Toll-Like Receptor 7 Agonists: Chemical Feature Based Pharmacophore Identification and Molecular Docking Studies

Recognition of Nucleic Acid Ligands by Toll-Like Receptors 7/8: Importance of Chemical Modification

(2012) Hui Yu et al.   CURRENT MEDICINAL CHEMISTRY

Discovery of a highly potent series of TLR7 agonists

(2011) Peter Jones et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Design and optimisation of orally active TLR7 agonists for the treatment of hepatitis C virus infection

(2011) Thien-Duc Tran et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

A Point Mutation in the Amino Terminus of TLR7 Abolishes Signaling without Affecting Ligand Binding

(2011) Carlo Iavarone et al.   JOURNAL OF IMMUNOLOGY

Comparative Analysis of Species-Specific Ligand Recognition in Toll-Like Receptor 8 Signaling: A Hypothesis

(2011) Rajiv Gandhi Govindaraj et al.   PLoS One

Synthesis and Biological Evaluation of 8-Oxoadenine Derivatives as Toll-like Receptor 7 Agonists Introducing the Antedrug Concept

(2010) Ayumu Kurimoto et al.   JOURNAL OF MEDICINAL CHEMISTRY

TollML: a database of toll-like receptor structural motifs

(2010) Jing Gong et al.   JOURNAL OF MOLECULAR MODELING

The discovery of a novel prototype small molecule TLR7 agonist for the treatment of hepatitis C virus infection

(2010) David C. Pryde et al.   MedChemComm

Homology modeling of human Toll-like receptors TLR7, 8, and 9 ligand-binding domains

(2009) Tiandi Wei et al.   PROTEIN SCIENCE

The ectodomain of Toll-like receptor 9 is cleaved to generate a functional receptor

(2008) Sarah E. Ewald et al.   NATURE