Article
Clinical Neurology
Kaitlin B. Casaletto, Emma Nichols, Vahan Aslanyan, Stephanie M. Simone, Jennifer S. Rabin, Renaud La Joie, Adam M. Brickman, Kristen Dams-O'Connor, Priya Palta, Raj G. Kumar, Kristen M. George, Claudia L. Satizabal, Julie Schneider, Judy Pa
Summary: Females with Alzheimer's disease are more susceptible than males, and microglial activation plays an important mediating role in females but not males. This finding is crucial for understanding the pathogenesis of Alzheimer's disease and providing precision health care.
Article
Neurosciences
Wanying Zhao, Yanchang Li, Yi Du
Summary: The study investigates how the frontal control region interacts with temporal representation in semantic integration by using inhibitory transcranial magnetic stimulation. The results suggest a two-stage gesture-speech integration circuit with sequential involvement of pMTG and IFG, providing new insights into the dynamic brain network of multimodal semantic processing.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Medicine, Research & Experimental
Benita Wiatrak, Paulina Jawien, Agnieszka Matuszewska, Adam Szelag, Adriana Kubis-Kubiak
Summary: This study aimed to investigate the impact of amyloid fragments on oxidative stress and found that amyloid fragments have antioxidant properties, protecting neurons from neuroinflammation-induced damage. Among the tested fragments, the 1-40 fragment showed a stronger antioxidant effect.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Multidisciplinary Sciences
Tommy Hosman, Jacqueline B. Hynes, Jad Saab, Kaitlin G. Wilcoxen, Bradley R. Buchbinder, Nicholas Schmansky, Sydney S. Cash, Emad N. Eskandar, John D. Simeral, Brian Franco, Jessica Kelemen, Carlos E. Vargas-Irwin, Leigh R. Hochberg
Summary: The study compares neuronal ensemble recordings from the left middle frontal gyrus (MFG) and precentral gyrus (PCG) of a tetraplegic individual using an iBCI. It found that PCG is more involved in choosing and executing intended movements, while MFG contributes to sensorimotor processing steps prior to the action plan in PCG, especially when actions are instructed using auditory cues. This highlights a novel function of neurons in the human left MFG in auditory processing for motor control.
SCIENTIFIC REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Alice Filippini, Valentina Salvi, Vincenzo Dattilo, Chiara Magri, Stefania Castrezzati, Robert Veerhuis, Daniela Bosisio, Massimo Gennarelli, Isabella Russo
Summary: The accumulation of amyloid-beta in Alzheimer's disease (AD) brains causes reactive astrogliosis and neuroinflammatory response. This study investigates the role of leucine-rich repeat kinase 2 (LRRK2) in regulating astrocytic activation in response to amyloid-beta(1-42) (A beta(1-42)). The results demonstrate that LRRK2 kinase activity modulates astrocytic reactivity and functions in the presence of A beta(1-42) deposits, suggesting a potential contribution of PD-linked LRRK2 to AD-related neuroinflammation and pathogenesis.
Article
Psychiatry
Yiping Chen, Risheng Yu, Joseph F. X. DeSouza, Yuze Shen, Hanyun Zhang, Chunpeng Zhu, Peiyu Huang, Caihua Wang
Summary: This study investigated the effects of meal ingestion on brain regions in functional dyspepsia (FD) patients using resting-state functional magnetic resonance imaging (rs-fMRI). The results showed that FD patients had different brain activation patterns before and after meals compared to healthy controls, providing useful insights into the pathogenic mechanisms of FD.
FRONTIERS IN PSYCHIATRY
(2023)
Review
Immunology
Deepali Singh
Summary: Neuroinflammation is caused by the misfiring of immune cells in the central nervous system and can have both positive and negative effects on neurodevelopment and post-injury tissue. Chronic or uncontrolled inflammatory responses may lead to neurodegenerative diseases, while abnormal activation of glial cells can mediate neuroinflammation.
JOURNAL OF NEUROINFLAMMATION
(2022)
Article
Anatomy & Morphology
Maryann P. Noonan, Maiya R. Geddes, Rogier B. Mars, Lesley K. Fellows
Summary: Lesion research not only focuses on the directly injured brain region, but also considers distant effects. In this study, multiple MRI imaging modalities were used to investigate network organization in patients with chronic focal damage and healthy controls. The results suggest widespread grey matter loss in distal regions, but relatively preserved white matter and resting state networks. Lesions to the prefrontal region had a similar impact on both structural and functional networks.
