Frizzled Receptors in Tumors, Focusing on Signaling, Roles, Modulation Mechanisms, and Targeted Therapies
出版年份 2020 全文链接
标题
Frizzled Receptors in Tumors, Focusing on Signaling, Roles, Modulation Mechanisms, and Targeted Therapies
作者
关键词
-
出版物
ONCOLOGY RESEARCH
Volume 28, Issue 6, Pages 661-674
出版商
Cognizant, LLC
发表日期
2020-10-01
DOI
10.3727/096504020x16014648664459
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- H3K27me3-mediated PGC1α gene silencing promotes melanoma invasion through WNT5A and YAP
- (2020) Chi Luo et al. JOURNAL OF CLINICAL INVESTIGATION
- WNT5A-Induced Activation of the Protein Kinase C Substrate MARCKS Is Required for Melanoma Cell Invasion
- (2020) Purusottam Mohapatra et al. Cancers
- Fzd2 Contributes to Breast Cancer Cell Mesenchymal-Like Stemness and Drug Resistance
- (2020) Ping Yin et al. ONCOLOGY RESEARCH
- WNT Signaling in Melanoma
- (2020) Anna Gajos-Michniewicz et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Frizzled-7 is required for Wnt signaling in gastric tumors with and without Apc mutations.
- (2019) Dustin Flanagan et al. CANCER RESEARCH
- Down-regulation of FZD3 receptor suppresses growth and metastasis of human melanoma independently of canonical WNT signaling
- (2019) Chen Li et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Integrated Genomic and Functional microRNA Analysis Identifies miR-30-5p as a Tumor Suppressor and Potential Therapeutic Nanomedicine in Head and Neck Cancer
- (2019) Anthony D. Saleh et al. CLINICAL CANCER RESEARCH
- Frizzled 2-induced epithelial-mesenchymal transition correlates with vasculogenic mimicry, stemness, and Hippo signaling in hepatocellular carcinoma
- (2019) Huohui Ou et al. CANCER SCIENCE
- A phase 1b dose escalation study of Wnt pathway inhibitor vantictumab in combination with nab-paclitaxel and gemcitabine in patients with previously untreated metastatic pancreatic cancer
- (2019) S. Lindsey Davis et al. INVESTIGATIONAL NEW DRUGS
- WNT-3A–induced β-catenin signaling does not require signaling through heterotrimeric G proteins
- (2019) Carl-Fredrik Bowin et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Wnt7a, frequently silenced by CpG methylation, inhibits tumor growth and metastasis via suppressing epithelial‐mesenchymal transition in gastric cancer
- (2019) Yuzhen Liu et al. JOURNAL OF CELLULAR BIOCHEMISTRY
- Cirmtuzumab blocks Wnt5a/ROR1 stimulation of NF-κB to repress autocrine STAT3 activation in chronic lymphocytic leukemia
- (2019) Yun Chen et al. BLOOD
- Pathogenic Epigenetic Consequences of Genetic Alterations in IDH-Wild-Type Diffuse Astrocytic Gliomas
- (2019) Fumiharu Ohka et al. CANCER RESEARCH
- A phase 1b dose escalation study of ipafricept (OMP 54F28) in combination with paclitaxel and carboplatin in patients with recurrent platinum-sensitive ovarian cancer
- (2019) Kathleen N. Moore et al. GYNECOLOGIC ONCOLOGY
- Frizzled3 and Frizzled6 Cooperate with Vangl2 to Direct Cochlear Innervation by Type II Spiral Ganglion Neurons
- (2019) Satish R. Ghimire et al. JOURNAL OF NEUROSCIENCE
- STAT3-Induced Wnt5a Provides Chronic Lymphocytic Leukemia Cells with Survival Advantage
- (2019) Uri Rozovski et al. JOURNAL OF IMMUNOLOGY
- Wnt/β-catenin signalling in ovarian cancer: Insights into its hyperactivation and function in tumorigenesis
- (2019) Vu Hong Loan Nguyen et al. Journal of Ovarian Research
- WNT Signaling Perturbations Underlie the Genetic Heterogeneity of Robinow Syndrome
- (2018) Janson J. White et al. AMERICAN JOURNAL OF HUMAN GENETICS
