Curcumin-primed human BMSC-derived extracellular vesicles reverse IL-1β-induced catabolic responses of OA chondrocytes by upregulating miR-126-3p

The Role of Inflammation in the Pathogenesis of Osteoarthritis

(2020) Yoke Yue Chow et al.   MEDIATORS OF INFLAMMATION

A Synthetic Curcuminoid Analog, (2E,6E)-2,6-bis(2-(trifluoromethyl)benzylidene)cyclohexanone, Ameliorates Impaired Wound Healing in Streptozotocin-Induced Diabetic Mice by Increasing miR-146a

(2020) Jingjuan Huang et al.   MOLECULES

Curcumin Delivery Mediated by Bio-Based Nanoparticles: A Review

(2020) Mahshid Moballegh Nasery et al.   MOLECULES

MSC-derived exosomes attenuate cell death through suppressing AIF nucleus translocation and enhance cutaneous wound healing

(2020) Guifang Zhao et al.   Stem Cell Research & Therapy

Chondrocyte-Targeted MicroRNA Delivery by Engineered Exosomes toward a Cell-Free Osteoarthritis Therapy

(2020) Yujie Liang et al.   ACS Applied Materials & Interfaces

Curcumin reinforces MSC‐derived exosomes in attenuating osteoarthritis via modulating the miR‐124/NF‐kB and miR‐143/ROCK1/TLR9 signalling pathways

(2020) Bo Qiu et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

hBMSC-Derived Extracellular Vesicles Attenuate IL-1β-Induced Catabolic Effects on OA-Chondrocytes by Regulating Pro-inflammatory Signaling Pathways

(2020) Shushan Li et al.   Frontiers in Bioengineering and Biotechnology

Curcumin reduces inflammation in knee osteoarthritis rats through blocking TLR4 /MyD88/NF-κB signal pathway

(2019) Yun Zhang et al.   DRUG DEVELOPMENT RESEARCH

IL-1α and IL-1β promote NOD2-induced immune responses by enhancing MAPK signaling

(2019) Sushan Li et al.   LABORATORY INVESTIGATION

Stress-activated miR-204 governs senescent phenotypes of chondrocytes to promote osteoarthritis development

(2019) Donghyun Kang et al.   Science Translational Medicine

The microRNAs miR-204 and miR-211 maintain joint homeostasis and protect against osteoarthritis progression

(2019) Jian Huang et al.   Nature Communications

NF-B Signaling Pathways in Osteoarthritic Cartilage Destruction

(2019) Choi et al.   Cells

Impregnation of Curcumin into a Biodegradable (Poly-lactic-co-glycolic acid, PLGA) Support, to Transfer Its Well Known In Vitro Effect to an In Vivo Prostate Cancer Model

(2019) Eulalio Gracia et al.   Nutrients

Mesenchymal stem cell-derived exosomes: a new therapeutic approach to osteoarthritis?

(2019) Elaheh Mianehsaz et al.   Stem Cell Research & Therapy

Secretome and Extracellular Vesicles as New Biological Therapies for Knee Osteoarthritis: A Systematic Review

(2019) Daniele D’Arrigo et al.   Journal of Clinical Medicine

Changes of serum inflammatory factors and miR-145 expression in patients with osteoarthritis before and after treatment and their clinical value

(2019) Xiao-Zhen Wang et al.   World Journal of Clinical Cases

Knockdown of lncRNA MFI2-AS1 inhibits lipopolysaccharide-induced osteoarthritis progression by miR-130a-3p/TCF4

(2019) Xiaofei Luo et al.   LIFE SCIENCES

Evidence that miR-146a attenuates aging- and trauma-induced osteoarthritis by inhibiting Notch1, IL-6, and IL-1 mediated catabolism

(2018) Ying-Jie Guan et al.   AGING CELL

Baicalin alleviates IL-1β-induced inflammatory injury via down-regulating miR-126 in chondrocytes

(2018) Xirui Yang et al.   BIOMEDICINE & PHARMACOTHERAPY

Aqueous extract of Codium fragile alleviates osteoarthritis through the MAPK/NF-κB pathways in IL-1β-induced rat primary chondrocytes and a rat osteoarthritis model

(2018) Sung-Min Moon et al.   BIOMEDICINE & PHARMACOTHERAPY

miR-140-5p/miR-149 Affects Chondrocyte Proliferation, Apoptosis, and Autophagy by Targeting FUT1 in Osteoarthritis

(2018) Zi Wang et al.   INFLAMMATION

Inhibition of miR-126 protects chondrocytes from IL-1β induced inflammation via upregulation of Bcl-2

(2018) C. D. Yu et al.   Bone & Joint Research

Production of Curcumin-Loaded Silk Fibroin Nanoparticles for Cancer Therapy

(2018) Mercedes Montalbán et al.   Nanomaterials

MiR-34a Enhances Chondrocyte Apoptosis, Senescence and Facilitates Development of Osteoarthritis by Targeting DLL1 and Regulating PI3K/AKT Pathway

(2018) Wei Zhang et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Exosomes derived from mesenchymal stem cells enhance radiotherapy-induced cell death in tumor and metastatic tumor foci

(2018) Virgínea de Araujo Farias et al.   Molecular Cancer

Exosomes derived from miR-92a-3p-overexpressing human mesenchymal stem cells enhance chondrogenesis and suppress cartilage degradation via targeting WNT5A

