标题
Low-grade inflammation as a key mediator of the pathogenesis of osteoarthritis
作者
关键词
-
出版物
Nature Reviews Rheumatology
Volume 12, Issue 10, Pages 580-592
出版商
Springer Nature
发表日期
2016-08-19
DOI
10.1038/nrrheum.2016.136
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- Inter-relations between osteoarthritis and metabolic syndrome: A common link?
- (2016) S. Le Clanche et al. BIOCHIMIE
- Relative efficacy and tolerability of etoricoxib, celecoxib, and naproxen in the treatment of osteoarthritis
- (2016) Gwan Gyu Song et al. ZEITSCHRIFT FUR RHEUMATOLOGIE
- Safe prescribing of non-steroidal anti-inflammatory drugs in patients with osteoarthritis – an expert consensus addressing benefits as well as gastrointestinal and cardiovascular risks
- (2015) Carmelo Scarpignato et al. BMC Medicine
- Is osteoarthritis a metabolic disorder?
- (2015) S. Kluzek et al. BRITISH MEDICAL BULLETIN
- Biologic basis of osteoarthritis
- (2015) Charles J. Malemud CURRENT OPINION IN RHEUMATOLOGY
- Targets, models and challenges in osteoarthritis research
- (2015) S. Thysen et al. Disease Models & Mechanisms
- Environmental Disruption of Circadian Rhythm Predisposes Mice to Osteoarthritis-Like Changes in Knee Joint
- (2015) Ranjan Kc et al. JOURNAL OF CELLULAR PHYSIOLOGY
- The chondrocyte clock gene Bmal1 controls cartilage homeostasis and integrity
- (2015) Michal Dudek et al. JOURNAL OF CLINICAL INVESTIGATION
- The Role of Innate Immunity in Osteoarthritis: When Our First Line of Defense Goes On the Offensive
- (2015) E. W. Orlowsky et al. JOURNAL OF RHEUMATOLOGY
- Catabolic cytokines disrupt the circadian clock and the expression of clock-controlled genes in cartilage via an NFкB-dependent pathway
- (2015) B. Guo et al. OSTEOARTHRITIS AND CARTILAGE
- Effects of total and regional fat loss on plasma CRP and IL-6 in overweight and obese, older adults with knee osteoarthritis
- (2015) K.M. Beavers et al. OSTEOARTHRITIS AND CARTILAGE
- Alarmins S100A8/S100A9 aggravate osteophyte formation in experimental osteoarthritis and predict osteophyte progression in early human symptomatic osteoarthritis
- (2014) R F P Schelbergen et al. ANNALS OF THE RHEUMATIC DISEASES
- Dispensable role of myeloid differentiation primary response gene 88 (MyD88) and MyD88-dependent toll-like receptors (TLRs) in a murine model of osteoarthritis
- (2014) Sonia Nasi et al. JOINT BONE SPINE
- Nerve Growth Factor Downregulates Inflammatory Response in Human Monocytes through TrkA
- (2014) G. Prencipe et al. JOURNAL OF IMMUNOLOGY
- Flavocoxid, a Nutraceutical Approach to Blunt Inflammatory Conditions
- (2014) Alessandra Bitto et al. MEDIATORS OF INFLAMMATION
- An epithelial circadian clock controls pulmonary inflammation and glucocorticoid action
- (2014) Julie Gibbs et al. NATURE MEDICINE
- Emerging regulators of the inflammatory process in osteoarthritis
- (2014) Ru Liu-Bryan et al. Nature Reviews Rheumatology
- Association between adiponectin and cartilage degradation in human osteoarthritis
- (2014) P.-J. Francin et al. OSTEOARTHRITIS AND CARTILAGE
- The hallmarks of osteoarthritis and the potential to develop personalised disease-modifying pharmacological therapeutics
- (2014) D.P. Tonge et al. OSTEOARTHRITIS AND CARTILAGE
- Resistin as a factor in osteoarthritis: synovial fluid resistin concentrations correlate positively with interleukin 6 and matrix metalloproteinases MMP-1 and MMP-3
- (2014) A Koskinen et al. SCANDINAVIAN JOURNAL OF RHEUMATOLOGY
- Acute Liver Injury due to Flavocoxid (Limbrel), a Medical Food for Osteoarthritis
- (2013) Naga Chalasani ANNALS OF INTERNAL MEDICINE
- NAMPT (visfatin), a direct target of hypoxia-inducible factor-2α, is an essential catabolic regulator of osteoarthritis
- (2013) Siyoung Yang et al. ANNALS OF THE RHEUMATIC DISEASES
- Strontium ranelate: ready for clinical use as disease-modifying osteoarthritis drug?
