Identification of a  -  opioid receptor heteromer-biased agonist with antinociceptive activity

The δ Opioid Receptor Agonist SNC80 Selectively Activates Heteromeric μ–δ Opioid Receptors

(2012) Matthew D. Metcalf et al.   ACS Chemical Neuroscience

Identification of a dual δ OR antagonist/μ OR agonist as a potential therapeutic for diarrhea-predominant Irritable Bowel Syndrome (IBS-d)

(2012) Henry J. Breslin et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Modulation of gastrointestinal function by MuDelta, a mixed µ opioid receptor agonist/ µ opioid receptor antagonist

(2012) PR Wade et al.   BRITISH JOURNAL OF PHARMACOLOGY

Crystal structure of the µ-opioid receptor bound to a morphinan antagonist

(2012) Aashish Manglik et al.   NATURE

G Protein-Coupled Receptor Heteromerization: A Role in Allosteric Modulation of Ligand Binding

(2011) I. Gomes et al.   MOLECULAR PHARMACOLOGY

Facilitation of μ-Opioid Receptor Activity by Preventing δ-Opioid Receptor-Mediated Codegradation

(2011) Shao-Qiu He et al.   NEURON

Chronic Morphine Alters the Presynaptic Protein Profile: Identification of Novel Molecular Targets Using Proteomics and Network Analysis

(2011) Noura S. Abul-Husn et al.   PLoS One

jCompoundMapper: An open source Java library and command-line tool for chemical fingerprints

(2011) Georg Hinselmann et al.   Journal of Cheminformatics

Similarity−Potency Trees: A Method to Search for SAR Information in Compound Data Sets and Derive SAR Rules

(2010) Mathias Wawer et al.   Journal of Chemical Information and Modeling

Increased Abundance of Opioid Receptor Heteromers After Chronic Morphine Administration

(2010) A. Gupta et al.   Science Signaling

Standard Opioid Agonists Activate Heteromeric Opioid Receptors: Evidence for Morphine and [d-Ala2-MePhe4-Glyol5]Enkephalin as Selective μ−δ Agonists

(2009) Ajay S. Yekkirala et al.   ACS Chemical Neuroscience