(2018) Guping Mao et al.   Stem Cell Research & Therapy

Interleukin-1β signaling in osteoarthritis – chondrocytes in focus

(2018) Zsuzsa Jenei-Lanzl et al.   CELLULAR SIGNALLING

Theaflavins prevent cartilage degeneration via AKT/FOXO3 signaling in�vitro

(2018) Jun Li et al.   Molecular Medicine Reports

Knee osteoarthritis: pathophysiology and current treatment modalities

(2018) Juan C Mora et al.   Journal of Pain Research

MiR-29b-3p promotes chondrocyte apoptosis and facilitates the occurrence and development of osteoarthritis by targeting PGRN

(2017) Lingqiang Chen et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Curcumin primed exosomes reverses LPS-induced pro-inflammatory gene expression in buffalo granulosa cells

(2017) Monika Vashisht et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

MicroRNA-126 Regulates Inflammatory Cytokine Secretion in Human Gingival Fibroblasts Under High Glucose via Targeting Tumor Necrosis Factor Receptor Associated Factor 6

(2017) Yi Wu et al.   JOURNAL OF PERIODONTOLOGY

MicroRNA-Directed Cancer Therapies: Implications in Melanoma Intervention

(2017) Anita Thyagarajan et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Regulation of type II collagen, matrix metalloproteinase-13 and cell proliferation by interleukin-1β is mediated by curcumin via inhibition of NF-κB signaling in rat chondrocytes

(2017) Jian Wang et al.   Molecular Medicine Reports

Attenuation of early phase inflammation by cannabidiol prevents pain and nerve damage in rat osteoarthritis

(2017) Holly T. Philpott et al.   PAIN

Achieving the Promise of Therapeutic Extracellular Vesicles: The Devil is in Details of Therapeutic Loading

(2017) Dhruvitkumar S. Sutaria et al.   PHARMACEUTICAL RESEARCH

Exosomes derived from miR-140-5p-overexpressing human synovial mesenchymal stem cells enhance cartilage tissue regeneration and prevent osteoarthritis of the knee in a rat model

(2017) Shi-Cong Tao et al.   Theranostics

miR-29b regulates expression of collagens I and III in chondrogenically differentiating BMSC in an osteoarthritic environment

(2017) Ute Mayer et al.   Scientific Reports

Oxidative damage induces apoptosis and promotes calcification in disc cartilage endplate cell through ROS/MAPK/NF-κB pathway: Implications for disc degeneration

(2017) Yingchao Han et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Mango polyphenolics reduce inflammation in intestinal colitis-involvement of the miR-126/PI3K/AKT/mTOR axis in vitro and in vivo

(2016) Hyemee Kim et al.   MOLECULAR CARCINOGENESIS

Low-grade inflammation as a key mediator of the pathogenesis of osteoarthritis

(2016) William H. Robinson et al.   Nature Reviews Rheumatology

Duloxetine in OsteoArthritis (DOA) study: study protocol of a pragmatic open-label randomised controlled trial assessing the effect of preoperative pain treatment on postoperative outcome after total hip or knee arthroplasty

(2016) T Blikman et al.   BMJ Open

MiR-126 inhibits vascular endothelial cell apoptosis through targeting PI3K/Akt signaling

(2015) Lingqiang Chen et al.   ANNALS OF HEMATOLOGY

Exosome-formed synthetic microRNA-143 is transferred to osteosarcoma cells and inhibits their migration

(2014) Keisuke Shimbo et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Curcumin-primed exosomes mitigate endothelial cell dysfunction during hyperhomocysteinemia

(2014) A. Kalani et al.   LIFE SCIENCES

Subchondral bone influences chondrogenic differentiation and collagen production of human bone marrow-derived mesenchymal stem cells and articular chondrocytes

(2014) Michaela Leyh et al.   ARTHRITIS RESEARCH & THERAPY

Osteoarthritic cartilage explants affect extracellular matrix production and composition in cocultured bone marrow-derived mesenchymal stem cells and articular chondrocytes

(2014) Michaela Leyh et al.   Stem Cell Research & Therapy

Nanotechnology-Applied Curcumin for Different Diseases Therapy

(2014) Negar Ghalandarlaki et al.   Biomed Research International

Curcumin facilitates a transitory cellular stress response in Trembler-J mice

(2013) Y. Okamoto et al.   HUMAN MOLECULAR GENETICS

Roles for MicroRNAs in Conferring Robustness to Biological Processes

(2012) Margaret S. Ebert et al.   CELL

Alternatives to revision total knee arthroplasty

(2012) R. E. Jones et al.   JOURNAL OF BONE AND JOINT SURGERY-BRITISH VOLUME

Systemically Injected Exosomes Targeted to EGFR Deliver Antitumor MicroRNA to Breast Cancer Cells

(2012) Shin-ichiro Ohno et al.   MOLECULAR THERAPY

clusterProfiler: an R Package for Comparing Biological Themes Among Gene Clusters

(2012) Guangchuang Yu et al.   OMICS-A JOURNAL OF INTEGRATIVE BIOLOGY

Epigenetic mechanisms in cartilage and osteoarthritis: DNA methylation, histone modifications and microRNAs

(2012) M.J. Barter et al.   OSTEOARTHRITIS AND CARTILAGE

Inflammation in osteoarthritis

(2011) Mary B. Goldring et al.   CURRENT OPINION IN RHEUMATOLOGY

Curcumin synergizes with resveratrol to stimulate the MAPK signaling pathway in human articular chondrocytes in vitro

(2010) Mehdi Shakibaei et al.   Genes and Nutrition

Secretory Mechanisms and Intercellular Transfer of MicroRNAs in Living Cells

(2010) Nobuyoshi Kosaka et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Novel Nanoparticle Drug Delivery System: The Anti-inflammatory Activity of Curcumin Is Enhanced When Encapsulated in Exosomes

(2010) Dongmei Sun et al.   MOLECULAR THERAPY