Evolution of Toll-like receptor 7/8 agonist therapeutics and their delivery approaches: From antiviral formulations to vaccine adjuvants
出版年份 2021 全文链接
标题
Evolution of Toll-like receptor 7/8 agonist therapeutics and their delivery approaches: From antiviral formulations to vaccine adjuvants
作者
关键词
Toll-like receptors, TLR7 agonists, Immunomodulators, Cancer, Infectious disease, Bioconjugation, Vaccine adjuvants, Nanoparticles
出版物
ADVANCED DRUG DELIVERY REVIEWS
Volume 175, Issue -, Pages 113803
出版商
Elsevier BV
发表日期
2021-05-29
DOI
10.1016/j.addr.2021.05.013
参考文献
相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。- TRAF6-IRF5 kinetics, TRIF, and biophysical factors drive synergistic innate responses to particle-mediated MPLA-CpG co-presentation
- (2021) P. Pradhan et al. Science Advances
- Receptor–Ligand Kinetics Influence the Mechanism of Action of Covalently Linked TLR Ligands
- (2021) Flora W. Kimani et al. ACS Chemical Biology
- Adjuvantation helps to optimise COVID-19 vaccine candidate
- (2021) Jing-Xin Li et al. LANCET INFECTIOUS DISEASES
- Structural and functional understanding of the toll‐like receptors
- (2021) Jinta Asami et al. PROTEIN SCIENCE
- Epitope spreading toward wild-type melanocyte-lineage antigens rescues suboptimal immune checkpoint blockade responses
- (2021) Jennifer A. Lo et al. Science Translational Medicine
- Immunogenicity and protective efficacy of inactivated SARS-CoV-2 vaccine candidate, BBV152 in rhesus macaques
- (2021) Pragya D. Yadav et al. Nature Communications
- Novel TLR 7/8 agonists for improving NK cell mediated antibody-dependent cellular cytotoxicity (ADCC)
- (2021) Vidhi Khanna et al. Scientific Reports
- Th1 Skewed immune response of Whole Virion Inactivated SARS CoV 2 Vaccine and its safety evaluation
- (2021) Brunda Ganneru et al. iScience
- Safety, tolerability, pharmacokinetics, and pharmacodynamics of a TLR7 agonist prodrug RO6870868 in healthy volunteers
- (2021) Joseph F. Grippo et al. CTS-Clinical and Translational Science
- Intratumoral immunotherapy using platelet-cloaked nanoparticles enhances antitumor immunity in solid tumors
- (2021) Baharak Bahmani et al. Nature Communications
- Enhanced antitumoral activity of TLR7 agonists via activation of human endogenous retroviruses by HDAC inhibitors
- (2021) David Díaz-Carballo et al. Communications Biology
- Intratumoral immunotherapy for early stage solid tumors
- (2020) Wan Xing Hong et al. CLINICAL CANCER RESEARCH
- Circadian control of interferon-sensitive gene expression in murine skin
- (2020) Elyse Noelani Greenberg et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Structural Insights into STING Signaling
- (2020) Sabrina L. Ergun et al. TRENDS IN CELL BIOLOGY
- Small-Molecule Modulators of Toll-like Receptors
- (2020) Yibo Wang et al. ACCOUNTS OF CHEMICAL RESEARCH
- Comparing the immunogenicity of glycosidase-directed resiquimod prodrugs mediated by cancer cell metabolism
- (2020) Austin T Ryan et al. ACTA PHARMACOLOGICA SINICA
- Control over Imidazoquinoline Immune Stimulation by pH-Degradable Poly(norbornene) Nanogels
- (2020) Johannes Kockelmann et al. BIOMACROMOLECULES
- A Single and Multiple Ascending Dose Study of Toll‐Like Receptor 7 Agonist (RO7020531) in Chinese Healthy Volunteers
- (2020) Andrea Luk et al. CTS-Clinical and Translational Science
- Agonist and antagonist ligands of toll-like receptors 7 and 8: Ingenious tools for therapeutic purposes
- (2020) Cindy Patinote et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- SBT6050, a HER2-directed TLR8 therapeutic, as a systemically administered, tumor-targeted human myeloid cell agonist.
