Functional advantages of dynamic protein disorder

Characterization of the p300 Taz2–p53 TAD2 Complex and Comparison with the p300 Taz2–p53 TAD1 Complex

(2015) Lisa M. Miller Jenkins et al.   BIOCHEMISTRY

Visualizing the Molecular Recognition Trajectory of an Intrinsically Disordered Protein Using Multinuclear Relaxation Dispersion NMR

(2015) Robert Schneider et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Intrinsically disordered proteins in cellular signalling and regulation

(2015) Peter E. Wright et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Autoinhibition of MDMX by intramolecular p53 mimicry

(2015) Lihong Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hydrogen exchange of disordered proteins inEscherichia coli

(2015) Austin E. Smith et al.   PROTEIN SCIENCE

Demonstration of a Folding after Binding Mechanism in the Recognition between the Measles Virus NTAIL and X Domains

(2014) Marion Dosnon et al.   ACS Chemical Biology

Helical Propensity in an Intrinsically Disordered Protein Accelerates Ligand Binding

(2014) Vytautas Iešmantavičius et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Structure of the human Mdmx protein bound to the p53 tumor suppressor transactivation domain

(2014) Grzegorz Popowicz et al.   CELL CYCLE

Short Linear Motifs: Ubiquitous and Functionally Diverse Protein Interaction Modules Directing Cell Regulation

(2014) Kim Van Roey et al.   CHEMICAL REVIEWS

Physicochemical Properties of Cells and Their Effects on Intrinsically Disordered Proteins (IDPs)

(2014) Francois-Xavier Theillet et al.   CHEMICAL REVIEWS

Classification of Intrinsically Disordered Regions and Proteins

(2014) Robin van der Lee et al.   CHEMICAL REVIEWS

The High-Risk HPV16 E7 Oncoprotein Mediates Interaction between the Transcriptional Coactivator CBP and the Retinoblastoma Protein pRb

(2014) Ariane L. Jansma et al.   JOURNAL OF MOLECULAR BIOLOGY

Rational Design of Topographical Helix Mimics as Potent Inhibitors of Protein–Protein Interactions

(2014) Brooke Bullock Lao et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Coupled Folding and Binding of the Disordered Protein PUMA Does Not Require Particular Residual Structure

(2014) Joseph M. Rogers et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A Million Peptide Motifs for the Molecular Biologist

(2014) Peter Tompa et al.   MOLECULAR CELL

The ensemble nature of allostery

(2014) Hesam N. Motlagh et al.   NATURE

Folding of an intrinsically disordered protein by phosphorylation as a regulatory switch

(2014) Alaji Bah et al.   NATURE

Targeting the disordered C terminus of PTP1B with an allosteric inhibitor

(2014) Navasona Krishnan et al.   Nature Chemical Biology

Disorder and residual helicity alter p53-Mdm2 binding affinity and signaling in cells

(2014) Wade Borcherds et al.   Nature Chemical Biology

In vivo modulation of hypoxia-inducible signaling by topographical helix mimetics

(2014) B. B. Lao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Allostery within a transcription coactivator is predominantly mediated through dissociation rate constants

(2014) S. L. Shammas et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural polymorphism in the N-terminal oligomerization domain of NPM1

(2014) D. M. Mitrea et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The structural and functional signatures of proteins that undergo multiple events of post-translational modification

(2014) Vikas Pejaver et al.   PROTEIN SCIENCE

Remarkably Fast Coupled Folding and Binding of the Intrinsically Disordered Transactivation Domain of cMyb to CBP KIX

(2013) Sarah L. Shammas et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Modulation of allostery by protein intrinsic disorder

(2013) Allan Chris M. Ferreon et al.   NATURE

Single-molecule imaging of transcription factor binding to DNA in live mammalian cells

(2013) J Christof M Gebhardt et al.   NATURE METHODS

The binding mechanisms of intrinsically disordered proteins

(2013) Jakob Dogan et al.   PHYSICAL CHEMISTRY CHEMICAL PHYSICS

Conformations of intrinsically disordered proteins are influenced by linear sequence distributions of oppositely charged residues

(2013) R. K. Das et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

From Sequence and Forces to Structure, Function, and Evolution of Intrinsically Disordered Proteins

(2013) Julie D. Forman-Kay et al.   STRUCTURE

Interaction of the Eukaryotic Initiation Factor 4E with 4E-BP2 at a Dynamic Bipartite Interface

(2013) Sabelo Lukhele et al.   STRUCTURE

Inteins: nature's gift to protein chemists

(2013) Neel H. Shah et al.   Chemical Science

A folding-after-binding mechanism describes the recognition between the transactivation domain of c-Myb and the KIX domain of the CREB-binding protein

(2012) Stefano Gianni et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Interplay between allostery and intrinsic disorder in an ensemble

(2012) Hesam N. Motlagh et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Bacterial in-cell NMR of human α-synuclein: a disordered monomer by nature?: Figure 1

(2012) Andres Binolfi et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Motif switches: decision-making in cell regulation

(2012) Kim Van Roey et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Rate constants and mechanisms of intrinsically disordered proteins binding to structured targets

(2012) Huan-Xiang Zhou et al.   PHYSICAL CHEMISTRY CHEMICAL PHYSICS

Probing the Role of Nascent Helicity in p27 Function as a Cell Cycle Regulator

(2012) Steve Otieno et al.   PLoS One

HMGB1-Facilitated p53 DNA Binding Occurs via HMG-Box/p53 Transactivation Domain Interaction, Regulated by the Acidic Tail

