期刊
MOLECULAR IMMUNOLOGY
卷 45, 期 1, 页码 253-258出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.molimm.2007.05.006
关键词
neutrophils; CD300a; inhibitory receptor; inflammation; reactive oxygen species; ITAM; ITIM
资金
- Intramural NIH HHS [Z01 AI000964-02, Z99 OD999999] Funding Source: Medline
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [ZIAAI000964] Funding Source: NIH RePORTER
To achieve an adequate response, cells of the immune system must be tightly regulated to avoid hypo or hyper responsiveness. One of the mechanisms used by the immune system to avoid excessive inflammation is the modulation of the response through inhibitory receptors containing immunoreceptor tyrosine based inhibitory motifs (ITIM). Here, we show that human neutrophils from peripheral blood express the ITIM containing CD300a (also known as lRp60 and CMRF-35H) receptor. By using the HL-60 differentiation model, we show that the expression of CD300a receptor is developmentally regulated. Stimulation of human neutrophils with LPS and GM-CSF increased the cell surface expression of CD300a as a result of the rapid translocation of an intracellular pool of the receptor to the cell surface. Co-figation of CD300a with the immunoreceptor tyrosine based activating motif (ITAM) containing CD32a (Fc gamma RIIa) activation receptor inhibited CD32a mediated signalling; whereas, it did not inhibit toll-like receptor (TLR)-4 mediated reactive oxygen species (ROS) production. Therefore, at least for human neutrophils, the inhibitory signals mediated by the CD300a receptor may be selective in their action. (C) Published by Elsevier Ltd.
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