G protein-coupled receptor-effector macromolecular membrane assemblies (GEMMAs)

Mechanisms for Regulating and Organizing Receptor Signaling by Endocytosis

(2021) Mark von Zastrow et al.   Annual Review of Biochemistry

G-protein activation by a metabotropic glutamate receptor

(2021) Alpay B. Seven et al.   NATURE

Structures of human mGlu2 and mGlu7 homo- and heterodimers

(2021) Juan Du et al.   NATURE

Structures of Gi-bound metabotropic glutamate receptors mGlu2 and mGlu4

(2021) Shuling Lin et al.   NATURE

Control of glutamate release by complexes of adenosine and cannabinoid receptors

(2020) Attila Köfalvi et al.   BMC BIOLOGY

The small molecule GAT1508 activates brain-specific GIRK1/2 channel heteromers and facilitates conditioned fear extinction in rodents

(2020) Yu Xu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structure of the neurotensin receptor 1 in complex with β-arrestin 1

(2020) Weijiao Huang et al.   NATURE

Dawn of a New RAMPage

(2020) D. Stephen Serafin et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

The belated US FDA approval of the adenosine A2A receptor antagonist istradefylline for treatment of Parkinson’s disease

(2020) Jiang-Fan Chen et al.   Purinergic Signalling

Altered Signaling in CB1R-5-HT2AR Heteromers in Olfactory Neuroepithelium Cells of Schizophrenia Patients is Modulated by Cannabis Use

(2020) Daniel Guinart et al.   SCHIZOPHRENIA BULLETIN

G protein-regulated endocytic trafficking of adenylyl cyclase type 9

(2020) André M Lazar et al.   eLife

Modulation of dopamine D1 receptors via histamine H3 receptors is a novel therapeutic target for Huntington's disease

(2020) David Moreno-Delgado et al.   eLife

Decreased striatal adenosine A2A-dopamine D2 receptor heteromerization in schizophrenia

(2020) Marta Valle-León et al.   NEUROPSYCHOPHARMACOLOGY

Structural and Biophysical Mechanisms of Class C G Protein-Coupled Receptor Function

(2020) Amr Ellaithy et al.   TRENDS IN BIOCHEMICAL SCIENCES

Shaky ground - The nature of metastable GPCR signalling complexes

(2019) Rory Sleno et al.   NEUROPHARMACOLOGY

The in vivo specificity of synaptic Gβ and Gγ subunits to the α2a adrenergic receptor at CNS synapses

(2019) Yun Young Yim et al.   Scientific Reports

Structural insights into the activation of metabotropic glutamate receptors

(2019) Antoine Koehl et al.   NATURE

Bioluminescence Resonance Energy Transfer as a Method to Study Protein-Protein Interactions: Application to G Protein Coupled Receptor Biology

(2019) Chayma El Khamlichi et al.   MOLECULES

Insights into the Regulatory Properties of Human Adenylyl Cyclase Type 9

(2019) Tanya A. Baldwin et al.   MOLECULAR PHARMACOLOGY

Biased G Protein-Independent Signaling of Dopamine D1-D3 Receptor Heteromers in the Nucleus Accumbens

(2019) Xavier Guitart et al.   MOLECULAR NEUROBIOLOGY

The structural basis of the arrestin binding to GPCRs

(2019) Vsevolod V. Gurevich et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Structural Insights into the Process of GPCR-G Protein Complex Formation

(2019) Xiangyu Liu et al.   CELL

Assembly of a GPCR-G Protein Complex

(2019) Yang Du et al.   CELL

Opioid–galanin receptor heteromers mediate the dopaminergic effects of opioids

(2019) Ning-Sheng Cai et al.   JOURNAL OF CLINICAL INVESTIGATION

The structure of a membrane adenylyl cyclase bound to an activated stimulatory G protein

