Article
Multidisciplinary Sciences
Felipe Valenca-Pereira, Qian Fang, Isabelle J. Marie, Emily L. Giddings, Karen A. Fortner, Rui Yang, Alejandro V. Villarino, Yina H. Huang, David A. Frank, Haitao Wen, David E. Levy, Mercedes Rincon
Summary: IL-6 enhances the mechanics of CD4 T cells, increasing their motility and mitochondrial Ca2+, ultimately improving their competitive fitness. This noncanonical pathway could lead to alternative therapeutic strategies for inflammatory diseases where IL-6 plays a pathogenic role.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Biotechnology & Applied Microbiology
Yanbo Wang, Yanling Yu, Wanjing Yu, Xun Bian, Linxia Gong
Summary: IL-35 inhibits cell pyroptosis and reduces asthma injury by suppressing the p38 MAPK pathway.
Article
Neurosciences
Houmin Lin, Steven Grant Dixon, Wei Hu, Eric D. Hamlett, Junfei Jin, Adviye Ergul, Gavin Y. Wang
Summary: Research suggests that the accumulation of amyloid beta (Aβ) plaques in the brain is a key factor in the development of Alzheimer's disease (AD). This study found that Aβ(1-40) oligomers stimulate the expression of IL-6 in human microglial cells. The activation of p38 MAPK is associated with this increase in IL-6. Inhibition of p38 MAPK can prevent Aβ-induced IL-6 production. These findings indicate that targeting p38 MAPK could be a potential approach to reduce neuroinflammation caused by Aβ accumulation in AD.
MOLECULAR NEUROBIOLOGY
(2022)
Article
Pharmacology & Pharmacy
Wei Yang, Jiaqi Su, Mingjing Li, Tiantian Li, Xu Wang, Mingdong Zhao, Xuemei Hu
Summary: Myricetin inhibits the proliferation of HCC cells by downregulating MARCH1 and affecting the p38 MAPK and Stat3 signaling pathways, ultimately suppressing HCC growth. This natural flavonol also induces autophagy and cell cycle arrest in HCC cells, demonstrating its anticancer properties.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Oncology
Stephen M. Douglass, Mitchell E. Fane, Emilio Sanseviero, Brett L. Ecker, Curtis H. Kugel, Reeti Behera, Vinit Kumar, Evgenii N. Tcyganov, Xiangfan Yin, Qin Liu, Yash Chhabra, Gretchen M. Alicea, Rejji Kuruvilla, Dmitry Gabrilovich, Ashani T. Weeraratna
Summary: The study demonstrates that myeloid cells play a major role in providing Wnt5A for metastatic potential in melanoma cells, and rely on Wnt5A for their immunosuppressive function.
Article
Chemistry, Multidisciplinary
Hyun-Soo Park, Joo-Hui Han, Jeong Won Park, Do-Hyung Lee, Keun-Woo Jang, Miji Lee, Kyung-Sun Heo, Chang-Seon Myung
Summary: The study found that sodium propionate (SP) inhibits proliferation and induces apoptosis in breast cancer cells by inhibiting JAK2/STAT3 signaling, increasing ROS levels, and activating p38 MAPK.
ACTA PHARMACOLOGICA SINICA
(2021)
Article
Dentistry, Oral Surgery & Medicine
Shohei Fukada, Kouji Ohta, Miyuki Sakuma, Misaki Akagi, Hiroki Kato, Takako Naruse, Takayuki Nakagawa, Hideo Shigeishi, Hiromi Nishi, Masaaki Takechi, Tomonao Aikawa
Summary: This study found that Sunitinib treatment can cause cell injury and apoptosis in oral keratinocytes, which is promoted by p38 activation and STAT3 downregulation. These findings suggest that oral mucosal complications may be associated with the cytotoxic effects of Sunitinib on oral keratinocytes.
Article
Multidisciplinary Sciences
Oleksi Petrenko, Jinyu Li, Velasco Cimica, Patricio Mena-Taboada, Ha Youn Shin, Stephen D'Amico, Nancy C. Reich
Summary: IL-6 is a critical tumor promoter in early stages of B cell lymphomagenesis, inhibiting tumor suppressors BIM and PTEN to advance MYC-driven B cell tumorigenesis.
Article
Biochemistry & Molecular Biology
Haoting Sun, Chaoqun Wang, Beiyuan Hu, Xiaomei Gao, Tiantian Zou, Qin Luo, Mo Chen, Yan Fu, Yuanyuan Sheng, Kaili Zhang, Yan Zheng, Xudong Ren, Shican Yan, Yan Geng, Luyu Yang, Qiongzhu Dong, Lunxiu Qin
Summary: Intercellular cross-talk in cancer progression and metastasis involves exosomes released by tumor cells, which play a crucial role in promoting metastasis potential. Specifically, exosomal S100A4 derived from highly metastatic hepatocellular carcinoma (HCC) cells was found to significantly enhance the invasion and metastasis of low metastatic HCC cells, serving as a potential prognostic marker and therapeutic target for HCC metastasis.