- (2020) Heather Metz et al. JOURNAL OF CLINICAL ONCOLOGY
- Discovery of GS-9688 (Selgantolimod), as a Potent and Selective Oral Toll-like Receptor 8 Agonist for the Treatment of Chronic Hepatitis B
- (2020) Richard L. Mackman et al. JOURNAL OF MEDICINAL CHEMISTRY
- TLR7/8 Agonist-Loaded Nanoparticles Augment NK Cell-Mediated Antibody-Based Cancer Immunotherapy
- (2020) Hyunjoon Kim et al. MOLECULAR PHARMACEUTICS
- Selective organ targeting (SORT) nanoparticles for tissue-specific mRNA delivery and CRISPR–Cas gene editing
- (2020) Qiang Cheng et al. Nature Nanotechnology
- A bi-adjuvant nanovaccine that potentiates immunogenicity of neoantigen for combination immunotherapy of colorectal cancer
- (2020) Qianqian Ni et al. Science Advances
- TLR7 Sensing by Neutrophils Is Critical for the Control of Cutaneous Leishmaniasis
- (2020) Ivo B. Regli et al. Cell Reports
- Targeting the innate immune receptor TLR8 using small-molecule agents
- (2020) Kentaro Sakaniwa et al. Acta Crystallographica Section D-Structural Biology
- High-capacity poly(2-oxazoline) formulation of TLR 7/8 agonist extends survival in a chemo-insensitive, metastatic model of lung adenocarcinoma
- (2020) Natasha Vinod et al. Science Advances
- 3M-052, a synthetic TLR-7/8 agonist, induces durable HIV-1 envelope–specific plasma cells and humoral immunity in nonhuman primates
- (2020) Sudhir Pai Kasturi et al. Science Immunology
- Nanoparticles Presenting Potent TLR7/8 Agonists Enhance Anti-PD-L1 Immunotherapy in Cancer Treatment
- (2020) Anton A. A. Smith et al. BIOMACROMOLECULES
- Enhancing KDM5A and TLR activity improves the response to immune checkpoint blockade
- (2020) Liangliang Wang et al. Science Translational Medicine
- TLR7 and RIG-I dual-adjuvant loaded nanoparticles drive broadened and synergistic responses in dendritic cells in vitro and generate unique cellular immune responses in influenza vaccination
- (2020) Randall Toy et al. JOURNAL OF CONTROLLED RELEASE
- Impact of polymer-TLR-7/8 agonist (adjuvant) morphology on the potency and mechanism of CD8 T cell induction
- (2019) Geoffrey M. Lynn et al. BIOMACROMOLECULES
- Antigens reversibly conjugated to a polymeric glyco-adjuvant induce protective humoral and cellular immunity
- (2019) D. Scott Wilson et al. NATURE MATERIALS
- Interferons α and β in cancer: therapeutic opportunities from new insights
- (2019) Ernest C. Borden NATURE REVIEWS DRUG DISCOVERY
- Systemic clinical tumor regressions and potentiation of PD1 blockade with in situ vaccination
- (2019) Linda Hammerich et al. NATURE MEDICINE
- Skin Directed Therapy in Cutaneous T-Cell Lymphoma
- (2019) Erica S. Tarabadkar et al. Frontiers in Oncology
- Formulation and preclinical evaluation of a toll-like receptor 7/8 agonist as an anti-tumoral immunomodulator
- (2019) Ruolin Lu et al. JOURNAL OF CONTROLLED RELEASE
- Human Toll-like Receptor 8 (TLR8) Is an Important Sensor of Pyogenic Bacteria, and Is Attenuated by Cell Surface TLR Signaling
- (2019) Siv H. Moen et al. Frontiers in Immunology
- Linked Toll-Like Receptor Triagonists Stimulate Distinct, Combination-Dependent Innate Immune Responses
- (2019) Tyler J. Albin et al. ACS Central Science
- Persistent Toll-like receptor 7 stimulation induces behavioral and molecular innate immune tolerance
- (2019) Katherine A. Michaelis et al. BRAIN BEHAVIOR AND IMMUNITY
- Intratumoral immunotherapy with TLR7/8 agonist MEDI9197 modulates the tumor microenvironment leading to enhanced activity when combined with other immunotherapies
- (2019) Stefanie R. Mullins et al. Journal for ImmunoTherapy of Cancer
- Synthetic Toll-like Receptors 7 and 8 Agonists: Structure–Activity Relationship in the Oxoadenine Series
- (2019) Jay T. Evans et al. ACS Omega
- Lyophilizable and Multifaceted Toll-like Receptor 7/8 Agonist-Loaded Nanoemulsion for the Reprogramming of Tumor Microenvironments and Enhanced Cancer Immunotherapy
- (2019) Sun-Young Kim et al. ACS Nano
- Potent Lymphatic Translocation and Spatial Control Over Innate Immune Activation by Polymer-Lipid Amphiphile Conjugates of Small-Molecule TLR7/8 Agonists
- (2019) Jana De Vrieze et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Pattern recognition receptors: immune targets to enhance cancer immunotherapy
- (2019) T Shekarian et al. ANNALS OF ONCOLOGY
- Co-delivery of immunomodulators in biodegradable nanoparticles improves therapeutic efficacy of cancer vaccines
- (2019) C.G. Da Silva et al. BIOMATERIALS
- Latest Advances in Small Molecule TLR 7/8 Agonist Drug Research
- (2019) David C. McGowan CURRENT TOPICS IN MEDICINAL CHEMISTRY
- Adjuvant effect of TLR7 agonist adsorbed on aluminum hydroxide (AS37): A phase I randomized, dose escalation study of an AS37-adjuvanted meningococcal C conjugated vaccine
- (2019) Antonio Gonzalez-Lopez et al. CLINICAL IMMUNOLOGY
- Materials for oral delivery of proteins and peptides
- (2019) Tyler D. Brown et al. Nature Reviews Materials
- Hyaluronic Acid Conjugates of TLR7/8 Agonists for Targeted Delivery to Secondary Lymphoid Tissue
- (2018) Euna Yoo et al. BIOCONJUGATE CHEMISTRY