(2019) Chao Qi et al.   SCIENCE

Conformational transitions of a neurotensin receptor 1–Gi1 complex

(2019) Hideaki E. Kato et al.   NATURE

Cryo-EM structure of the rhodopsin-Gαi-βγ complex reveals binding of the rhodopsin C-terminal tail to the gβ subunit

(2019) Ching-Ju Tsai et al.   eLife

G-protein βγ subunits as multi-functional scaffolds and transducers in G-protein-coupled receptor signaling

(2019) Alan V. Smrcka et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Fluorescent ligands: Bringing light to emerging GPCR paradigms

(2019) Mark Soave et al.   BRITISH JOURNAL OF PHARMACOLOGY

Activation of µ-δ opioid receptor heteromers inhibits neuropathic pain behavior in rodents

(2019) Vinod Tiwari et al.   PAIN

The Molecular Basis of G Protein–Coupled Receptor Activation

(2018) William I. Weis et al.   Annual Review of Biochemistry

Single Proteoliposome High-Content Analysis Reveals Differences in the Homo-Oligomerization of GPCRs

(2018) Samuel M. Walsh et al.   BIOPHYSICAL JOURNAL

Related GPCRs couple differently to Gs: preassociation between G protein and 5-HT7 serotonin receptor reveals movement of Gαs upon receptor activation

(2018) Kjetil Wessel Andressen et al.   FASEB JOURNAL

Adenosine A1-Dopamine D1 Receptor Heteromers Control the Excitability of the Spinal Motoneuron

(2018) Marla Rivera-Oliver et al.   MOLECULAR NEUROBIOLOGY

Gs- versus Golf-dependent functional selectivity mediated by the dopamine D1 receptor

(2018) Hideaki Yano et al.   Nature Communications

Evidence for functional pre-coupled complexes of receptor heteromers and adenylyl cyclase

(2018) Gemma Navarro et al.   Nature Communications

Essential Control of the Function of the Striatopallidal Neuron by Pre-coupled Complexes of Adenosine A2A-Dopamine D2 Receptor Heterotetramers and Adenylyl Cyclase

(2018) Sergi Ferré et al.   Frontiers in Pharmacology

Postsynaptic localization and regulation of AMPA receptors and Cav1.2 by β2 adrenergic receptor/PKA and Ca2+/CaMKII signaling

(2018) Tommaso Patriarchi et al.   EMBO JOURNAL

Design of a true bivalent ligand with picomolar binding affinity for a G protein-coupled receptor homodimer

(2018) Daniel Pulido et al.   JOURNAL OF MEDICINAL CHEMISTRY

Selectivity determinants of GPCR–G-protein binding

(2017) Tilman Flock et al.   NATURE

Single-molecule imaging reveals receptor–G protein interactions at cell surface hot spots

(2017) Titiwat Sungkaworn et al.   NATURE

International Union of Basic and Clinical Pharmacology. CI. Structures and Small Molecule Modulators of Mammalian Adenylyl Cyclases

(2017) Carmen W. Dessauer et al.   PHARMACOLOGICAL REVIEWS

Receptor Activity-Modifying Proteins (RAMPs): New Insights and Roles

(2016) Debbie L. Hay et al.   Annual Review of Pharmacology and Toxicology

G Protein–Coupled Receptor Heteromers

(2016) Ivone Gomes et al.   Annual Review of Pharmacology and Toxicology

Identifying ligands at orphan GPCRs: current status using structure-based approaches

(2016) Tony Ngo et al.   BRITISH JOURNAL OF PHARMACOLOGY

A Significant Role of the Truncated Ghrelin Receptor GHS-R1b in Ghrelin-induced Signaling in Neurons

(2016) Gemma Navarro et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Functional μ-Opioid-Galanin Receptor Heteromers in the Ventral Tegmental Area

(2016) Estefanía Moreno et al.   JOURNAL OF NEUROSCIENCE

Cross-signaling in metabotropic glutamate 2 and serotonin 2A receptor heteromers in mammalian cells