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2021)
Article
Pharmacology & Pharmacy
Run-Jing Li, Jia-Jia Xu, Zheng-Hao Zhang, Min-Wei Chen, Shi-Xiao Liu, Cui Yang, Yan-Ling Li, Ping Luo, Yi-Jiang Liu, Rong Tang, Zhong-Gui Shan
Summary: The anthraquinone rhein has been found to reduce transverse aortic constriction (TAC)-induced cardiac hypertrophy by inhibiting the molecular function of ERK and downregulating STAT3 and p38 MAPK signaling. Therapeutic doses of rhein have no significant adverse effects on liver and kidney function.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Vladimir Cermak, Aneta Skarkova, Ladislav Merta, Veronika Kolomaznikova, Veronika Palusova, Stjepan Uldrijan, Daniel Rosel, Jan Brabek
Summary: This study shows that phenotype plasticity in melanoma can be induced by treatment with p38 MAPK inhibitors, leading to a switch from a more dedifferentiated invasive phenotype to a more differentiated state. This phenotypic change is accompanied by alterations in gene expression and morphological transition, contributing to invasion and metastasis in melanoma.
Article
Cell Biology
Tongzhou Liang, Taiqiu Chen, Jincheng Qiu, Wenjie Gao, Xianjian Qiu, Yuanxin Zhu, Xudong Wang, Yanbo Chen, Hang Zhou, Zhihuai Deng, Pengfei Li, Caixia Xu, Yan Peng, Anjing Liang, Peiqiang Su, Bo Gao, Dongsheng Huang
Summary: Evidence suggests that ROR alpha plays a crucial role in cartilage development and OA pathogenesis by regulating the expression of cartilage matrix components. Blocking ROR alpha can reverse cartilage damage and elevate the expression of cartilage matrix components. Additionally, ROR alpha affects the IL-6/STAT3 signaling pathway, highlighting its potential as a treatment target in OA therapy.
CELL DEATH & DISEASE
(2021)
Article
Biochemistry & Molecular Biology
Zhihai Yuan, Zhen Yang, Weiqin Li, Aimei Wu, Zhixiang Su, Bin Jiang, Sakthivigneswari Ganesan
Summary: Triphlorethol-A (TA), a phlorotannin compound, exhibits cytoprotective and anticancer properties. By inhibiting JAK2/STAT3 and p38 MAPK/ERK signaling pathways, TA reduces GBM cell proliferation and induces apoptosis.
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Yin Shi, Shengfeng Xu, Natalie Y. L. Ngoi, Qi Zeng, Zu Ye
Summary: Hypoxia in the tumor microenvironment, causing excessive ROS and genomic instability, is a hallmark of cancer contributing to self-renewal, metastasis, and therapy resistance. PRL-3, an oncoprotein, has been found to regulate apoptosis resistance by negatively affecting p38 MAPK activity in response to hypoxia stress.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Junjue Chen, Huimin Zhong, Huan Yu, Jun Sun, Bingqiao Shen, Xing Xu, Shouyue Huang, Ping Huang, Yisheng Zhong
Summary: IL-17A plays a significant role in the regulation of retinal immune response and retinal ganglion cell death in glaucoma by promoting retinal microglial activation via p38 MAPK signaling pathway. Suppression of IL-17A contributes to alleviate glaucoma neuropathy.
Article
Oncology
Purusottam Mohapatra, Chandra Prakash Prasad, Tommy Andersson
MOLECULAR ONCOLOGY
(2019)
Review
Oncology
Abhishek Shankar, Anusha Dubey, Deepak Saini, Mayank Singh, Chandra Prakash Prasad, Shubham Roy, Sachidanand Jee Bharati, Minakshi Rinki, Navneet Singh, Tulika Seth, Meghal Khanna, Niharika Sethi, Sunil Kumar, Bhawna Sirohi, Anant Mohan, Randeep Guleria, Goura Kishor Rath
TRANSLATIONAL LUNG CANCER RESEARCH
(2019)
Article
Integrative & Complementary Medicine
Abhishek Shankar, Anusha Dubey, Deepak Saini, Chandra Prakash Prasad
CHINESE JOURNAL OF INTEGRATIVE MEDICINE
(2020)
Review
Biochemistry & Molecular Biology
J. R. Dev Arundhathi, Sandeep R. Mathur, Ajay Gogia, S. V. S. Deo, Purusottam Mohapatra, Chandra Prakash Prasad
Summary: Triple negative breast cancer (TNBC) has the worst prognosis among breast cancer subtypes and standard chemotherapy is the main treatment. Metabolic reprogramming, specifically altered glycolysis, plays a crucial role in TNBC progression, offering potential therapeutic targets.
MOLECULAR BIOLOGY REPORTS
(2021)
Article
Oncology
Sheikh Mohammad Umar, Sushmita Patra, Akanksha Kashyap, Arundhathi J. R. Dev, Lalit Kumar, Chandra Prakash Prasad
Summary: The study shows that overexpression of HuR protein is associated with reduced overall survival in TNBC patients, and the inhibition of cytoplasmic HuR by quercetin can suppress adhesion and migration of TNBC cells. This suggests a potential therapeutic role for quercetin in aggressive TNBC treatment.
NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL
(2022)
Article
Hematology
Sudhir Kumar, Atul Sharma, Prabhat Singh Malik, Ajay Gogia, Neha Pathak, Ranjit Kumar Sahoo, Ritu Gupta, Chandra Prakash Prasad, Lalit Kumar
Summary: This study evaluated the role of bendamustine, pomalidomide, and dexamethasone combination therapy in patients with resistant/refractory multiple myeloma. The results showed an overall response rate of 57.6% and median progression-free survival of 6.2 months. The combination therapy was well-tolerated with manageable toxicity.
BRITISH JOURNAL OF HAEMATOLOGY
(2022)
Article
Medicine, Research & Experimental
Akhil Santhosh, Akash Kumar, Raja Pramanik, Ajay Gogia, Chandra Prakash Prasad, Ishaan Gupta, Nishkarsh Gupta, Winson Y. Cheung, Ravindra Mohan Pandey, Atul Sharma, Atul Batra
Summary: This study aims to compare the efficacy of 1% topical diclofenac gel with placebo in preventing capecitabine-induced hand-foot syndrome. If the trial meets the primary endpoint, 1% topical diclofenac will become the new standard of care for HFS prevention.
Meeting Abstract
Oncology
B. Kataria, A. Sharma, R. Pramanik, R. Sahoo, S. Thulkar, M. Yadav, S. Mishra, C. Prasad, S. Vishnubhatla
ANNALS OF ONCOLOGY
(2022)
Article
Oncology
Neha Pathak, Aparna Sharma, Arunmozhimaran Elavarasi, Jeeva Sankar, S. V. S. Deo, Daya N. Sharma, Sandeep Mathur, Sudhir Kumar, Chandra P. Prasad, Akash Kumar, Atul Batra
Summary: The addition of carboplatin to neoadjuvant chemotherapy improves survival outcomes and pathological complete remission rate in patients with triple negative breast cancer.
Review
Oncology
Ajaz A. Bhat, Sabah Nisar, Mayank Singh, Bazella Ashraf, Tariq Masoodi, Chandra P. Prasad, Atul Sharma, Selma Maacha, Thasni Karedath, Sheema Hashem, Syed Besina Yasin, Puneet Bagga, Ravinder Reddy, Michael P. Frennaux, Shahab Uddin, Punita Dhawan, Mohammad Haris, Muzafar A. Macha
Summary: Colorectal cancer is a life-threatening cancer primarily caused by liver and peritoneal metastases. Intestinal inflammation, a known risk factor, creates an inflammatory environment enriched with various cells and factors. Aberrantly expressed cytokines and chemokines play a role in promoting CRC pathogenesis and influencing disease outcomes.
CANCER COMMUNICATIONS
(2022)
Review
Biotechnology & Applied Microbiology
Chandra Prakash Prasad, Satyendra Chandra Tripathi, Manish Kumar, Purusottam Mohapatra
Summary: Cancer cell lines are valuable models in cancer research, allowing for the examination and advancement of cancer progression, diagnostics, and treatments. Selecting the appropriate passage number is crucial to maintaining consistency and reliability of results.
BIOTECHNOLOGY AND BIOENGINEERING
(2023)
Article
Biochemistry & Molecular Biology
Akanksha Kashyap, Sheikh Mohammad Umar, J. R. Arundhathi Dev, Sandeep R. Mathur, Ajay Gogia, Atul Batra, S. V. S. Deo, Chandra Prakash Prasad
Summary: This study evaluated the prognostic and therapeutic relevance of PFKFB3 in triple-negative breast cancer (TNBC). It was found that PFKFB3 expression was associated with poor prognosis in TNBC patients, and treatment with PFK15 reduced the survival and migration of TNBC cells. These findings suggest that PFK15 could be a potential therapeutic agent for TNBC.
