Nuclear actin filaments in DNA repair dynamics

Evolving imprinting control regions: KRAB zinc fingers hold the key

(2019) Aimee M. Juan et al.   GENES & DEVELOPMENT

Sleep increases chromosome dynamics to enable reduction of accumulating DNA damage in single neurons

(2019) D. Zada et al.   Nature Communications

Ribosomal RNA gene repeats associate with the nuclear pore complex for maintenance after DNA damage

(2019) Chihiro Horigome et al.   PLoS Genetics

Dynamic relocalization of replication origins by Fkh1 requires execution of DDK function and Cdc45 loading at origins

(2019) Haiyang Zhang et al.   eLife

Actin’ between phase separated domains for heterochromatin repair

(2019) Chetan C. Rawal et al.   DNA REPAIR

Arp2/3 and Unc45 maintain heterochromatin stability in Drosophila polytene chromosomes

(2019) George Dialynas et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Baculovirus Actin-Based Motility Drives Nuclear Envelope Disruption and Nuclear Egress

(2018) Taro Ohkawa et al.   CURRENT BIOLOGY

β-Actin–dependent global chromatin organization and gene expression programs control cellular identity

(2018) Xin Xie et al.   FASEB JOURNAL

Myosin-Driven Intracellular Transport

(2018) Margaret A. Titus   Cold Spring Harbor Perspectives in Biology

Nuclear microtubule filaments mediate non-linear directional motion of chromatin and promote DNA repair

(2018) Roxanne Oshidari et al.   Nature Communications

Nuclear myosin/actin-motored contact between homologous chromosomes is initiated by ATM kinase and homology-directed repair proteins at double-strand DNA breaks to suppress chromosome rearrangements

(2018) Viktoria N. Evdokimova et al.   Oncotarget

Rif1 Binding and Control of Chromosome-Internal DNA Replication Origins Is Limited by Telomere Sequestration

(2018) Lukas Hafner et al.   Cell Reports

Comprehensive Mapping of Histone Modifications at DNA Double-Strand Breaks Deciphers Repair Pathway Chromatin Signatures

(2018) Thomas Clouaire et al.   MOLECULAR CELL

Nuclear F-actin and myosins drive relocalization of heterochromatic breaks

(2018) Christopher P. Caridi et al.   NATURE

Nuclear ARP2/3 drives DNA break clustering for homology-directed repair

(2018) Benjamin R. Schrank et al.   NATURE

The Nature of Actin-Family Proteins in Chromatin-Modifying Complexes

(2018) Naeh L. Klages-Mundt et al.   Frontiers in Genetics

β-actin regulates a heterochromatin landscape essential for optimal induction of neuronal programs during direct reprograming

(2018) Xin Xie et al.   PLoS Genetics

Dynamizing nuclear actin filaments

(2018) Matthias Plessner et al.   CURRENT OPINION IN CELL BIOLOGY

Dbf4 recruitment by forkhead transcription factors defines an upstream rate-limiting step in determining origin firing timing

(2017) Dingqiang Fang et al.   GENES & DEVELOPMENT

Chromatin tethering to the nuclear envelope by nuclear actin filaments: a novel role of the actin cytoskeleton in theXenopusblastula

(2017) Haruka Oda et al.   GENES TO CELLS

Actin visualization at a glance

(2017) Michael Melak et al.   JOURNAL OF CELL SCIENCE

Actin assembly mechanisms at a glance

(2017) Klemens Rottner et al.   JOURNAL OF CELL SCIENCE

Multi-scale tracking reveals scale-dependent chromatin dynamics after DNA damage

(2017) Judith Miné-Hattab et al.   MOLECULAR BIOLOGY OF THE CELL

Microtubule dynamics drive enhanced chromatin motion and mobilize telomeres in response to DNA damage

(2017) Josh Lawrimore et al.   MOLECULAR BIOLOGY OF THE CELL

Live-cell single-molecule labeling and analysis of myosin motors with quantum dots

