Knockdown of IRE1α inhibits colonic tumorigenesis through decreasing β-catenin and IRE1α targeting suppresses colon cancer cells

Protein misfolding in the endoplasmic reticulum as a conduit to human disease

(2016) Miao Wang et al.   NATURE

The Role of Endoplasmic Reticulum Stress in Human Pathology

(2015) Scott A. Oakes et al.   Annual Review of Pathology-Mechanisms of Disease

The Endoplasmic Reticulum Stress Sensor IRE1α in Intestinal Epithelial Cells Is Essential for Protecting against Colitis

(2015) Hai-Sheng Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Targeting the IRE1α–XBP1 branch of the unfolded protein response in human diseases

(2015) Dadi Jiang et al.   SEMINARS IN CANCER BIOLOGY

Endoplasmic Reticulum Stress-Activated Cell Reprogramming in Oncogenesis

(2015) E. Chevet et al.   Cancer Discovery

Repression of Intestinal Stem Cell Function and Tumorigenesis through Direct Phosphorylation of β-Catenin and Yap by PKCζ

(2015) Victoria Llado et al.   Cell Reports

Endoplasmic Reticulum Stress in Malignancy

(2014) Hanna J. Clarke et al.   CANCER CELL

Wnt some lose some: transcriptional governance of stem cells by Wnt/ -catenin signaling

(2014) W.-H. Lien et al.   GENES & DEVELOPMENT

ER stress induces epithelial differentiation in the mouse oesophagus

(2014) Sanne L Rosekrans et al.   GUT

XBP1 promotes triple-negative breast cancer by controlling the HIF1α pathway

(2014) Xi Chen et al.   NATURE

Epithelial-to-Mesenchymal Transition Activates PERK-eIF2  and Sensitizes Cells to Endoplasmic Reticulum Stress

(2014) Y.-x. Feng et al.   Cancer Discovery

ER stress-induced cell death mechanisms

(2013) Renata Sano et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Wnt signaling in stem and cancer stem cells

(2013) Jane D Holland et al.   CURRENT OPINION IN CELL BIOLOGY

p53 and Translation Attenuation Regulate Distinct Cell Cycle Checkpoints during Endoplasmic Reticulum (ER) Stress

(2013) Sally E. Thomas et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The von Hippel-Lindau Protein pVHL Inhibits Ribosome Biogenesis and Protein Synthesis

(2013) Wen-Ting Zhao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ER stress transcription factor Xbp1 suppresses intestinal tumorigenesis and directs intestinal stem cells

(2013) Lukas Niederreiter et al.   JOURNAL OF EXPERIMENTAL MEDICINE

ER Stress Causes Rapid Loss of Intestinal Epithelial Stemness through Activation of the Unfolded Protein Response

(2013) Jarom Heijmans et al.   Cell Reports

Blockade of XBP1 splicing by inhibition of IRE1  is a promising therapeutic option in multiple myeloma

(2012) N. Mimura et al.   BLOOD

PAX2 Protein Induces Expression of Cyclin D1 through Activating AP-1 Protein and Promotes Proliferation of Colon Cancer Cells

(2012) Hai-Sheng Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ER stress–mediated autophagy promotes Myc-dependent transformation and tumor growth

(2012) Lori S. Hart et al.   JOURNAL OF CLINICAL INVESTIGATION

The molecular basis for selective inhibition of unconventional mRNA splicing by an IRE1-binding small molecule

(2012) B. C. S. Cross et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Alveolar Epithelial Cells Undergo Epithelial-to-Mesenchymal Transition in Response to Endoplasmic Reticulum Stress

(2011) Harikrishna Tanjore et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PKA phosphorylation couples hepatic inositol-requiring enzyme 1  to glucagon signaling in glucose metabolism

(2011) T. Mao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of an Ire1alpha endonuclease specific inhibitor with cytotoxic activity against human multiple myeloma

(2010) I. Papandreou et al.   BLOOD

Wnt activity defines colon cancer stem cells and is regulated by the microenvironment

(2010) Louis Vermeulen et al.   NATURE CELL BIOLOGY

A Crucial Role for RACK1 in the Regulation of Glucose-Stimulated IRE1  Activation in Pancreatic   Cells

(2010) Y. Qiu et al.   Science Signaling

Prolyl Hydroxylase-3 Is Down-regulated in Colorectal Cancer Cells and Inhibits IKKβ Independent of Hydroxylase Activity

(2009) Jing Xue et al.   GASTROENTEROLOGY

Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche

(2009) Toshiro Sato et al.   NATURE

ER stress is associated with dedifferentiation and an epithelial-to-mesenchymal transition-like phenotype in PC Cl3 thyroid cells

(2008) Luca Ulianich et al.   JOURNAL OF CELL SCIENCE