(2016) Lia Baki et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Gβγ subunits—Different spaces, different faces

(2016) Shahriar M. Khan et al.   PHARMACOLOGICAL RESEARCH

Allosteric signaling through an mGlu2 and 5-HT2Aheteromeric receptor complex and its potential contribution to schizophrenia

(2016) José L. Moreno et al.   Science Signaling

Allosteric signaling through an mGlu2 and 5-HT2Aheteromeric receptor complex and its potential contribution to schizophrenia

(2016) José L. Moreno et al.   Science Signaling

Phosphoinositide Control of Membrane Protein Function: A Frontier Led by Studies on Ion Channels

(2015) Diomedes E. Logothetis et al.   Annual Review of Physiology

Galanin receptors as a potential target for neurological disease

(2015) Krista Freimann et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Revealing G-protein-coupled receptor oligomerization at the single-molecule level through a nanoscopic lens: methods, dynamics and biological function

(2015) Marco Scarselli et al.   FEBS Journal

Ghrelin receptor conformational dynamics regulate the transition from a preassembled to an active receptor:Gq complex

(2015) Marjorie Damian et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Allosteric interactions between agonists and antagonists within the adenosine A2Areceptor-dopamine D2receptor heterotetramer

(2015) Jordi Bonaventura et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The GPCR heterotetramer: challenging classical pharmacology

(2015) Sergi Ferré   TRENDS IN PHARMACOLOGICAL SCIENCES

Cognitive Impairment Induced by Delta9-tetrahydrocannabinol Occurs through Heteromers between Cannabinoid CB1 and Serotonin 5-HT2A Receptors

(2015) Xavier Viñals et al.   PLOS BIOLOGY

Stable G protein-effector complexes in striatal neurons: mechanism of assembly and role in neurotransmitter signaling

(2015) Keqiang Xie et al.   eLife

Heteromers of μ-δ opioid receptors: new pharmacology and novel therapeutic possibilities

(2014) Wakako Fujita et al.   BRITISH JOURNAL OF PHARMACOLOGY

The Specific Monomer/Dimer Equilibrium of the Corticotropin-releasing Factor Receptor Type 1 Is Established in the Endoplasmic Reticulum

(2014) Anke Teichmann et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Differential Effects of Presynaptic versus Postsynaptic Adenosine A2A Receptor Blockade on  9-Tetrahydrocannabinol (THC) Self-Administration in Squirrel Monkeys

(2014) Z. Justinova et al.   JOURNAL OF NEUROSCIENCE

PKA-GluA1 Coupling via AKAP5 Controls AMPA Receptor Phosphorylation and Cell-Surface Targeting during Bidirectional Homeostatic Plasticity

(2014) Graham H. Diering et al.   NEURON

Regulation of G Protein-Coupled Receptor Kinases by Phospholipids

(2013) K.T. Homan et al.   CURRENT MEDICINAL CHEMISTRY

Heterodimerization with Its Splice Variant Blocks the Ghrelin Receptor 1a in a Non-signaling Conformation

(2013) Sophie Mary et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Role of AKAP79/150 Protein in β1-Adrenergic Receptor Trafficking and Signaling in Mammalian Cells

(2013) Xin Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Adenylyl Cyclase Anchoring by a Kinase Anchor Protein AKAP5 (AKAP79/150) Is Important for Postsynaptic β-Adrenergic Signaling

(2013) Mingxu Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

X-ray structure of the mammalian GIRK2–βγ G-protein complex

(2013) Matthew R. Whorton et al.   NATURE

Crystal structure of oligomeric β1-adrenergic G protein–coupled receptors in ligand-free basal state

(2013) Jianyun Huang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Identification of a  -  opioid receptor heteromer-biased agonist with antinociceptive activity

(2013) I. Gomes et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Heteromeric MT1/MT2 Melatonin Receptors Modulate Photoreceptor Function