- Potent anti-viral vaccine adjuvant based on pH-degradable nanogels with covalently linked small molecule imidazoquinoline TLR7/8 agonist
- (2018) Lutz Nuhn et al. BIOMATERIALS
- Polymeric nanoparticles encapsulating novel TLR7/8 agonists as immunostimulatory adjuvants for enhanced cancer immunotherapy
- (2018) Hyunjoon Kim et al. BIOMATERIALS
- The Preparation and Physicochemical Characterization of Aluminum Hydroxide/TLR7a, a Novel Vaccine Adjuvant Comprising a Small Molecule Adsorbed to Aluminum Hydroxide
- (2018) Padma Malyala et al. JOURNAL OF PHARMACEUTICAL SCIENCES
- Induction of oligoclonal CD8 T cell responses against pulmonary metastatic cancer by a phospholipid-conjugated TLR7 agonist
- (2018) Tadashi Hosoya et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- TLR7 agonists induce transient viremia and reduce the viral reservoir in SIV-infected rhesus macaques on antiretroviral therapy
- (2018) So-Yon Lim et al. Science Translational Medicine
- Extended release of perioperative immunotherapy prevents tumor recurrence and eliminates metastases
- (2018) Chun Gwon Park et al. Science Translational Medicine
- Eradication of spontaneous malignancy by local immunotherapy
- (2018) Idit Sagiv-Barfi et al. Science Translational Medicine
- The choice of linker for conjugating R848 to inactivated influenza virus determines the stimulatory capacity for innate immune cells
- (2018) Marlena M. Westcott et al. VACCINE
- Systemic administration of a TLR7 agonist attenuates regulatory T cells by dendritic cell modification and overcomes resistance to PD-L1 blockade therapy
- (2018) Naoto Nishii et al. Oncotarget
- Modulators of innate immunity as novel therapeutics for treatment of chronic hepatitis B
- (2018) Aleksei Suslov et al. Current Opinion in Virology
- Recent Advances in Targeting CD8 T-Cell Immunity for More Effective Cancer Immunotherapy
- (2018) Aurélie Durgeau et al. Frontiers in Immunology
- TLR7/8-agonist-loaded nanoparticles promote the polarization of tumour-associated macrophages to enhance cancer immunotherapy
- (2018) Christopher B. Rodell et al. Nature Biomedical Engineering
- Enhanced Cancer Vaccination by In Situ Nanomicelle-Generating Dissolving Microneedles
- (2018) Nak Won Kim et al. ACS Nano
- Abstract 4726: Novel intravenous injectable TLR7 agonist, DSP-0509, synergistically enhanced antitumor immune responses in combination with anti-PD-1 antibody
- (2018) Yosuke Ota et al. CANCER RESEARCH
- Nanoparticle-Conjugate TLR7/8 Agonist Localized Immunotherapy Provokes Safe Antitumoral Responses
- (2018) Lutz Nuhn et al. ADVANCED MATERIALS
- Amphiphilic nanoparticle delivery enhances the anticancer efficacy of a TLR7 ligand via local immune activation
- (2018) Inès Mottas et al. BIOMATERIALS
- Recent clinical trends in Toll-like receptor targeting therapeutics
- (2018) Muhammad Ayaz Anwar et al. MEDICINAL RESEARCH REVIEWS
- Antibody and TLR7 agonist delay viral rebound in SHIV-infected monkeys
- (2018) Erica N. Borducchi et al. NATURE
- Structural Analyses of Toll-like Receptor 7 Reveal Detailed RNA Sequence Specificity and Recognition Mechanism of Agonistic Ligands
- (2018) Zhikuan Zhang et al. Cell Reports
- Trial Watch: Toll-like receptor agonists in cancer immunotherapy
- (2018) Melody Smith et al. OncoImmunology
- An R848 adjuvanted influenza vaccine promotes early activation of B cells in the draining lymph nodes of non-human primate neonates
- (2017) Beth C. Holbrook et al. IMMUNOLOGY
- Toll-like receptor 8 agonist nanoparticles mimic immunomodulating effects of the live BCG vaccine and enhance neonatal innate and adaptive immune responses
- (2017) David J. Dowling et al. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
- Identification of High-Potency Human TLR8 and Dual TLR7/TLR8 Agonists in Pyrimidine-2,4-diamines
- (2017) Mallesh Beesu et al. JOURNAL OF MEDICINAL CHEMISTRY
- Thermosensitive Gel–Based Formulation for Intratumoral Delivery of Toll-Like Receptor 7/8 Dual Agonist, MEDI9197
- (2017) Amir Fakhari et al. JOURNAL OF PHARMACEUTICAL SCIENCES
- Addition of a TLR7 agonist to an acellular pertussis vaccine enhances Th1 and Th17 responses and protective immunity in a mouse model
- (2017) Alicja Misiak et al. VACCINE
- Adjuvanting an inactivated influenza vaccine with conjugated R848 improves the level of antibody present at 6 months in a nonhuman primate neonate model
- (2017) Beth C. Holbrook et al. VACCINE
- Design and Synthesis of N1-Modified Imidazoquinoline Agonists for Selective Activation of Toll-like Receptors 7 and 8
- (2017) Peter Larson et al. ACS Medicinal Chemistry Letters
- T cell-targeting nanoparticles focus delivery of immunotherapy to improve antitumor immunity
- (2017) Daniela Schmid et al. Nature Communications
- Anti-tumor Activity of Toll-Like Receptor 7 Agonists
- (2017) Huju Chi et al. Frontiers in Pharmacology
- The Toll for Trafficking: Toll-Like Receptor 7 Delivery to the Endosome
- (2017) Carlene Petes et al. Frontiers in Immunology
- Phase I open-label, dose-escalation study of ANA773 tosylate, an oral prodrug of a toll-like receptor-7 agonist, in patients with advanced solid tumors.