(2017) Hiroyasu Hatakeyama et al.   MOLECULAR BIOLOGY OF THE CELL

Phase separation drives heterochromatin domain formation

(2017) Amy R. Strom et al.   NATURE

Liquid droplet formation by HP1α suggests a role for phase separation in heterochromatin

(2017) Adam G. Larson et al.   NATURE

A transient pool of nuclear F-actin at mitotic exit controls chromatin organization

(2017) Christian Baarlink et al.   NATURE CELL BIOLOGY

Non-homologous DNA end joining and alternative pathways to double-strand break repair

(2017) Howard H. Y. Chang et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Genome-wide mapping of long-range contacts unveils clustering of DNA double-strand breaks at damaged active genes

(2017) François Aymard et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

And yet, it moves: nuclear and chromatin dynamics of a heterochromatic double-strand break

(2017) P. Christopher Caridi et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Nuclear Dynamics of Heterochromatin Repair

(2017) Nuno Amaral et al.   TRENDS IN GENETICS

DNA damage causes rapid accumulation of phosphoinositides for ATR signaling

(2017) Yu-Hsiu Wang et al.   Nature Communications

Genome-wide mapping of long-range contacts unveils clustering of DNA double-strand breaks at damaged active genes

(2017) François Aymard et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Visualization of Chromatin Decompaction and Break Site Extrusion as Predicted by Statistical Polymer Modeling of Single-Locus Trajectories

(2017) Assaf Amitai et al.   Cell Reports

Inhibition of RIF1 by SCAI Allows BRCA1-Mediated Repair

(2017) Shin-Ya Isobe et al.   Cell Reports

The Emerging Role of the Cytoskeleton in Chromosome Dynamics

(2017) Maya Spichal et al.   Frontiers in Genetics

DNA Double-Strand Breaks Induce the Nuclear Actin Filaments Formation in Cumulus-Enclosed Oocytes but Not in Denuded Oocytes

(2017) Ming-Hong Sun et al.   PLoS One

Aging impairs double-strand break repair by homologous recombination in Drosophila germ cells

(2016) Laetitia Delabaere et al.   AGING CELL

ReiNF4rcing repair pathway choice during cell cycle

(2016) Laetitia Delabaere et al.   CELL CYCLE

A single double-strand break system reveals repair dynamics and mechanisms in heterochromatin and euchromatin

(2016) Aniek Janssen et al.   GENES & DEVELOPMENT

Persistent nuclear actin filaments inhibit transcription by RNA polymerase II

(2016) Leonid A. Serebryannyy et al.   JOURNAL OF CELL SCIENCE

Evidence for a dual role of actin in regulating chromosome organization and dynamics in yeast

(2016) Maya Spichal et al.   JOURNAL OF CELL SCIENCE

Temporal and Spatial Uncoupling of DNA Double Strand Break Repair Pathways within Mammalian Heterochromatin

(2016) Katerina Tsouroula et al.   MOLECULAR CELL

SCAI promotes DNA double-strand break repair in distinct chromosomal contexts

(2016) Rebecca Kring Hansen et al.   NATURE CELL BIOLOGY

Chromosome territory relocation during DNA repair requires nuclear myosin 1 recruitment to chromatin mediated by ϒ-H2AX signaling

(2016) Mugdha Kulashreshtha et al.   NUCLEIC ACIDS RESEARCH

Crystal structure of a nuclear actin ternary complex

(2016) Tingting Cao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Role for Nuclear F-Actin Induction in Human Cytomegalovirus Nuclear Egress

(2016) Adrian R. Wilkie et al.   mBio

Actin and Actin-Binding Proteins

(2016) Thomas D. Pollard   Cold Spring Harbor Perspectives in Biology

SUMO-Dependent Relocalization of Eroded Telomeres to Nuclear Pore Complexes Controls Telomere Recombination

(2016) Dmitri Churikov et al.   Cell Reports

Investigating the Interplay between Sister Chromatid Cohesion and Homolog Pairing in Drosophila Nuclei

(2016) T. Niroshini Senaratne et al.   PLoS Genetics

Cervantes and Quijote protect heterochromatin from aberrant recombination and lead the way to the nuclear periphery