- Cell growth inhibition and apoptosis in breast cancer cells induced by anti-FZD7 scFvs: involvement of bioinformatics-based design of novel epitopes
- (2018) Neda Zarei et al. BREAST CANCER RESEARCH AND TREATMENT
- Knockdown of the Wnt receptor Frizzled-1 (FZD1) reduces MDR1 /P-glycoprotein expression in multidrug resistant leukemic cells and inhibits leukemic cell proliferation
- (2018) Yan-Hua Wang et al. LEUKEMIA RESEARCH
- Frizzled-8 integrates Wnt-11 and transforming growth factor-β signaling in prostate cancer
- (2018) Virginia Murillo-Garzón et al. Nature Communications
- Role of WNT5A receptors FZD5 and RYK in prostate cancer cells
- (2018) Stefanie Thiele et al. Oncotarget
- Luteolin attenuates Wnt signaling via upregulation of FZD6 to suppress prostate cancer stemness revealed by comparative proteomics
- (2018) Kun Han et al. Scientific Reports
- Wnt signaling in human and mouse breast cancer: Focusing on Wnt ligands, receptors and antagonists
- (2018) Ping Yin et al. CANCER SCIENCE
- Functional redundancy of Frizzled 3 and Frizzled 6 in planar cell polarity control of mouse hair follicles
- (2018) Bo Dong et al. DEVELOPMENT
- A synthetic anti-Frizzled antibody engineered for broadened specificity exhibits enhanced anti-tumor properties
- (2018) Zvezdan Pavlovic et al. mAbs
- Crystal structure of the Frizzled 4 receptor in a ligand-free state
- (2018) Shifan Yang et al. NATURE
- Breast cancer stem cells: Features, key drivers and treatment options
- (2018) Jürgen Dittmer SEMINARS IN CANCER BIOLOGY
- Oligomerization of Frizzled and LRP5/6 protein initiates intracellular signaling for the canonical WNT/β-catenin pathway
- (2018) Yue Hua et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- The signaling protein Wnt5a promotes TGFβ1-mediated macrophage polarization and kidney fibrosis by inducing the transcriptional regulators Yap/Taz
- (2018) Ye Feng et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- FZD5 is a Gαq-coupled receptor that exhibits the functional hallmarks of prototypical GPCRs
- (2018) Shane C. Wright et al. Science Signaling
- Frizzled-7 mediates TGF-β-induced pulmonary fibrosis by transmitting non-canonical Wnt signaling
- (2017) Shuhong Guan et al. EXPERIMENTAL CELL RESEARCH
- Mapping of Wnt-Frizzled interactions by multiplex CRISPR targeting of receptor gene families
- (2017) Oksana Voloshanenko et al. FASEB JOURNAL
- Wnt5a promotes Frizzled-4 signalosome assembly by stabilizing cysteine-rich domain dimerization
- (2017) Zachary J. DeBruine et al. GENES & DEVELOPMENT
- Bevacizumab and paclitaxel–carboplatin chemotherapy and secondary cytoreduction in recurrent, platinum-sensitive ovarian cancer (NRG Oncology/Gynecologic Oncology Group study GOG-0213): a multicentre, open-label, randomised, phase 3 trial
- (2017) Robert L Coleman et al. LANCET ONCOLOGY
- CAMK2γ in intestinal epithelial cells modulates colitis-associated colorectal carcinogenesis via enhancing STAT3 activation
- (2017) X Ma et al. ONCOGENE
- WNT antagonists exhibit unique combinatorial antitumor activity with taxanes by potentiating mitotic cell death
- (2017) Marcus M. Fischer et al. Science Advances
- Wnt-5a/Frizzled9 Receptor Signaling through the Gαo-Gβγ Complex Regulates Dendritic Spine Formation
- (2016) Valerie T. Ramírez et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Functional and prognostic significance of the genomic amplification of frizzled 6 (FZD6 ) in breast cancer
- (2016) Gabriele Corda et al. JOURNAL OF PATHOLOGY
- Genome-wide CRISPR screens reveal a Wnt–FZD5 signaling circuit as a druggable vulnerability of RNF43-mutant pancreatic tumors