- (2017) G. A. Daniels et al. JOURNAL OF CLINICAL ONCOLOGY
- Combinatorial Delivery of Dual and Triple TLR Agonists via Polymeric Pathogen-like Particles Synergistically Enhances Innate and Adaptive Immune Responses
- (2017) Ranjna Madan-Lala et al. Scientific Reports
- Immune Response Modulation of Conjugated Agonists with Changing Linker Length
- (2016) Keun Ah Ryu et al. ACS Chemical Biology
- Non-Viral CRISPR/Cas Gene Editing In Vitro and In Vivo Enabled by Synthetic Nanoparticle Co-Delivery of Cas9 mRNA and sgRNA
- (2016) Jason B. Miller et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- TLR7 Agonist GS-9620 Is a Potent Inhibitor of Acute HIV-1 Infection in Human Peripheral Blood Mononuclear Cells
- (2016) Rujuta A. Bam et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Covalent Conjugation of Small-Molecule Adjuvants to Nanoparticles Induces Robust Cytotoxic T Cell Responses via DC Activation
- (2016) Woo Gyum Kim et al. BIOCONJUGATE CHEMISTRY
- Ly6C+ monocyte efferocytosis and cross-presentation of cell-associated antigens
- (2016) S R Larson et al. CELL DEATH AND DIFFERENTIATION
- An Enzyme-Directed Imidazoquinoline for Cancer Immunotherapy
- (2016) Joseph D. Hantho et al. ChemMedChem
- TLR7 Structure: Cut in Z-Loop
- (2016) Kazuhiko Maeda et al. IMMUNITY
- K + Efflux-Independent NLRP3 Inflammasome Activation by Small Molecules Targeting Mitochondria
- (2016) Christina J. Groß et al. IMMUNITY
- Structural Analysis Reveals that Toll-like Receptor 7 Is a Dual Receptor for Guanosine and Single-Stranded RNA
- (2016) Zhikuan Zhang et al. IMMUNITY
- Strategies for designing synthetic immune agonists
- (2016) Tom Y.-H. Wu IMMUNOLOGY
- Distinct TLR-mediated cytokine production and immunoglobulin secretion in human newborn naïve B cells
- (2016) Matthew A Pettengill et al. Innate Immunity
- Adsorption of a synthetic TLR7/8 ligand to aluminum oxyhydroxide for enhanced vaccine adjuvant activity: A formulation approach
- (2016) Christopher B. Fox et al. JOURNAL OF CONTROLLED RELEASE
- Imiquimod activates p53-dependent apoptosis in a human basal cell carcinoma cell line
- (2016) Shi-Wei Huang et al. JOURNAL OF DERMATOLOGICAL SCIENCE
- Intratumoral Delivery of Immunotherapy—Act Locally, Think Globally
- (2016) M. Angela Aznar et al. JOURNAL OF IMMUNOLOGY
- Emerging roles of the processing of nucleic acids and Toll-like receptors in innate immune responses to nucleic acids
- (2016) Kensuke Miyake et al. JOURNAL OF LEUKOCYTE BIOLOGY
- Discovery of 6-Amino-2-{[(1S)-1-methylbutyl]oxy}-9-[5-(1-piperidinyl)pentyl]-7,9-dihydro-8H-purin-8-one (GSK2245035), a Highly Potent and Selective Intranasal Toll-Like Receptor 7 Agonist for the Treatment of Asthma
- (2016) Keith Biggadike et al. JOURNAL OF MEDICINAL CHEMISTRY
- Incorporation of Phosphonate into Benzonaphthyridine Toll-like Receptor 7 Agonists for Adsorption to Aluminum Hydroxide
- (2016) Alex Cortez et al. JOURNAL OF MEDICINAL CHEMISTRY
- Adjuvanting a Simian Immunodeficiency Virus Vaccine with Toll-Like Receptor Ligands Encapsulated in Nanoparticles Induces Persistent Antibody Responses and Enhanced Protection in TRIM5α Restrictive Macaques
- (2016) Sudhir Pai Kasturi et al. JOURNAL OF VIROLOGY
- Holding the Inflammatory System in Check: TLRs and Their Targeted Therapy in Asthma
- (2016) Zhiyong Dong et al. MEDIATORS OF INFLAMMATION
- Ad26/MVA therapeutic vaccination with TLR7 stimulation in SIV-infected rhesus monkeys
- (2016) Erica N. Borducchi et al. NATURE
- Adjuvant-dependent innate and adaptive immune signatures of risk of SIVmac251 acquisition
- (2016) Monica Vaccari et al. NATURE MEDICINE
- TLR4 and TLR7/8 Adjuvant Combinations Generate Different Vaccine Antigen-Specific Immune Outcomes in Minipigs when Administered via the ID or IN Routes
- (2016) Paul F. McKay et al. PLoS One
- T Cell Production of IFNγ in Response to TLR7/IL-12 Stimulates Optimal B Cell Responses to Viruses
- (2016) Kira Rubtsova et al. PLoS One
- pH-degradable imidazoquinoline-ligated nanogels for lymph node-focused immune activation
- (2016) Lutz Nuhn et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- TLR-7 activation enhances IL-22–mediated colonization resistance against vancomycin-resistant enterococcus
- (2016) Michael C. Abt et al. Science Translational Medicine
- Toll-Like Receptor 7-Targeted Therapy in Respiratory Disease
- (2016) Katie M. Lebold et al. TRANSFUSION MEDICINE AND HEMOTHERAPY
- Fatty Acid-Mimetic Micelles for Dual Delivery of Antigens and Imidazoquinoline Adjuvants
- (2016) Sema Sevimli et al. ACS Biomaterials-Science & Engineering
- Fatty Acid-Mimetic Micelles for Dual Delivery of Antigens and Imidazoquinoline Adjuvants
- (2016) Sema Sevimli et al. ACS Biomaterials Science & Engineering