(2016) Taehyun Ryu et al.   Nucleus

Cervantes and Quijote protect heterochromatin from aberrant recombination and lead the way to the nuclear periphery

(2016) Taehyun Ryu et al.   Nucleus

53BP1 and the LINC Complex Promote Microtubule-Dependent DSB Mobility and DNA Repair

(2015) Francisca Lottersberger et al.   CELL

Regulation of recombination at yeast nuclear pores controls repair and triplet repeat stability

(2015) Xiaofeng A. Su et al.   GENES & DEVELOPMENT

A localized nucleolar DNA damage response facilitates recruitment of the homology-directed repair machinery independent of cell cycle stage

(2015) Marjolein van Sluis et al.   GENES & DEVELOPMENT

Topologically associating domains and their long-range contacts are established during early G1 coincident with the establishment of the replication-timing program

(2015) Vishnu Dileep et al.   GENOME RESEARCH

The Release 6 reference sequence of theDrosophila melanogastergenome

(2015) Roger A. Hoskins et al.   GENOME RESEARCH

Nuclear F-actin Formation and Reorganization upon Cell Spreading

(2015) Matthias Plessner et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Chromothripsis from DNA damage in micronuclei

(2015) Cheng-Zhong Zhang et al.   NATURE

Heterochromatic breaks move to the nuclear periphery to continue recombinational repair

(2015) Taehyun Ryu et al.   NATURE CELL BIOLOGY

Filamin A interacts with the coactivator MKL1 to promote the activity of the transcription factor SRF and cell migration

(2015) Philipp Kircher et al.   Science Signaling

An Overview of the Molecular Mechanisms of Recombinational DNA Repair

(2015) Stephen C. Kowalczykowski   Cold Spring Harbor Perspectives in Biology

Perinuclear tethers license telomeric DSBs for a broad kinesin- and NPC-dependent DNA repair process

(2015) Daniel K.C. Chung et al.   Nature Communications

ATM Dependent Silencing Links Nucleolar Chromatin Reorganization to DNA Damage Recognition

(2015) Shane M. Harding et al.   Cell Reports

DNA damage induces nuclear actin filament assembly by Formin-2 and Spire-1/2 that promotes efficient DNA repair

(2015) Brittany J Belin et al.   eLife

Wiskott-Aldrich syndrome proteins in the nucleus: aWASH with possibilities

(2015) Jeffrey M Verboon et al.   Nucleus

Filamin A interacts with the coactivator MKL1 to promote the activity of the transcription factor SRF and cell migration

(2015) Philipp Kircher et al.   Science Signaling

Wiskott-Aldrich syndrome proteins in the nucleus: aWASH with possibilities

(2015) Jeffrey M Verboon et al.   Nucleus

ATR Mediates a Checkpoint at the Nuclear Envelope in Response to Mechanical Stress

(2014) Amit Kumar et al.   CELL

Interchromosomal Homology Searches Drive Directional ALT Telomere Movement and Synapsis

(2014) Nam Woo Cho et al.   CELL

The pros and cons of common actin labeling tools for visualizing actin dynamics during Drosophila oogenesis

(2014) Andrew J. Spracklen et al.   DEVELOPMENTAL BIOLOGY

Human Heterochromatin Protein 1α Promotes Nucleosome Associations That Drive Chromatin Condensation

(2014) Abdelhamid M. Azzaz et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A role for nuclear envelope–bridging complexes in homology-directed repair

(2014) Rebecca K. Swartz et al.   MOLECULAR BIOLOGY OF THE CELL

SWR1 and INO80 Chromatin Remodelers Contribute to DNA Double-Strand Break Perinuclear Anchorage Site Choice

(2014) Chihiro Horigome et al.   MOLECULAR CELL

Comparative analysis of metazoan chromatin organization

(2014) Joshua W. K. Ho et al.   NATURE

Rif1 Regulates Initiation Timing of Late Replication Origins throughout the S. cerevisiae Genome

(2014) Jared M. Peace et al.   PLoS One

Rosa26-GFP Direct Repeat (RaDR-GFP) Mice Reveal Tissue- and Age-Dependence of Homologous Recombination in Mammals In Vivo

