Exploring avidity: understanding the potential gains in functional affinity and target residence time of bivalent and heterobivalent ligands

The Best of Both Worlds? Bitopic Orthosteric/Allosteric Ligands of G Protein–Coupled Receptors

(2011) Celine Valant et al.   Annual Review of Pharmacology and Toxicology

Guide to Receptors and Channels (GRAC), 5th edition

(2011) SPH Alexander et al.   BRITISH JOURNAL OF PHARMACOLOGY

Conformational adaptation in drug–target interactions and residence time

(2011) Robert A Copeland   Future Medicinal Chemistry

Long-lasting target binding and rebinding as mechanisms to prolong in vivo drug action

(2010) Georges Vauquelin et al.   BRITISH JOURNAL OF PHARMACOLOGY

Rebinding: or why drugs may act longerin vivothan expected from theirin vitrotarget residence time

(2010) Georges Vauquelin   Expert Opinion on Drug Discovery

Binding properties of antagonists to Cannabinoid receptors in intact cells

(2010) Marie Wennerberg et al.   FUNDAMENTAL & CLINICAL PHARMACOLOGY

THRX-198321 Is a Bifunctional Muscarinic Receptor Antagonist and  2-Adrenoceptor Agonist (MABA) That Binds in a Bimodal and Multivalent Manner

(2010) T. Steinfeld et al.   MOLECULAR PHARMACOLOGY

CXCR4 nanobodies (VHH-based single variable domains) potently inhibit chemotaxis and HIV-1 replication and mobilize stem cells

(2010) S. Jahnichen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural Basis of Allosteric Ligand-Receptor Interactions in the Insulin/Relaxin Peptide Family

(2009) Pierre De Meyts et al.   Annals of the New York Academy of Sciences

Molecular mechanisms for the persistent bronchodilatory effect of the β2-adrenoceptor agonist salmeterol

(2009) A Szczuka et al.   BRITISH JOURNAL OF PHARMACOLOGY

Affinity and Avidity in Antibody-Based Tumor Targeting

(2009) Stephen I. Rudnick et al.   CANCER BIOTHERAPY AND RADIOPHARMACEUTICALS

Ligands, their receptors and … plasma membranes

(2009) G. Vauquelin et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Cellular assays as portals to seven-transmembrane receptor-based drug discovery

(2009) Terry P. Kenakin   NATURE REVIEWS DRUG DISCOVERY

Antagonist-radioligand binding to D2L-receptors in intact cells

(2008) Ann Packeu et al.   BIOCHEMICAL PHARMACOLOGY

Direct Visualization of Heterogeneous Extravascular Distribution of Trastuzumab in Human Epidermal Growth Factor Receptor Type 2 Overexpressing Xenografts

(2008) J. H.E. Baker et al.   CLINICAL CANCER RESEARCH

Proteomics and diagnostics: Let's Get Specific, again

(2008) Dom Zichi et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Dualsteric GPCR targeting: a novel route to binding and signaling pathway selectivity

(2008) Johannes Antony et al.   FASEB JOURNAL