Early clinical evaluation of the intranasal TLR7 agonist GSK2245035: Use of translational biomarkers to guide dosing and confirm target engagement

A New Era of Targeting the Ancient Gatekeepers of the Immune System: Toll-Like Agonists in the Treatment of Allergic Rhinitis and Asthma

(2014) Zahra Aryan et al.   INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY

Safety, pharmacokinetics and pharmacodynamics of GS-9620, an oral Toll-like receptor 7 agonist

(2013) Uri Lopatin et al.   ANTIVIRAL THERAPY

The novel TLR-9 agonist QbG10 shows clinical efficacy in persistent allergic asthma

(2013) Kai-Michael Beeh et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Pollinex Quattro: An innovative four injections immunotherapy In allergic rhinitis

(2013) Martin Rosewich et al.   Human Vaccines & Immunotherapeutics

Plasmacytoid dendritic cells in allergic asthma and the role of inhaled corticosteroid treatment

(2012) K. Bratke et al.   CLINICAL AND EXPERIMENTAL ALLERGY

Repeated intranasal TLR7 stimulation reduces allergen responsiveness in allergic rhinitis

(2012) Lennart Greiff et al.   RESPIRATORY RESEARCH

Systemic Cancer Therapy with a Small Molecule Agonist of Toll-like Receptor 7 Can Be Improved by Circumventing TLR Tolerance

(2011) C. Bourquin et al.   CANCER RESEARCH

MicroRNA in TLR signaling and endotoxin tolerance

(2011) Md A Nahid et al.   Cellular & Molecular Immunology

Assessment of clinical efficacy of CYT003-QbG10 in patients with allergic rhinoconjunctivitis: a phase IIb study

(2011) L. Klimek et al.   CLINICAL AND EXPERIMENTAL ALLERGY

The Innate Immune Response, Clinical Outcomes, and Ex Vivo HCV Antiviral Efficacy of a TLR7 Agonist (PF-4878691)

(2011) M D Fidock et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

VTX-1463, a novel TLR8 agonist for the treatment of allergic rhinitis

(2011) Friedrich Horak   EXPERT OPINION ON INVESTIGATIONAL DRUGS

TLR agonist mediated suppression of allergic responses is associated with increased innate inflammation in the airways

(2011) Matthias J. Duechs et al.   PULMONARY PHARMACOLOGY & THERAPEUTICS

Toll-like Receptor 7–triggered Immune Response in the Lung Mediates Acute and Long-Lasting Suppression of Experimental Asthma

(2010) Charoula Xirakia et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors

(2010) Taro Kawai et al.   NATURE IMMUNOLOGY

The antiviral activity of toll-like receptor 7 and 7/8 agonists

(2009) R.L. Miller et al.   DRUG NEWS & PERSPECTIVES

Toll-like receptor 7 function is reduced in adolescents with asthma

(2009) M. Roponen et al.   EUROPEAN RESPIRATORY JOURNAL

Prevention of autoimmune disease by induction of tolerance to Toll-like receptor 7

(2009) Tomoko Hayashi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Association analysis identifies TLR7 and TLR8 as novel risk genes in asthma and related disorders

(2008) S Moller-Larsen et al.   THORAX

Expression and function of Toll-like receptors on dendritic cells and other antigen presenting cells from non-human primates

(2008) Chutitorn Ketloy et al.   VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY