PHD1 controls muscle mTORC1 in a hydroxylation-independent manner by stabilizing leucyl tRNA synthetase

The skeletal muscle fiber: a mechanically sensitive cell

(2019) Luke A. Olsen et al.   EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY

Resistance Exercise-Induced Hypertrophy

(2019) Riki Ogasawara et al.   EXERCISE AND SPORT SCIENCES REVIEWS

Sensing and Transmitting Intracellular Amino Acid Signals through Reversible Lysine Aminoacylations

(2018) Xia-Di He et al.   Cell Metabolism

Financial impact of sarcopenia or low muscle mass – a short review

(2018) Kristina Norman et al.   CLINICAL NUTRITION

JNK regulates muscle remodeling via myostatin/SMAD inhibition

(2018) Sarah J. Lessard et al.   Nature Communications

MuscleJ: a high-content analysis method to study skeletal muscle with a new Fiji tool

(2018) Alicia Mayeuf-Louchart et al.   Skeletal Muscle

The role of raptor in the mechanical load-induced regulation of mTOR signaling, protein synthesis, and skeletal muscle hypertrophy

(2018) Jae-Sung You et al.   FASEB JOURNAL

Age-Related Anabolic Resistance of Myofibrillar Protein Synthesis Is Exacerbated in Obese Inactive Individuals

(2017) Benoit Smeuninx et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Control of leucine-dependent mTORC1 pathway through chemical intervention of leucyl-tRNA synthetase and RagD interaction

(2017) Jong Hyun Kim et al.   Nature Communications

Fluorescence colocalization microscopy analysis can be improved by combining object-recognition with pixel-intensity-correlation

(2016) Bernhard Moser et al.   Biotechnology Journal

Leucine induced dephosphorylation of Sestrin2 promotes mTORC1 activation

(2016) Scot R. Kimball et al.   CELLULAR SIGNALLING

PHD3 Loss in Cancer Enables Metabolic Reliance on Fatty Acid Oxidation via Deactivation of ACC2

(2016) Natalie J. German et al.   MOLECULAR CELL

Hypoxia-inducible factor prolyl hydroxylase 1 (PHD1) deficiency promotes hepatic steatosis and liver-specific insulin resistance in mice

(2016) Amandine Thomas et al.   Scientific Reports

Fluorescence colocalization microscopy analysis can be improved by combining object-recognition with pixel-intensity-correlation

(2016) Bernhard Moser et al.   Biotechnology Journal

Longevity and skeletal muscle mass: the role of IGF signalling, the sirtuins, dietary restriction and protein intake

(2015) Adam P. Sharples et al.   AGING CELL

Nutrient-Sensing Mechanisms across Evolution

(2015) Lynne Chantranupong et al.   CELL

EglN2 associates with the NRF1‐PGC1α complex and controls mitochondrial function in breast cancer

(2015) Jing Zhang et al.   EMBO JOURNAL

PHD1 regulates p53-mediated colorectal cancer chemoresistance

(2015) S. Deschoemaeker et al.   EMBO Molecular Medicine

GCN2 sustains mTORC1 suppression upon amino acid deprivation by inducing Sestrin2

(2015) Jiangbin Ye et al.   GENES & DEVELOPMENT

CDK-dependent phosphorylation of PHD1 on serine 130 alters its substrate preference in cells

(2015) Brian Ortmann et al.   JOURNAL OF CELL SCIENCE

Fatty acid carbon is essential for dNTP synthesis in endothelial cells

(2015) Sandra Schoors et al.   NATURE

Sestrin2 is a leucine sensor for the mTORC1 pathway

(2015) R. L. Wolfson et al.   SCIENCE

Regulation of mTORC1 by PI3K signaling

(2015) Christian C. Dibble et al.   TRENDS IN CELL BIOLOGY

Regulation of mTORC1 by amino acids

(2014) Liron Bar-Peled et al.   TRENDS IN CELL BIOLOGY

The Sestrins Interact with GATOR2 to Negatively Regulate the Amino-Acid-Sensing Pathway Upstream of mTORC1

(2014) Lynne Chantranupong et al.   Cell Reports

Central tenet of cancer cachexia therapy: do patients with advanced cancer have exploitable anabolic potential?

