标题
G-protein activation by a metabotropic glutamate receptor
作者
关键词
-
出版物
NATURE
Volume 595, Issue 7867, Pages 450-454
出版商
Springer Science and Business Media LLC
发表日期
2021-07-01
DOI
10.1038/s41586-021-03680-3
参考文献
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- Differences in interactions between transmembrane domains tune the activation of metabotropic glutamate receptors
- (2021) Jordana K Thibado et al. eLife
- Asymmetric activation of the calcium-sensing receptor homodimer
- (2021) Yang Gao et al. NATURE
- Structures of metabotropic GABAB receptor
- (2020) Makaía M. Papasergi-Scott et al. NATURE
- GemSpot: A Pipeline for Robust Modeling of Ligands into Cryo-EM Maps
- (2020) Michael J. Robertson et al. STRUCTURE
- UCSF ChimeraX : Structure visualization for researchers, educators, and developers
- (2020) Eric F. Pettersen et al. PROTEIN SCIENCE
- Structural and Biophysical Mechanisms of Class C G Protein-Coupled Receptor Function
- (2020) Amr Ellaithy et al. TRENDS IN BIOCHEMICAL SCIENCES
- Structure of a Signaling Cannabinoid Receptor 1-G Protein Complex
- (2019) Kaavya Krishna Kumar et al. CELL
- Structural insights into the activation of metabotropic glutamate receptors
- (2019) Antoine Koehl et al. NATURE
- Multiple liquid crystalline geometries of highly compacted nucleic acid in a dsRNA virus
- (2019) Serban L. Ilca et al. NATURE
- Structures of the M1 and M2 muscarinic acetylcholine receptor/G-protein complexes
- (2019) Shoji Maeda et al. SCIENCE
- Macromolecular structure determination using X-rays, neutrons and electrons: recent developments in Phenix
- (2019) Dorothee Liebschner et al. Acta Crystallographica Section D-Structural Biology
- The Molecular Basis of G Protein–Coupled Receptor Activation
- (2018) William I. Weis et al. Annual Review of Biochemistry
- Structure-Based Optimization Strategies for G Protein-Coupled Receptor (GPCR) Allosteric Modulators: A Case Study from Analyses of New Metabotropic Glutamate Receptor 5 (mGlu5) X-ray Structures
- (2018) John A. Christopher et al. JOURNAL OF MEDICINAL CHEMISTRY
- SWISS-MODEL: homology modelling of protein structures and complexes
- (2018) Andrew Waterhouse et al. NUCLEIC ACIDS RESEARCH
- Structure of the µ-opioid receptor–Gi protein complex
- (2018) Antoine Koehl et al. NATURE
- Development of an antibody fragment that stabilizes GPCR/G-protein complexes
- (2018) Shoji Maeda et al. Nature Communications
- New tools for automated high-resolution cryo-EM structure determination in RELION-3
- (2018) Jasenko Zivanov et al. eLife
- MotionCor2: anisotropic correction of beam-induced motion for improved cryo-electron microscopy
- (2017) Shawn Q Zheng et al. NATURE METHODS
- cryoSPARC: algorithms for rapid unsupervised cryo-EM structure determination
- (2017) Ali Punjani et al. NATURE METHODS
- MolProbity: More and better reference data for improved all-atom structure validation
- (2017) Christopher J. Williams et al. PROTEIN SCIENCE
- Molecular Switches of Allosteric Modulation of the Metabotropic Glutamate 2 Receptor
- (2017) Laura Pérez-Benito et al. STRUCTURE
- Design and Synthesis of mGlu2 NAMs with Improved Potency and CNS Penetration Based on a Truncated Picolinamide Core
- (2017) Katrina A. Bollinger et al. ACS Medicinal Chemistry Letters
- Allosteric control of an asymmetric transduction in a G protein-coupled receptor heterodimer
- (2017) Junke Liu et al. eLife
