On the specificity of protein–protein interactions in the context of disorder

Binding Revisited—Avidity in Cellular Function and Signaling

(2021) Simon Erlendsson et al.   Frontiers in Molecular Biosciences

Binding Dynamics of Disordered Linker Histone H1 with a Nucleosomal Particle

(2021) Hao Wu et al.   JOURNAL OF MOLECULAR BIOLOGY

An intrinsically disordered region-mediated confinement state contributes to the dynamics and function of transcription factors

(2021) David A. Garcia et al.   MOLECULAR CELL

Biomolecular condensates at the nexus of cellular stress, protein aggregation disease and ageing

(2021) Simon Alberti et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Interplay of folded domains and the disordered low-complexity domain in mediating hnRNPA1 phase separation

(2021) Erik W Martin et al.   NUCLEIC ACIDS RESEARCH

Cavin1 intrinsically disordered domains are essential for fuzzy electrostatic interactions and caveola formation

(2021) Vikas A. Tillu et al.   Nature Communications

Valency and Binding Affinity Variations Can Regulate the Multilayered Organization of Protein Condensates with Many Components

(2021) Ignacio Sanchez-Burgos et al.   Biomolecules

Get closer and make hotspots: liquid–liquid phase separation in plants

(2021) Jiwoo Kim et al.   EMBO REPORTS

The (un)structural biology of biomolecular liquid-liquid phase separation using NMR spectroscopy

(2020) Anastasia C. Murthy et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Valence and patterning of aromatic residues determine the phase behavior of prion-like domains

(2020) Erik W. Martin et al.   SCIENCE

Emerging Features of Linear Motif-Binding Hub Proteins

(2020) Nathan Jespersen et al.   TRENDS IN BIOCHEMICAL SCIENCES

Competing Protein-RNA Interaction Networks Control Multiphase Intracellular Organization

(2020) David W. Sanders et al.   CELL

Phase separation of TAZ compartmentalizes the transcription machinery to promote gene expression

(2020) Yi Lu et al.   NATURE CELL BIOLOGY

Increasing ambient temperature progressively disassembles Arabidopsis phytochrome B from individual photobodies with distinct thermostabilities

(2020) Joseph Hahm et al.   Nature Communications

Human PCNA Structure, Function and Interactions

(2020) Amaia González-Magaña et al.   Biomolecules

Biomolecular Condensates in the Nucleus

(2020) Benjamin R. Sabari et al.   TRENDS IN BIOCHEMICAL SCIENCES

Liquid-liquid phase separation induces pathogenic tau conformations in vitro

(2020) Nicholas M. Kanaan et al.   Nature Communications

Molecular basis of host-adaptation interactions between influenza virus polymerase PB2 subunit and ANP32A

(2020) Aldo R. Camacho-Zarco et al.   Nature Communications

Interactions by Disorder – A Matter of Context

(2020) Katrine Bugge et al.   Frontiers in Molecular Biosciences

Fragment‐Based Stabilizers of Protein–Protein Interactions through Imine‐Based Tethering

(2020) Madita Wolter et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Liquid Phase Separation Controlled by pH

(2020) Omar Adame-Arana et al.   BIOPHYSICAL JOURNAL

Orchestration of signaling by structural disorder in class 1 cytokine receptors

(2020) Pernille Seiffert et al.   Cell Communication and Signaling

Intrinsically disordered linkers control tethered kinases via effective concentration

(2020) Mateusz Dyla et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Phase Separation as a Missing Mechanism for Interpretation of Disease Mutations

(2020) Brian Tsang et al.   CELL

Sequence dependent phase separation of protein-polynucleotide mixtures elucidated using molecular simulations

(2020) Roshan Mammen Regy et al.   NUCLEIC ACIDS RESEARCH

Micellar TIA1 with folded RNA binding domains as a model for reversible stress granule formation

(2020) Keith J. Fritzsching et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Role of Backbone Dynamics in Modulating the Interactions of Disordered Ligands with the TAZ1 Domain of the CREB-Binding Protein

(2019) Rebecca B. Berlow et al.   BIOCHEMISTRY

Side chain to main chain hydrogen bonds stabilize a polyglutamine helix in a transcription factor