- Into the clinic: Talimogene laherparepvec (T-VEC), a first-in-class intratumoral oncolytic viral therapy
- (2016) Hasan Rehman et al. Journal for ImmunoTherapy of Cancer
- One Dose of Staphylococcus aureus 4C-Staph Vaccine Formulated with a Novel TLR7-Dependent Adjuvant Rapidly Protects Mice through Antibodies, Effector CD4+ T Cells, and IL-17A
- (2016) Francesca Mancini et al. PLoS One
- Novel adjuvant Alum-TLR7 significantly potentiates immune response to glycoconjugate vaccines
- (2016) Cecilia Buonsanti et al. Scientific Reports
- Enhancement of the Immunostimulatory Activity of a TLR7 Ligand by Conjugation to Polysaccharides
- (2015) Hiroyuki Shinchi et al. BIOCONJUGATE CHEMISTRY
- Targeted Activation of Toll-Like Receptors: Conjugation of a Toll-Like Receptor 7 Agonist to a Monoclonal Antibody Maintains Antigen Binding and Specificity
- (2015) Adam J. R. Gadd et al. BIOCONJUGATE CHEMISTRY
- Structural requirements for TLR7-selective signaling by 9-(4-piperidinylalkyl)-8-oxoadenine derivatives
- (2015) Hélène G. Bazin et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Topical resiquimod can induce disease regression and enhance T-cell effector functions in cutaneous T-cell lymphoma
- (2015) A. H. Rook et al. BLOOD
- TLR7 tolerance is independent of the type I IFN pathway and leads to loss of anti-tumor efficacy in mice
- (2015) Erina Koga-Yamakawa et al. CANCER IMMUNOLOGY IMMUNOTHERAPY
- Late-Stage Cancer Patients Remain Highly Responsive to Immune Activation by the Selective TLR8 Agonist Motolimod (VTX-2337)
- (2015) G. N. Dietsch et al. CLINICAL CANCER RESEARCH
- Pharmacokinetic, Pharmacodynamic, and Activity Evaluation of TMX-101 in a Multicenter Phase 1 Study in Patients With Papillary Non-Muscle-Invasive Bladder Cancer
- (2015) Tom J.H. Arends et al. Clinical Genitourinary Cancer
- Early clinical evaluation of the intranasal TLR7 agonist GSK2245035: Use of translational biomarkers to guide dosing and confirm target engagement
- (2015) D Tsitoura et al. CLINICAL PHARMACOLOGY & THERAPEUTICS
- Monocyte targeting and activation by cationic liposomes formulated with a TLR7 agonist
- (2015) Pia T Johansen et al. Expert Opinion on Drug Delivery
- Successful treatment of hypertrophic herpes simplex genitalis in HIV-infected patient with topical imiquimod
- (2015) Gustavo Deza et al. JOURNAL OF DERMATOLOGY
- The oral toll-like receptor-7 agonist GS-9620 in patients with chronic hepatitis B virus infection
- (2015) Edward J. Gane et al. JOURNAL OF HEPATOLOGY
- Sustained efficacy and seroconversion with the Toll-like receptor 7 agonist GS-9620 in the Woodchuck model of chronic hepatitis B
- (2015) Stephan Menne et al. JOURNAL OF HEPATOLOGY
- Bacterial RNA: An Underestimated Stimulus for Innate Immune Responses
- (2015) Tatjana Eigenbrod et al. JOURNAL OF IMMUNOLOGY
- Structure-Based Design of Human TLR8-Specific Agonists with Augmented Potency and Adjuvanticity
- (2015) Mallesh Beesu et al. JOURNAL OF MEDICINAL CHEMISTRY
- Synthetic Toll-Like Receptor 4 (TLR4) and TLR7 Ligands as Influenza Virus Vaccine Adjuvants Induce Rapid, Sustained, and Broadly Protective Responses
- (2015) Peter H. Goff et al. JOURNAL OF VIROLOGY
- In vivo characterization of the physicochemical properties of polymer-linked TLR agonists that enhance vaccine immunogenicity
- (2015) Geoffrey M Lynn et al. NATURE BIOTECHNOLOGY
- Control of adaptive immunity by the innate immune system
- (2015) Akiko Iwasaki et al. NATURE IMMUNOLOGY
- Vaccine composition formulated with a novel TLR7-dependent adjuvant induces high and broad protection againstStaphylococcus aureus
- (2015) Fabio Bagnoli et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Dual roles of TLR7 in the lung cancer microenvironment
- (2015) Marion Dajon et al. OncoImmunology
- Modulation of Innate Immune Responses via Covalently Linked TLR Agonists
- (2015) Janine K. Tom et al. ACS Central Science
- The Imidazoquinoline Toll-Like Receptor-7/8 Agonist Hybrid-2 Potently Induces Cytokine Production by Human Newborn and Adult Leukocytes
- (2015) Lakshmi Ganapathi et al. PLoS One
- A Phase I Dose-Finding Study of the Novel Toll-like Receptor 8 Agonist VTX-2337 in Adult Subjects with Advanced Solid Tumors or Lymphoma
- (2014) D. W. Northfelt et al. CLINICAL CANCER RESEARCH
- Intralesional therapy for metastatic melanoma
- (2014) Sarah Sloot et al. EXPERT OPINION ON PHARMACOTHERAPY
- Novel drugs targeting Toll-like receptors for antiviral therapy
- (2014) Mira C Patel et al. Future Virology
- A novel systemically administered toll-like receptor 7 agonist potentiates the effect of ionizing radiation in murine solid tumor models
- (2014) Amy L. Adlard et al. INTERNATIONAL JOURNAL OF CANCER