(2012) John P. Rowell et al.   STRUCTURE

A conserved motif within the flexible C-terminus of the translational regulator 4E-BP is required for tight binding to the mRNA cap-binding protein eIF4E

(2011) Keum Soon Paku et al.   BIOCHEMICAL JOURNAL

The role of protein conformational fluctuations in allostery, function, and evolution

(2011) James O. Wrabl et al.   BIOPHYSICAL CHEMISTRY

Constructing ensembles for intrinsically disordered proteins

(2011) Charles K Fisher et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Structural Dynamics, Intrinsic Disorder, and Allostery in Nuclear Receptors as Transcription Factors

(2011) Vincent J. Hilser et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Attributes of short linear motifs

(2011) Norman E. Davey et al.   Molecular BioSystems

MultiBac: expanding the research toolbox for multiprotein complexes

(2011) Christoph Bieniossek et al.   TRENDS IN BIOCHEMICAL SCIENCES

Intrinsic disorder: signaling via highly specific but short-lived association

(2011) Huan-Xiang Zhou   TRENDS IN BIOCHEMICAL SCIENCES

Structure of the p53 Transactivation Domain in Complex with the Nuclear Receptor Coactivator Binding Domain of CREB Binding Protein

(2010) Chul Won Lee et al.   BIOCHEMISTRY

Allostery and Intrinsic Disorder Mediate Transcription Regulation by Conditional Cooperativity

(2010) Abel Garcia-Pino et al.   CELL

Targeting protein–protein interactions for therapeutic intervention: a challenge for the future

(2010) Giovanna Zinzalla et al.   Future Medicinal Chemistry

ESPRIT: An automated, library-based method for mapping and soluble expression of protein domains from challenging targets

(2010) Hayretin Yumerefendi et al.   JOURNAL OF STRUCTURAL BIOLOGY

Detecting the conformation of individual proteins in live cells

(2010) John J Sakon et al.   NATURE METHODS

Graded enhancement of p53 binding to CREB-binding protein (CBP) by multisite phosphorylation

(2010) C. W. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure/Function Implications in a Dynamic Complex of the Intrinsically Disordered Sic1 with the Cdc4 Subunit of an SCF Ubiquitin Ligase

(2010) Tanja Mittag et al.   STRUCTURE

Reconciling binding mechanisms of intrinsically disordered proteins

(2009) L. Michel Espinoza-Fonseca   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Mapping the Interactions of the p53 Transactivation Domain with the KIX Domain of CBP†

(2009) Chul Won Lee et al.   BIOCHEMISTRY

Regulation of Translation Initiation in Eukaryotes: Mechanisms and Biological Targets

(2009) Nahum Sonenberg et al.   CELL

Comprehensive bioinformatics analysis of cell-free protein synthesis: identification of multiple protein properties that correlate with successful expression

(2009) Atsushi Kurotani et al.   FASEB JOURNAL

Potent and Orally Active Small-Molecule Inhibitors of the MDM2−p53 Interaction

(2009) Shanghai Yu et al.   JOURNAL OF MEDICINAL CHEMISTRY

Multiple Independent Binding Sites for Small-Molecule Inhibitors on the Oncoprotein c-Myc

(2009) Dalia I. Hammoudeh et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Isotope labeling methods for studies of excited protein states by relaxation dispersion NMR spectroscopy

(2009) Patrik Lundström et al.   Nature Protocols

ELM: the status of the 2010 eukaryotic linear motif resource

(2009) Cathryn M. Gould et al.   NUCLEIC ACIDS RESEARCH

Conformational selection or induced fit: A flux description of reaction mechanism

(2009) G. G. Hammes et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cooperative regulation of p53 by modulation of ternary complex formation with CBP/p300 and HDM2

(2009) J. C. Ferreon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural basis for subversion of cellular control mechanisms by the adenoviral E1A oncoprotein

(2009) J. C. Ferreon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The rules of disorder or why disorder rules

(2009) Jörg Gsponer et al.   PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY

Structural Basis for p300 Taz2-p53 TAD1 Binding and Modulation by Phosphorylation

(2009) Hanqiao Feng et al.   STRUCTURE

Cell regulation: determined to signal discrete cooperation

(2009) Toby J. Gibson   TRENDS IN BIOCHEMICAL SCIENCES

Small-Molecule Inhibitors of the MDM2-p53 Protein-Protein Interaction to Reactivate p53 Function: A Novel Approach for Cancer Therapy

(2008) Sanjeev Shangary et al.   Annual Review of Pharmacology and Toxicology

Flexible nets: disorder and induced fit in the associations of p53 and 14-3-3 with their partners

(2008) Christopher J Oldfield et al.   BMC GENOMICS

Thermodynamic and Structural Basis of Phosphorylation-Induced Disorder-to-Order Transition in the Regulatory Light Chain of Smooth Muscle Myosin

(2008) L. Michel Espinoza-Fonseca et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

In situ observation of protein phosphorylation by high-resolution NMR spectroscopy

(2008) Philipp Selenko et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Epigenetic Reprogramming by Adenovirus e1a

(2008) R. Ferrari et al.   SCIENCE

The human papillomavirus E7 oncoprotein

(2008) Margaret E. McLaughlin-Drubin et al.   VIROLOGY

Fuzzy complexes: polymorphism and structural disorder in protein–protein interactions

(2007) Peter Tompa et al.   TRENDS IN BIOCHEMICAL SCIENCES