Autophagy in Alzheimer’s Disease Pathogenesis: Therapeutic Potential and Future Perspectives

Machine learning identifies candidates for drug repurposing in Alzheimer’s disease

(2021) Steve Rodriguez et al.   Nature Communications

Re-emphasizing early Alzheimer’s disease pathology starting in select entorhinal neurons, with a special focus on mitophagy

(2021) Asgeir Kobro-Flatmoen et al.   AGEING RESEARCH REVIEWS

Chaperone-mediated autophagy prevents collapse of the neuronal metastable proteome

(2021) Mathieu Bourdenx et al.   CELL

Microglia use TAM receptors to detect and engulf amyloid β plaques

(2021) Youtong Huang et al.   NATURE IMMUNOLOGY

Acetylated tau inhibits chaperone-mediated autophagy and promotes tau pathology propagation in mice

(2021) Benjamin Caballero et al.   Nature Communications

Mechanisms of Selective Autophagy

(2021) Trond Lamark et al.   Annual Review of Cell and Developmental Biology

Machinery, regulation and pathophysiological implications of autophagosome maturation

(2021) Yan G. Zhao et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Developmental Consequences of Defective ATG7-Mediated Autophagy in Humans

(2021) Jack J. Collier et al.   NEW ENGLAND JOURNAL OF MEDICINE

Metformin activates chaperone-mediated autophagy and improves disease pathologies in an Alzheimer disease mouse model

(2021) Xiaoyan Xu et al.   Protein & Cell

Targeting Aggrephagy for the Treatment of Alzheimer’s Disease

(2020) Sandeep Malampati et al.   Cells

Nilotinib Effects on Safety, Tolerability, and Biomarkers in Alzheimer's Disease

(2020) Raymond S. Turner et al.   ANNALS OF NEUROLOGY

TFEB regulates lysosomal exocytosis of tau and its loss of function exacerbates tau pathology and spreading

(2020) Yin Xu et al.   MOLECULAR PSYCHIATRY

Metformin Ameliorates Aβ Pathology by Insulin-Degrading Enzyme in a Transgenic Mouse Model of Alzheimer’s Disease

(2020) Xin-Yi Lu et al.   Oxidative Medicine and Cellular Longevity

Prolonged tau clearance and stress vulnerability rescue by pharmacological activation of autophagy in tauopathy neurons

(2020) M. Catarina Silva et al.   Nature Communications

Noncanonical function of an autophagy protein prevents spontaneous Alzheimer’s disease

(2020) Bradlee L. Heckmann et al.   Science Advances

Effect of rapamycin on aging and age-related diseases—past and future

(2020) Ramasamy Selvarani et al.   GeroScience

LC3-Associated Endocytosis Facilitates β-Amyloid Clearance and Mitigates Neurodegeneration in Murine Alzheimer’s Disease

(2020) Bradlee L. Heckmann et al.   CELL

Autophagy Is Required for Memory Formation and Reverses Age-Related Memory Decline

(2019) Mélissa Glatigny et al.   CURRENT BIOLOGY

Genome-wide meta-analysis identifies new loci and functional pathways influencing Alzheimer’s disease risk

(2019) Iris E. Jansen et al.   NATURE GENETICS

Efficacy and safety of mTOR inhibitors (rapamycin and its analogues) for tuberous sclerosis complex: a meta-analysis

(2019) Min Li et al.   Orphanet Journal of Rare Diseases

Mitophagy inhibits amyloid-β and tau pathology and reverses cognitive deficits in models of Alzheimer’s disease

(2019) Evandro F. Fang et al.   NATURE NEUROSCIENCE

Next generation strategies for geroprotection via mTORC1 inhibition

(2019) Sabrina N Dumas et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Mitophagy and NAD+ inhibit Alzheimer disease

(2019) Evandro F. Fang   Autophagy

Autophagy dysfunction in Alzheimer’s disease: mechanistic insights and new therapeutic opportunities

(2019) Antonio Di Meco et al.   BIOLOGICAL PSYCHIATRY

Trehalose as a promising therapeutic candidate for the treatment of Parkinson's disease

(2019) Masoomeh Khalifeh et al.   BRITISH JOURNAL OF PHARMACOLOGY

Watch What You (Self-) Eat: Autophagic Mechanisms that Modulate Metabolism

(2019) Vikramjit Lahiri et al.   Cell Metabolism

Nilotinib: A Tyrosine Kinase Inhibitor Mediates Resistance to Intracellular Mycobacterium Via Regulating Autophagy