- (2013) Floris P J G Lafeber et al. ANNALS OF THE RHEUMATIC DISEASES
- Disease-modifying effect of strontium ranelate in a subset of patients from the Phase III knee osteoarthritis study SEKOIA using quantitative MRI: reduction in bone marrow lesions protects against cartilage loss
- (2013) Jean-Pierre Pelletier et al. ANNALS OF THE RHEUMATIC DISEASES
- The coupling of bone and cartilage turnover in osteoarthritis: opportunities for bone antiresorptives and anabolics as potential treatments?
- (2013) M A Karsdal et al. ANNALS OF THE RHEUMATIC DISEASES
- The Circadian Clock in Murine Chondrocytes Regulates Genes Controlling Key Aspects of Cartilage Homeostasis
- (2013) Nicole Gossan et al. ARTHRITIS AND RHEUMATISM
- Recent Advances in the Search for Novel 5-Lipoxygenase Inhibitors
- (2013) Dieter Steinhilber et al. BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY
- Immunopathogenesis of osteoarthritis
- (2013) Abdul Haseeb et al. CLINICAL IMMUNOLOGY
- Different circadian expression of major matrix-related genes in various types of cartilage: modulation by light–dark conditions
- (2013) Kiyomasa K. Honda et al. JOURNAL OF BIOCHEMISTRY
- Biologic agents in osteoarthritis: hopes and disappointments
- (2013) Xavier Chevalier et al. Nature Reviews Rheumatology
- Progress in intra-articular therapy
- (2013) Christopher H. Evans et al. Nature Reviews Rheumatology
- Effect of iNOS inhibitor S-methylisothiourea in monosodium iodoacetate-induced osteoathritic pain: Implication for osteoarthritis therapy
- (2013) Amar S. More et al. PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
- Circadian Gene Bmal1 Regulates Diurnal Oscillations of Ly6Chi Inflammatory Monocytes
- (2013) K. D. Nguyen et al. SCIENCE
- Synovium and the Innate Inflammatory Network in Osteoarthritis Progression
- (2013) Ru Liu-Bryan Current Rheumatology Reports
- The Future of Osteoarthritis Therapeutics: Targeted Pharmacological Therapy
- (2013) A. Mobasheri Current Rheumatology Reports
- The Future of Osteoarthritis Therapeutics: Emerging Biological Therapy
- (2013) A. Mobasheri Current Rheumatology Reports
- Brief Report: Carboxypeptidase B Serves as a Protective Mediator in Osteoarthritis
- (2013) Christin M. Lepus et al. Arthritis & Rheumatology
- Targeting the synovial angiogenesis as a novel treatment approach to osteoarthritis
- (2013) Yves Henrotin et al. Therapeutic Advances in Musculoskeletal Disease
- Role of inflammation in the pathogenesis of osteoarthritis: latest findings and interpretations
- (2013) Jeremy Sokolove et al. Therapeutic Advances in Musculoskeletal Disease
- Efficacy and safety of strontium ranelate in the treatment of knee osteoarthritis: results of a double-blind, randomised placebo-controlled trial
- (2012) Jean-Yves Reginster et al. ANNALS OF THE RHEUMATIC DISEASES
- Strontium ranelate reduces the progression of experimental dog osteoarthritis by inhibiting the expression of key proteases in cartilage and of IL-1β in the synovium
- (2012) Jean-Pierre Pelletier et al. ANNALS OF THE RHEUMATIC DISEASES
- A 2-year randomised, double-blind, placebo-controlled, multicentre study of oral selective iNOS inhibitor, cindunistat (SD-6010), in patients with symptomatic osteoarthritis of the knee
- (2012) Marie-Pierre Hellio le Graverand et al. ANNALS OF THE RHEUMATIC DISEASES