- (2016) Zachary Steinhart et al. NATURE MEDICINE
- WNT5A: a motility-promoting factor in Hodgkin lymphoma
- (2016) F Linke et al. ONCOGENE
- USP6 oncogene promotes Wnt signaling by deubiquitylating Frizzleds
- (2016) Babita Madan et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Prostacyclin reverses the cigarette smoke-induced decrease in pulmonary Frizzled 9 expression through miR-31
- (2016) M. A. Tennis et al. Scientific Reports
- DNA methylation and hormone receptor status in breast cancer
- (2016) Elizaveta V. Benevolenskaya et al. Clinical Epigenetics
- WNT5A Inhibits Hepatocyte Proliferation and Concludes β-Catenin Signaling in Liver Regeneration
- (2015) Jing Yang et al. AMERICAN JOURNAL OF PATHOLOGY
- Paracrine WNT5A Signaling Inhibits Expansion of Tumor-Initiating Cells
- (2015) N. Borcherding et al. CANCER RESEARCH
- Alternative Wnt Signaling Activates YAP/TAZ
- (2015) Hyun Woo Park et al. CELL
- K-Ras Promotes Tumorigenicity through Suppression of Non-canonical Wnt Signaling
- (2015) Man-Tzu Wang et al. CELL
- Autocrine Signaling by Wnt-5a Deregulates Chemotaxis of Leukemic Cells and Predicts Clinical Outcome in Chronic Lymphocytic Leukemia
- (2015) P. Janovska et al. CLINICAL CANCER RESEARCH
- Insights into Frizzled evolution and new perspectives
- (2015) Quentin Schenkelaars et al. EVOLUTION & DEVELOPMENT
- A mutation in FRIZZLED2 impairs Wnt signaling and causes autosomal dominant omodysplasia
- (2015) H. M. Saal et al. HUMAN MOLECULAR GENETICS
- WNT5A Has Anti-Prostate Cancer Effects In Vitro and Reduces Tumor Growth in the Skeleton In Vivo
- (2015) Stefanie Thiele et al. JOURNAL OF BONE AND MINERAL RESEARCH
- Expression of WNT5A in Idiopathic Pulmonary Fibrosis and Its Control by TGF-β and WNT7B in Human Lung Fibroblasts
- (2015) Donna R. Newman et al. JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY
- Dishevelled Promotes Wnt Receptor Degradation through Recruitment of ZNRF3/RNF43 E3 Ubiquitin Ligases
- (2015) Xiaomo Jiang et al. MOLECULAR CELL
- Non-Canonical Wnt Predominates in Activated Rat Hepatic Stellate Cells, Influencing HSC Survival and Paracrine Stimulation of Kupffer Cells
- (2015) Laura Corbett et al. PLoS One
- Frizzled7 Functions as a Wnt Receptor in Intestinal Epithelial Lgr5+ Stem Cells
- (2015) Dustin J. Flanagan et al. Stem Cell Reports
- Frizzled receptor 6 marks rare, highly tumourigenic stem-like cells in mouse and human neuroblastomas.
- (2015) Sandra Cantilena et al. Oncotarget
- MiR-23a/-24-induced gene silencing results in mesothelial cell integration of pancreatic cancer
- (2014) H Listing et al. BRITISH JOURNAL OF CANCER
- Targeting the c-Met/FZD8 Signaling Axis Eliminates Patient-Derived Cancer Stem-like Cells in Head and Neck Squamous Carcinomas
- (2014) S. Sun et al. CANCER RESEARCH
- A Noncanonical Frizzled2 Pathway Regulates Epithelial-Mesenchymal Transition and Metastasis
- (2014) Taranjit S. Gujral et al. CELL
- Epigenetic Regulation of EMT: The Snail Story
- (2014) Yiwei Lin et al. CURRENT PHARMACEUTICAL DESIGN
- A microarray-based DNA methylation study of glioblastoma multiforme
- (2014) Ramon Martinez et al. Epigenetics
- Disheveled regulates precoupling of heterotrimeric G proteins to Frizzled 6
- (2014) Michaela B. C. Kilander et al. FASEB JOURNAL
- WNT5A induces release of exosomes containing pro-angiogenic and immunosuppressive factors from malignant melanoma cells
- (2014) Elin J Ekström et al. Molecular Cancer
- Interleukin-6 drives melanoma cell motility through p38α-MAPK-dependent up-regulation of WNT5A expression
