Review
Chemistry, Medicinal
Saeed Mohammadian Haftcheshmeh, Maliheh Abedi, Kazem Mashayekhi, Mohammad Javad Mousavi, Jamshid Gholizadeh Navashenaq, Asadollah Mohammadi, Amir Abbas Momtazi-Borojeni
Summary: This review discusses the modulatory effects of berberine (BBR) on various inflammatory signaling pathways in the immune system and explores its therapeutic efficacy and anti-inflammatory effects.
PHYTOTHERAPY RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Xue Luan, Zhongcheng Cong, Tassos P. Anastassiades, Yin Gao
Summary: In this study, it was found that N-butyrylated hyaluronic acid (BHA) has anti-inflammatory and antioxidative activities by inhibiting pro-inflammatory cytokines, reducing ROS production, and regulating signaling pathways. BHA alleviated joint swelling, inflammatory cell infiltration, and protein level increase in a rat model. This study reveals the potential of BHA in treating inflammatory arthritis.
Article
Immunology
Chenchen Liu, Wei Zhao, Jia Su, Xiaochun Chen, Feifan Zhao, Jindai Fan, Xiaowen Li, Xiaodi Liu, Linke Zou, Mengru Zhang, Zilin Zhang, Liangliang Zhang, Shuangqi Fan, Yuwan Li, Mingqiu Zhao, Jinding Chen, Lin Yi
Summary: Heat shock protein HSP90AA1 plays an important role in classical swine fever virus (CSFV) infection by inhibiting viral replication and activating JAK/STAT and NF-κB signaling pathways through interaction with NS5A protein.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Virology
Chunfu Zheng, Yan-Dong Tang
Summary: This article introduces the role of CDKs family members in the cell cycle and emphasizes their emerging role in antiviral innate immunity.
JOURNAL OF MEDICAL VIROLOGY
(2022)
Article
Immunology
Jing Xu, Xinxin Zhang, Mingming Zhou, Peizhe Lu, Yuting Xu, Lihong Wu, Qianyue Zhang, Zhihua Wu, Xiaoyu Xu, Pengfei Shi, Qingda Wei, Xiaoyu Li, Qiaoling Song
Summary: In this study, a new bioactive compound C498-0670 was identified as a dual inhibitor of JAK/STAT and NF kappa B signaling pathways. C498-0670 exhibited anti-inflammatory effects by inhibiting the activation of STATs and p-IKK alpha/beta, suppressing the expression of inflammatory mediators, and reducing tissue damage and pro-inflammatory cytokine production in vivo. Target fishing and molecular docking approaches confirmed the high affinities of C498-0670 for JAK2, NFKBIA, IL-1 beta, and NLRP1b. These findings suggest C498-0670 as a potential therapeutic option for various inflammatory diseases, particularly septic shock.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Jian Xie, Xiaowei Wu, Shang Zheng, Kaili Lin, Jiansheng Su
Summary: Delayed wound healing is a challenge, and this study demonstrates that aligned electrospun nanofibers can promote wound healing by influencing macrophage morphology and phenotype, as well as alleviate the local inflammatory response and promote angiogenesis.
JOURNAL OF NANOBIOTECHNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Hamed Hosseinalizadeh, Omid Mohamadzadeh, Mohammad Saeed Kahrizi, Zahra Razaghi Bahabadi, Daniel J. J. Klionsky, Hamed Mirzei
Summary: GBM is a highly aggressive primary brain tumor that has a high mortality rate in adults. TRIM8, a member of the TRIM protein family, is abnormally expressed in high-grade gliomas and is associated with poor clinical prognosis. It functions as a double-edged sword in glioblastoma development by selectively regulating multiple cellular signaling pathways and stem cell properties. This review provides a detailed analysis of TRIM8 in GBM and its involvement in essential signaling pathways and stem cell-related processes.