(2014) Michelle R. Sukup-Jackson et al.   PLoS Genetics

Direct actin binding to A- and B-type lamin tails and actin filament bundling by the lamin A tail

(2014) Dan N. Simon et al.   Nucleus

Stimulation of in vivo nuclear transport dynamics of actin and its co-factors IQGAP1 and Rac1 in response to DNA replication stress

(2013) Michael A. Johnson et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Chromatin Movement in the Maintenance of Genome Stability

(2013) Vincent Dion et al.   CELL

Arp2/3-Mediated Actin-Based Motility: A Tail of Pathogen Abuse

(2013) Matthew D. Welch et al.   Cell Host & Microbe

Visualization of actin filaments and monomers in somatic cell nuclei

(2013) Brittany J. Belin et al.   MOLECULAR BIOLOGY OF THE CELL

Nuclear dynamics of radiation-induced foci in euchromatin and heterochromatin

(2013) Irene Chiolo et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

A nuclear F-actin scaffold stabilizes ribonucleoprotein droplets against gravity in large cells

(2013) Marina Feric et al.   NATURE CELL BIOLOGY

Double-Strand Break Repair by Interchromosomal Recombination: An In Vivo Repair Mechanism Utilized by Multiple Somatic Tissues in Mammals

(2013) Ryan R. White et al.   PLoS One

Nuclear Wave1 Is Required for Reprogramming Transcription in Oocytes and for Normal Development

(2013) K. Miyamoto et al.   SCIENCE

Spatial Dynamics of Chromosome Translocations in Living Cells

(2013) V. Roukos et al.   SCIENCE

Nuclear Actin Network Assembly by Formins Regulates the SRF Coactivator MAL

(2013) C. Baarlink et al.   SCIENCE

Mechanisms of nuclear actin in chromatin-remodeling complexes

(2013) Prabodh Kapoor et al.   TRENDS IN CELL BIOLOGY

Forkhead Transcription Factors Establish Origin Timing and Long-Range Clustering in S. cerevisiae

(2012) Simon R.V. Knott et al.   CELL

Three-Dimensional Folding and Functional Organization Principles of the Drosophila Genome

(2012) Tom Sexton et al.   CELL

Targeted INO80 enhances subnuclear chromatin movement and ectopic homologous recombination

(2012) F. R. Neumann et al.   GENES & DEVELOPMENT

Cells Lacking β-Actin are Genetically Reprogrammed and Maintain Conditional Migratory Capacity*

(2012) Davina Tondeleir et al.   MOLECULAR & CELLULAR PROTEOMICS

Increased chromosome mobility facilitates homology search during recombination

(2012) Judith Miné-Hattab et al.   NATURE CELL BIOLOGY

Increased mobility of double-strand breaks requires Mec1, Rad9 and the homologous recombination machinery

(2012) Vincent Dion et al.   NATURE CELL BIOLOGY

Active maintenance of nuclear actin by importin 9 supports transcription

(2012) J. Dopie et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Profilin is associated with transcriptionally active genes

(2012) Emilia Söderberg et al.   Nucleus

A requirement for polymerized actin in DNA double-strand break repair

(2012) Christi Andrin et al.   Nucleus

Double-Strand Breaks in Heterochromatin Move Outside of a Dynamic HP1a Domain to Complete Recombinational Repair

(2011) Irene Chiolo et al.   CELL

The Replication Checkpoint Protects Fork Stability by Releasing Transcribed Genes from Nuclear Pores

(2011) Rodrigo Bermejo et al.   CELL

Structural biochemistry of nuclear actin-related proteins 4 and 8 reveals their interaction with actin

(2011) Sebastian Fenn et al.   EMBO JOURNAL

Nuclear actin polymerization is required for transcriptional reprogramming of Oct4 by oocytes

(2011) K. Miyamoto et al.   GENES & DEVELOPMENT

Mutant huntingtin causes defective actin remodeling during stress: defining a new role for transglutaminase 2 in neurodegenerative disease

