Article
Gastroenterology & Hepatology
Marco Gasparetto, Felicity Payne, Komal Nayak, Judith Kraiczy, Claire Glemas, Yosef Philip-McKenzie, Alexander Ross, Rachel D. Edgar, Daniel R. Zerbino, Camilla Salvestrini, Franco Torrente, Nicholas T. Ventham, Rahul Kalla, Jack Satsangi, Peter Sarkies, Robert Heuschkel, Matthias Zilbauer
Summary: The study aimed to validate the correlation between CD8(+) T-cell gene expression and disease outcome in IBD patients, but failed to reproduce the previously reported findings. It highlights the challenges of developing prognostic biomarkers for IBD patients and stresses the importance of validation in large, independent cohorts before clinical application.
Article
Biotechnology & Applied Microbiology
Qinglin Zhang, Jiadong Pan, Fangmei An, He Nie, Qiang Zhan
Summary: This study found that decreased expression of SLC39A1 is associated with clinical features and survival rates in early-stage hepatocellular carcinoma (EHCC), with patients showing lower expression having poorer prognosis. The expression level of SLC39A1 may serve as a potential diagnostic and prognostic biomarker for EHCC patients.
Article
Multidisciplinary Sciences
Sisi Deng, Xiang Feng, Miao Yang, Wenjing Yu, Zixuan Wu, Xu Zhu, Zhenyan Song, Shaowu Cheng
Summary: Autism spectrum disorder (ASD) is a neurodevelopmental disorder caused by a complex interaction of genetic, environmental, and immune factors. This study found that the lysosomal-associated membrane protein 1 (LAMP1) was upregulated in ASD blood, brain cortex, and genetic animal models or cells. LAMP1 showed favorable diagnostic ability and correlated with immune function genes. Abnormal elevations of LAMP1 may influence ASD development through immune cell activity regulation.
SCIENTIFIC REPORTS
(2023)
Article
Immunology
Shanqiang Qu, Jin Liu, Huafu Wang
Summary: The study found that EVA1B was upregulated in glioma and correlated with tumor grade. High EVA1B expression was associated with unfavorable clinicopathological features and poorer survival of patients, confirmed by multiple cohorts. EVA1B overexpression was also linked to higher levels of immune cell infiltration in glioma and showed superior predictive power for immune infiltration compared to other immune-related markers.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Cell Biology
Shen Shen, Yanfang Wang, Yize Zhang, Zihui Dong, Jiyuan Xing
Summary: SNHG14 is a long non-coding RNA that is overexpressed in various cancers, with its expression level closely linked to clinicopathological characteristics. It has been shown to promote cancer cell viability, invasion, and migration, possibly through regulating target gene expression via sponging distinct miRNAs. Therefore, SNHG14 holds promise as a prognostic biomarker and therapeutic target for cancers.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Medicine, Research & Experimental
Zhenshan Zhang, Leilei Wu, Juan Li, Jiayan Chen, Qi Yu, Hui Yao, Yaping Xu, Liang Liu
Summary: The study found that ZBTB9 is overexpressed in Liver Hepatocellular Carcinoma (LIHC) and is associated with tumor progression and prognosis. ZBTB9 promotes tumor development by activating multiple signaling pathways and causing immune dysregulation. Silencing ZBTB9 inhibits tumor cell proliferation and migration. Therefore, ZBTB9 may serve as a prognostic biomarker and therapeutic target for LIHC.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Article
Immunology
Wanzun Lin, Yun Sun, Xianxin Qiu, Qingting Huang, Lin Kong, Jiade J. Lu
Summary: The study found that high expression of VMP1 in glioma patients is associated with faster disease progression and poorer prognosis. Depletion of VMP1 by CRISPR-Cas9 gene editing significantly inhibits cell proliferation, increases cell death, and induces cell cycle arrest. Knockout of VMP1 blocks autophagic flux and sensitizes glioma cells to radiotherapy and chemotherapy.