(2013) Carla M Prado et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Sustained Activation of mTORC1 in Skeletal Muscle Inhibits Constitutive and Starvation-Induced Autophagy and Causes a Severe, Late-Onset Myopathy

(2013) Perrine Castets et al.   Cell Metabolism

PHD1 Links Cell-Cycle Progression to Oxygen Sensing through Hydroxylation of the Centrosomal Protein Cep192

(2013) Sandra C. Moser et al.   DEVELOPMENTAL CELL

Anabolic Resistance of Muscle Protein Synthesis with Aging

(2013) Nicholas A. Burd et al.   EXERCISE AND SPORT SCIENCES REVIEWS

mTOR Signaling in Growth Control and Disease

(2012) Mathieu Laplante et al.   CELL

Leucyl-tRNA Synthetase Is an Intracellular Leucine Sensor for the mTORC1-Signaling Pathway

(2012) Jung Min Han et al.   CELL

Maintenance of Metabolic Homeostasis by Sestrin2 and Sestrin3

(2012) Jun Hee Lee et al.   Cell Metabolism

Cellular and molecular mechanisms of muscle atrophy

(2012) P. Bonaldo et al.   Disease Models & Mechanisms

HIF2α Acts as an mTORC1 Activator through the Amino Acid Carrier SLC7A5

(2012) Ainara Elorza et al.   MOLECULAR CELL

Glutaminolysis Activates Rag-mTORC1 Signaling

(2012) Raúl V. Durán et al.   MOLECULAR CELL

HIF-independent role of prolyl hydroxylases in the cellular response to amino acids

(2012) R V Durán et al.   ONCOGENE

Emerging novel functions of the oxygen-sensing prolyl hydroxylase domain enzymes

(2012) Brian W. Wong et al.   TRENDS IN BIOCHEMICAL SCIENCES

Correction: Inducible Cre transgenic mouse strain for skeletal muscle-specific gene targeting

(2012) John J McCarthy et al.   Skeletal Muscle

Downregulation of Akt/mammalian target of rapamycin pathway in skeletal muscle is associated with increased REDD1 expression in response to chronic hypoxia

(2010) François B. Favier et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Fat-free mass change after nutritional rehabilitation in weight losing COPD: role of insulin, C-reactive protein and tissue hypoxia

(2010) Simonetta Baldi   International Journal of Chronic Obstructive Pulmonary Disease

Cellular oxygen sensing: Importins and exportins are mediators of intracellular localisation of prolyl-4-hydroxylases PHD1 and PHD2

(2009) Amrei Steinhoff et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Control of Cyclin D1 and Breast Tumorigenesis by the EglN2 Prolyl Hydroxylase

(2009) Qing Zhang et al.   CANCER CELL

Bidirectional Transport of Amino Acids Regulates mTOR and Autophagy

(2009) Paul Nicklin et al.   CELL

The role of phosphoinositide 3-kinase and phosphatidic acid in the regulation of mammalian target of rapamycin following eccentric contractions

(2009) T. K. O’Neil et al.   JOURNAL OF PHYSIOLOGY-LONDON

p53 Target Genes Sestrin1 and Sestrin2 Connect Genotoxic Stress and mTOR Signaling

(2008) Andrei V. Budanov et al.   CELL

Skeletal Muscle-Specific Ablation of raptor, but Not of rictor, Causes Metabolic Changes and Results in Muscle Dystrophy

(2008) C. Florian Bentzinger et al.   Cell Metabolism

Overexpression of the Oxygen Sensors PHD-1, PHD-2, PHD-3, and FIH Is Associated with Tumor Aggressiveness in Pancreatic Endocrine Tumors

(2008) A. Couvelard et al.   CLINICAL CANCER RESEARCH

Hypoxia regulates TSC1/2 mTOR signaling and tumor suppression through REDD1-mediated 14 3 3 shuttling

(2008) M. P. DeYoung et al.   GENES & DEVELOPMENT

Exercise training and protein metabolism: influences of contraction, protein intake, and sex-based differences

(2008) Nicholas A. Burd et al.   JOURNAL OF APPLIED PHYSIOLOGY

Ordered Organelle Degradation during Starvation-induced Autophagy

(2008) Anders Riis Kristensen et al.   MOLECULAR & CELLULAR PROTEOMICS

Oxygen Sensing by Metazoans: The Central Role of the HIF Hydroxylase Pathway

(2008) William G. Kaelin et al.   MOLECULAR CELL

AMPK Phosphorylation of Raptor Mediates a Metabolic Checkpoint

(2008) Dana M. Gwinn et al.   MOLECULAR CELL

Regulation of TORC1 by Rag GTPases in nutrient response

(2008) Eunjung Kim et al.   NATURE CELL BIOLOGY

Deficiency or inhibition of oxygen sensor Phd1 induces hypoxia tolerance by reprogramming basal metabolism

(2008) Julián Aragonés et al.   NATURE GENETICS

The Rag GTPases Bind Raptor and Mediate Amino Acid Signaling to mTORC1

(2008) Y. Sancak et al.   SCIENCE