- Osteoarthritis: A disease of the joint as an organ
- (2012) Richard F. Loeser et al. ARTHRITIS AND RHEUMATISM
- The role of synovitis in osteoarthritis pathogenesis
- (2012) Carla R. Scanzello et al. BONE
- Small leucine-rich proteoglycans orchestrate receptor crosstalk during inflammation
- (2012) Kristin Moreth et al. CELL CYCLE
- Efficacy of Infliximab in a Rabbit Model of Osteoarthritis
- (2012) Qiankun Zhang et al. CONNECTIVE TISSUE RESEARCH
- Osteoarthritis, inflammation and obesity
- (2012) Francis Berenbaum et al. CURRENT OPINION IN RHEUMATOLOGY
- Clock Genes Influence Gene Expression in Growth Plate and Endochondral Ossification in Mice
- (2012) Takeshi Takarada et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Fibroblast growth factor control of cartilage homeostasis
- (2012) M.B. Ellman et al. JOURNAL OF CELLULAR BIOCHEMISTRY
- Complement Protein C1q Directs Macrophage Polarization and Limits Inflammasome Activity during the Uptake of Apoptotic Cells
- (2012) M. E. Benoit et al. JOURNAL OF IMMUNOLOGY
- Metabolic syndrome meets osteoarthritis
- (2012) Qi Zhuo et al. Nature Reviews Rheumatology
- Serum adipokines in osteoarthritis; comparison with controls and relationship with local parameters of synovial inflammation and cartilage damage
- (2012) T.N. de Boer et al. OSTEOARTHRITIS AND CARTILAGE
- Synovial inflammation, immune cells and their cytokines in osteoarthritis: a review
- (2012) B.J.E. de Lange-Brokaar et al. OSTEOARTHRITIS AND CARTILAGE
- Plasma proteins present in osteoarthritic synovial fluid can stimulate cytokine production via Toll-like receptor 4
- (2012) Dong Sohn et al. ARTHRITIS RESEARCH & THERAPY
- Obesity and Weight Loss in the Treatment and Prevention of Osteoarthritis
- (2012) Heather K. Vincent et al. PM&R
- Presence of MRI-detected joint effusion and synovitis increases the risk of cartilage loss in knees without osteoarthritis at 30-month follow-up: the MOST study
- (2011) F. W. Roemer et al. ANNALS OF THE RHEUMATIC DISEASES
- Tumour necrosis factor blockade for the treatment of erosive osteoarthritis of the interphalangeal finger joints: a double blind, randomised trial on structure modification
- (2011) Gust Verbruggen et al. ANNALS OF THE RHEUMATIC DISEASES
- Quantitative magnetic resonance imaging evidence of synovial proliferation is associated with radiographic severity of knee osteoarthritis
- (2011) Svetlana Krasnokutsky et al. ARTHRITIS AND RHEUMATISM
- Active involvement of alarmins S100A8 and S100A9 in the regulation of synovial activation and joint destruction during mouse and human osteoarthritis
- (2011) Peter L. E. M. van Lent et al. ARTHRITIS AND RHEUMATISM
- Strontium ranelate inhibits key factors affecting bone remodeling in human osteoarthritic subchondral bone osteoblasts
- (2011) Steeve Kwan Tat et al. BONE
- Inflammation in osteoarthritis
- (2011) Mary B. Goldring et al. CURRENT OPINION IN RHEUMATOLOGY
- Associations of Anatomical Measures from MRI with Radiographically Defined Knee Osteoarthritis Score, Pain, and Physical Functioning
- (2011) MaryFran Sowers et al. JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME
- Identification of a central role for complement in osteoarthritis
- (2011) Qian Wang et al. NATURE MEDICINE
- What's new in our understanding of the role of adipokines in rheumatic diseases?
