Article
Biochemistry & Molecular Biology
Emmanuelle M. Ruiz, Solomon A. Alhassan, Youssef Errami, Zakaria Y. Abd Elmageed, Jennifer S. Fang, Guangdi Wang, Margaret A. Brooks, Joe A. Abi-Rached, Emad Kandil, Mourad Zerfaoui
Summary: A 13-gene panel was identified to accurately predict resistance to BRAF/MEK inhibitor therapy in melanoma patients. Dysregulation of HMOX1, ICAM, MMP2, and SPARC defined a treatment-resistant landscape, and HMOX1-mediated mitochondrial stress response was identified as a potential key driver of resistance. These findings highlight the importance of these genes in predicting treatment outcomes and targeting underlying mechanisms to reduce resistance development.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Dermatology
Dimitrios C. Ziogas, Frosso Konstantinou, Spyros Bouros, Maria Theochari, Helen Gogas
Summary: The management and prognosis of BRAF-mutant metastatic melanoma have undergone significant changes with the introduction of immune checkpoint inhibitors and molecularly targeted agents. Combining BRAF/MEK inhibitors with immune checkpoint inhibitors is thought to improve sensitivity to immunotherapy, with ongoing clinical trials exploring optimal timing and eligible patient subsets for these regimens.
AMERICAN JOURNAL OF CLINICAL DERMATOLOGY
(2021)
Review
Oncology
Jonathan N. Priantti, Maysa Vilbert, Thiago Madeira, Francisco Cezar A. Moraes, Erica C. Koch Hein, Anwaar Saeed, Ludimila Cavalcante
Summary: Approximately 50% of melanoma patients with a specific mutation can receive targeted therapy with BRAF/MEK inhibitors. However, many develop resistance and experience disease progression. Rechallenging these patients with the inhibitors has been found to improve outcomes in terms of survival and response. This systematic review and meta-analysis evaluated the efficacy and safety of rechallenging advanced melanoma patients with BRAF/MEK inhibitors. The results showed improvement in progression-free survival and overall survival rates, with no unexpected safety concerns.
Article
Oncology
Silvia Mezi, Andrea Botticelli, Simone Scagnoli, Giulia Pomati, Giulia Fiscon, Federica De Galitiis, Francesca Romana Di Pietro, Sofia Verkhovskaia, Sasan Amirhassankhani, Simona Pisegna, Giovanna Gentile, Maurizio Simmaco, Bjoern Gohlke, Robert Preissner, Paolo Marchetti
Summary: Drug-drug interactions (DDIs) are significantly associated with treatment-related cardiovascular toxicity. Our findings support the utility of DDI assessment in melanoma patients treated with BRAF/MEK inhibitors.
Correction
Oncology
Jesper van Breeschoten, Michel W. J. M. Wouters, Doranne L. Hilarius, John B. Haanen, Christian U. Blank, Maureen J. B. Aarts, Franchette W. P. J. van den Berkmortel, Jan-Willem B. de Groot, Geke A. P. Hospers, Ellen Kapiteijn, Djura Piersma, Roos S. van Rijn, Karijn P. M. Suijkerbuijk, Willeke A. M. Blokx, Bert-Jan J. ten Tije, Astrid A. M. van der Veldt, Art Vreugdenhil, Marye J. Boers-Sonderen, Alfonsus J. M. van den Eertwegh
Summary: Correction to the paper has been published.
BRITISH JOURNAL OF CANCER
(2021)
Article
Oncology
Mattia Garutti, Melissa Bergnach, Jerry Polesel, Lorenza Palmero, Maria Antonietta Pizzichetta, Fabio Puglisi
Summary: To date, the combination of BRAF and MEK inhibitors is commonly used for the treatment of mutated BRAF metastatic melanoma. However, there is no evidence to support the superiority of one combination over others, and safety data is limited. In this meta-analysis, we evaluated the adverse events associated with each treatment combination to provide clinicians with information for tailored patient treatment.
Article
Oncology
Francesco Spagnolo, Bruna Dalmasso, Enrica Tanda, Miriam Potrony, Susana Puig, Remco van Doorn, Ellen Kapiteijn, Paola Queirolo, Hildur Helgadottir, Paola Ghiorzo
Summary: The study retrospectively collected data of patients with germline CDKN2A pathogenic variants who received targeted therapy for advanced melanoma across four European centers. The results support treatment with targeted therapy in this subset of patients, showing that the clinical activity of BRAF+/-MEK inhibitors in patients with germline CDKN2A pathogenic variants was not inferior to that of clinical trials and real-world studies.