(2011) Lise Munsie et al.   HUMAN MOLECULAR GENETICS

KAP-1 phosphorylation regulates CHD3 nucleosome remodeling during the DNA double-strand break response

(2011) Aaron A Goodarzi et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

DNA double-strand breaks in heterochromatin elicit fast repair protein recruitment, histone H2AX phosphorylation and relocation to euchromatin

(2011) Burkhard Jakob et al.   NUCLEIC ACIDS RESEARCH

MU2 and HP1a Regulate the Recognition of Double Strand Breaks in Drosophila melanogaster

(2011) Raghuvar Dronamraju et al.   PLoS One

Evidence for formation of DNA repair centers and dose-response nonlinearity in human cells

(2011) T. Neumaier et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Human INO80 chromatin-remodelling complex contributes to DNA double-strand break repair via the expression ofRad54BandXRCC3genes

(2010) Eun-Jung Park et al.   BIOCHEMICAL JOURNAL

Identification of Filamin A as a BRCA1-interacting protein required for efficient DNA repair

(2010) Aneliya Velkova et al.   CELL CYCLE

Developmental Control of Late Replication and S Phase Length

(2010) Antony W. Shermoen et al.   CURRENT BIOLOGY

Plasticity in patterns of histone modifications and chromosomal proteins in Drosophila heterochromatin

(2010) N. C. Riddle et al.   GENOME RESEARCH

Molecular Maps of the Reorganization of Genome-Nuclear Lamina Interactions during Differentiation

(2010) Daan Peric-Hupkes et al.   MOLECULAR CELL

Spatiotemporal characterization of ionizing radiation induced DNA damage foci and their relation to chromatin organization

(2010) S.V. Costes et al.   MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH

The Cytoskeleton Protein Filamin-A Is Required for an Efficient Recombinational DNA Double Strand Break Repair

(2009) J. Yue et al.   CANCER RESEARCH

ATM and Artemis promote homologous recombination of radiation-induced DNA double-strand breaks in G2

(2009) Andrea Beucher et al.   EMBO JOURNAL

Mechanisms that regulate localization of a DNA double-strand break to the nuclear periphery

(2009) P. Oza et al.   GENES & DEVELOPMENT

Chromosome-wide Rad51 Spreading and SUMO-H2A.Z-Dependent Chromosome Fixation in Response to a Persistent DNA Double-Strand Break

(2009) Marian Kalocsay et al.   MOLECULAR CELL

The DNA damage response at eroded telomeres and tethering to the nuclear pore complex

(2009) Basheer Khadaroo et al.   NATURE CELL BIOLOGY

p53-cofactor JMY is a multifunctional actin nucleation factor

(2009) J. Bradley Zuchero et al.   NATURE CELL BIOLOGY

SCAI acts as a suppressor of cancer cell invasion through the transcriptional control of β1-integrin

(2009) Dominique T. Brandt et al.   NATURE CELL BIOLOGY

Heterochromatic Genome Stability Requires Regulators of Histone H3 K9 Methylation

(2009) Jamy C. Peng et al.   PLoS Genetics

Epigenetic regulation of heterochromatic DNA stability

(2008) Jamy C Peng et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

ATM Signaling Facilitates Repair of DNA Double-Strand Breaks Associated with Heterochromatin

(2008) Aaron A. Goodarzi et al.   MOLECULAR CELL

HP1-β mobilization promotes chromatin changes that initiate the DNA damage response

(2008) Nabieh Ayoub et al.   NATURE

Domain organization of human chromosomes revealed by mapping of nuclear lamina interactions

(2008) Lars Guelen et al.   NATURE

Actin-driven chromosomal motility leads to symmetry breaking in mammalian meiotic oocytes

(2008) Hongbin Li et al.   NATURE CELL BIOLOGY

The HP1–p150/CAF-1 interaction is required for pericentric heterochromatin replication and S-phase progression in mouse cells

(2008) Jean-Pierre Quivy et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Functional Targeting of DNA Damage to a Nuclear Pore-Associated SUMO-Dependent Ubiquitin Ligase

(2008) S. Nagai et al.   SCIENCE