- Discovery of (1S,2R,3S,4S,5R,6R)-2-Amino-3-[(3,4-difluorophenyl)sulfanylmethyl]-4-hydroxy-bicyclo[3.1.0]hexane-2,6-dicarboxylic Acid Hydrochloride (LY3020371·HCl): A Potent, Metabotropic Glutamate 2/3 Receptor Antagonist with Antidepressant-Like Activity
- (2016) Mark D. Chappell et al. JOURNAL OF MEDICINAL CHEMISTRY
- Gctf: Real-time CTF determination and correction
- (2016) Kai Zhang JOURNAL OF STRUCTURAL BIOLOGY
- Crystal structures of the M1 and M4 muscarinic acetylcholine receptors
- (2016) David M. Thal et al. NATURE
- Molecular determinants of positive allosteric modulation of the human metabotropic glutamate receptor 2
- (2015) A Farinha et al. BRITISH JOURNAL OF PHARMACOLOGY
- Synthesis and Pharmacological Characterization of C4-(Thiotriazolyl)-substituted-2-aminobicyclo[3.1.0]hexane-2,6-dicarboxylates. Identification of (1R,2S,4R,5R,6R)-2-Amino-4-(1H-1,2,4-triazol-3-ylsulfanyl)bicyclo[3.1.0]hexane-2,6-dicarboxylic Acid (LY2812223), a Highly Potent, Functionally Selective mGlu2 Receptor Agonist
- (2015) James A. Monn et al. JOURNAL OF MEDICINAL CHEMISTRY
- Fragment and Structure-Based Drug Discovery for a Class C GPCR: Discovery of the mGlu5 Negative Allosteric Modulator HTL14242 (3-Chloro-5-[6-(5-fluoropyridin-2-yl)pyrimidin-4-yl]benzonitrile)
- (2015) John A. Christopher et al. JOURNAL OF MEDICINAL CHEMISTRY
- Adhesion G protein-coupled receptors are activated by exposure of a cryptic tethered agonist
- (2015) Hannah M. Stoveken et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Structural basis for nucleotide exchange in heterotrimeric G proteins
- (2015) R. O. Dror et al. SCIENCE
- Epock: rapid analysis of protein pocket dynamics
- (2014) Benoist Laurent et al. BIOINFORMATICS
- Structure of class C GPCR metabotropic glutamate receptor 5 transmembrane domain
- (2014) Andrew S. Doré et al. NATURE
- Major ligand-induced rearrangement of the heptahelical domain interface in a GPCR dimer
- (2014) Li Xue et al. Nature Chemical Biology
- Action of Molecular Switches in GPCRs - Theoretical and Experimental Studies
- (2012) B. Trzaskowski et al. CURRENT MEDICINAL CHEMISTRY
- Structural determinants of allosteric antagonism at metabotropic glutamate receptor 2: mechanistic studies with new potent negative allosteric modulators
- (2011) L Lundström et al. BRITISH JOURNAL OF PHARMACOLOGY
- Crystal structure of the β2 adrenergic receptor–Gs protein complex
- (2011) Søren G. F. Rasmussen et al. NATURE
- SignalP 4.0: discriminating signal peptides from transmembrane regions
- (2011) Thomas Nordahl Petersen et al. NATURE METHODS
- Features and development ofCoot
- (2010) P. Emsley et al. ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY
- Metabotropic Glutamate Receptors: Physiology, Pharmacology, and Disease
- (2010) Colleen M. Niswender et al. Annual Review of Pharmacology and Toxicology
- Prediction of the Water Content in Protein Binding Sites
- (2009) Julien Michel et al. JOURNAL OF PHYSICAL CHEMISTRY B
- Identification of a novel transmembrane domain involved in the negative modulation of mGluR1 using a newly discovered allosteric mGluR1 antagonist, 3-cyclohexyl-5-fluoro-6-methyl-7-(2-morpholin-4-ylethoxy)-4H-chromen-4-one
- (2009) Junko Fukuda et al. NEUROPHARMACOLOGY
- Activation of metabotropic glutamate receptors as a novel approach for the treatment of schizophrenia
- (2008) P. Jeffrey Conn et al. TRENDS IN PHARMACOLOGICAL SCIENCES
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