期刊
EXPERIMENTAL GERONTOLOGY
卷 48, 期 2, 页码 109-114出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.exger.2012.12.007
关键词
Lysyl oxidase; Cerebral amyloid angiopathy; Alzheimer's disease; Extracellular matrix
资金
- Brain Foundation of the Netherlands [F2010(1)-06]
Accumulation of amyloid-beta (A beta) in brain vessel walls and parenchyma, known as cerebral amyloid angiopathy (CAA) and senile plaques (SPs), respectively, plays a key role in Alzheimer's disease (AD) and hereditary cerebral hemorrhage with amyloidosis of the Dutch type (HCHWA-D) pathogenesis. Although the mechanisms underlying CAA and SP formation remain largely unknown, evidence is mounting that local alterations of the extracellular matrix (ECM) in the brain vessel wall and/or parenchyma play an important role. Lysyl oxidase (LOX, E.C. 1.4.3.13) is an inducible amine oxidase that modulates the ECM by catalyzing the formation of molecular covalent cross-links in ECM proteins. The aim of this study is to investigate the association of LOX with CAA and with classic and diffuse SPs in both AD and HCHWA-D cases. We observed an association of LOX with A beta in CAA and with A beta in both classic and diffuse SPs in AD and HCHWA-D cases. In addition, LOX staining was observed in reactive astrocytes associated with these lesions. We conclude that the ECM modulating enzyme LOX is associated with the A beta-related pathological hallmarks of both AD and HCHWA-D, and that our findings provide additional insights into the mechanisms underlying the formation of these lesions. (c) 2012 Elsevier Inc. All rights reserved.
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