(2019) Tariq Hussain et al.   Cells

Metformin Improves Learning and Memory in the SAMP8 Mouse Model of Alzheimer’s Disease

(2019) Susan A. Farr et al.   JOURNAL OF ALZHEIMERS DISEASE

Mitophagy and Neuroprotection

(2019) Guofeng Lou et al.   TRENDS IN MOLECULAR MEDICINE

Sodium oligomannate therapeutically remodels gut microbiota and suppresses gut bacterial amino acids-shaped neuroinflammation to inhibit Alzheimer’s disease progression

(2019) Xinyi Wang et al.   CELL RESEARCH

Phosphorylation of Beclin-1 by BCR-ABL suppresses autophagy in chronic myeloid leukemia

(2019) Chuanjiang Yu et al.   HAEMATOLOGICA

Alzheimer Disease: An Update on Pathobiology and Treatment Strategies

(2019) Justin M. Long et al.   CELL

NAD+ in Brain Aging and Neurodegenerative Disorders

(2019) Sofie Lautrup et al.   Cell Metabolism

A Diversity of Selective Autophagy Receptors Determines the Specificity of the Autophagy Pathway

(2019) Vladimir Kirkin et al.   MOLECULAR CELL

Autophagy protein NRBF2 has reduced expression in Alzheimer’s brains and modulates memory and amyloid-beta homeostasis in mice

(2019) Véronik Lachance et al.   Molecular Neurodegeneration

Microglial mitophagy mitigates neuroinflammation in Alzheimer's disease

(2019) Sofie Lautrup et al.   NEUROCHEMISTRY INTERNATIONAL

Lithium targeting of AMPK protects against cisplatin-induced acute kidney injury by enhancing autophagy in renal proximal tubular epithelial cells

(2019) Hui Bao et al.   FASEB JOURNAL

The Synaptic Autophagy Cycle

(2019) Ori J. Lieberman et al.   JOURNAL OF MOLECULAR BIOLOGY

ULK1 phosphorylates Ser30 of BECN1 in association with ATG14 to stimulate autophagy induction

(2018) Ji-Man Park et al.   Autophagy

NAD + Intermediates: The Biology and Therapeutic Potential of NMN and NR

(2018) Jun Yoshino et al.   Cell Metabolism

PTEN-L is a novel protein phosphatase for ubiquitin dephosphorylation to inhibit PINK1–Parkin-mediated mitophagy

(2018) Liming Wang et al.   CELL RESEARCH

Mitophagy and Quality Control Mechanisms in Mitochondrial Maintenance

(2018) Sarah Pickles et al.   CURRENT BIOLOGY

A Systematic Review and Meta-Analysis of the Effectiveness of Acetylcholinesterase Inhibitors and Memantine in Treating the Cognitive Symptoms of Dementia

(2018) Ruth Knight et al.   DEMENTIA AND GERIATRIC COGNITIVE DISORDERS

The RAB11A-Positive Compartment Is a Primary Platform for Autophagosome Assembly Mediated by WIPI2 Recognition of PI3P-RAB11A

(2018) Claudia Puri et al.   DEVELOPMENTAL CELL

The deubiquitinating enzyme USP20 stabilizes ULK1 and promotes autophagy initiation

(2018) Jun Hwan Kim et al.   EMBO REPORTS

Cargo recognition and degradation by selective autophagy

(2018) Damián Gatica et al.   NATURE CELL BIOLOGY

The coming of age of chaperone-mediated autophagy

(2018) Susmita Kaushik et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Mechanisms of selective autophagy and mitophagy: Implications for neurodegenerative diseases

(2018) Charleen T. Chu   NEUROBIOLOGY OF DISEASE

Alzheimer’s disease and the autophagic-lysosomal system

(2018) Kyung Min Chung et al.   NEUROSCIENCE LETTERS

Rab GTPase Function in Endosome and Lysosome Biogenesis

(2018) Lars Langemeyer et al.   TRENDS IN CELL BIOLOGY

Regulation and Roles of Autophagy at Synapses

(2018) Vassiliki Nikoletopoulou et al.   TRENDS IN CELL BIOLOGY

Effectiveness and safety of glucosamine and chondroitin for the treatment of osteoarthritis: a meta-analysis of randomized controlled trials