(2019) Albert Escobedo et al.   Nature Communications

The PCNA interaction motifs revisited: thinking outside the PIP-box

(2019) Andreas Prestel et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Molecular interactions underlying liquid−liquid phase separation of the FUS low-complexity domain

(2019) Anastasia C. Murthy et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Intrinsically Disordered Proteins in Chronic Diseases

(2019) Kulkarni et al.   Biomolecules

Solution structure of MUL1-RING domain and its interaction with p53 transactivation domain

(2019) Min-Sung Lee et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Multi-functionality of proteins involved in GPCR and G protein signaling: making sense of structure–function continuum with intrinsic disorder-based proteoforms

(2019) Alexander V. Fonin et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Protein abundance biases the amino-acid composition of disordered regions to minimize non-functional interactions

(2019) Benjamin Dubreuil et al.   JOURNAL OF MOLECULAR BIOLOGY

Linker Dependence of Avidity in Multivalent Interactions between Disordered Proteins

(2019) Charlotte S. Sørensen et al.   JOURNAL OF MOLECULAR BIOLOGY

The liquid state of FG-nucleoporins mimics permeability barrier properties of nuclear pore complexes

(2019) Giorgia Celetti et al.   JOURNAL OF CELL BIOLOGY

Mapping low-affinity/high-specificity peptide–protein interactions using ligand-footprinting mass spectrometry

(2019) Benjamin W. Parker et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanisms of noncanonical binding dynamics in multivalent protein–protein interactions

(2019) Wesley J. Errington et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Targeting the Stress-Induced Protein NUPR1 to Treat Pancreatic Adenocarcinoma

(2019) Santofimia-Castaño et al.   Cells

Relationship of Sequence and Phase Separation in Protein Low-Complexity Regions

(2018) Erik W. Martin et al.   BIOCHEMISTRY

Thermodynamic characterization of the multivalent interactions underlying rapid and selective translocation through the nuclear pore complex

(2018) Ryo Hayama et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Association of Multiple Phosphorylated Proteins with the 14-3-3 Regulatory Hubs: Problems and Perspectives

(2018) Nikolai N. Sluchanko   JOURNAL OF MOLECULAR BIOLOGY

Structural Ensemble Modulation upon Small-Molecule Binding to Disordered Proteins

(2018) Gabriella T. Heller et al.   JOURNAL OF MOLECULAR BIOLOGY

Mechanistic View of hnRNPA2 Low-Complexity Domain Structure, Interactions, and Phase Separation Altered by Mutation and Arginine Methylation

(2018) Veronica H. Ryan et al.   MOLECULAR CELL

Short linear motif core and flanking regions modulate retinoblastoma protein binding affinity and specificity

(2018) Nicolás Palopoli et al.   PROTEIN ENGINEERING DESIGN & SELECTION

Imaging dynamic and selective low-complexity domain interactions that control gene transcription

(2018) Shasha Chong et al.   SCIENCE

Extreme disorder in an ultrahigh-affinity protein complex

(2018) Alessandro Borgia et al.   NATURE

RNA polymerase II clustering through carboxy-terminal domain phase separation

(2018) Marc Boehning et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

IDPpi: Protein-Protein Interaction Analyses of Human Intrinsically Disordered Proteins

(2018) Vladimir Perovic et al.   Scientific Reports

Binding Affinity and Function of the Extremely Disordered Protein Complex Containing Human Linker Histone H1.0 and Its Chaperone ProTα

(2018) Hanqiao Feng et al.   BIOCHEMISTRY

Transcription Factors Activate Genes through the Phase-Separation Capacity of Their Activation Domains

(2018) Ann Boija et al.   CELL

Evolution of weak cooperative interactions for biological specificity

(2018) Ang Gao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Affinity and specificity of motif-based protein–protein interactions

(2018) Ylva Ivarsson et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Functional Analysis of Human Hub Proteins and Their Interactors Involved in the Intrinsic Disorder-Enriched Interactions

(2017) Gang Hu et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Hypersensitive termination of the hypoxic response by a disordered protein switch