CELLULAR & MOLECULAR BIOLOGY LETTERS
(2023)
Article
Cell Biology
Jiaqi Fang, Qian Ou, Boheng Wu, Sisi Li, Mian Wu, Jialing Qiu, Nuo Cen, Kaixin Hu, Yangfei Che, Yuan Ma, Jianping Pan
Summary: This study investigated the influence of TcpC, a virulence factor of Uropathogenic Escherichia coli (UPEC), on the polarization of macrophages into M1 and M2 subsets and the potential mechanisms involved. The results showed that TcpC inhibits M1 macrophage polarization through down-regulation of p38, ERK/NF-κB signaling pathways, while promoting M2 macrophage polarization through up-regulation of the Akt/STAT6 signaling pathway. These findings not only shed light on the regulatory effects of TcpC on macrophage polarization and signaling pathways, but also provide a novel mechanism for TcpC-mediated evasion of macrophage-mediated innate immunity.
Article
Biochemistry & Molecular Biology
Fabio Sarais, Sophia Kummerow, Ruth Montero, Henrike Rebl, Bernd Koellner, Tom Goldammer, Bertrand Collet, Alexander Rebl
Summary: The study revealed the existence of eight pias genes in the rainbow trout genome, each showing differential expression in tissues and cells. Three structurally different Pias protein variants were found to suppress the activity of the NF-kappa B promoter in a dose-dependent manner, with potential different immune gene regulation in ifn γ-expressing cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Immunology
Sherihan Salaheldin Abdelhamid Ibrahim, Kristiina M. Huttunen
Summary: Cell signaling is crucial for regulating basic cellular activities, with dysregulated activation and crosstalk between multiple pathways implicated in diseases like rheumatoid arthritis. Understanding the orchestrated modulation of these pathways is key to developing more effective therapeutic options.
INFLAMMOPHARMACOLOGY
(2021)
Review
Cell Biology
Flaviana Marzano, Luisa Guerrini, Graziano Pesole, Elisabetta Sbisa, Apollonia Tullo
Summary: TRIM8, a member of the TRIM protein family, plays crucial roles in immune response, carcinogenesis, and cell survival, among other biological processes. Apart from its ubiquitination functions, TRIM8 can act as either an oncogene or a tumor suppressor gene, selectively regulating three pivotal cellular signaling pathways.
Article
Cell Biology
Leonie T. D. Wuerger, Felicia Kudiabor, Jimmy Alarcan, Markus Templin, Oliver Poetz, Holger Sieg, Albert Braeuning
Summary: Okadaic acid (OA) is a marine biotoxin that is produced by algae and accumulates in filter-feeding shellfish. It enters the human food chain and causes diarrheic shellfish poisoning (DSP). In addition, OA also exhibits cytotoxicity and downregulates the expression of xenobiotic-metabolizing enzymes in the liver. This study investigated the underlying mechanism of OA-induced downregulation of cytochrome P450 (CYP) enzymes and the nuclear receptors PXR and RXR alpha in human HepaRG hepatocarcinoma cells through NF-kappa B and subsequent JAK/STAT activation.
Article
Biochemistry & Molecular Biology
Hengke Guo, Min Li, Hongmei Liu
Summary: The study found that selenium-rich yeast peptide fraction (SeP) could significantly alleviate imiquimod-induced psoriasis-like dermatitis in mice, and inhibit the expression of inflammatory cytokines. Mechanistically, SeP exerted its effects by inhibiting the activation of MAPK and NF-kappa B signaling pathways.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Nazia Afroze, Sreepoorna Pramodh, Jasmin Shafarin, Khuloud Bajbouj, Mawieh Hamad, Madhumitha Kedhari Sundaram, Shafiul Haque, Arif Hussain