- (2014) Rickard Linnskog et al. Molecular Oncology
- ΔNp63 promotes stem cell activity in mammary gland development and basal-like breast cancer by enhancing Fzd7 expression and Wnt signalling
- (2014) Rumela Chakrabarti et al. NATURE CELL BIOLOGY
- RNF43 is frequently mutated in colorectal and endometrial cancers
- (2014) Marios Giannakis et al. NATURE GENETICS
- The WNT receptor FZD7 is required for maintenance of the pluripotent state in human embryonic stem cells
- (2014) A. Fernandez et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- FZD7 drives in vitro aggressiveness in Stem-A subtype of ovarian cancer via regulation of non-canonical Wnt/PCP pathway
- (2014) M Asad et al. Cell Death & Disease
- BRMS1L suppresses breast cancer metastasis by inducing epigenetic silence of FZD10
- (2014) Chang Gong et al. Nature Communications
- Early aberrant DNA methylation events in a mouse model of acute myeloid leukemia
- (2014) Miriam Sonnet et al. Genome Medicine
- The Planar Cell Polarity Pathway Drives Pathogenesis of Chronic Lymphocytic Leukemia by the Regulation of B-Lymphocyte Migration
- (2013) M. Kaucka et al. CANCER RESEARCH
- Canonical Wnt Signaling Is Required for Pancreatic Carcinogenesis
- (2013) Y. Zhang et al. CANCER RESEARCH
- Tumor-Initiating Cells and FZD8 Play a Major Role in Drug Resistance in Triple-Negative Breast Cancer
- (2013) S. Yin et al. MOLECULAR CANCER THERAPEUTICS
- Identification of Highly Methylated Genes across Various Types of B-Cell Non-Hodgkin Lymphoma
- (2013) Nicole Bethge et al. PLoS One
- Inactivating mutations of RNF43 confer Wnt dependency in pancreatic ductal adenocarcinoma
- (2013) X. Jiang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Interference of Frizzled 1 (FZD1) reverses multidrug resistance in breast cancer cells through the Wnt/β-catenin pathway
- (2012) Hui Zhang et al. CANCER LETTERS
- Planar Cell Polarity Links Axes of Spatial Dynamics in Neural-Tube Closure
- (2012) Tamako Nishimura et al. CELL
- OCEANS: A Randomized, Double-Blind, Placebo-Controlled Phase III Trial of Chemotherapy With or Without Bevacizumab in Patients With Platinum-Sensitive Recurrent Epithelial Ovarian, Primary Peritoneal, or Fallopian Tube Cancer
- (2012) Carol Aghajanian et al. JOURNAL OF CLINICAL ONCOLOGY
- WNT7A Regulates Tumor Growth and Progression in Ovarian Cancer through the WNT/ -Catenin Pathway
- (2012) S. Yoshioka et al. MOLECULAR CANCER RESEARCH
- Tumour suppressor RNF43 is a stem-cell E3 ligase that induces endocytosis of Wnt receptors
- (2012) Bon-Kyoung Koo et al. NATURE
- Wnt5a-Ror-Dishevelled signaling constitutes a core developmental pathway that controls tissue morphogenesis
- (2012) H.-Y. H. Ho et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Wnt pathway inhibition via the targeting of Frizzled receptors results in decreased growth and tumorigenicity of human tumors
- (2012) A. Gurney et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Frizzled 4 Regulates Stemness and Invasiveness of Migrating Glioma Cells Established by Serial Intracranial Transplantation
- (2011) X. Jin et al. CANCER RESEARCH
- Systematic CpG Islands Methylation Profiling of Genes in the Wnt Pathway in Epithelial Ovarian Cancer Identifies Biomarkers of Progression-Free Survival
- (2011) W. Dai et al. CLINICAL CANCER RESEARCH
- Aberrations of EZH2 in Cancer
- (2011) A. Chase et al. CLINICAL CANCER RESEARCH
- MicroRNA-194 is a target of transcription factor 1 (Tcf1, HNF1α) in adult liver and controls expression of frizzled-6
- (2011) Jan Krützfeldt et al. HEPATOLOGY