(2017) Rebecca B. Berlow et al.   NATURE

Phase behaviour of disordered proteins underlying low density and high permeability of liquid organelles

(2017) Ming-Tzo Wei et al.   Nature Chemistry

Biomolecular condensates: organizers of cellular biochemistry

(2017) Salman F. Banani et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Weak protein–protein interactions in live cells are quantified by cell-volume modulation

(2017) Shahar Sukenik et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural and hydrodynamic properties of an intrinsically disordered region of a germ cell-specific protein on phase separation

(2017) Jacob P. Brady et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Liquid phase condensation in cell physiology and disease

(2017) Yongdae Shin et al.   SCIENCE

Protein interaction evolution from promiscuity to specificity with reduced flexibility in an increasingly complex network

(2017) T. Alhindi et al.   Scientific Reports

Intrinsically disordered linkers determine the interplay between phase separation and gelation in multivalent proteins

(2017) Tyler S Harmon et al.   eLife

Alzheimer's Disease and the Amyloid-β Peptide

(2017) M. Paul Murphy et al.   JOURNAL OF ALZHEIMERS DISEASE

Identification of a Drug Targeting an Intrinsically Disordered Protein Involved in Pancreatic Adenocarcinoma

(2017) José L. Neira et al.   Scientific Reports

Higher‐order oligomerization promotes localization of SPOP to liquid nuclear speckles

(2016) Melissa R Marzahn et al.   EMBO JOURNAL

Structures and Short Linear Motif of Disordered Transcription Factor Regions Provide Clues to the Interactome of the Cellular Hub Protein Radical-induced Cell Death1

(2016) Charlotte O'Shea et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Modulation of Intrinsically Disordered Protein Function by Post-translational Modifications

(2016) Alaji Bah et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Slide-and-exchange mechanism for rapid and selective transport through the nuclear pore complex

(2016) Barak Raveh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Transactivation Domains of the p53 Protein

(2016) Nitin Raj et al.   Cold Spring Harbor Perspectives in Medicine

Characterization of the p300 Taz2–p53 TAD2 Complex and Comparison with the p300 Taz2–p53 TAD1 Complex

(2015) Lisa M. Miller Jenkins et al.   BIOCHEMISTRY

Plasticity of an Ultrafast Interaction between Nucleoporins and Nuclear Transport Receptors

(2015) Sigrid Milles et al.   CELL

Aggregation-Prone Amyloid-β⋅CuIISpecies Formed on the Millisecond Timescale under Mildly Acidic Conditions

(2015) Jeppe T. Pedersen et al.   CHEMBIOCHEM

Functional advantages of dynamic protein disorder

(2015) Rebecca B. Berlow et al.   FEBS LETTERS

Modeling competitive substitution in a polyelectrolyte complex

(2015) B. Peng et al.   JOURNAL OF CHEMICAL PHYSICS

Phase Transition of a Disordered Nuage Protein Generates Environmentally Responsive Membraneless Organelles

(2015) Timothy J. Nott et al.   MOLECULAR CELL

Intrinsically disordered proteins in cellular signalling and regulation

(2015) Peter E. Wright et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Molecular stripping in theNF-κB/IκB/DNAgenetic regulatory network

(2015) Davit A. Potoyan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Designing multivalent probes for tunable superselective targeting

(2015) Galina V. Dubacheva et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Quinary structure modulates protein stability in cells

(2015) William B. Monteith et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Version 4.0 of PaxDb: Protein abundance data, integrated across model organisms, tissues, and cell-lines

(2015) Mingcong Wang et al.   PROTEOMICS

Targeting disordered proteins with small molecules using entropy

(2015) Gabriella T. Heller et al.   TRENDS IN BIOCHEMICAL SCIENCES

Functional Advantages of Conserved Intrinsic Disorder in RNA-Binding Proteins

(2015) Mihaly Varadi et al.   PLoS One

Helical Propensity in an Intrinsically Disordered Protein Accelerates Ligand Binding

(2014) Vytautas Iešmantavičius et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Extended String Binding Mode of the Phosphorylated Transactivation Domain of Tumor Suppressor p53