BRAIN STRUCTURE & FUNCTION
(2022)
Article
Chemistry, Medicinal
Young-Jung Lee, In Jun Yeo, Dong Young Choi, Jaesuk Yun, Dong Ju Son, Sang-Bae Han, Jin Tae Hong
Summary: HIV-1 infection can lead to various HIV-associated neurocognitive disorders, with the gp120 protein playing a role in memory impairment through inducing Aβ accumulation and neuroinflammation.
ARCHIVES OF PHARMACAL RESEARCH
(2021)
Review
Immunology
Cuicui Wang, Shuai Zong, Xiaolin Cui, Xueying Wang, Shuang Wu, Le Wang, Yingchao Liu, Zhiming Lu
Summary: Alzheimer's disease (AD) is a severe chronic degenerative neurological disease. The main pathogenic mechanism of AD is the pathological accumulation of beta-amyloid (A beta) peptides outside the cell. However, growing evidence suggests that this hypothesis cannot fully explain the pathogenesis of AD. Neuroinflammation plays a crucial role in AD development, as evidenced by elevated levels of inflammatory markers and the identification of AD risk genes related to innate immune function.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Maite Solas, Silvia Vela, Cristian Smerdou, Eva Martisova, Ivan Martinez-Valbuena, Maria-Rosario Luquin, Maria J. Ramirez
Summary: c-Jun N-terminal kinase 3 (JNK3) is believed to be involved in the pathogenesis of AD, but it is unclear whether JNK or amyloid beta (Aβ) comes first in disease onset. This study found that pJNK expression is significantly increased in AD patients and Tg2576 mice, and there is a correlation and interaction between pJNK expression and Aβ levels in AD. Overexpression of JNK3 in the brain can induce cognitive deficiencies and Tau misfolding in AD mice, possibly triggered by increased Aβ.
ACS CHEMICAL NEUROSCIENCE
(2023)
Article
Clinical Neurology
Ramin A. Morshed, Anthony T. Lee, Elaina J. Wang, Jacob S. Young, Soonmee Cha, Shawn L. Hervey-Jumper, Mitchel S. Berger
Summary: This study retrospectively analyzed the surgical outcomes and postoperative neurological deficits of 39 patients with diffuse gliomas within the middle frontal gyrus. The results showed that extensive resection of these gliomas had minimal risk for long-term morbidity. Partial subcortical tract interruption may lead to transient but not permanent deficits.
JOURNAL OF NEUROSURGERY
(2022)
Article
Neurosciences
Tasha R. Womack, Craig T. Vollert, Odochi Ohia-Nwoko, Monika Schmitt, Saghi Montazari, Tina L. Beckett, David Mayerich, Michael Paul Murphy, Jason L. Eriksen
Summary: Alzheimer's disease is the most common form of dementia in aged populations, and chronic neuroinflammation accelerates the neurodegenerative pathologies. The role of prostacyclin in the brain is poorly understood. A study found that upregulated prostacyclin expression worsens Aβ disease pathologies and impairs learning, memory, and behavior in a mouse model of AD.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Review
Neurosciences
Guimei Zhang, Zicheng Wang, Huiling Hu, Meng Zhao, Li Sun
Summary: Alzheimer's disease is a common type of age-related dementia, where dysregulated microglia activity can lead to chronic neuroinflammation, promote pathological protein accumulation, and impair mitophagy. Targeting microglia may offer new therapeutic interventions for the disease.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Xia Zhao, Jinfeng Sun, Li Xiong, Lingyu She, Liwei Li, Hao Tang, Yuqing Zeng, Fan Chen, Xue Han, Shiju Ye, Wei Wang, Xu Wang, Guang Liang
Summary: Dectin-1, a pattern recognition receptor, is involved in microglia-mediated neuroinflammation and the development of Alzheimer's disease (AD). It directly binds to beta-amyloid (Aβ), activating downstream signaling pathways and inducing the expression of inflammatory factors and AD pathology.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2023)
Review
Anesthesiology
Hongtao Liu, Katharina M. Busl, Sylvain Dore
Summary: Dexmedetomidine (DEX), an alpha(2)-adrenergic agonist, has various beneficial effects such as anti-inflammation, antioxidation, and anticell death. It has shown potential as a protective therapy for patients with subarachnoid hemorrhage (SAH) by maintaining stable intracerebral homeostasis, repairing blood-brain barrier damage, and preventing vasospasm and cortical spreading depolarization. However, more clinical trials and translational research are needed to further evaluate its effectiveness.