Correction
Oncology
Jesper van Breeschoten, Michel W. J. M. Wouters, Doranne L. Hilarius, John B. Haanen, Christian U. Blank, Maureen J. B. Aarts, Franchette W. P. J. van den Berkmortel, Jan-Willem B. de Groot, Geke A. P. Hospers, Ellen Kapiteijn, Djura Piersma, Roos S. van Rijn, Karijn P. M. Suijkerbuijk, Willeke A. M. Blokx, Bert-Jan J. ten Tije, Astrid A. M. van der Veldt, Art Vreugdenhil, Marye J. Boers-Sonderen, Alfonsus J. M. van den Eertwegh
Summary: A correction to the paper has been published.
BRITISH JOURNAL OF CANCER
(2022)
Review
Biochemistry & Molecular Biology
A. Marani, H. Gioacchini, M. Paolinelli, A. Offidani, A. Campanati
Summary: This review provides a comprehensive analysis of the drug-drug interactions of MEK inhibitors used in the treatment of patients with BRAF-mutated advanced melanoma. The review discusses the impact of these interactions on efficacy and safety of the treatments and differentiates between interactions supported by pharmacokinetic or pharmacodynamic mechanisms, those encountered in clinical practice, and those observed in preclinical studies.
EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Ahlem Jebali, Maxime Battistella, Celeste Lebbe, Nicolas Dumaz
Summary: The network involving PI3K, AKT, and mTOR is important in melanoma oncogenesis, with RICTOR overexpression associated with poor prognosis. RICTOR enhances melanoma-initiating cells with stemness properties and contributes to resistance to BRAF inhibitors. An interaction between RICTOR and STAT3 in resistant cells, as well as a connection between RAS and RICTOR in resistant melanoma, were identified, suggesting RICTOR as a valuable therapeutic target in melanoma.
Article
Gastroenterology & Hepatology
Franck Carbonnel, Emilie Routier, Thierry Lazure, Charlotte Mussini, Christophe Bellanger, Carine Merklen, Bakhtiar Bejou, Anthony Buisson, Aurelien Amiot, Antoine Meyer, Catherine Dong, Caroline Robert
Summary: This study provides the first systematic description of colitis caused by dual blockade of BRAF and MEK kinases in the treatment of melanoma. The study found that severe colitis characterized by ulcerations of the right colon can occur, leading to symptoms such as diarrhea, rectal bleeding, abdominal pain, and intestinal obstruction. In some cases, the colitis was associated with ischemic changes and inflammation.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Oncology
Maximilian Haist, Henner Stege, Ronja Ebner, Maria Isabel Fleischer, Carmen Loquai, Stephan Grabbe
Summary: Sequential treatment with front-line CPI is associated with favorable tumor control and overall survival in untreated BRAF-mutant metastatic melanoma patients.
Article
Oncology
Hima Patel, Rosalin Mishra, Nour Yacoub, Samar Alanazi, Mary Kate Kilroy, Joan T. Garrett
Summary: Melanoma, accounting for only 4% of skin cancer, is a major cause of skin cancer related deaths. Resistance to FDA approved drugs dabrafenib and trametinib in treating BRAFV600E melanoma is mediated by the activation of IGF1R and IR. Combining dabrafenib and trametinib with IGF1R/IR inhibitor BMS-754807 effectively inhibits proliferation and tumor growth, offering potential treatment options for patients with BRAF-mutant melanoma.
Article
Chemistry, Multidisciplinary
OPhir Nave, Moria Sigron
Summary: Skin cancer treatment involves the combination of BRAF and MEK inhibitors with immunotherapy. By using a mathematical model with explicit analytical functions, we are able to control critical parameters such as time and dose for personalized treatment.
APPLIED SCIENCES-BASEL
(2022)
Article
Oncology
Nalan Akgul Babacan, Edwin Peguero, Peter Forsyth, Zeynep Eroglu
Summary: This case report describes a patient who developed encephalitis due to treatment with BRAF inhibitors. The patient experienced encephalitis symptoms shortly after treatment initiation, which resolved after discontinuation of the BRAF inhibitor.