(2013) K. Baba et al.   Science Signaling

Clinically Employed Opioid Analgesics Produce Antinociception via μ-δ Opioid Receptor Heteromers in Rhesus Monkeys

(2012) Ajay S. Yekkirala et al.   ACS Chemical Neuroscience

GTPase Networks in Membrane Traffic

(2012) Emi Mizuno-Yamasaki et al.   Annual Review of Biochemistry

Creating Order from Chaos: Cellular Regulation by Kinase Anchoring

(2012) John D. Scott et al.   Annual Review of Pharmacology and Toxicology

Identification of Three Residues Essential for 5-Hydroxytryptamine 2A-Metabotropic Glutamate 2 (5-HT2A·mGlu2) Receptor Heteromerization and Its Psychoactive Behavioral Function

(2012) José L. Moreno et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Crystal structure of the µ-opioid receptor bound to a morphinan antagonist

(2012) Aashish Manglik et al.   NATURE

GKAP orchestrates activity-dependent postsynaptic protein remodeling and homeostatic scaling

(2012) Seung Min Shin et al.   NATURE NEUROSCIENCE

Single-molecule analysis of fluorescently labeled G-protein-coupled receptors reveals complexes with distinct dynamics and organization

(2012) D. Calebiro et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of new binding partners of the chemosensory signaling protein Gγ13 expressed in taste and olfactory sensory cells

(2012) Zhenhui Liu et al.   Frontiers in Cellular Neuroscience

BRET and Time-resolved FRET strategy to study GPCR oligomerization: from cell lines toward native tissues

(2012) Martin Cottet et al.   Frontiers in Endocrinology

Decoding the Signaling of a GPCR Heteromeric Complex Reveals a Unifying Mechanism of Action of Antipsychotic Drugs

(2011) Miguel Fribourg et al.   CELL

The truncated ghrelin receptor polypeptide (GHS-R1b) is localized in the endoplasmic reticulum where it forms heterodimers with ghrelin receptors (GHS-R1a) to attenuate their cell surface expression

(2011) Kevin B.S. Chow et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Confinement of β1- and β2-adrenergic receptors in the plasma membrane of cardiomyocyte-like H9c2 cells is mediated by selective interactions with PDZ domain and A-kinase anchoring proteins but not caveolae

(2011) Cathleen D. Valentine et al.   MOLECULAR BIOLOGY OF THE CELL

Conformational changes in the G protein Gs induced by the β2 adrenergic receptor

(2011) Ka Young Chung et al.   NATURE

Crystal structure of the β2 adrenergic receptor–Gs protein complex

(2011) Søren G. F. Rasmussen et al.   NATURE

Inactive-state preassembly of Gq-coupled receptors and Gq heterotrimers

(2011) Kou Qin et al.   Nature Chemical Biology

MAGUKs, Synaptic Development, and Synaptic Plasticity

(2011) Chan-Ying Zheng et al.   NEUROSCIENTIST

G protein-coupled receptor kinases: More than just kinases and not only for GPCRs

(2011) Eugenia V. Gurevich et al.   PHARMACOLOGY & THERAPEUTICS

Striatal Pre- and Postsynaptic Profile of Adenosine A2A Receptor Antagonists

(2011) Marco Orru et al.   PLoS One

Interaction of a G protein with an activated receptor opens the interdomain interface in the alpha subunit

(2011) N. Van Eps et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural flexibility of the G s  -helical domain in the  2-adrenoceptor Gs complex

(2011) G. H. Westfield et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of a Specific Assembly of the G Protein Golf as a Critical and Regulated Module of Dopamine and Adenosine-Activated cAMP Pathways in the Striatum

(2011) Denis Hervé   Frontiers in Neuroanatomy

Characterization of the A2AR–D2R interface: Focus on the role of the C-terminal tail and the transmembrane helices

(2010) Dasiel O. Borroto-Escuela et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

A serine point mutation in the adenosine A2AR C-terminal tail reduces receptor heteromerization and allosteric modulation of the dopamine D2R

