The ribosomal P-stalk couples amino acid starvation to GCN2 activation in mammalian cells

Activation of GCN2 by the ribosomal P-stalk

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Metascape provides a biologist-oriented resource for the analysis of systems-level datasets

(2019) Yingyao Zhou et al.   Nature Communications

Ribosomes and cryo-EM: a duet

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Translational Control through Differential Ribosome Pausing during Amino Acid Limitation in Mammalian Cells

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Translation Elongation and Recoding in Eukaryotes

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Role of eIF2α Kinases in Translational Control and Adaptation to Cellular Stress

(2018) Ronald C. Wek   Cold Spring Harbor Perspectives in Biology

The integrated stress response

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Activation of GCN2 kinase by ribosome stalling links translation elongation with translation initiation

(2016) Ryuta Ishimura et al.   eLife

Gcn1 contacts the small ribosomal protein Rps10, which is required for full activation of the protein kinase Gcn2

(2015) Su Jung Lee et al.   BIOCHEMICAL JOURNAL

G-actin provides substrate-specificity to eukaryotic initiation factor 2α holophosphatases

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The Scanning Mechanism of Eukaryotic Translation Initiation

(2014) Alan G. Hinnebusch   Annual Review of Biochemistry

Rational design of highly active sgRNAs for CRISPR-Cas9–mediated gene inactivation

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Improved vectors and genome-wide libraries for CRISPR screening

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Purification, characterization and crystallization of the human 80S ribosome

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Phosphorylation of Initiation Factor eIF2 in Response to Stress Conditions Is Mediated by Acidic Ribosomal P1/P2 Proteins in Saccharomyces cerevisiae

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Ribosome stalling induced by mutation of a CNS-specific tRNA causes neurodegeneration

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Genome-wide recessive genetic screening in mammalian cells with a lentiviral CRISPR-guide RNA library

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Archaeal ribosomal stalk protein interacts with translation factors in a nucleotide-independent manner via its conserved C terminus

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