Article
Biochemistry & Molecular Biology
Youming Zhu, Leu Jin, Ronghua Shi, Jinming Li, Yan Wang, Li Zhang, Chao-Zhao Liang, Vinod K. Narayana, David P. De Souza, Rick F. Thorne, Li Rong Zhang, Xu Dong Zhang, Mian Wu
Summary: This study reveals a novel long noncoding RNA (lncRNA) called gLINC that acts as a backbone for the formation of a metabolon involving glycolytic enzymes and lactate dehydrogenase A. The gLINC metabolon enhances glycolytic flux, ATP production, and cell survival under serine deprivation. Overexpression of gLINC in cancer cells promotes xenograft growth in mice on a serine-deprived diet, suggesting its role in cancer cell adaptation.
Article
Oncology
Sara Alavi, Abdullah Al Emran, Hsin-Yi Tseng, Jessamy C. Tiffen, Helen Marie McGuire, Peter Hersey
Summary: This study explores the role of nicotinamide in preventing and reversing T cell exhaustion, which has important implications for immunotherapy against cancers and viral infections. Nicotinamide supplementation was found to prevent the development of inhibitory receptors in T cells and promote the differentiation of T cells to effector states, suggesting a potential therapeutic strategy for enhancing immune responses.
Article
Endocrinology & Metabolism
I-Cheng Lu, Hao Tan, Sheng-Hua Wu, Tzu-Yen Huang, Hsin-Yi Tseng, Jia-Joanna Wang, Gianlorenzo Dionigi, Young Jun Chai, Feng-Yu Chiang, Pi-Ying Chang, Che-Wei Wu
Summary: This study investigated the effect of neostigmine on the signal recovery of electromyography (EMG) following the administration of cisatracurium and rocuronium in a pig model. The results demonstrated that neostigmine accelerated the recovery of EMG signals and improved the amplitude recovery.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Medicine, General & Internal
Feng-Yu Chiang, Ching-Feng Lien, Chih-Chun Wang, Chien-Chung Wang, Tzer-Zen Hwang, Yu-Chen Shih, Hsin-Yi Tseng, Che-Wei Wu, Yaw-Chang Huang, Tzu-Yen Huang
Summary: This article reviews the current literature and proposes standardized FNM procedures during parotid surgery to achieve uniformity, improve application quality, and contribute to future research.
Article
Biochemistry & Molecular Biology
Leixi Cao, Ruijie Wang, Guangzhi Liu, Yuwei Zhang, Rick Francis Thorne, Xu Dong Zhang, Jinming Li, Yang Xia, Lili Guo, Fengmin Shao, Hao Gu, Mian Wu
Summary: This study reveals an interaction between LIF-Stat3 signaling and the glycolytic enzyme Pfkp in the differentiation of murine ESCs into specific cell lineages. The repression of Pfkp by Stat3 maintains pluripotency in ESCs, and lifting this repression results in differentiation towards the ectodermal lineage. Pfkp acts as a protein kinase to phosphorylate Lin41, stabilizing its expression and promoting the binding and degradation of mRNAs encoding ectodermal specification markers.
Article
Oncology
Huiwu Geng, Cheng Feng, Zhangran Sun, Xu Fan, Yiqing Xie, Jinghua Gu, Libin Fan, Gang Liu, Chao Li, Rick F. Thorne, Xu Dong Zhang, Xinying Li, Xiaoying Liu
Summary: CLIC1 expression is increased in esophageal squamous cell carcinoma (ESCC) and contributes to its progression by promoting cell proliferation through the mTOR signaling pathway.
TRANSLATIONAL ONCOLOGY
(2023)
Article
Education & Educational Research
Ni Zhang, Hsin Yi Tseng, Jasmine Thai, Pranuthi Pagidipati, Chulwoo Park, Nikita Madan, Huda Assaf, Sarah Ahmed, Yoshitaka Iwasaki
Summary: College students faced information overload and misinformation during the early COVID-19 pandemic, highlighting the need for clear and culturally appropriate health communication tailored to their needs. They preferred regular and concise email updates from campus leadership and sought COVID-19 control and prevention information on social media.
JOURNAL OF AMERICAN COLLEGE HEALTH
(2022)
Article
Biodiversity Conservation
Bo Cao, Chengke Bai, Kunyi Wu, Ting La, Yiyang Su, Lingyu Che, Meng Zhang, Yumeng Lu, Pufan Gao, Jingjing Yang, Ying Xue, Guishuang Li
Summary: Climate plays critical roles in the origin, pathogenesis and transmission of infectious zoonotic diseases. This study projected the distribution shifts of transmission risks of main zoonotic diseases under climate change in China. Results showed that Central China, Southeast China, and South China are concentrated regions with high transmission risks for main zoonotic diseases.
