期刊
TRENDS IN CELL BIOLOGY
卷 28, 期 8, 页码 646-661出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tcb.2018.03.006
关键词
-
类别
资金
- European Research Council [ERC-GA695190-MANNA, ERC-GA737599-NeuronAgeScreen, ERC-GA714983-NEUROPHAGY]
- European Commission Framework Programmes
- Greek Ministry of Education
Genetic studies have demonstrated that conditional ablation of core autophagy genes in the neural lineage leads to progressive neurodegeneration, indicating that this catabolic pathway is indispensable for neuronal maintenance. However, accumulating evidence also indicates that autophagy is not merely a housekeeping process. Instead, autophagy may be dynamically regulated in different neuronal compartments and dictate the turnover of selected cargo in a time- and space-dependent manner and thus contribute to specialized neuronal functions. Here, we review the mechanisms regulating autophagy in neurons and discuss recent findings on the role of autophagy in synaptic morphology and function. Moreover, we discuss relevant questions that remain open and highlight forthcoming issues in the field of neuronal autophagy.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据