Sestrin2 prevents age-related intolerance to ischemia and reperfusion injury by modulating substrate metabolism

Cardioprotective actions of Notch1 against myocardial infarction via LKB1-dependent AMPK signaling pathway

(2016) Hui Yang et al.   BIOCHEMICAL PHARMACOLOGY

Sestrin2, as a negative feedback regulator of mTOR, provides neuroprotection by activation AMPK phosphorylation in neonatal hypoxic-ischemic encephalopathy in rat pups

(2016) Xudan Shi et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Sestrin2 induced by hypoxia inducible factor1 alpha protects the blood-brain barrier via inhibiting VEGF after severe hypoxic-ischemic injury in neonatal rats

(2016) Xudan Shi et al.   NEUROBIOLOGY OF DISEASE

Cardiac-Specific Deletion of thePdha1Gene Sensitizes Heart to Toxicological Actions of Ischemic Stress

(2016) Wanqing Sun et al.   TOXICOLOGICAL SCIENCES

Sestrin2–AMPK activation protects mitochondrial function against glucose deprivation-induced cytotoxicity

(2015) Kyuhwa Seo et al.   CELLULAR SIGNALLING

Sestrin2 promotes LKB1-mediated AMPK activation in the ischemic heart

(2015) Alex Morrison et al.   FASEB JOURNAL

Antithrombin up-regulates AMP-activated protein kinase signalling during myocardial ischaemia/reperfusion injury

(2015) Yina Ma et al.   THROMBOSIS AND HAEMOSTASIS

Janus-faced Sestrin2 controls ROS and mTOR signalling through two separate functional domains

(2015) Hanseong Kim et al.   Nature Communications

Limiting Cardiac Ischemic Injury by Pharmacological Augmentation of Macrophage Migration Inhibitory Factor–AMP-Activated Protein Kinase Signal Transduction

(2013) Jingying Wang et al.   CIRCULATION

Antithrombin is protective against myocardial ischemia and reperfusion injury

(2013) J. Wang et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Maintenance of Metabolic Homeostasis by Sestrin2 and Sestrin3

(2012) Jun Hee Lee et al.   Cell Metabolism

Impaired SIRT1 nucleocytoplasmic shuttling in the senescent heart during ischemic stress

(2012) Chao Tong et al.   FASEB JOURNAL

Activated protein C modulates cardiac metabolism and augments autophagy in the ischemic heart

(2012) R. COSTA et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Sestrin2 Modulates AMPK Subunit Expression and Its Response to Ionizing Radiation in Breast Cancer Cells

(2012) Toran Sanli et al.   PLoS One

AMPK in myocardial infarction and diabetes: the yin/yang effect

(2012) Amr Moussa et al.   Acta Pharmaceutica Sinica B

Acute rosiglitazone treatment is cardioprotective against ischemia-reperfusion injury by modulating AMPK, Akt, and JNK signaling in nondiabetic mice

(2011) Alex Morrison et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Activation of hypoxia-inducible factor-1 protects airway epithelium against oxidant-induced barrier dysfunction

(2011) Nels Olson et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

PPAR-γ and AMPK – Advantageous targets for myocardial ischemia/reperfusion therapy

(2011) Alex Morrison et al.   BIOCHEMICAL PHARMACOLOGY

A small molecule AMPK activator protects the heart against ischemia–reperfusion injury

(2011) Agnes S. Kim et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Activated protein C protects against myocardial ischemic/reperfusion injury through AMP-activated protein kinase signaling

(2011) J. WANG et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

AMP-activated protein kinase deficiency exacerbates aging-induced myocardial contractile dysfunction

(2010) Subat Turdi et al.   AGING CELL

Pathogenesis of Myocardial Ischemia-Reperfusion Injury and Rationale for Therapy

(2010) Aslan T. Turer et al.   AMERICAN JOURNAL OF CARDIOLOGY

Stimulation of autophagy by the p53 target gene Sestrin2

(2010) Maria Chiara Maiuri et al.   CELL CYCLE

Impaired Macrophage Migration Inhibitory Factor–AMP-Activated Protein Kinase Activation and Ischemic Recovery in the Senescent Heart

(2010) Heng Ma et al.   CIRCULATION

Compensatory Increases in Nuclear PGC1  Protein Are Primarily Associated With Subsarcolemmal Mitochondrial Adaptations in ZDF Rats

(2010) G. P. Holloway et al.   DIABETES

Stressin' Sestrins take an aging fight

(2010) Andrei V. Budanov et al.   EMBO Molecular Medicine

Sestrin as a Feedback Inhibitor of TOR That Prevents Age-Related Pathologies

(2010) J. H. Lee et al.   SCIENCE

AMP-activated protein kinase: a core signalling pathway in the heart

(2009) A. S. Kim et al.   Acta Physiologica

AMPK: An Emerging Drug Target for Diabetes and the Metabolic Syndrome

(2009) Bei B. Zhang et al.   Cell Metabolism

Role of sestrin2 in peroxide signaling in macrophages

(2009) Silke Essler et al.   FEBS LETTERS

p53 Target Genes Sestrin1 and Sestrin2 Connect Genotoxic Stress and mTOR Signaling

(2008) Andrei V. Budanov et al.   CELL

AMP-Activated Protein Kinase Conducts the Ischemic Stress Response Orchestra

(2008) Lawrence H. Young   CIRCULATION

Macrophage migration inhibitory factor stimulates AMP-activated protein kinase in the ischaemic heart

(2008) Edward J. Miller et al.   NATURE