JOURNAL OF CELLULAR BIOCHEMISTRY
(2023)
Review
Immunology
Abhinava K. Mishra, Ashna Gupta, Gunjan Dagar, Dayasagar Das, Abhijit Chakraborty, Shabirul Haque, Chandra Prakash Prasad, Archana Singh, Ajaz A. Bhat, Muzafar A. Macha, Moez Benali, Kamal S. Saini, Rebecca Ann Previs, Deepak Saini, Dwaipayan Saha, Preyangsee Dutta, Aseem Rai Bhatnagar, Mrinalini Darswal, Abhishek Shankar, Mayank Singh
Summary: Significant progress has been made in the treatment of multiple myeloma, with CAR-T cell therapy showing promise as a cellular treatment option, particularly with BCMA as the target antigen. However, there are challenges such as antigenic escape and potential adverse reactions associated with CAR-T cell therapy.
Review
Oncology
Chandra Prakash Prasad, Ajay Gogia, Atul Batra
Summary: This review discusses the significance of epithelial-to-mesenchymal transition (EMT) in the metastasis and drug resistance of cancer cells, and highlights the important role of glycolytic enzymes in inducing this process.
CLINICAL & TRANSLATIONAL ONCOLOGY
(2022)
Article
Oncology
Sheikh Mohammad Umar, Akanksha Kashyap, Shruti Kahol, Sandeep R. Mathur, Ajay Gogia, S. V. S. Deo, Chandra Prakash Prasad
EXPERIMENTAL CELL RESEARCH
(2020)
Article
Oncology
Andra S. Martinikova, Miroslav Stoyanov, Anna Oravetzova, Yannick P. Kok, Shibo Yu, Jana Dobrovolna, Pavel Janscak, Marcel van Vugt, Libor Macurek
Summary: Oncogene-induced replication stress is a major cause of genome instability in cancer cells. This study reveals that increased activity of PPM1D exacerbates replication stress caused by cyclin E1 overexpression, leading to abnormal cell cycle progression and accumulation of DNA copy number alterations. Pharmacological inhibition of PPM1D can alleviate replication stress-induced genome instability.
MOLECULAR ONCOLOGY
(2024)
Article
Oncology
Alamelu G. Bharadwaj, Meghan E. McLean, Margaret L. Dahn, Hannah F. Cahill, Marie-Claire D. Wasson, Raj Pranap Arun, Olivia L. Walker, Brianne M. Cruickshank, Wasundara Fernando, Jaganathan Venkatesh, Penelope J. Barnes, Gillian Bethune, Gregory Knapp, Lucy K. Helyer, Carman A. Giacomantonio, David M. Waisman, Paola Marcato
Summary: ALDH1A3 regulates the plasminogen activation pathway to promote breast cancer metastasis. Co-expression of ALDH1A3 and tPA is associated with TNBC subtype, high tumor grade, and recurrent metastatic disease.
MOLECULAR ONCOLOGY
(2024)
Article
Oncology
Nayela N. Chowdhury, Yi Yang, Ananya Dutta, Michelle Luo, Zimu Wei, Sara R. Abrahams, Alexey S. Revenko, Fenil Shah, Lindsey A. Miles, Robert J. Parmer, Bas de Laat, Alisa S. Wolberg, James P. Luyendyk, Melissa L. Fishel, Matthew J. Flick
Summary: Pancreatic ductal adenocarcinoma (PDAC) is a highly fatal metastatic disease associated with robust activation of the coagulation and fibrinolytic systems. Primary fibrinolytic protease plasminogen promotes PDAC tumor growth and metastatic potential through engaging plasminogen receptors on tumor cells.
MOLECULAR ONCOLOGY
(2024)
Article
Oncology
Nuria Gendrau-Sanclemente, Agnes Figueras, Kristina Gracova, Alvaro Lahiguera, Elisenda Alsina-Sanchis, Juan A. Marin-Jimenez, August Vidal, Xavier Matias-Guiu, Sergi Fernandez-Gonzalez, Marc Barahona, Lola Marti, Jordi Ponce, Francesc Vinals
Summary: High-grade serous ovarian cancer (HGSOC), the deadliest gynecological malignancy, spreads through transcoelomic dissemination. This study reveals that platelet-derived growth factor receptor beta (PDGFRβ) is essential for the formation of tumorspheres in HGSOC. Inhibition of PDGFRβ blocks the clustering of ovarian cancer cells and prevents peritoneal dissemination.
MOLECULAR ONCOLOGY
(2024)