JOURNAL OF NEUROSURGICAL ANESTHESIOLOGY
(2022)
Article
Clinical Neurology
Aaron M. Gusdon, Jude Savarraj, Liang Zhu, Peeyush K. Thankamani Pandit, Sylvain Dore, Devin W. McBride, HuiMahn A. Choi, Spiros L. Blackburn
Summary: This study revealed that patients with the HP 2-2 genotype showed higher levels of inflammatory cytokines at all time points compared to those with HP 1-1/1-2 genotypes. However, there were no significant differences in functional outcomes between the two groups. These findings may guide future research in identifying markers for functional prognosis or treatment targets.
CURRENT NEUROVASCULAR RESEARCH
(2021)
Review
Biochemistry & Molecular Biology
Ayon Bhattacharya, Rani Ashouri, Madison Fangman, Alexandra Mazur, Timothy Garett, Sylvain Dore
Summary: Soluble receptors, formed through cleavage from membrane-bound counterparts, play key roles in inflammation, oxidative stress, and stroke management. Their unique structures enable them to modulate receptor signaling and exhibit dual functions in cell protection.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell & Tissue Engineering
Janak Gaire, Justin A. Varholick, Sabhya Rana, Michael D. Sunshine, Sylvain Dore, W. Brad Barbazuk, David D. Fuller, Malcolm Maden, Chelsey S. Simmons
Summary: The spiny mouse is an exciting research organism due to its remarkable scarless healing abilities in various tissues beyond the skin, which could shed light on numerous clinically relevant human diseases. However, there are challenges in working with this emerging research organism that require future strategies and methods.
NPJ REGENERATIVE MEDICINE
(2021)
Review
Clinical Neurology
Rani Ashouri, Madison Fangman, Jordan Brielmaier, Zoe A. Fields, Natalie Campo, Sylvain Dore
Summary: Vitamin D deficiency is associated with bone disorders, cardiovascular damage, and an increased risk of ischemic stroke if left untreated. Research suggests that dietary vitamin D may impact the pathology of hemorrhagic stroke through potential mechanisms.
FRONTIERS IN NEUROLOGY
(2021)
Article
Biochemistry & Molecular Biology
Kai Fu, Cynthia S. Garvan, Shelley C. Heaton, Nandakumar Nagaraja, Sylvain Dore
Summary: This study found that higher levels of direct bilirubin were associated with greater stroke severity at presentation and worse outcomes at discharge among patients with ICH. On the other hand, higher levels of albumin were associated with lower stroke severity and better clinical outcomes. Future prospective studies on the free bioactive bilirubin are needed to better understand the intricate relationships between bilirubin and ICH.
Review
Biochemistry & Molecular Biology
Daniel A. Lichlyter, Zachary A. Krumm, Todd A. Golde, Sylvain Dore
Summary: Ischaemic neurovascular stroke is a major cause of death in developed countries, and the corticotropin-releasing factor (CRF) family of neuropeptides plays an important role in the pathology of acute neurovascular injury. However, there is still limited understanding of the pathway, temporality, and systemic impact of CRF signaling and stress biology in the progression of neurovascular injury. This review aims to investigate the potential benefits of a CRF antibody in modulating CRF and corticotropin-releasing factor receptor 1 signaling, glucocorticoids, and autonomic nervous system activity, and compare the modulation of CRF and HPA axis activity in neuropsychiatric diseases and post-stroke outcomes with lessons learned from antibody therapies in neurodegenerative diseases.
Article
Clinical Neurology
Ben Gaastra, Sheila Alexander, Mark K. Bakker, Hemant Bhagat, Philippe Bijlenga, Spiros Blackburn, Malie K. Collins, Sylvain Dore, Christoph Griessenauer, Philipp Hendrix, Eun Pyo Hong, Isabel C. Hostettler, Henry Houlden, Koji IIhara, Jin Pyeong Jeon, Bong Jun Kim, Munish Kumar, Sandrine Morel, Paul Nyquist, Dianxu Ren, Ynte M. Ruigrok, David Werring, Ian Galea, Diederik Bulters, Will Tapper
Summary: This article introduces a two-stage genome-wide association study on susceptibility loci for clinical outcome after aneurysmal subarachnoid hemorrhage (aSAH). Only a small fraction of the variation in clinical outcome can be explained by known clinical, demographic, and imaging variables, suggesting the involvement of unknown factors. Understanding the genetic determinants of outcome is crucial for improving prognostic modeling, stratifying patients in clinical trials, and developing novel treatment strategies.