- Soluble Frizzled-7 receptor inhibits Wnt signaling and sensitizes hepatocellular carcinoma cells towards doxorubicin
- (2011) Wei Wei et al. Molecular Cancer
- Tumor Suppressor MicroRNA-493 Decreases Cell Motility and Migration Ability in Human Bladder Cancer Cells by Downregulating RhoC and FZD4
- (2011) K. Ueno et al. MOLECULAR CANCER THERAPEUTICS
- Resistance or sensitivity of Wilms’ tumor to anti-FZD7 antibody highlights the Wnt pathway as a possible therapeutic target
- (2011) N Pode-Shakked et al. ONCOGENE
- FZD7 has a critical role in cell proliferation in triple negative breast cancer
- (2011) L Yang et al. ONCOGENE
- Genome-wide functional screening of miR-23b as a pleiotropic modulator suppressing cancer metastasis
- (2011) Hanshuo Zhang et al. Nature Communications
- FZD4 as a Mediator of ERG Oncogene-Induced WNT Signaling and Epithelial-to-Mesenchymal Transition in Human Prostate Cancer Cells
- (2010) S. Gupta et al. CANCER RESEARCH
- Canonical and noncanonical Wnts use a common mechanism to activate completely unrelated coreceptors
- (2010) L. Grumolato et al. GENES & DEVELOPMENT
- Pharmacological inhibition of Frizzled-7 displays anti-tumor properties in hepatocellular carcinoma
- (2010) Sarah Beseme Nambotin et al. JOURNAL OF HEPATOLOGY
- Transcriptional down-regulation of the Wnt antagonist SFRP1 in haematopoietic cells of patients with different risk types of MDS
- (2010) Jana Reins et al. LEUKEMIA RESEARCH
- Ror2/Frizzled Complex Mediates Wnt5a-Induced AP-1 Activation by Regulating Dishevelled Polymerization
- (2010) M. Nishita et al. MOLECULAR AND CELLULAR BIOLOGY
- Sprouty-4 Inhibits Transformed Cell Growth, Migration and Invasion, and Epithelial-Mesenchymal Transition, and Is Regulated by Wnt7A through PPAR in Non-Small Cell Lung Cancer
- (2010) M. A. Tennis et al. MOLECULAR CANCER RESEARCH
- RETRACTED: A Pleiotropically Acting MicroRNA, miR-31, Inhibits Breast Cancer Metastasis
- (2009) Scott Valastyan et al. CELL
- Wnt5a regulates distinct signalling pathways by binding to Frizzled2
- (2009) Akira Sato et al. EMBO JOURNAL
- Canonical Wnt signaling is antagonized by noncanonical Wnt5a in hepatocellular carcinoma cells
- (2009) Haluk Yuzugullu et al. Molecular Cancer
- The Wnt receptor FZD1 mediates chemoresistance in neuroblastoma through activation of the Wnt/β-catenin pathway
- (2009) M Flahaut et al. ONCOGENE
- Aberrant DNA methylation is a dominant mechanism in MDS progression to AML
- (2008) Y. Jiang et al. BLOOD
- Wnt5A Regulates Expression of Tumor-Associated Antigens in Melanoma via Changes in Signal Transducers and Activators of Transcription 3 Phosphorylation
- (2008) S. K. Dissanayake et al. CANCER RESEARCH
- Radioimmunotherapy of human synovial sarcoma using a monoclonal antibody against FZD10
- (2008) Chikako Fukukawa et al. CANCER SCIENCE
- Functional interaction between Wnt3 and Frizzled-7 leads to activation of the Wnt/β-catenin signaling pathway in hepatocellular carcinoma cells
- (2008) Miran Kim et al. JOURNAL OF HEPATOLOGY
- Frizzled-1 is down-regulated in follicular thyroid tumours and modulates growth and invasiveness
- (2008) A Ulivieri et al. JOURNAL OF PATHOLOGY
- The Extracellular Domain of Lrp5/6 Inhibits Noncanonical Wnt Signaling In Vivo
- (2008) Vitezslav Bryja et al. MOLECULAR BIOLOGY OF THE CELL
- Secreted Frizzled-Related Protein 4 Regulates Two Wnt7a Signaling Pathways and Inhibits Proliferation in Endometrial Cancer Cells
- (2008) K. S. Carmon et al. MOLECULAR CANCER RESEARCH
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