GLOBAL CHANGE BIOLOGY
(2023)
Article
Medicine, General & Internal
Chih-Yun Kuo, Hsin-Yi Tseng, Ivo Stachiv, Chon-Haw Tsai, Yi-Chun Lai, Tomas Nikolai
Summary: Neuropsychological tests are widely used for dementia assessment in clinical practice and are also important for differentiating between Alzheimer's disease (AD) and frontotemporal lobar degeneration (FTLD), especially in the initial clinical presentations of behavioral variants of frontotemporal dementia (bvFTD) and primary progressive aphasia (PPA). However, the overlapping signs and cultural differences raise concerns about the validity and reliability of these tests. This case series combined NPTs with neuroimaging to examine their effectiveness in distinguishing between AD and FTLD, and the results showed that participants diagnosed with FTLD had lower scores in language and social cognition tests compared to AD participants, while PPA participants had lower scores in the Free and Cued Selective Reminding Test compared to bvFTD participants.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Chemistry, Analytical
Szu-Ying Li, Hsin-Yi Tseng, Bo-Wei Chen, Yu-Chun Lo, Huai-Hsuan Shao, Yen-Ting Wu, Ssu-Ju Li, Ching-Wen Chang, Ta-Chung Liu, Fu-Yu Hsieh, Yi Yang, Yan-Bo Lai, Po-Chun Chen, You-Yin Chen
Summary: Increasing requirements for neural implantation have led to advancements in semiconductor technologies, allowing for high-density electrode arrays to improve neural recordings. However, there are technological challenges, such as complex manufacturing processes and environmental concerns. A new eco-fabrication process for neural electrode arrays reduces carbon emissions and offers customization.
Article
Chemistry, Analytical
Yao-Wen Liang, Ming-Liang Lai, Feng-Mao Chiu, Hsin-Yi Tseng, Yu-Chun Lo, Ssu-Ju Li, Ching-Wen Chang, Po-Chuan Chen, You-Yin Chen
Summary: Fiber photometry can overcome methodological limitations and provide new insights into neural systems. It can accurately measure neural activity under deep brain stimulation without artifacts. This study demonstrated the use of a self-assembled optrode as a stimulator and biosensor to record both Ca2+ fluorescence and electrophysiological signals, revealing a correlation between local field potential and Ca2+ fluorescence signal in the evoked region.
Article
Engineering, Multidisciplinary
Na Zhang, Ling Qin, Ping Yu, Wei Gao, Yupeng Li
Summary: With the development of e-commerce and the increase in online shopping, users have higher demands on products. Enterprises need to design products that meet user demands accurately and quickly in order to improve user satisfaction and product competitiveness. This paper proposes a Grey-Markov model of user demands prediction based on online reviews, which predicts the monthly changing trend of user demands in advance. By using LDA topic model and sentiment analysis, user attention values and satisfaction values are obtained. The effectiveness of the proposed method is illustrated through examples of demand prediction and optimization design for smartphones and automobiles, providing a reference for manufacturing enterprises to optimize product design.
JOURNAL OF ENGINEERING DESIGN
(2023)
Review
Medicine, Research & Experimental
Qingjuan Chen, Binhui Yang, Xiaochen Liu, Xu D. Zhang, Lirong Zhang, Tao Liu
Summary: CBP/p300, critical drivers of oncogenesis, promote tumorigenesis and have been shown to be over-expressed in cancer cells; their inhibitors and degraders are considered promising anticancer agents that reduce H3K27ac, regulate oncogene transcription, induce cancer cell death and activate immune response.
Article
Biochemistry & Molecular Biology
Dong Li, Li Na Hu, Si Min Zheng, Ting La, Li Yuan Wei, Xiao Jun Zhang, Zhen Hua Zhang, Jun Xing, Li Wang, Ruo Qi Li, Qin Zhu, Rick F. Thorne, Yu Chen Feng, Hubert Hondermarck, Xu Dong Zhang, Li Li, Jin Nan Gao
Summary: Active crosstalk between the nervous system and breast cancer cells has been experimentally demonstrated. Previous studies may have underestimated the importance of peripheral nerves in breast cancer development and progression. This study found that nerves are commonly present in breast cancers, predominantly of sympathetic origin, and high nerve density is associated with poor patient outcomes.