(2014) Masahiko Okuda et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Coupled Folding and Binding of the Disordered Protein PUMA Does Not Require Particular Residual Structure

(2014) Joseph M. Rogers et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Phase transitions of multivalent proteins can promote clustering of membrane receptors

(2014) Sudeep Banjade et al.   eLife

Promiscuity as a functional trait: intrinsically disordered regions as central players of interactomes

(2013) Alexander Cumberworth et al.   BIOCHEMICAL JOURNAL

Anti-apoptosis Proteins Mcl-1 and Bcl-xL Have Different p53-Binding Profiles

(2013) Hongwei Yao et al.   BIOCHEMISTRY

Exploring avidity: understanding the potential gains in functional affinity and target residence time of bivalent and heterobivalent ligands

(2013) Georges Vauquelin et al.   BRITISH JOURNAL OF PHARMACOLOGY

Folding and Binding of an Intrinsically Disordered Protein: Fast, but Not ‘Diffusion-Limited’

(2013) Joseph M. Rogers et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The transition state structure for coupled binding and folding of disordered protein domains

(2013) Jakob Dogan et al.   Scientific Reports

PaxDb, a Database of Protein Abundance Averages Across All Three Domains of Life

(2012) M. Wang et al.   MOLECULAR & CELLULAR PROTEOMICS

Direct substitution and assisted dissociation pathways for turning off transcription by a MerR-family metalloregulator

(2012) C. P. Joshi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Counterbalance of ligand- and self-coupled motions characterizes multispecificity of ubiquitin

(2012) Bhaskar Dasgupta et al.   PROTEIN SCIENCE

HMGB1-Facilitated p53 DNA Binding Occurs via HMG-Box/p53 Transactivation Domain Interaction, Regulated by the Acidic Tail

(2012) John P. Rowell et al.   STRUCTURE

Rapid Formation of a Preoligomeric Peptide-Metal-Peptide Complex Following Copper(II) Binding to Amyloid β Peptides

(2011) Jeppe T. Pedersen et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Multispecific Recognition: Mechanism, Evolution, and Design

(2011) Ariel Erijman et al.   BIOCHEMISTRY

Intrinsically disordered proteins: regulation and disease

(2011) M Madan Babu et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Disease mutations in disordered regions—exception to the rule?

(2011) Vladimir Vacic et al.   Molecular BioSystems

Active liquid-like behavior of nucleoli determines their size and shape in Xenopus laevis oocytes

(2011) C. P. Brangwynne et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Positively charged residues located downstream of PIP box, together with TD amino acids within PIP box, are important for CRL4Cdt2-mediated proteolysis

(2010) Masato Michishita et al.   GENES TO CELLS

Hub Promiscuity in Protein-Protein Interaction Networks

(2010) Ashwini Patil et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

A Bimodal Distribution of Two Distinct Categories of Intrinsically Disordered Structures with Separate Functions in FG Nucleoporins

(2010) Justin Yamada et al.   MOLECULAR & CELLULAR PROTEOMICS

Concentration-dependent exchange accelerates turnover of proteins bound to double-stranded DNA

(2010) J. S. Graham et al.   NUCLEIC ACIDS RESEARCH

Net charge per residue modulates conformational ensembles of intrinsically disordered proteins

(2010) A. H. Mao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Multivalency-Assisted Control of Intracellular Signaling Pathways: Application for Ubiquitin- Dependent N-End Rule Pathway

(2009) Shashikanth M. Sriram et al.   CHEMISTRY & BIOLOGY

Identification of a novel, widespread, and functionally important PCNA-binding motif

(2009) Karin M. Gilljam et al.   JOURNAL OF CELL BIOLOGY

Docking of a Specialized PIP Box onto Chromatin-Bound PCNA Creates a Degron for the Ubiquitin Ligase CRL4Cdt2

(2009) Courtney G. Havens et al.   MOLECULAR CELL

Flexible nets: disorder and induced fit in the associations of p53 and 14-3-3 with their partners

(2008) Christopher J Oldfield et al.   BMC GENOMICS

Dynamic equilibrium engagement of a polyvalent ligand with a single-site receptor

(2008) T. Mittag et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA