期刊
出版社
ELSEVIER
DOI: 10.1016/j.mrfmmm.2020.111714
关键词
Nuclear actin; DNA damage repair; Transcription; Chromatin remodeling; Intranuclear mobility; Post-translational modifications
资金
- Center for Cardiovascular Research, University of Illinois
The presence of actin in the nucleus has historically been a highly contentious issue. It is now, however, well accepted that actin has physiologically important roles in the nucleus. In this Review, we describe the evolution of our thinking about actin in the nucleus starting with evidence supporting its involvement in transcription, chromatin remodeling and intranuclear movements. We also review the growing literature on the mechanisms that regulate the import and export of actin and how post-translational modifications of actin could regulate nuclear actin. We end with an extended discussion of the role of nuclear actin in the repair of DNA double stranded breaks.
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