- (2011) Rodolfo Gómez et al. Nature Reviews Rheumatology
- The nuclear receptor REV-ERB mediates circadian regulation of innate immunity through selective regulation of inflammatory cytokines
- (2011) J. E. Gibbs et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Relationships between biomarkers of cartilage, bone, synovial metabolism and knee pain provide insights into the origins of pain in early knee osteoarthritis
- (2011) Muneaki Ishijima et al. ARTHRITIS RESEARCH & THERAPY
- A randomized, double-blind study of AMG 108 (a fully human monoclonal antibody to IL-1R1) in patients with osteoarthritis of the knee
- (2011) Stanley B Cohen et al. ARTHRITIS RESEARCH & THERAPY
- Efficacy and safety of flavocoxid, a novel therapeutic, compared with naproxen: a randomized multicenter controlled trial in subjects with osteoarthritis of the knee
- (2010) Robert M. Levy et al. ADVANCES IN THERAPY
- Articular cartilage and subchondral bone in the pathogenesis of osteoarthritis
- (2010) Mary B. Goldring et al. Annals of the New York Academy of Sciences
- Relation of synovitis to knee pain using contrast-enhanced MRIs
- (2010) K. Baker et al. ANNALS OF THE RHEUMATIC DISEASES
- Assessment of synovitis with contrast-enhanced MRI using a whole-joint semiquantitative scoring system in people with, or at high risk of, knee osteoarthritis: the MOST study
- (2010) A. Guermazi et al. ANNALS OF THE RHEUMATIC DISEASES
- Regulation of complement by cartilage oligomeric matrix protein allows for a novel molecular diagnostic principle in rheumatoid arthritis
- (2010) Kaisa E. Happonen et al. ARTHRITIS AND RHEUMATISM
- The role of synovial macrophages and macrophage-produced mediators in driving inflammatory and destructive responses in osteoarthritis
- (2010) Jan Bondeson et al. ARTHRITIS AND RHEUMATISM
- Synovial inflammation in patients undergoing arthroscopic meniscectomy: Molecular characterization and relationship to symptoms
- (2010) Carla R. Scanzello et al. ARTHRITIS AND RHEUMATISM
- Activated Synovial Macrophages as Targets for Osteoarthritis Drug Therapy
- (2010) Jan Bondeson CURRENT DRUG TARGETS
- Crystals, inflammation, and osteoarthritis
- (2010) Ann K Rosenthal CURRENT OPINION IN RHEUMATOLOGY
- Quantitative determination of the diagnostic accuracy of the synovitis score and its components
- (2010) Elisabeth Slansky et al. HISTOPATHOLOGY
- Shifting HIFs in osteoarthritis
- (2010) Matthew Husa et al. NATURE MEDICINE
- The role of synovitis in pathophysiology and clinical symptoms of osteoarthritis
- (2010) Jérémie Sellam et al. Nature Reviews Rheumatology
- Role of proinflammatory cytokines in the pathophysiology of osteoarthritis
- (2010) Mohit Kapoor et al. Nature Reviews Rheumatology
- Tanezumab for the Treatment of Pain from Osteoarthritis of the Knee
- (2010) Nancy E. Lane et al. NEW ENGLAND JOURNAL OF MEDICINE
- Chemokine profile of synovial fluid from normal, osteoarthritis and rheumatoid arthritis patients: CCL25, CXCL10 and XCL1 recruit human subchondral mesenchymal progenitor cells
- (2010) M. Endres et al. OSTEOARTHRITIS AND CARTILAGE
- Endogenous antibodies promote rapid myelin clearance and effective axon regeneration after nerve injury
- (2010) M. E. Vargas et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Anti-inflammatory and cartilage-protecting effects of an intra-articularly injected anti-TNF single-chain Fv antibody (ESBA105) designed for local therapeutic use
- (2009) D M Urech et al. ANNALS OF THE RHEUMATIC DISEASES
- Association between weight or body mass index and hand osteoarthritis: a systematic review
- (2009) E. Yusuf et al. ANNALS OF THE RHEUMATIC DISEASES
- Increased serum adiponectin levels in female patients with erosive compared with non-erosive osteoarthritis
