A role for keratin 17 during DNA damage response and tumor initiation

Nuclear actin: The new normal

(2020) Leonid Serebryannyy et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

TIP60 K430 SUMOylation attenuates its interaction with DNA-PKcs in S-phase cells: Facilitating homologous recombination and emerging target for cancer therapy

(2020) Shan-Shan Gao et al.   Science Advances

The Intermediate Filament Synemin Regulates Non-Homologous End Joining in an ATM-Dependent Manner

(2020) Sara Sofia Deville et al.   Cancers

Keratin 17 regulates nuclear morphology and chromatin organization

(2020) Justin T. Jacob et al.   JOURNAL OF CELL SCIENCE

Nuclear Actin and Actin-Binding Proteins in DNA Repair

(2019) Verena Hurst et al.   TRENDS IN CELL BIOLOGY

Nuclear actin filaments in DNA repair dynamics

(2019) Christopher Patrick Caridi et al.   NATURE CELL BIOLOGY

Keratin 17 identifies the most lethal molecular subtype of pancreatic cancer

(2019) Lucia Roa-Peña et al.   Scientific Reports

E3 ligase Trim21 ubiquitylates and stabilizes Keratin 17 to induce STAT3 activation in psoriasis

(2018) Luting Yang et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Mechanisms of DNA damage, repair, and mutagenesis

(2017) Nimrat Chatterjee et al.   ENVIRONMENTAL AND MOLECULAR MUTAGENESIS

Keratin 17 is overexpressed and predicts poor survival in estrogen receptor–negative/human epidermal growth factor receptor-2–negative breast cancer

(2017) Ross D. Merkin et al.   HUMAN PATHOLOGY

Non-homologous DNA end joining and alternative pathways to double-strand break repair

(2017) Howard H. Y. Chang et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Epidermal Rac1 regulates the DNA damage response and protects from UV-light-induced keratinocyte apoptosis and skin carcinogenesis

(2017) Jayesh Deshmukh et al.   Cell Death & Disease

Application of Laser Micro-irradiation for Examination of Single and Double Strand Break Repair in Mammalian Cells

(2017) Nathaniel W Holton et al.   Jove-Journal of Visualized Experiments

p53 Is a Direct Transcriptional Repressor of Keratin 17: Lessons from a Rat Model of Radiation Dermatitis

(2016) Chunyan Liao et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

A comprehensive compilation of SUMO proteomics

(2016) Ivo A. Hendriks et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Loss of Keratin 17 induces tissue-specific cytokine polarization and cellular differentiation in HPV16-driven cervical tumorigenesis in vivo

(2016) R P Hobbs et al.   ONCOGENE

Keratin-17 Promotes p27KIP1 Nuclear Export and Degradation and Offers Potential Prognostic Utility

(2015) L. F. Escobar-Hoyos et al.   CANCER RESEARCH

AIRE: From promiscuous molecular partnerships to promiscuous gene expression

(2015) Jakub Abramson et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Regulation of C-X-C chemokine gene expression by keratin 17 and hnRNP K in skin tumor keratinocytes

(2015) Byung Min Chung et al.   JOURNAL OF CELL BIOLOGY

Keratin-dependent regulation of Aire and gene expression in skin tumor keratinocytes

(2015) Ryan P Hobbs et al.   NATURE GENETICS

SUMO-2 Orchestrates Chromatin Modifiers in Response to DNA Damage

(2015) Ivo A. Hendriks et al.   Cell Reports

DNA-PK: A dynamic enzyme in a versatile DSB repair pathway

(2014) Anthony J. Davis et al.   DNA REPAIR

Temporally distinct roles of ATM and ROS in genotoxic-stress-dependent induction and maintenance of cellular senescence

(2014) R. R. Nair et al.   JOURNAL OF CELL SCIENCE

Double-strand break repair: 53BP1 comes into focus

(2013) Stephanie Panier et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Overexpression of keratin 17 is associated with poor prognosis in epithelial ovarian cancer

(2013) Ya-Feng Wang et al.   TUMOR BIOLOGY

SUMOylation of hnRNP-K is required for p53-mediated cell-cycle arrest in response to DNA damage

(2012) Seong Won Lee et al.   EMBO JOURNAL

Systematic Identification of Functional Residues in Mammalian Histone H2AX

(2012) W.-T. Chen et al.   MOLECULAR AND CELLULAR BIOLOGY

Keratin 15-Positive Stem Cells Give Rise to Basal Cell Carcinomas in Irradiated Ptch1+/− Mice

(2011) John T. Seykora et al.   CANCER CELL

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Type I Keratin 17 Protein Is Phosphorylated on Serine 44 by p90 Ribosomal Protein S6 Kinase 1 (RSK1) in a Growth- and Stress-dependent Fashion

(2011) Xiaoou Pan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mommy — where do tumors come from?

(2011) Ervin H. Epstein   JOURNAL OF CLINICAL INVESTIGATION

Keratin 17 promotes epithelial proliferation and tumor growth by polarizing the immune response in skin

(2010) Daryle DePianto et al.   NATURE GENETICS

Keratins in health and cancer: more than mere epithelial cell markers

(2010) V Karantza   ONCOGENE

Human skin pigmentation as an adaptation to UV radiation

(2010) N. G. Jablonski et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

DNA Damage Response

(2010) G. Giglia-Mari et al.   Cold Spring Harbor Perspectives in Biology

Mammalian SUMO E3-ligases PIAS1 and PIAS4 promote responses to DNA double-strand breaks

(2009) Yaron Galanty et al.   NATURE

Multi-stage chemical carcinogenesis in mouse skin: Fundamentals and applications

(2009) Erika L Abel et al.   Nature Protocols

An Oligomerized 53BP1 Tudor Domain Suffices for Recognition of DNA Double-Strand Breaks

(2008) O. Zgheib et al.   MOLECULAR AND CELLULAR BIOLOGY