- Structure–Activity Relationship Analysis of Imidazoquinolines with Toll-like Receptors 7 and 8 Selectivity and Enhanced Cytokine Induction
- (2014) Charles E. Schiaffo et al. JOURNAL OF MEDICINAL CHEMISTRY
- Determinants of Activity at Human Toll-like Receptors 7 and 8: Quantitative Structure–Activity Relationship (QSAR) of Diverse Heterocyclic Scaffolds
- (2014) Euna Yoo et al. JOURNAL OF MEDICINAL CHEMISTRY
- Stimulation of Innate Immune Cells by Light-Activated TLR7/8 Agonists
- (2014) Keun Ah Ryu et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Toll-Like Receptor 7/8 (TLR7/8) and TLR9 Agonists Cooperate To Enhance HIV-1 Envelope Antibody Responses in Rhesus Macaques
- (2014) M. A. Moody et al. JOURNAL OF VIROLOGY
- Unleashing the potential of NOD- and Toll-like agonists as vaccine adjuvants
- (2014) C. Maisonneuve et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Rational design of small molecules as vaccine adjuvants
- (2014) T. Y.- H. Wu et al. Science Translational Medicine
- Adjuvant-carrying synthetic vaccine particles augment the immune response to encapsulated antigen and exhibit strong local immune activation without inducing systemic cytokine release
- (2014) Petr O. Ilyinskii et al. VACCINE
- Dendritic cell subsets require cis-activation for cytotoxic CD8 T-cell induction
- (2014) A Nicole Desch et al. Nature Communications
- Toll-Like Receptor 8 Agonist and Bacteria Trigger Potent Activation of Innate Immune Cells in Human Liver
- (2014) Juandy Jo et al. PLoS Pathogens
- A nanoliposome delivery system to synergistically trigger TLR4 AND TLR7
- (2014) Christopher B Fox et al. JOURNAL OF NANOBIOTECHNOLOGY
- TLR Agonists for Cancer Immunotherapy: Tipping the Balance between the Immune Stimulatory and Inhibitory Effects
- (2014) Hailing Lu Frontiers in Immunology
- Toll-like Receptor 7 Rapidly Relaxes Human Airways
- (2013) Matthew G. Drake et al. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
- The Dendritic Cell Lineage: Ontogeny and Function of Dendritic Cells and Their Subsets in the Steady State and the Inflamed Setting
- (2013) Miriam Merad et al. Annual Review of Immunology
- Programmed nanoparticles for combined immunomodulation, antigen presentation and tracking of immunotherapeutic cells
- (2013) Min Beom Heo et al. BIOMATERIALS
- Toll-like receptor (TLR) 7 decreases and TLR9 increases the airway responses in mice with established allergic inflammation
- (2013) Mikael Adner et al. EUROPEAN JOURNAL OF PHARMACOLOGY
- GS-9620, an Oral Agonist of Toll-Like Receptor-7, Induces Prolonged Suppression of Hepatitis B Virus in Chronically Infected Chimpanzees
- (2013) Robert E. Lanford et al. GASTROENTEROLOGY
- Co-delivery of viral proteins and a TLR7 agonist from polysaccharide nanocapsules: A needle-free vaccination strategy
- (2013) Sara Vicente et al. JOURNAL OF CONTROLLED RELEASE
- Identification and Optimization of Pteridinone Toll-like Receptor 7 (TLR7) Agonists for the Oral Treatment of Viral Hepatitis
- (2013) Paul A. Roethle et al. JOURNAL OF MEDICINAL CHEMISTRY
- Multifunctional PLGA-Based Nanoparticles Encapsulating Simultaneously Hydrophilic Antigen and Hydrophobic Immunomodulator for Mucosal Immunization
- (2013) Charlotte Primard et al. MOLECULAR PHARMACEUTICS
- Electrospray Encapsulation of Toll-Like Receptor Agonist Resiquimod in Polymer Microparticles for the Treatment of Visceral Leishmaniasis
- (2013) Anthony D. Duong et al. MOLECULAR PHARMACEUTICS
- Structure–activity relationships in Toll-like receptor 7 agonistic 1H-imidazo[4,5-c]pyridines
- (2013) Euna Yoo et al. ORGANIC & BIOMOLECULAR CHEMISTRY
- Toll-Like Receptor 7 Agonists: Chemical Feature Based Pharmacophore Identification and Molecular Docking Studies
- (2013) Hui Yu et al. PLoS One
- Structural Reorganization of the Toll-Like Receptor 8 Dimer Induced by Agonistic Ligands
- (2013) H. Tanji et al. SCIENCE
- Chemical cross-linking of HIV-1 Env for direct TLR7/8 ligand conjugation compromises recognition of conserved antigenic determinants
- (2013) Yu Feng et al. VIROLOGY
- Learning from the Messengers: Innate Sensing of Viruses and Cytokine Regulation of Immunity — Clues for Treatments and Vaccines
- (2013) Jesper Melchjorsen Viruses-Basel
- Optimal treatment of actinic keratoses
- (2013) Elizabeth Uhlenhake Clinical Interventions in Aging
- Dendritic cell activation and T cell priming with adjuvant- and antigen-loaded oxidation-sensitive polymersomes
- (2012) Evan A. Scott et al. BIOMATERIALS
- Synthesis and evaluation of 8-oxoadenine derivatives as potent Toll-like receptor 7 agonists with high water solubility
- (2012) Tomoaki Nakamura et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Systemic delivery of a TLR7 agonist in combination with radiation primes durable antitumor immune responses in mouse models of lymphoma