(2018) Xiaoyue Zhu et al.   Journal of Orthopaedic Surgery and Research

USP1 (ubiquitin specific peptidase 1) targets ULK1 and regulates its cellular compartmentalization and autophagy

(2018) Marzia Raimondi et al.   Autophagy

Trehalose induces autophagy via lysosomal-mediated TFEB activation in models of motoneuron degeneration

(2018) Paola Rusmini et al.   Autophagy

Autophagic dysfunction in Alzheimer’s disease: Cellular and molecular mechanistic approaches to halt Alzheimer’s pathogenesis

(2018) Md. Sahab Uddin et al.   JOURNAL OF CELLULAR PHYSIOLOGY

VPS34 complexes from a structural perspective

(2018) Yohei Ohashi et al.   JOURNAL OF LIPID RESEARCH

mTOR as a central hub of nutrient signalling and cell growth

(2018) Joungmok Kim et al.   NATURE CELL BIOLOGY

Translating the biology of aging into novel therapeutics for Alzheimer disease

(2018) Yuko Hara et al.   NEUROLOGY

Synaptic dysfunction in Alzheimer's disease: Mechanisms and therapeutic strategies

(2018) Yu Chen et al.   PHARMACOLOGY & THERAPEUTICS

Influenza A Virus NS1 Protein Suppresses JNK1-Dependent Autophagosome Formation Mediated by Rab11a Recycling Endosomes

(2018) Takahiro Kuroki et al.   Frontiers in Microbiology

The therapeutic potential of curcumin: A review of clinical trials

(2018) Bahare Salehi et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

The discovery of Alzheimer-causing mutations in the APP gene and the formulation of the “amyloid cascade hypothesis”

(2017) John Hardy   FEBS Journal

Trehalose Improves Cognition in the Transgenic Tg2576 Mouse Model of Alzheimer’s Disease

(2017) Stuart D. Portbury et al.   JOURNAL OF ALZHEIMERS DISEASE

Autophagy and Neurodegeneration: Pathogenic Mechanisms and Therapeutic Opportunities

(2017) Fiona M. Menzies et al.   NEURON

Mitophagy and Alzheimer’s Disease: Cellular and Molecular Mechanisms

(2017) Jesse S. Kerr et al.   TRENDS IN NEUROSCIENCES

Resveratrol as a Natural Autophagy Regulator for Prevention and Treatment of Alzheimer’s Disease

(2017) et al.   Nutrients

Alzheimer’s disease prevention: from risk factors to early intervention

(2017) Marta Crous-Bou et al.   Alzheimers Research & Therapy

A Becn1 mutation mediates hyperactive autophagic sequestration of amyloid oligomers and improved cognition in Alzheimer's disease

(2017) Altea Rocchi et al.   PLoS Genetics

Evaluating the Effectiveness of GTM-1, Rapamycin, and Carbamazepine on Autophagy and Alzheimer Disease

(2017) Lijuan Zhang et al.   MEDICAL SCIENCE MONITOR

Alzheimer’s Disease: From Genetic Variants to the Distinct Pathological Mechanisms

(2017) Qiying Sun et al.   Frontiers in Molecular Neuroscience

Nicotinamide mononucleotide supplementation reverses vascular dysfunction and oxidative stress with aging in mice

(2016) Natalie E. de Picciotto et al.   AGING CELL

The ULK1 complex mediates MTORC1 signaling to the autophagy initiation machinery via binding and phosphorylating ATG14

(2016) Ji-Man Park et al.   Autophagy

AMPK regulates autophagy by phosphorylating BECN1 at threonine 388

(2016) Deyi Zhang et al.   Autophagy

Autophagy flux in CA1 neurons of Alzheimer hippocampus: Increased induction overburdens failing lysosomes to propel neuritic dystrophy

(2016) Matteo Bordi et al.   Autophagy

The intricate regulation and complex functions of the Class III phosphoinositide 3-kinase Vps34

(2016) J. M. Backer   BIOCHEMICAL JOURNAL

Pexophagy in yeasts

(2016) Masahide Oku et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Regulation of amyloid precursor protein processing by its KFERQ motif

(2016) Ji-Seon Park et al.   BMB Reports

Long-Term Administration of Nicotinamide Mononucleotide Mitigates Age-Associated Physiological Decline in Mice