(2010) Dasiel O. Borroto-Escuela et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Differential association modes of the thrombin receptor PAR1 with Gαi1, Gα12, and β-arrestin 1

(2010) Mohammed Akli Ayoub et al.   FASEB JOURNAL

AKAP79 Interacts with Multiple Adenylyl Cyclase (AC) Isoforms and Scaffolds AC5 and -6 to α-Amino-3-hydroxyl-5-methyl-4-isoxazole-propionate (AMPA) Receptors

(2010) Riad Efendiev et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Adenosine A2AReceptor Signaling and GolfAssembly Show a Specific Requirement for the γ7Subtype in the Striatum

(2010) William F. Schwindinger et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Allostery at G Protein-Coupled Receptor Homo- and Heteromers: Uncharted Pharmacological Landscapes

(2010) N. J. Smith et al.   PHARMACOLOGICAL REVIEWS

Coexpression of  - and  -opioid receptors in nociceptive sensory neurons

(2010) H.-B. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structures of the CXCR4 Chemokine GPCR with Small-Molecule and Cyclic Peptide Antagonists

(2010) B. Wu et al.   SCIENCE

Kinetic Scaffolding Mediated by a Phospholipase C-  and Gq Signaling Complex

(2010) G. L. Waldo et al.   SCIENCE

Signaling by internalized G-protein-coupled receptors

(2010) Davide Calebiro et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Standard Opioid Agonists Activate Heteromeric Opioid Receptors: Evidence for Morphine and [d-Ala2-MePhe4-Glyol5]Enkephalin as Selective μ−δ Agonists

(2009) Ajay S. Yekkirala et al.   ACS Chemical Neuroscience

Dissociation of the Opioid Receptor Mechanisms that Control Mechanical and Heat Pain

(2009) Grégory Scherrer et al.   CELL

Assembly of a β2-adrenergic receptor—GluR1 signalling complex for localized cAMP signalling

(2009) Mei-ling A Joiner et al.   EMBO JOURNAL

Adenosine A2AReceptor-Antagonist/Dopamine D2Receptor-Agonist Bivalent Ligands as Pharmacological Tools to Detect A2A-D2Receptor Heteromers

(2009) Aroa Soriano et al.   JOURNAL OF MEDICINAL CHEMISTRY

N Terminus of Type 5 Adenylyl Cyclase Scaffolds Gs Heterotrimer

(2009) R. Sadana et al.   MOLECULAR PHARMACOLOGY

Adenylyl Cyclase-A-kinase Anchoring Protein Complexes: The Next Dimension in cAMP Signaling

(2009) C. W. Dessauer   MOLECULAR PHARMACOLOGY

Building a new conceptual framework for receptor heteromers

(2009) Sergi Ferré et al.   Nature Chemical Biology

Sustained cyclic AMP production by parathyroid hormone receptor endocytosis

(2009) Sébastien Ferrandon et al.   Nature Chemical Biology

Analysis of receptor oligomerization by FRAP microscopy

(2009) Sandra Dorsch et al.   NATURE METHODS

The Role of Gβγ Subunits in the Organization, Assembly, and Function of GPCR Signaling Complexes

(2008) Denis J. Dupré et al.   Annual Review of Pharmacology and Toxicology

Structures of Rhodopsin Kinase in Different Ligand States Reveal Key Elements Involved in G Protein-coupled Receptor Kinase Activation

(2008) Puja Singh et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification of a serotonin/glutamate receptor complex implicated in psychosis

(2008) Javier González-Maeso et al.   NATURE

Physiological Roles for G Protein-Regulated Adenylyl Cyclase Isoforms: Insights from Knockout and Overexpression Studies

(2008) Rachna Sadana et al.   NEUROSIGNALS

Cell surface targeting of  -  opioid receptor heterodimers by RTP4

(2008) F. M. Decaillot et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA