Systematic review of human post‐mortem immunohistochemical studies and bioinformatics analyses unveil the complexity of astrocyte reaction in Alzheimer's disease

Physiological and Pathological Ageing of Astrocytes in the Human Brain

(2021) Marloes Verkerke et al.   NEUROCHEMICAL RESEARCH

Machine learning identifies candidates for drug repurposing in Alzheimer’s disease

(2021) Steve Rodriguez et al.   Nature Communications

Frontal cortex chitinase and pentraxin neuroinflammatory alterations during the progression of Alzheimer’s disease

(2020) Marta Moreno-Rodriguez et al.   Journal of Neuroinflammation

Large-scale proteomic analysis of Alzheimer’s disease brain and cerebrospinal fluid reveals early changes in energy metabolism associated with microglia and astrocyte activation

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Astrocyte layers in the mammalian cerebral cortex revealed by a single-cell in situ transcriptomic map

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Spatial Transcriptomics and In Situ Sequencing to Study Alzheimer’s Disease

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Meta-analysis of mouse transcriptomic studies supports a context-dependent astrocyte reaction in acute CNS injury versus neurodegeneration

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Combined Transcriptomics and Proteomics in Frontal Cortex Area 8 in Frontotemporal Lobar Degeneration Linked to C9ORF72 Expansion

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Chronic Microglial Activation in the GFAP-IL6 Mouse Contributes to Age-Dependent Cerebellar Volume Loss and Impairment in Motor Function

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Impact of TREM2 risk variants on brain region-specific immune activation and plaque microenvironment in Alzheimer’s disease patient brain samples

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Characterization of the 18 kDa translocator protein (TSPO) expression in post‐mortem normal and Alzheimer's disease brains

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A single-cell atlas of entorhinal cortex from individuals with Alzheimer’s disease reveals cell-type-specific gene expression regulation

(2019) Alexandra Grubman et al.   NATURE NEUROSCIENCE

Neurotoxic astrocytes express the d-serine synthesizing enzyme, serine racemase, in Alzheimer's disease

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Brain alpha-amylase: a novel energy regulator important in Alzheimer disease?

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Remote Memory and Cortical Synaptic Plasticity Require Neuronal CCCTC-Binding Factor (CTCF)

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Activated forms of astrocytes with higher GLT-1 expression are associated with cognitive normal subjects with Alzheimer pathology in human brain

(2018) Eiji Kobayashi et al.   Scientific Reports

Deciphering the Astrocyte Reaction in Alzheimer’s Disease

(2018) Beatriz G. Perez-Nievas et al.   Frontiers in Aging Neuroscience

Metallothionein-I/II expression associates with the astrocyte DNA damage response and not Alzheimer-type pathology in the aging brain

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Identification of N-Terminally Truncated Pyroglutamate Amyloid-β in Cholesterol-Enriched Diet-Fed Rabbit and AD Brain

(2018) Roxanna Perez-Garmendia et al.   JOURNAL OF ALZHEIMERS DISEASE

Alzheimer's Disease: Evidence for the Expression of Interleukin-33 and Its Receptor ST2 in the Brain

(2018) Zhi Xiong et al.   JOURNAL OF ALZHEIMERS DISEASE

Targeted Assessment of Enlargement of the Perivascular Space in Alzheimer’s Disease and Vascular Dementia Subtypes Implicates Astroglial Involvement Specific to Alzheimer’s Disease

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The Gene Ontology Resource: 20 years and still GOing strong

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Modulation of astrocyte reactivity improves functional deficits in mouse models of Alzheimer’s disease

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Altered Sphingolipid Balance in Capillary Cerebral Amyloid Angiopathy

(2017) Nienke M. de Wit et al.   JOURNAL OF ALZHEIMERS DISEASE

YKL-40 (Chitinase 3-like I) is expressed in a subset of astrocytes in Alzheimer’s disease and other tauopathies

(2017) Marta Querol-Vilaseca et al.   Journal of Neuroinflammation

Evaluating the Patterns of Aging-Related Tau Astrogliopathy Unravels Novel Insights Into Brain Aging and Neurodegenerative Diseases

(2017) Gabor G. Kovacs et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Abnormal Microglia and Enhanced Inflammation-Related Gene Transcription in Mice with Conditional Deletion ofCtcfinCamk2a-Cre-Expressing Neurons.

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YKL-40 in the brain and cerebrospinal fluid of neurodegenerative dementias

(2017) Franc Llorens et al.   Molecular Neurodegeneration

Review: Astrocytes in Alzheimer's disease and other age-associated dementias: a supporting player with a central role

(2017) C. J. Garwood et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

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Association of Perivascular Localization of Aquaporin-4 With Cognition and Alzheimer Disease in Aging Brains

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Plaque-Associated Local Toxicity Increases over the Clinical Course of Alzheimer Disease

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Calcineurin proteolysis in astrocytes: Implications for impaired synaptic function

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p53 isoforms regulate astrocyte-mediated neuroprotection and neurodegeneration

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Increased occurrence of protein kinase CK2 in astrocytes in Alzheimer’s disease pathology

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KCa3.1 constitutes a pharmacological target for astrogliosis associated with Alzheimer's disease

(2016) Mengni Yi et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Neurofilament-labeled pyramidal neurons and astrocytes are deficient in DNA methylation marks in Alzheimer's disease

(2016) Andrew J. Phipps et al.   NEUROBIOLOGY OF AGING

Clusterin expression is upregulated following acute head injury and localizes to astrocytes in old head injury

(2016) Claire Troakes et al.   NEUROPATHOLOGY

Aberrant expression of the pore-forming KATP channel subunit Kir6.2 in hippocampal reactive astrocytes in the 3xTg-AD mouse model and human Alzheimer’s disease

(2016) Chelsea M. Griffith et al.   NEUROSCIENCE

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Neuronal CTCF Is Necessary for Basal and Experience-Dependent Gene Regulation, Memory Formation, and Genomic Structure of BDNF and Arc

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Analysis of the Putative Role of CR1 in Alzheimer’s Disease: Genetic Association, Expression and Function

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High Resolution Dissection of Reactive Glial Nets in Alzheimer’s Disease

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An isoform-specific role of FynT tyrosine kinase in Alzheimer's disease

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The JAK/STAT3 Pathway Is a Common Inducer of Astrocyte Reactivity in Alzheimer's and Huntington's Diseases

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Astrocytic adenosine receptor A2A and Gs-coupled signaling regulate memory

(2015) Anna G Orr et al.   NATURE NEUROSCIENCE

The nuclear retention of transcription factor FOXO3a correlates with a DNA damage response and increased glutamine synthetase expression by astrocytes suggesting a neuroprotective role in the ageing brain

(2015) Adeline Fluteau et al.   NEUROSCIENCE LETTERS

The participation of insulin-like growth factor-binding protein 3 released by astrocytes in the pathology of Alzheimer’s disease

(2015) Kiwamu Watanabe et al.   Molecular Brain

Hook Proteins: Association with Alzheimer Pathology and Regulatory Role of Hook3 in Amyloid Beta Generation

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Metabotropic Glutamate Receptor 5 in Down's Syndrome Hippocampus During Development: Increased Expression in Astrocytes

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GABA from reactive astrocytes impairs memory in mouse models of Alzheimer's disease

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CTCF: an architectural protein bridging genome topology and function

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Isolation of glia from Alzheimer's mice reveals inflammation and dysfunction

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Tonic inhibition in dentate gyrus impairs long-term potentiation and memory in an Alzheimer’s disease model

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Abundant kif21b is associated with accelerated progression in neurodegenerative diseases

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A Phenotypic Change But Not Proliferation Underlies Glial Responses in Alzheimer Disease

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Reactive astrocytes associated with plaques in TgCRND8 mouse brain and in human Alzheimer brain express phosphoprotein enriched in astrocytes (PEA-15)

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Amyloid beta deregulates astroglial mGluR5-mediated calcium signaling via calcineurin and Nf-kB

(2013) Dmitry Lim et al.   GLIA

Differential Relationships of Reactive Astrocytes and Microglia to Fibrillar Amyloid Deposits in Alzheimer Disease

(2013) Alberto Serrano-Pozo et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Glial fibrillary acidic protein isoform expression in plaque related astrogliosis in Alzheimer's disease

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Global changes in DNA methylation and hydroxymethylation in Alzheimer's disease human brain

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Glia Maturation Factor Expression in Hippocampus of Human Alzheimer’s Disease

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Calcium dysregulation in relation to Alzheimer-type pathology in the ageing brain

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Immunohistochemical detection of sphingosine-1-phosphate receptor 1 and 5 in human multiple sclerosis lesions

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Prolyl oligopeptidase colocalizes with α-synuclein, β-amyloid, tau protein and astroglia in the post-mortem brain samples with Parkinson’s and Alzheimer’s diseases

(2013) M.J. Hannula et al.   NEUROSCIENCE

The systemic iron-regulatory proteins hepcidin and ferroportin are reduced in the brain in Alzheimer’s disease

(2013) Animesh Raha et al.   Acta Neuropathologica Communications

Characterization of Thorn-Shaped Astrocytes in White Matter of Temporal Lobe in Alzheimer's Disease Brains

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Secretory Sorting Receptors Carboxypeptidase E and Secretogranin III in Amyloid β-Associated Neural Degeneration in Alzheimer's Disease

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Extracellular matrix modulator lysyl oxidase colocalizes with amyloid-beta pathology in Alzheimer's disease and hereditary cerebral hemorrhage with amyloidosis—Dutch type

(2012) Micha M.M. Wilhelmus et al.   EXPERIMENTAL GERONTOLOGY

Neuronal PAD4 expression and protein citrullination: Possible role in production of autoantibodies associated with neurodegenerative disease

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Tissue transglutaminase colocalizes with extracellular matrix proteins in cerebral amyloid angiopathy

(2012) Mieke de Jager et al.   NEUROBIOLOGY OF AGING

Astrocyte Senescence as a Component of Alzheimer’s Disease

(2012) Rekha Bhat et al.   PLoS One

Reactive Glia not only Associates with Plaques but also Parallels Tangles in Alzheimer's Disease

(2011) Alberto Serrano-Pozo et al.   AMERICAN JOURNAL OF PATHOLOGY

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(2011) A. Liberzon et al.   BIOINFORMATICS

Astrocytes contain amyloid-β annular protofibrils in Alzheimer's disease brains

(2011) Cristian A. Lasagna-Reeves et al.   FEBS LETTERS

Small Heat Shock Proteins Induce a Cerebral Inflammatory Reaction

(2011) I. B. Bruinsma et al.   JOURNAL OF NEUROSCIENCE

Microarray analysis of the astrocyte transcriptome in the aging brain: relationship to Alzheimer's pathology and APOE genotype

(2011) Julie E. Simpson et al.   NEUROBIOLOGY OF AGING

Expression of glia maturation factor in neuropathological lesions of Alzheimer's disease

(2011) R. Thangavel et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

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(2010) Alexander Lachmann et al.   BIOINFORMATICS

YKL-40: A Novel Prognostic Fluid Biomarker for Preclinical Alzheimer's Disease

(2010) Rebecca Craig-Schapiro et al.   BIOLOGICAL PSYCHIATRY

Alzheimer's disease modifies progenitor cell expression of monoamine oxidase B in the subventricular zone

(2010) Marco Pugliese et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Depletion of Beclin-1 due to proteolytic cleavage by caspases in the Alzheimer's disease brain

(2010) Troy T. Rohn et al.   NEUROBIOLOGY OF DISEASE

Accumulation of tumor-suppressor PTEN in Alzheimer neurofibrillary tangles

(2010) Yuma Sonoda et al.   NEUROSCIENCE LETTERS

Receptor for advanced glycation end products is upregulated in optic neuropathy of Alzheimer’s disease

(2009) Michelle Y. Wang et al.   ACTA NEUROPATHOLOGICA

Up-regulation of astrocyte metabotropic glutamate receptor 5 by amyloid-β peptide

(2009) Christopher S. Casley et al.   BRAIN RESEARCH

Altered expression of claudin family proteins in Alzheimer's disease and vascular dementia brains

(2009) Mihaela O. Romanitan et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Cognitive Decline in Alzheimer's Disease Is Associated with Selective Changes in Calcineurin/NFAT Signaling

(2009) H. M. Abdul et al.   JOURNAL OF NEUROSCIENCE

Parkinson's disease-associated parkin colocalizes with Alzheimer's disease and multiple sclerosis brain lesions

(2009) Maarten E. Witte et al.   NEUROBIOLOGY OF DISEASE

Population variation in oxidative stress and astrocyte DNA damage in relation to Alzheimer-type pathology in the ageing brain

(2009) J. E. Simpson et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Vascular amyloid alters astrocytic water and potassium channels in mouse models and humans with Alzheimer's disease

(2009) D.M. Wilcock et al.   NEUROSCIENCE

A peptidyl–prolyl isomerase, FKBP12, accumulates in Alzheimer neurofibrillary tangles

(2009) Hisato Sugata et al.   NEUROSCIENCE LETTERS

Specific Human Astrocyte Subtype Revealed by Affinity Purified GFAP+1 Antibody; Unpurified Serum Cross-Reacts with Neurofilament-L in Alzheimer

(2009) Jinte Middeldorp et al.   PLoS One

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(2009) Alessandro Liberati et al.   PLOS MEDICINE

Close association of water channel AQP1 with amyloid-β deposition in Alzheimer disease brains

(2008) Tamako Misawa et al.   ACTA NEUROPATHOLOGICA

Peroxiredoxin 6 in human brain: molecular forms, cellular distribution and association with Alzheimer’s disease pathology

(2008) John H. T. Power et al.   ACTA NEUROPATHOLOGICA

Evidence of DNA damage in Alzheimer disease: phosphorylation of histone H2AX in astrocytes

(2008) Na-Hye Myung et al.   AGE

Transglutaminases and Transglutaminase-Catalyzed Cross-Links Colocalize with the Pathological Lesions in Alzheimer's Disease Brain

(2008) Micha M.M. Wilhelmus et al.   BRAIN PATHOLOGY

Monocyte Chemoattractant Protein-1 Plays a Dominant Role in the Chronic Inflammation Observed in Alzheimer's Disease

(2008) Anna Sokolova et al.   BRAIN PATHOLOGY

Differential distribution of neuregulin in human brain and spinal fluid

(2008) Mark S. Pankonin et al.   BRAIN RESEARCH

Aberrant Expression of Myeloperoxidase in Astrocytes Promotes Phospholipid Oxidation and Memory Deficits in a Mouse Model of Alzheimer Disease

(2008) Richard A. Maki et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A leaky blood-brain barrier, fibrinogen infiltration and microglial reactivity in inflamed Alzheimer’s disease brain

(2008) Jae K. Ryu et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Cerebral Small Vessel Disease-Induced Apolipoprotein E Leakage Is Associated With Alzheimer Disease and the Accumulation of Amyloid β-Protein in Perivascular Astrocytes

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(2008) Verónica Berta Dorfman et al.   NEUROBIOLOGY OF AGING

Astrocyte phenotype in relation to Alzheimer-type pathology in the ageing brain

(2008) J.E. Simpson et al.   NEUROBIOLOGY OF AGING

Defects in IGF-1 receptor, insulin receptor and IRS-1/2 in Alzheimer's disease indicate possible resistance to IGF-1 and insulin signalling

(2008) Aileen M. Moloney et al.   NEUROBIOLOGY OF AGING

A possible link between astrocyte activation and tau nitration in Alzheimer's disease

(2008) Juan F. Reyes et al.   NEUROBIOLOGY OF DISEASE

Expression of estrogen receptor α and β in reactive astrocytes at the male rat hippocampus after status epilepticus

(2008) Satoru Sakuma et al.   NEUROPATHOLOGY

Expression of the translocator protein of 18 kDa by microglia, macrophages and astrocytes based on immunohistochemical localization in abnormal human brain

(2008) M. Cosenza-Nashat et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Elevated microsomal prostaglandin-E synthase–1 in Alzheimer’s disease

(2007) Uzma A. Chaudhry et al.   Alzheimers & Dementia

Expression of interleukin-18 is increased in the brains of Alzheimer's disease patients

(2007) Johanna Ojala et al.   NEUROBIOLOGY OF AGING