- (2012) S. J. Dovedi et al. BLOOD
- Abstract 4745: TLR8 agonist and Doxil chemotherapy potently activate human antitumor immune response in a human immune system mouse model
- (2012) Andrea Facciabene et al. CANCER RESEARCH
- TLR8: the forgotten relative revindicated
- (2012) Jorge L Cervantes et al. Cellular & Molecular Immunology
- Topical TLR7 Agonist Imiquimod Can Induce Immune-Mediated Rejection of Skin Metastases in Patients with Breast Cancer
- (2012) S. Adams et al. CLINICAL CANCER RESEARCH
- The Circadian Clock Controls Toll-like Receptor 9-Mediated Innate and Adaptive Immunity
- (2012) Adam C. Silver et al. IMMUNITY
- Imidazoquinoline Toll-like receptor 8 agonists activate human newborn monocytes and dendritic cells through adenosine-refractory and caspase-1–dependent pathways
- (2012) Victoria J. Philbin et al. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
- Antiviral applications of Toll-like receptor agonists
- (2012) N. J. Horscroft et al. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
- Cubosomes containing the adjuvants imiquimod and monophosphoryl lipid A stimulate robust cellular and humoral immune responses
- (2012) S.B. Rizwan et al. JOURNAL OF CONTROLLED RELEASE
- Type I IFN Receptor and the B Cell Antigen Receptor Regulate TLR7 Responses via Distinct Molecular Mechanisms
- (2012) J. S. Poovassery et al. JOURNAL OF IMMUNOLOGY
- Toll-Like Receptor (TLR)-7 and -8 Modulatory Activities of Dimeric Imidazoquinolines
- (2012) Nikunj M. Shukla et al. JOURNAL OF MEDICINAL CHEMISTRY
- Toll-like receptor-8 agonistic activities in C2, C4, and C8 modified thiazolo[4,5-c]quinolines
- (2012) Hari Prasad Kokatla et al. ORGANIC & BIOMOLECULAR CHEMISTRY
- Potent Adjuvanticity of a Pure TLR7-Agonistic Imidazoquinoline Dendrimer
- (2012) Nikunj M. Shukla et al. PLoS One
- Dissecting negative regulation of Toll-like receptor signaling
- (2012) Takeshi Kondo et al. TRENDS IN IMMUNOLOGY
- Discovery of Imidazoquinolines with Toll-Like Receptor 7/8 Independent Cytokine Induction
- (2012) Ce Shi et al. ACS Medicinal Chemistry Letters
- Synthesis and Characterization of PEGylated Toll Like Receptor 7 Ligands
- (2011) Michael Chan et al. BIOCONJUGATE CHEMISTRY
- Targeted delivery of TLR ligands to human and mouse dendritic cells strongly enhances adjuvanticity
- (2011) P. J. Tacken et al. BLOOD
- Biological characterization of a novel class of toll-like receptor 7 agonists designed to have reduced systemic activity
- (2011) M Biffen et al. BRITISH JOURNAL OF PHARMACOLOGY
- Systemic Cancer Therapy with a Small Molecule Agonist of Toll-like Receptor 7 Can Be Improved by Circumventing TLR Tolerance
- (2011) C. Bourquin et al. CANCER RESEARCH
- The Innate Immune Response, Clinical Outcomes, and Ex Vivo HCV Antiviral Efficacy of a TLR7 Agonist (PF-4878691)
- (2011) M D Fidock et al. CLINICAL PHARMACOLOGY & THERAPEUTICS
- VTX-1463, a novel TLR8 agonist for the treatment of allergic rhinitis
- (2011) Friedrich Horak EXPERT OPINION ON INVESTIGATIONAL DRUGS
- Human and rhesus plasmacytoid dendritic cell and B-cell responses to Toll-like receptor stimulation
- (2011) Cornelia Gujer et al. IMMUNOLOGY
- Protective T cell immunity in mice following protein-TLR7/8 agonist-conjugate immunization requires aggregation, type I IFN, and multiple DC subsets
- (2011) Kathrin Kastenmüller et al. JOURNAL OF CLINICAL INVESTIGATION
- Immunomodulation by Imiquimod in Patients with High-Risk Primary Melanoma
- (2011) Rupa Narayan et al. JOURNAL OF INVESTIGATIVE DERMATOLOGY
- Programming the magnitude and persistence of antibody responses with innate immunity
- (2011) Sudhir Pai Kasturi et al. NATURE
- A tolerogenic role for Toll-like receptor 9 is revealed by B-cell interaction with DNA complexes expressed on apoptotic cells
- (2011) K. Miles et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Local and systemic adverse effects to topical imiquimod due to systemic immune stimulation
- (2011) B. Kumar et al. SEXUALLY TRANSMITTED INFECTIONS
- Vaccine adjuvant activity of 3M-052: An imidazoquinoline designed for local activity without systemic cytokine induction
- (2011) Dmitri Smirnov et al. VACCINE
- The pharmacokinetics of Toll-like receptor agonists and the impact on the immune system
- (2011) Abbi L Engel et al. Expert Review of Clinical Pharmacology
- Phase II trial of imiquimod and HPV therapeutic vaccination in patients with vulval intraepithelial neoplasia
- (2010) S Daayana et al. BRITISH JOURNAL OF CANCER
- Pattern Recognition Receptors and Inflammation
- (2010) Osamu Takeuchi et al. CELL
- Reciprocal Regulation of Activating and Inhibitory Fc Receptors by TLR7/8 Activation: Implications for Tumor Immunotherapy
