Secretome and Extracellular Vesicles as New Biological Therapies for Knee Osteoarthritis: A Systematic Review

Stem Cell-Derived Extracellular Vesicles for Treating Joint Injury and Osteoarthritis

(2019) Jiao Li et al.   Nanomaterials

Interaction with hyaluronan matrix and miRNA cargo as contributors for in vitro potential of mesenchymal stem cell-derived extracellular vesicles in a model of human osteoarthritic synoviocytes

(2019) Enrico Ragni et al.   Stem Cell Research & Therapy

Exosomes derived from mesenchymal stem cells inhibit mitochondrial dysfunction-induced apoptosis of chondrocytes via p38, ERK, and Akt pathways

(2019) Hui Qi et al.   IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL

miR-100-5p-abundant exosomes derived from infrapatellar fat pad MSCs protect articular cartilage and ameliorate gait abnormalities via inhibition of mTOR in osteoarthritis

(2019) Jiangyi Wu et al.   BIOMATERIALS

Adipose-derived stromal cell secretome reduces TNFα-induced hypertrophy and catabolic markers in primary human articular chondrocytes

(2019) Stefania Niada et al.   Stem Cell Research

MSC exosomes mediate cartilage repair by enhancing proliferation, attenuating apoptosis and modulating immune reactivity

(2018) Shipin Zhang et al.   BIOMATERIALS

Microvesicles from Human Adipose Tissue-Derived Mesenchymal Stem Cells as a New Protective Strategy in Osteoarthritic Chondrocytes

(2018) Miguel Tofiño-Vian et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Subpopulations of extracellular vesicles and their therapeutic potential

(2018) Cecilia Lässer et al.   MOLECULAR ASPECTS OF MEDICINE

Sphingosine-1-phosphate mediates the therapeutic effects of bone marrow mesenchymal stem cell-derived microvesicles on articular cartilage defect

(2018) Chuan Xiang et al.   Translational Research

Mesenchymal Stromal/stem Cell-derived Extracellular Vesicles Promote Human Cartilage Regeneration In Vitro

(2018) Lucienne A. Vonk et al.   Theranostics

Updated Estimates Suggest a Much Higher Prevalence of Arthritis in United States Adults Than Previous Ones

(2018) S. Reza Jafarzadeh et al.   Arthritis & Rheumatology

Exosomal miR-95-5p regulates chondrogenesis and cartilage degradation via histone deacetylase 2/8

(2018) Guping Mao et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Expression of exosomal microRNAs during chondrogenic differentiation of human bone mesenchymal stem cells

(2018) Hao Sun et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Injective mesenchymal stem cell-based treatments for knee osteoarthritis: from mechanisms of action to current clinical evidences

(2018) Silvia Lopa et al.   KNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPY

Exosomes derived from miR-92a-3p-overexpressing human mesenchymal stem cells enhance chondrogenesis and suppress cartilage degradation via targeting WNT5A

(2018) Guping Mao et al.   Stem Cell Research & Therapy

Exosomal KLF3-AS1 from hMSCs promoted cartilage repair and chondrocyte proliferation in osteoarthritis

(2018) Yubao Liu et al.   BIOCHEMICAL JOURNAL

MSC-derived exosomes promote proliferation and inhibit apoptosis of chondrocytes via lncRNA-KLF3-AS1/miR-206/GIT1 axis in osteoarthritis

(2018) Yubao Liu et al.   CELL CYCLE

Injectable Systems for Intra-Articular Delivery of Mesenchymal Stromal Cells for Cartilage Treatment: A Systematic Review of Preclinical and Clinical Evidence

(2018) Alice Roffi et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Extracellular Vesicles from Adipose-Derived Mesenchymal Stem Cells Downregulate Senescence Features in Osteoarthritic Osteoblasts

(2017) Miguel Tofiño-Vian et al.   Oxidative Medicine and Cellular Longevity

Exosomes: Therapy delivery tools and biomarkers of diseases

(2017) Lucio Barile et al.   PHARMACOLOGY & THERAPEUTICS

Mesenchymal stem cells derived exosomes and microparticles protect cartilage and bone from degradation in osteoarthritis

(2017) Stella Cosenza et al.   Scientific Reports

Comparison of exosomes secreted by induced pluripotent stem cell-derived mesenchymal stem cells and synovial membrane-derived mesenchymal stem cells for the treatment of osteoarthritis

(2017) Yu Zhu et al.   Stem Cell Research & Therapy

Exosomes from embryonic mesenchymal stem cells alleviate osteoarthritis through balancing synthesis and degradation of cartilage extracellular matrix

(2017) Yafei Wang et al.   Stem Cell Research & Therapy

Exosomes derived from miR-140-5p-overexpressing human synovial mesenchymal stem cells enhance cartilage tissue regeneration and prevent osteoarthritis of the knee in a rat model

(2017) Shi-Cong Tao et al.   Theranostics

Selling Stem Cells in the USA: Assessing the Direct-to-Consumer Industry

(2016) Leigh Turner et al.   Cell Stem Cell

Extracellular vesicles — new tool for joint repair and regeneration

(2016) Jos Malda et al.   Nature Reviews Rheumatology

Exosomes derived from human embryonic mesenchymal stem cells promote osteochondral regeneration

(2016) S. Zhang et al.   OSTEOARTHRITIS AND CARTILAGE

Number of Persons With Symptomatic Knee Osteoarthritis in the US: Impact of Race and Ethnicity, Age, Sex, and Obesity

(2016) Bhushan R. Deshpande et al.   ARTHRITIS CARE & RESEARCH

Stem cells in articular cartilage regeneration

(2016) Giuseppe Filardo et al.   Journal of Orthopaedic Surgery and Research

Osteoarthritis in the XXIst Century: Risk Factors and Behaviours that Influence Disease Onset and Progression

(2015) Giuseppe Musumeci et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

A review of therapeutic effects of mesenchymal stem cell secretions and induction of secretory modification by different culture methods

(2014) Marialaura Madrigal et al.   Journal of Translational Medicine

Aging processes and the development of osteoarthritis

(2012) Richard F. Loeser   CURRENT OPINION IN RHEUMATOLOGY

The MSC: An Injury Drugstore

(2011) Arnold I. Caplan et al.   Cell Stem Cell

Osteoarthritis: an update with relevance for clinical practice

(2011) Johannes WJ Bijlsma et al.   LANCET

Mesenchymal Stem/Stromal Cells (MSCs): Role as Guardians of Inflammation

(2011) Darwin J Prockop et al.   MOLECULAR THERAPY

Stem cell paracrine actions and tissue regeneration

(2009) Priya R Baraniak et al.   Regenerative Medicine

Bone marrow stromal cells attenuate sepsis via prostaglandin E2–dependent reprogramming of host macrophages to increase their interleukin-10 production

(2008) Krisztián Németh et al.   NATURE MEDICINE

Osteoarthritis in the context of ageing and evolution

(2007) Peter M. van der Kraan et al.   AGEING RESEARCH REVIEWS