(2016) Kathryn F. Mills et al.   Cell Metabolism

Phosphatidylinositol 3‐phosphates—at the interface between cell signalling and membrane traffic

(2016) Andrea L Marat et al.   EMBO JOURNAL

The amyloid hypothesis of Alzheimer's disease at 25 years

(2016) Dennis J Selkoe et al.   EMBO Molecular Medicine

The Dynamics and Turnover of Tau Aggregates in Cultured Cells

(2016) Jing L. Guo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Functions of Polyamines in Mammals

(2016) Anthony E. Pegg   JOURNAL OF BIOLOGICAL CHEMISTRY

Cardioprotection and lifespan extension by the natural polyamine spermidine

(2016) Tobias Eisenberg et al.   NATURE MEDICINE

SNARE-mediated membrane fusion in autophagy

(2016) Yongyao Wang et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Digesting the Expanding Mechanisms of Autophagy

(2016) Nicholas T. Ktistakis et al.   TRENDS IN CELL BIOLOGY

Autophagic and lysosomal defects in human tauopathies: analysis of post-mortem brain from patients with familial Alzheimer disease, corticobasal degeneration and progressive supranuclear palsy

(2016) Antonio Piras et al.   Acta Neuropathologica Communications

Autophagy-Related Protein 7 Deficiency in Amyloid β (Aβ) Precursor Protein Transgenic Mice Decreases Aβ in the Multivesicular Bodies and Induces Aβ Accumulation in the Golgi

(2015) Per Nilsson et al.   AMERICAN JOURNAL OF PATHOLOGY

Inflammation in Alzheimer’s Disease and Molecular Genetics: Recent Update

(2015) Zhi-Gang Zhang et al.   ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS

The Function of Autophagy in Neurodegenerative Diseases

(2015) Yoshimitsu Kiriyama et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Axonal autophagosomes recruit dynein for retrograde transport through fusion with late endosomes

(2015) Xiu-Tang Cheng et al.   JOURNAL OF CELL BIOLOGY

Anti-autophagic and anti-apoptotic effects of memantine in a SH-SY5Y cell model of Alzheimer's disease via mammalian target of rapamycin-dependent and -independent pathways

(2015) GUIJUN SONG et al.   Molecular Medicine Reports

The ubiquitin kinase PINK1 recruits autophagy receptors to induce mitophagy

(2015) Michael Lazarou et al.   NATURE

mTOR signaling in aging and neurodegeneration: At the crossroad between metabolism dysfunction and impairment of autophagy

(2015) Marzia Perluigi et al.   NEUROBIOLOGY OF DISEASE

A randomized, double-blind, placebo-controlled trial of resveratrol for Alzheimer disease

(2015) R. Scott Turner et al.   NEUROLOGY

Epigallocatechin-3-gallate enhances clearance of phosphorylated tau in primary neurons

(2015) Adrianne S. Chesser et al.   NUTRITIONAL NEUROSCIENCE

Protecting the mitochondrial powerhouse

(2015) Morten Scheibye-Knudsen et al.   TRENDS IN CELL BIOLOGY

The unexpected role of polyubiquitin chains in the formation of fibrillar aggregates

(2015) Daichi Morimoto et al.   Nature Communications

Autophagosome–lysosome fusion is independent of V-ATPase-mediated acidification

(2015) Caroline Mauvezin et al.   Nature Communications

Oleuropein aglycone induces autophagy via the AMPK/mTOR signalling pathway: a mechanistic insight

(2015) Stefania Rigacci et al.   Oncotarget

Effectiveness and safety of Glucosamine, chondroitin, the two in combination, or celecoxib in the treatment of osteoarthritis of the knee

(2015) Chao Zeng et al.   Scientific Reports

The GTPase Rab26 links synaptic vesicles to the autophagy pathway

(2015) Beyenech Binotti et al.   eLife

Tetrahydrohyperforin Inhibits the Proteolytic Processing of Amyloid Precursor Protein and Enhances Its Degradation by Atg5-Dependent Autophagy

(2015) Viviana A. Cavieres et al.   PLoS One

NDP52 associates with phosphorylated tau in brains of an Alzheimer disease mouse model

(2014) Sunhyo Kim et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Defective Mitophagy in XPA via PARP-1 Hyperactivation and NAD+/SIRT1 Reduction

(2014) Evandro Fei Fang et al.   CELL

Selective clearance of aberrant tau proteins and rescue of neurotoxicity by transcription factor EB

