Sodium oligomannate therapeutically remodels gut microbiota and suppresses gut bacterial amino acids-shaped neuroinflammation to inhibit Alzheimer’s disease progression

Brain-Gut-Microbiota Axis in Alzheimer’s Disease

(2019) Karol Kowalski et al.   Journal of Neurogastroenterology and Motility

Sex-specific effects of microbiome perturbations on cerebral Aβ amyloidosis and microglia phenotypes

(2019) Hemraj B. Dodiya et al.   JOURNAL OF EXPERIMENTAL MEDICINE

High-Dimensional Single-Cell Mapping of Central Nervous System Immune Cells Reveals Distinct Myeloid Subsets in Health, Aging, and Disease

(2018) Dunja Mrdjen et al.   IMMUNITY

Gut Microbiota is Altered in Patients with Alzheimer’s Disease

(2018) Zhen-Qian Zhuang et al.   JOURNAL OF ALZHEIMERS DISEASE

The Gut Microbiome Alterations and Inflammation-Driven Pathogenesis of Alzheimer’s Disease—a Critical Review

(2018) Marta Sochocka et al.   MOLECULAR NEUROBIOLOGY

Dietary salt promotes neurovascular and cognitive dysfunction through a gut-initiated TH17 response

(2018) Giuseppe Faraco et al.   NATURE NEUROSCIENCE

Single-cell mass cytometry reveals distinct populations of brain myeloid cells in mouse neuroinflammation and neurodegeneration models

(2018) Bahareh Ajami et al.   NATURE NEUROSCIENCE

Extravascular CD3+ T Cells in Brains of Alzheimer Disease Patients Correlate with Tau but Not with Amyloid Pathology: An Immunohistochemical Study

(2018) Mario Merlini et al.   Neurodegenerative Diseases

The prodrug of 7,8-dihydroxyflavone development and therapeutic efficacy for treating Alzheimer’s disease

(2018) Chun Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neuroinflammation: Microglia and T Cells Get Ready to Tango

(2018) Sjoerd T. T. Schetters et al.   Frontiers in Immunology

Human milk oligosaccharides and infant gut bifidobacteria: Molecular strategies for their utilization

(2017) Pamela Thomson et al.   FOOD MICROBIOLOGY

The TREM2-APOE Pathway Drives the Transcriptional Phenotype of Dysfunctional Microglia in Neurodegenerative Diseases

(2017) Susanne Krasemann et al.   IMMUNITY

Evaluating in Vitro Culture Medium of Gut Microbiome with Orthogonal Experimental Design and a Metaproteomics Approach

(2017) Leyuan Li et al.   JOURNAL OF PROTEOME RESEARCH

Microglia-derived ASC specks cross-seed amyloid-β in Alzheimer’s disease

(2017) Carmen Venegas et al.   NATURE

Amyloid-β plaques enhance Alzheimer's brain tau-seeded pathologies by facilitating neuritic plaque tau aggregation

(2017) Zhuohao He et al.   NATURE MEDICINE

Points of Significance: Principal component analysis

(2017) Jake Lever et al.   NATURE METHODS

The role of peripheral immune cells in the CNS in steady state and disease

(2017) Marco Prinz et al.   NATURE NEUROSCIENCE

High-dimensional, single-cell characterization of the brain's immune compartment

(2017) Ben Korin et al.   NATURE NEUROSCIENCE

Trial watch: Tracing investment in drug development for Alzheimer disease

(2017) Alpha Tom Kodamullil et al.   NATURE REVIEWS DRUG DISCOVERY

Association of brain amyloidosis with pro-inflammatory gut bacterial taxa and peripheral inflammation markers in cognitively impaired elderly

(2017) Annamaria Cattaneo et al.   NEUROBIOLOGY OF AGING

Mannoside recognition and degradation by bacteria

(2016) Simon Ladevèze et al.   BIOLOGICAL REVIEWS

The Central Nervous System and the Gut Microbiome

(2016) Gil Sharon et al.   CELL

Linking T cells to Alzheimer's disease: from neurodegeneration to neurorepair

(2016) Karen J Bryson et al.   CURRENT OPINION IN PHARMACOLOGY

The microbiota in adaptive immune homeostasis and disease

(2016) Kenya Honda et al.   NATURE

The microbiome and innate immunity

(2016) Christoph A. Thaiss et al.   NATURE

Commensal microbiota affects ischemic stroke outcome by regulating intestinal γδ T cells

(2016) Corinne Benakis et al.   NATURE MEDICINE

Human gut microbiota: the links with dementia development

(2016) Rashad Alkasir et al.   Protein & Cell

Antibiotic-induced perturbations in gut microbial diversity influences neuro-inflammation and amyloidosis in a murine model of Alzheimer’s disease

(2016) Myles R. Minter et al.   Scientific Reports

Differential Roles of M1 and M2 Microglia in Neurodegenerative Diseases

(2015) Yu Tang et al.   MOLECULAR NEUROBIOLOGY

A Genome-wide Gene-Expression Analysis and Database in Transgenic Mice during Development of Amyloid or Tau Pathology

(2015) Mar Matarin et al.   Cell Reports

Mouse Naïve CD4+ T Cell Isolation and In vitro Differentiation into T Cell Subsets

(2015) Stephanie Flaherty et al.   Jove-Journal of Visualized Experiments

Hyperphosphorylation of Tau at Ser396 occurs in the much earlier stage than appearance of learning and memory disorders in 5XFAD mice

(2014) Takeshi Kanno et al.   BEHAVIOURAL BRAIN RESEARCH

Assessment of different carbohydrates as exogenous carbon source in cultivation of cyanobacteria

(2014) Érika Cristina Francisco et al.   BIOPROCESS AND BIOSYSTEMS ENGINEERING

Control of amino-acid transport by antigen receptors coordinates the metabolic reprogramming essential for T cell differentiation

(2013) Linda V Sinclair et al.   NATURE IMMUNOLOGY

Glucosamine as carbon source for amino acid-producing Corynebacterium glutamicum

(2012) Andreas Uhde et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

NLRP3 is activated in Alzheimer’s disease and contributes to pathology in APP/PS1 mice

(2012) Michael T. Heneka et al.   NATURE

MBRole: enrichment analysis of metabolomic data

(2011) M. Chagoyen et al.   BIOINFORMATICS

Motor deficits, neuron loss, and reduced anxiety coinciding with axonal degeneration and intraneuronal Aβ aggregation in the 5XFAD mouse model of Alzheimer's disease

(2010) Sadim Jawhar et al.   NEUROBIOLOGY OF AGING

Impairments in remote memory stabilization precede hippocampal synaptic and cognitive failures in 5XFAD Alzheimer mouse model

(2008) Ryoichi Kimura et al.   NEUROBIOLOGY OF DISEASE