyeloma Activity of DNA-Damaging Chemotherapy

(2011) Y. Pan et al.   CLINICAL CANCER RESEARCH

Measurements of Tumor Cell Autophagy Predict Invasiveness, Resistance to Chemotherapy, and Survival in Melanoma

(2011) X.-H. Ma et al.   CLINICAL CANCER RESEARCH

Principles and Current Strategies for Targeting Autophagy for Cancer Treatment

(2011) R. K. Amaravadi et al.   CLINICAL CANCER RESEARCH

The Multifaceted Roles of Autophagy in Tumors—Implications for Breast Cancer

(2011) Jayanta Debnath   JOURNAL OF MAMMARY GLAND BIOLOGY AND NEOPLASIA

The Role of Autophagy in Cancer: Therapeutic Implications

(2011) Z. J. Yang et al.   MOLECULAR CANCER THERAPEUTICS

Oncosuppressive Functions of Autophagy

(2010) Eugenia Morselli et al.   ANTIOXIDANTS & REDOX SIGNALING

Inhibition of Autophagosome Formation by the Benzoporphyrin Derivative Verteporfin

(2010) Elizabeth Donohue et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Autophagy and the Integrated Stress Response

(2010) Guido Kroemer et al.   MOLECULAR CELL

Autophagy and Metabolism

(2010) J. D. Rabinowitz et al.   SCIENCE

Rates and predictors of hydroxychloroquine retinal toxicity in patients with rheumatoid arthritis and systemic lupus erythematosus

(2010) Frederick Wolfe et al.   ARTHRITIS CARE & RESEARCH

Bicarbonate Increases Tumor pH and Inhibits Spontaneous Metastases

(2009) I. F. Robey et al.   CANCER RESEARCH

The Double-Edged Sword of Autophagy Modulation in Cancer

(2009) E. White et al.   CLINICAL CANCER RESEARCH

Chloroquine and its analogs: A new promise of an old drug for effective and safe cancer therapies

(2009) V. Raja Solomon et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

pH-dependent antitumor activity of proton pump inhibitors against human melanoma is mediated by inhibition of tumor acidity

(2009) Angelo De Milito et al.   INTERNATIONAL JOURNAL OF CANCER

Autophagy inhibition enhances vorinostat-induced apoptosis via ubiquitinated protein accumulation

(2009) Jennifer S. Carew et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Combined Bcl2 /mTOR Inhibition Leads to Enhanced Radiosensitization via Induction of Autophagy and Apoptosis in Non-small Lung Tumor Xenograft Model

(2008) K. Kim et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

Magnetic resonance imaging of pH in vivo using hyperpolarized 13C-labelled bicarbonate

(2008) Ferdia A. Gallagher et al.   NATURE

Autophagy fights disease through cellular self-digestion

(2008) Noboru Mizushima et al.   NATURE