(2014) V. A. Polito et al.   EMBO Molecular Medicine

Downregulation of PI3K/Akt/mTOR signaling pathway in curcumin-induced autophagy in APP/PS1 double transgenic mice

(2014) Chen Wang et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

PINK1 Kinase Catalytic Activity Is Regulated by Phosphorylation on Serines 228 and 402

(2014) Liesbeth Aerts et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PINK1 phosphorylates ubiquitin to activate Parkin E3 ubiquitin ligase activity

(2014) Lesley A. Kane et al.   JOURNAL OF CELL BIOLOGY

Classes of phosphoinositide 3-kinases at a glance

(2014) S. Jean et al.   JOURNAL OF CELL SCIENCE

The HOPS complex mediates autophagosome–lysosome fusion through interaction with syntaxin 17

(2014) Peidu Jiang et al.   MOLECULAR BIOLOGY OF THE CELL

Ubiquitin is phosphorylated by PINK1 to activate parkin

(2014) Fumika Koyano et al.   NATURE

Chaperone-mediated autophagy regulates T cell responses through targeted degradation of negative regulators of T cell activation

(2014) Rut Valdor et al.   NATURE IMMUNOLOGY

Nrf2 reduces levels of phosphorylated tau protein by inducing autophagy adaptor protein NDP52

(2014) Chulman Jo et al.   Nature Communications

D-Glucosamine supplementation extends life span of nematodes and of ageing mice

(2014) Sandra Weimer et al.   Nature Communications

Balance between autophagic pathways preserves retinal homeostasis

(2013) Natalia Rodríguez-Muela et al.   AGING CELL

mTOR regulates tau phosphorylation and degradation: implications for Alzheimer's disease and other tauopathies

(2013) Antonella Caccamo et al.   AGING CELL

Glucosamine Activates Autophagy In Vitro and In Vivo

(2013) Beatriz Caramés et al.   ARTHRITIS AND RHEUMATISM

Historical landmarks of autophagy research

(2013) Yoshinori Ohsumi   CELL RESEARCH

Autophagy Enhancer Carbamazepine Alleviates Memory Deficits and Cerebral Amyloid-β Pathology in a Mouse Model of Alzheimer's Disease

(2013) Lixi Li et al.   Current Alzheimer Research

Tyrosine kinase inhibition increases functional parkin-Beclin-1 interaction and enhances amyloid clearance and cognitive performance

(2013) Irina Lonskaya et al.   EMBO Molecular Medicine

Autophagy failure in Alzheimer's disease and the role of defective lysosomal acidification

(2013) Devin M. Wolfe et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Membrane remodeling by the PX-BAR protein SNX18 promotes autophagosome formation

(2013) Helene Knævelsrud et al.   JOURNAL OF CELL BIOLOGY

Chronic Rapamycin Restores Brain Vascular Integrity and Function Through NO Synthase Activation and Improves Memory in Symptomatic Mice Modeling Alzheimer’s Disease

(2013) Ai-Ling Lin et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Trehalose rescues Alzheimer's disease phenotypes in APP/PS1 transgenic mice

(2013) Jing Du et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

Class IA PI3K p110β Subunit Promotes Autophagy through Rab5 Small GTPase in Response to Growth Factor Limitation

(2013) Zhixun Dou et al.   MOLECULAR CELL

mTOR inhibits autophagy by controlling ULK1 ubiquitylation, self-association and function through AMBRA1 and TRAF6

(2013) Francesca Nazio et al.   NATURE CELL BIOLOGY

ULK1 induces autophagy by phosphorylating Beclin-1 and activating VPS34 lipid kinase

(2013) Ryan C. Russell et al.   NATURE CELL BIOLOGY

Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease

(2013) Jean-Charles Lambert et al.   NATURE GENETICS

The role of autophagy in neurodegenerative disease

(2013) Ralph A Nixon   NATURE MEDICINE

The autophagosome: origins unknown, biogenesis complex

(2013) Christopher A. Lamb et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Nicotinamide riboside restores cognition through an upregulation of proliferator-activated receptor-γ coactivator 1α regulated β-secretase 1 degradation and mitochondrial gene expression in Alzheimer's mouse models

(2013) Bing Gong et al.   NEUROBIOLOGY OF AGING

Relationship between amyloid-beta and the ubiquitin–proteasome system in Alzheimer’s disease

(2013) Liang Hong et al.   NEUROLOGICAL RESEARCH

Microglial Beclin 1 Regulates Retromer Trafficking and Phagocytosis and Is Impaired in Alzheimer’s Disease

(2013) Kurt M. Lucin et al.   NEURON

Rapamycin Attenuates the Progression of Tau Pathology in P301S Tau Transgenic Mice

(2013) Sefika Ozcelik et al.   PLoS One

The Polyphenol Oleuropein Aglycone Protects TgCRND8 Mice against Aß Plaque Pathology

(2013) Cristina Grossi et al.   PLoS One

Structure of Parkin Reveals Mechanisms for Ubiquitin Ligase Activation

(2013) J.-F. Trempe et al.   SCIENCE

Phosphatidylinositol-3-phosphate regulates sorting and processing of amyloid precursor protein through the endosomal system

(2013) Etienne Morel et al.   Nature Communications

Aβ Secretion and Plaque Formation Depend on Autophagy

(2013) Per Nilsson et al.   Cell Reports

MTORC1 functions as a transcriptional regulator of autophagy by preventing nuclear transport of TFEB

(2012) Jose A. Martina et al.   Autophagy

Stimulation of autophagy reduces neurodegeneration in a mouse model of human tauopathy

(2012) Véronique Schaeffer et al.   BRAIN

Mechanism and functions of membrane binding by the Atg5-Atg12/Atg16 complex during autophagosome formation

(2012) Julia Romanov et al.   EMBO JOURNAL

A lysosome-to-nucleus signalling mechanism senses and regulates the lysosome via mTOR and TFEB

(2012) Carmine Settembre et al.   EMBO JOURNAL

Autophagosomes initiate distally and mature during transport toward the cell soma in primary neurons

(2012) Sandra Maday et al.   JOURNAL OF CELL BIOLOGY

Macroautophagy deficiency mediates age-dependent neurodegeneration through a phospho-tau pathway

(2012) Keiichi Inoue et al.   Molecular Neurodegeneration

Nicotinamide forestalls pathology and cognitive decline in Alzheimer mice: evidence for improved neuronal bioenergetics and autophagy procession

(2012) Dong Liu et al.   NEUROBIOLOGY OF AGING

Regulation of Presynaptic Neurotransmission by Macroautophagy

(2012) Daniela Hernandez et al.   NEURON

Ambra1 at the crossroad between autophagy and cell death

(2012) G M Fimia et al.   ONCOGENE

PINK1 is activated by mitochondrial membrane potential depolarization and stimulates Parkin E3 ligase activity by phosphorylating Serine 65

(2012) C. Kondapalli et al.   Open Biology

Microautophagy: lesser-known self-eating

(2011) Wen-wen Li et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Regulation of TFEB and V-ATPases by mTORC1

(2011) Samuel Peña-Llopis et al.   EMBO JOURNAL

Rab5 and Class III Phosphoinositide 3-Kinase Vps34 Are Involved in Hepatitis C Virus NS4B-Induced Autophagy

(2011) W.-C. Su et al.   JOURNAL OF VIROLOGY

AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

(2011) Joungmok Kim et al.   NATURE CELL BIOLOGY

Autophagy failure in Alzheimer's disease—locating the primary defect

(2011) Ralph A. Nixon et al.   NEUROBIOLOGY OF DISEASE

Inducing Autophagy by Rapamycin Before, but Not After, the Formation of Plaques and Tangles Ameliorates Cognitive Deficits

(2011) Smita Majumder et al.   PLoS One

Common toxicities of mammalian target of rapamycin inhibitors

(2011) Scott A. Soefje et al.   Targeted Oncology

Lysosomal Proteolysis and Autophagy Require Presenilin 1 and Are Disrupted by Alzheimer-Related PS1 Mutations

(2010) Ju-Hyun Lee et al.   CELL

Metformin, Independent of AMPK, Inhibits mTORC1 in a Rag GTPase-Dependent Manner

(2010) Adem Kalender et al.   Cell Metabolism

Autophagy for the avoidance of degenerative, inflammatory, infectious, and neoplastic disease

(2010) Guido Kroemer et al.   CURRENT OPINION IN CELL BIOLOGY

AMP-activated Protein Kinase Signaling Activation by Resveratrol Modulates Amyloid-β Peptide Metabolism

(2010) Valérie Vingtdeux et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Molecular Interplay between Mammalian Target of Rapamycin (mTOR), Amyloid-β, and Tau

(2010) Antonella Caccamo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Autophagy: cellular and molecular mechanisms

(2010) Danielle Glick et al.   JOURNAL OF PATHOLOGY

Identification of Regulators of Chaperone-Mediated Autophagy

(2010) Urmi Bandyopadhyay et al.   MOLECULAR CELL

Selective autophagy: ubiquitin-mediated recognition and beyond

(2010) Claudine Kraft et al.   NATURE CELL BIOLOGY

PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1

(2010) Sven Geisler et al.   NATURE CELL BIOLOGY

Depletion of Beclin-1 due to proteolytic cleavage by caspases in the Alzheimer's disease brain

(2010) Troy T. Rohn et al.   NEUROBIOLOGY OF DISEASE

Alzheimer's Disease

(2010) Henry W. Querfurth et al.   NEW ENGLAND JOURNAL OF MEDICINE

Metformin Induces a Dietary Restriction–Like State and the Oxidative Stress Response to Extend C. elegans Healthspan via AMPK, LKB1, and SKN-1

(2010) Brian Onken et al.   PLoS One

Inhibition of mTOR by Rapamycin Abolishes Cognitive Deficits and Reduces Amyloid-β Levels in a Mouse Model of Alzheimer's Disease

(2010) Patricia Spilman et al.   PLoS One

PINK1 Is Selectively Stabilized on Impaired Mitochondria to Activate Parkin

(2010) Derek P. Narendra et al.   PLOS BIOLOGY

Memantine Improves Cognition and Reduces Alzheimer’s-Like Neuropathology in Transgenic Mice

(2009) Hilda Martinez-Coria et al.   AMERICAN JOURNAL OF PATHOLOGY

Tau fragmentation, aggregation and clearance: the dual role of lysosomal processing

(2009) Yipeng Wang et al.   HUMAN MOLECULAR GENETICS

Lithium Trial in Alzheimer's Disease

(2009) Harald Hampel et al.   JOURNAL OF CLINICAL PSYCHIATRY

Induction of autophagy by spermidine promotes longevity

(2009) Tobias Eisenberg et al.   NATURE CELL BIOLOGY

The autophagy effector Beclin 1: a novel BH3-only protein

(2009) S Sinha et al.   ONCOGENE

Autophagic-lysosomal perturbation enhances tau aggregation in transfectants with induced wild-type tau expression

(2008) Tadanori Hamano et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Autophagosome formation from membrane compartments enriched in phosphatidylinositol 3-phosphate and dynamically connected to the endoplasmic reticulum

(2008) Elizabeth L. Axe et al.   JOURNAL OF CELL BIOLOGY

Rab5 modulates aggregation and toxicity of mutant huntingtin through macroautophagy in cell and fly models of Huntington disease

(2008) B. Ravikumar et al.   JOURNAL OF CELL SCIENCE

Phase I Trial of the Novel Mammalian Target of Rapamycin Inhibitor Deforolimus (AP23573; MK-8669) Administered Intravenously Daily for 5 Days Every 2 Weeks to Patients With Advanced Malignancies

(2008) Monica M. Mita et al.   JOURNAL OF CLINICAL ONCOLOGY

Nicotinamide Restores Cognition in Alzheimer's Disease Transgenic Mice via a Mechanism Involving Sirtuin Inhibition and Selective Reduction of Thr231-Phosphotau

(2008) K. N. Green et al.   JOURNAL OF NEUROSCIENCE

Autophagy Induction and Autophagosome Clearance in Neurons: Relationship to Autophagic Pathology in Alzheimer's Disease

(2008) B. Boland et al.   JOURNAL OF NEUROSCIENCE

The Chaperone-Mediated Autophagy Receptor Organizes in Dynamic Protein Complexes at the Lysosomal Membrane

(2008) U. Bandyopadhyay et al.   MOLECULAR AND CELLULAR BIOLOGY

AMPK Phosphorylation of Raptor Mediates a Metabolic Checkpoint

(2008) Dana M. Gwinn et al.   MOLECULAR CELL

Restoration of chaperone-mediated autophagy in aging liver improves cellular maintenance and hepatic function

(2008) Cong Zhang et al.   NATURE MEDICINE

Mitochondria in Neuroplasticity and Neurological Disorders

(2008) Mark P. Mattson et al.   NEURON