- (2009) M Filkova et al. ANNALS OF THE RHEUMATIC DISEASES
- Intraarticular injection of anakinra in osteoarthritis of the knee: A multicenter, randomized, double-blind, placebo-controlled study
- (2009) X. Chevalier et al. ARTHRITIS AND RHEUMATISM
- Thrombin-activatable carboxypeptidase B cleavage of osteopontin regulates neutrophil survival and synoviocyte binding in rheumatoid arthritis
- (2009) Shadi A. Sharif et al. ARTHRITIS AND RHEUMATISM
- Targeting Matrix Metalloproteinases in Inflammatory Conditions
- (2009) A. Clutterbuck et al. CURRENT DRUG TARGETS
- Etoricoxib
- (2009) Katherine F. Croom et al. DRUGS
- Analysing the role of endogenous matrix molecules in the development of osteoarthritis
- (2009) Nidhi Sofat INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY
- Tenascin-C is an endogenous activator of Toll-like receptor 4 that is essential for maintaining inflammation in arthritic joint disease
- (2009) Kim Midwood et al. NATURE MEDICINE
- Risk factors for onset of osteoarthritis of the knee in older adults: a systematic review and meta-analysis
- (2009) M. Blagojevic et al. OSTEOARTHRITIS AND CARTILAGE
- Commentary: Is It Useful to Subset “Primary” Osteoarthritis? A Critique Based on Evidence Regarding the Etiopathogenesis of Osteoarthritis
- (2009) Kenneth D. Brandt et al. SEMINARS IN ARTHRITIS AND RHEUMATISM
- Developments in the clinical understanding of osteoarthritis
- (2009) David T Felson ARTHRITIS RESEARCH & THERAPY
- Protective effects of licofelone, a 5-lipoxygenase and cyclo-oxygenase inhibitor, versus naproxen on cartilage loss in knee osteoarthritis: a first multicentre clinical trial using quantitative MRI
- (2008) J-P Raynauld et al. ANNALS OF THE RHEUMATIC DISEASES
- The synovitis of "non-inflammatory" orthopaedic arthropathies: a quantitative histological and immunohistochemical analysis
- (2008) F Pessler et al. ANNALS OF THE RHEUMATIC DISEASES
- Contrast-enhanced ultrasound in monitoring the efficacy of a bradykinin receptor 2 antagonist in painful knee osteoarthritis compared with MRI
- (2008) I H Song et al. ANNALS OF THE RHEUMATIC DISEASES
- Innate immune system activation in osteoarthritis: is osteoarthritis a chronic wound?
- (2008) Carla R Scanzello et al. CURRENT OPINION IN RHEUMATOLOGY
- Knee osteoarthritis: a role for bradykinin?
- (2008) S. Meini et al. INFLAMMATION RESEARCH
- Adipokines in osteoarthritis: friends or foes of cartilage homeostasis?
- (2008) Pascale Pottie Gegout et al. JOINT BONE SPINE
- CXCR4 signaling in the regulation of stem cell migration and development
- (2008) Richard J. Miller et al. JOURNAL OF NEUROIMMUNOLOGY
- Regulation of tissue inflammation by thrombin-activatable carboxypeptidase B (or TAFI)
- (2008) Lawrence L.K. Leung et al. MOLECULAR IMMUNOLOGY
- Short leucine-rich glycoproteins of the extracellular matrix display diverse patterns of complement interaction and activation
- (2008) Andreas P. Sjöberg et al. MOLECULAR IMMUNOLOGY
- Osteoarthritis and nitric oxide
- (2008) Steven B. Abramson OSTEOARTHRITIS AND CARTILAGE
- Are there promising biologic therapies for osteoarthritis?
- (2008) David J. Hunter Current Rheumatology Reports
- The contribution of the synovium, synovial derived inflammatory cytokines and neuropeptides to the pathogenesis of osteoarthritis
- (2007) Saski Sutton et al. VETERINARY JOURNAL
Publish scientific posters with Peeref
Peeref publishes scientific posters from all research disciplines. Our Diamond Open Access policy means free access to content and no publication fees for authors.
Learn MoreBecome a Peeref-certified reviewer
The Peeref Institute provides free reviewer training that teaches the core competencies of the academic peer review process.
Get Started