TRANSLATIONAL STROKE RESEARCH
(2022)
Article
Genetics & Heredity
Olivia Edwards, Alicia Burris, Josh Lua, Diana J. Wilkie, Miriam O. Ezenwa, Sylvain Dore
Summary: This review examines the role of haptoglobin genetic polymorphism and stroke occurrence in the pathophysiology of sickle cell disease. It suggests that further research should be conducted to explore potential clinical advancements in gene therapy and Hp infusions.
Review
Clinical Neurology
Siddharth Kumar, Matthew Andoniadis, Ali Solhpour, Salman Asghar, Madison Fangman, Rani Ashouri, Sylvain Dore
Summary: This study reviews transfusion therapies with platelets, fresh frozen plasma, prothrombin complex concentrate, and red blood cells in patients with intracerebral hemorrhage, aiming to limit hematoma expansion and reduce brain edema development.
FRONTIERS IN NEUROLOGY
(2021)
Review
Neurosciences
Sean Sachdeva, Sushmita Persaud, Milani Patel, Peyton Popard, Aaron Colverson, Sylvain Dore
Summary: This review discusses the effects of music/sound on blood-brain barrier permeability and meningeal lymphatic clearance, highlighting its potential positive impact on brain and body functions. However, there is limited knowledge regarding the systematic investigation and outcomes of using music/sound in medical interventions. Further research is needed to explore the potential of music/sound in healthcare.
Article
Clinical Neurology
Ben Gaastra, Sheila Alexander, Mark K. Bakker, Hemant Bhagat, Philippe Bijlenga, Spiros L. Blackburn, Malie K. Collins, Sylvain Dore, Christoph J. Griessenauer, Philipp Hendrix, Eun Pyo Hong, Isabel C. Hostettler, Henry Houlden, Koji IIhara, Jin Pyeong Jeon, Bong Jun Kim, Jiang Li, Sandrine Morel, Paul Nyquist, Dianxu Ren, Ynte M. Ruigrok, David Werring, Will Tapper, Ian Galea, Diederik Bulters
Summary: This study identified 157 genetic variants associated with outcomes after aneurysmal subarachnoid haemorrhage (aSAH) through a genome-wide association study, with one variant in the SPNS2 gene achieving genome-wide significance. Validation of these findings will provide significant insights into the pathophysiology of outcomes after aSAH and may have implications for treatment.
TRANSLATIONAL STROKE RESEARCH
(2023)
Article
Neurosciences
Ben Gaastra, Dianxu Ren, Sheila Alexander, Issam A. Awad, Spiros Blackburn, Sylvain Dore, Dan Hanley, Paul Nyquist, Diederik Bulters, Ian Galea
Summary: This study demonstrates the high correlation between the modified Rankine Scale (mRS) and Glasgow Outcome Scale (GOS) and establishes the optimal dichotomization threshold for agreement. The study also provides a method for interconversion and finds that conversion from mRS to GOS is better than the reverse direction.
JOURNAL OF STROKE & CEREBROVASCULAR DISEASES
(2022)
Review
Clinical Neurology
Basma Mohamed, Keerthi Yarlagadda, Zachary Self, Alexandra Simon, Frank Rigueiro, Maryam Sohooli, Stephan Eisenschenk, Sylvain Dore
Summary: Sleep-disordered breathing, including obstructive sleep apnea, is a common sequela and risk factor for stroke. This scoping review investigates the relationship between obstructive sleep apnea and stroke outcomes, highlighting the pathophysiology and the importance of treatment. Understanding this relationship has implications for the clinical management and prognosis of patients with acute ischemic stroke.
TRANSLATIONAL STROKE RESEARCH
(2023)
Meeting Abstract
Endocrinology & Metabolism
Marietta Zille, Jaroslaw Aronowski, Nicole A. Terpolilli, Sylvain Dore
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2022)
