TLR7 tolerance is independent of the type I IFN pathway and leads to loss of anti-tumor efficacy in mice

Synthesis and evaluation of 8-oxoadenine derivatives as potent Toll-like receptor 7 agonists with high water solubility

(2012) Tomoaki Nakamura et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Intratracheal and oral administration of SM-276001: A selective TLR7 agonist, leads to antitumor efficacy in primary and metastatic models of cancer

(2012) Erina Koga-Yamakawa et al.   INTERNATIONAL JOURNAL OF CANCER

Type I IFN Receptor and the B Cell Antigen Receptor Regulate TLR7 Responses via Distinct Molecular Mechanisms

(2012) J. S. Poovassery et al.   JOURNAL OF IMMUNOLOGY

Systemic Cancer Therapy with a Small Molecule Agonist of Toll-like Receptor 7 Can Be Improved by Circumventing TLR Tolerance

(2011) C. Bourquin et al.   CANCER RESEARCH

The Innate Immune Response, Clinical Outcomes, and Ex Vivo HCV Antiviral Efficacy of a TLR7 Agonist (PF-4878691)

(2011) M D Fidock et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Type I interferon negatively controls plasmacytoid dendritic cell numbers in vivo

(2011) Melissa Swiecki et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Toll-like receptor-7 agonist administered subcutaneously in a prolonged dosing schedule in heavily pretreated recurrent breast, ovarian, and cervix cancers

(2010) Melissa A. Geller et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

A major role for TLR8 in the recognition of vaccinia viral DNA by murine pDC?

(2010) S. Bauer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CpG Therapy is Superior to BCG in an Orthotopic Bladder Cancer Model and Generates CD4+ T-cell Immunity

(2009) Sara M. Mangsbo et al.   JOURNAL OF IMMUNOTHERAPY

Prevention of autoimmune disease by induction of tolerance to Toll-like receptor 7

(2009) Tomoko Hayashi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An Exploratory Study of Systemic Administration of the Toll-like Receptor-7 Agonist 852A in Patients with Refractory Metastatic Melanoma

(2008) R. Dummer et al.   CLINICAL CANCER RESEARCH