Summary: Fisetin inhibits cell proliferation, promotes apoptosis, and improves oxidative stress and inflammation through regulating various signaling pathways, suggesting its potential therapeutic value in cancer management.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Jiwen Yang, Daiwen Chen, Gang Tian, Xiangbing Mao, Jun He, Ping Zheng, Jie Yu, Yuheng Luo, Junqiu Luo, Zhiqing Huang, Aimin Wu, Hui Yan, Bing Yu
Summary: In this study, it was found that 1,25-dihydroxyvitamin D3 (1,25(OH)(2)D-3) can alleviate the inflammatory response induced by PEDV infection by regulating the NF-kappa B and JAK/STAT signaling pathways and inhibiting the expression of inflammatory genes and proteins induced by PEDV infection.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, Research & Experimental
Abdulkarim Tutakhail, Qand Agha Nazary, Delila Lebsir, Saadia Kerdine-Romer, Francois Coudore
Article
Chemistry, Medicinal
Rami Bechara, Myriam Nabhan, Diane Antonios, Hayat Azouri, Marc Pallardy
CHEMICAL RESEARCH IN TOXICOLOGY
(2018)
Article
Toxicology
Elodie Clouet, Rami Bechara, Chloe Raffalli, Marie-Helene Damiens, Herve Groux, Marc Pallardy, Pierre-Jacques Ferret, Saadia Kerdine-Romer
ARCHIVES OF TOXICOLOGY
(2019)
Article
Immunology
Doumet Georges Helou, Benoit Noel, Francoise Gaudin, Herve Groux, Zeina El Ali, Marc Pallardy, Sylvie Chollet-Martin, Saadia Kerdine-Romer
JOURNAL OF IMMUNOLOGY
(2019)
Article
Nanoscience & Nanotechnology
S. Barillet, E. Fattal, S. Mura, N. Tsapis, M. Pallardy, H. Hillaireau, S. Kerdine-Romer
Article
Public, Environmental & Occupational Health
Maria Kmeid, Hayat Azouri, Racha Aaraj, Elissa Bechara, Diane Antonios
INTERNATIONAL HEALTH
(2019)
Review
Immunology
Doumet Georges Helou, Stefan F. Martin, Marc Pallardy, Sylvie Chollet-Martin, Saadia Kerdine-Romer
FRONTIERS IN IMMUNOLOGY
(2019)
Article
Multidisciplinary Sciences
Doumet Georges Helou, Sarah Braham, Luc De Chaisemartin, Vanessa Granger, Marie-Helene Damien, Marc Pallardy, Saadia Kerdine-Romer, Sylvie Chollet-Martin
Review
Toxicology
Amelie Thelu, Sophie Catoire, Saadia Kerdine-Romer
TOXICOLOGY IN VITRO
(2020)
Article
Biochemistry & Molecular Biology
Alice Prigent, Guillaume Chapelet, Adrien De Guilliem de Lataillade, Thibauld Outlier, Emilie Durieu, Arnaud Bourreille, Emilie Duchalais, Kevin Hardonniere, Michel Neunlist, Wendy Noble, Saadia Kercline-Romer, Pascal Derkinderen, Malvyne Rolli-Derkinderen
Article
Immunology
Elien Grajchen, Elien Wouters, Britt van de Haterd, Mansour Haidar, Kevin Hardonniere, Tess Dierckx, Jana Van Broeckhoven, Celine Erens, Sven Hendrix, Saadia Kerdine-Romer, Jerome J. A. Hendriks, Jeroen F. J. Bogie
JOURNAL OF NEUROINFLAMMATION
(2020)
Article
Public, Environmental & Occupational Health
Maria Lteif, Marylene Samia El Hayek, Hayat Azouri, Diane Antonios
TOXICOLOGY AND INDUSTRIAL HEALTH
(2020)
Article
Biochemistry & Molecular Biology
Romain Vallion, Kevin Hardonniere, Abderrahmane Bouredji, Marie-Helene Damiens, Claudine Delomenie, Marc Pallardy, Pierre-Jacques Ferret, Saadia Kerdine-Romer
Summary: The fate of Nrf2 in keratinocytes controls the production of proinflammatory cytokines, which may be linked to its ability to preserve mitochondrial metabolism.
Article
Health Policy & Services
Maria Lteif, Marylene Samia El Hayek, Hayat Azouri, Diane Antonios
JOURNAL OF COMMUNITY HEALTH
(2020)
Article
Rheumatology
Sabine Trellu, Alice Courties, Stephane Jaisson, Laetitia Gorisse, Philippe Gillery, Saadia Kerdine-Roemer, Carlos Vaamonde-Garcia, Xavier Houard, Francois-Paul Ekhirch, Alain Sautet, Bertrand Friguet, Claire Jacques, Francis Berenbaum, Jeremie Sellam
ARTHRITIS RESEARCH & THERAPY
(2019)