- (2010) J. P. Butchar et al. CLINICAL CANCER RESEARCH
- Intravesical Toll-like receptor 7 agonist R-837: Optimization of its formulation in an orthotopic mouse model of bladder cancer
- (2010) Tomoko Hayashi et al. INTERNATIONAL JOURNAL OF UROLOGY
- Structure−Activity Relationships in Human Toll-Like Receptor 7-Active Imidazoquinoline Analogues
- (2010) Nikunj M. Shukla et al. JOURNAL OF MEDICINAL CHEMISTRY
- Additive melanoma suppression with intralesional phospholipid-conjugated TLR7 agonists and systemic IL-2
- (2010) Tomoko Hayashi et al. MELANOMA RESEARCH
- The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors
- (2010) Taro Kawai et al. NATURE IMMUNOLOGY
- IFN- abrogates endotoxin tolerance by facilitating Toll-like receptor-induced chromatin remodeling
- (2010) J. Chen et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- 2-Azidoalkoxy-7-hydro-8-oxoadenine derivatives as TLR7 agonists inducing dendritic cell maturation
- (2009) Jimmy J. Weterings et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Pemphigus-like lesions induced by imiquimod
- (2009) A. Bauza et al. CLINICAL AND EXPERIMENTAL DERMATOLOGY
- The antiviral activity of toll-like receptor 7 and 7/8 agonists
- (2009) R.L. Miller et al. DRUG NEWS & PERSPECTIVES
- Selective and direct activation of human neutrophils but not eosinophils by Toll-like receptor 8
- (2009) Markus Janke et al. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
- Human Papillomaviruses and the Interferon Response
- (2009) Melanie Beglin et al. JOURNAL OF INTERFERON AND CYTOKINE RESEARCH
- TLR7 and TLR8 agonists trigger different signaling pathways for human dendritic cell maturation
- (2009) A. Larange et al. JOURNAL OF LEUKOCYTE BIOLOGY
- Use of tumour-responsive T cells as cancer treatment
- (2009) Mary L Disis et al. LANCET
- Prevention of autoimmune disease by induction of tolerance to Toll-like receptor 7
- (2009) Tomoko Hayashi et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Endotoxin tolerance: new mechanisms, molecules and clinical significance
- (2009) Subhra K. Biswas et al. TRENDS IN IMMUNOLOGY
- Mast cell-dependent anorexia and hypothermia induced by mucosal activation of Toll-like receptor 7
- (2008) Tomoko Hayashi et al. AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
- Toll-like receptor-mediated activation of neutrophils by influenza A virus
- (2008) J. P. Wang et al. BLOOD
- Plasmacytoid dendritic cells efficiently cross-prime naive T cells in vivo after TLR activation
- (2008) J. Mouries et al. BLOOD
- A phase II dose-ranging study of topical resiquimod to treat actinic keratosis
- (2008) R.-M. Szeimies et al. BRITISH JOURNAL OF DERMATOLOGY
- Clinical and Immunologic Results of a Phase II Trial of Sequential Imiquimod and Photodynamic Therapy for Vulval Intraepithelial Neoplasia
- (2008) U. Winters et al. CLINICAL CANCER RESEARCH
- An Exploratory Study of Systemic Administration of the Toll-like Receptor-7 Agonist 852A in Patients with Refractory Metastatic Melanoma
- (2008) R. Dummer et al. CLINICAL CANCER RESEARCH
- Toll-like Receptors Activate Innate and Adaptive Immunity by using Dendritic Cell-Intrinsic and -Extrinsic Mechanisms
- (2008) Baidong Hou et al. IMMUNITY
- Twelve immunotherapy drugs that could cure cancers
- (2008) Martin A. ‘Mac’ Cheever IMMUNOLOGICAL REVIEWS
- A pharmaceutical comparison of different commercially available imiquimod 5% cream products
- (2008) Lester I. Harrison et al. JOURNAL OF DERMATOLOGICAL TREATMENT
- TLR7 Agonist 852A Inhibition of Tumor Cell Proliferation Is Dependent on Plasmacytoid Dendritic Cells and Type I IFN
- (2008) Jon R. Inglefield et al. JOURNAL OF INTERFERON AND CYTOKINE RESEARCH
- Signalling pathways leading to IFN-α production in human plasmacytoid dendritic cell and the possible use of agonists or antagonists of TLR7 and TLR9 in clinical indications
- (2008) C. Guiducci et al. JOURNAL OF INTERNAL MEDICINE
- Toll-like receptors — taking an evolutionary approach
- (2008) François Leulier et al. NATURE REVIEWS GENETICS
- Toll-like receptor 9 (TLR9) agonists in the treatment of cancer
- (2008) A M Krieg ONCOGENE
- TLR7 and TLR8 as targets in cancer therapy
- (2008) M P Schön et al. ONCOGENE
- The Use of TLR7 and TLR8 Ligands for the Enhancement of Cancer Immunotherapy
- (2008) E. L. J. M. Smits et al. ONCOLOGIST
- Expression and function of Toll-like receptors on dendritic cells and other antigen presenting cells from non-human primates
- (2008) Chutitorn Ketloy et al. VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreAdd your recorded webinar
Do you already have a recorded webinar? Grow your audience and get more views by easily listing your recording on Peeref.
Upload Now