JOURNAL OF NEUROINFLAMMATION
(2021)
Article
Immunology
Dean Rao, Chengpeng Yu, Tiantian Wang, Jiaqi Sheng, Enjun Lv, Huifang Liang, Wenjie Huang, Hanhua Dong
Summary: IL4I1 is a secreted enzyme involved in the regulation of adaptive immune responses and affects tumor development. IL4I1 is associated with the infiltration status of immune cells and may serve as a potential biomarker and therapeutic target.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Paula Lucia Farre, Rocio Belen Duca, Cintia Massillo, Guillermo Nicolas Dalton, Karen Daniela Grana, Kevin Gardner, Ezequiel Lacunza, Adriana De Siervi
Summary: Breast cancer is the leading cause of death by cancer in women globally. A miRNA signature deregulated in preclinical and clinical BCa models was identified for potential biomarker discovery, useful for BCa diagnosis and/or prognosis. Certain miRNAs were up-regulated and down-regulated in BCa, showing negative correlation with the expression of related genes. Genes such as GAB1, GNG12, HBP1, and SESN1 have been found to have expression levels related to patient survival in aggressive BCa subtypes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Neurosciences
Longbin Guo, Yulei Chen, Shushu Hu, Lianxuan Gao, Nan Tang, Rongping Liu, Yue Qin, Chen Ren, Shasha Du
Summary: This study found that GDF15 is upregulated in various malignant phenotypes of glioma and is associated with malignant progression and NF-kappa B pathway. GDF15 is closely correlated to inflammatory response, infiltrating immune cells, and immune checkpoint molecules, especially in lower grade glioma (LGG). High expression level of GDF15 predicted poor survival in LGG, while the effect on glioblastoma (GBM) was not significant.
CNS NEUROSCIENCE & THERAPEUTICS
(2022)
Article
Biochemistry & Molecular Biology
Silvia Cagnin, Rossella Donghia, Andrea Martini, Pasqua Letizia Pesole, Sergio Coletta, Endrit Shahini, Giulia Boninsegna, Alessandra Biasiolo, Patrizia Pontisso, Gianluigi Giannelli
Summary: The GALAD score shows promise as a prognostic tool for hepatocellular carcinoma (HCC), with implications for improving patient management and treatment strategies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Chunyan Zhang, Caifang Sun, Yabin Zhao, Qiwen Wang, Jianlin Guo, Bingyu Ye, Guoying Yu
Summary: MicroRNAs (miRNAs) play a significant role in gene regulation and are closely associated with the occurrence and development of various cancers. The abnormal expression of miRNAs in cancer can serve as potential biomarkers for diagnosis and prognosis, offering improved accuracy and lower costs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Lukas Geisler, Raphael Mohr, Joeri Lambrecht, Jana Knorr, Henning Jann, Sven H. Loosen, Burcin Ozdirik, Tom Luedde, Linda Hammerich, Frank Tacke, Alexander Wree, Teresa Hellberg, Christoph Roderburg
Summary: Neuroendocrine tumors (NETs) are rare and heterogeneous, with prognosis determined by tumor grading and metastases. Despite intensive research efforts, progress in diagnostic and therapeutic approaches has been modest. miRNA, known for its role in cancer pathophysiology, shows potential as a biomarker for NET, but challenges remain for its clinical application.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Oncology
Marianna Aprile, Valerio Costa, Amelia Cimmino, George Adrian Calin
Summary: The view of long noncoding RNAs as nonfunctional garbage has been outdated, as evidence suggests their role as golden junk, particularly in precision oncology. They have potential use as diagnostic and/or prognostic biomarkers, and advancements in technology have made it easier to profile them in multiple tumors and large cohorts.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Article
Biochemistry & Molecular Biology
Hung-Ming Chen, Chun-Chi Lin, Wei-Shone Chen, Jeng-Kai Jiang, Shung-Haur Yang, Shih-Ching Chang, Ching-Liang Ho, Chung-Chi Yang, Shih-Ching Huang, Yee Chao, Tsai-Tsen Liao, Wei-Lun Hwang, Hao-Wei Teng
Summary: IGF2BP1 is overexpressed in CRC, associated with young age and advanced stage, serving as an independent prognostic marker. High IGF2BP1 expression is linked to lower survival rate and chemotherapy resistance in CRC patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
