The signaling protein Wnt5a promotes TGFβ1-mediated macrophage polarization and kidney fibrosis by inducing the transcriptional regulators Yap/Taz

Deregulation of Hippo–TAZ pathway during renal injury confers a fibrotic maladaptive phenotype

(2018) Sandybell Anorga et al.   FASEB JOURNAL

Paracrine Wnt5a-β-Catenin Signaling Triggers a Metabolic Program that Drives Dendritic Cell Tolerization

(2018) Fei Zhao et al.   IMMUNITY

TGF-β1 regulates the expression and transcriptional activity of TAZ protein via a Smad3-independent, myocardin-related transcription factor-mediated mechanism

(2017) Maria Zena Miranda et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ovatodiolide suppresses colon tumorigenesis and prevents polarization of M2 tumor-associated macrophages through YAP oncogenic pathways

(2017) Yan-Jiun Huang et al.   Journal of Hematology & Oncology

Wnt5a is elevated in heart failure and affects cardiac fibroblast function

(2017) Aurelija Abraityte et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Tubule-Derived Wnts Are Required for Fibroblast Activation and Kidney Fibrosis

(2017) Dong Zhou et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Yap/Taz Deletion in Gli+Cell-Derived Myofibroblasts Attenuates Fibrosis

(2017) Ming Liang et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Wnt/ β -Catenin–Promoted Macrophage Alternative Activation Contributes to Kidney Fibrosis

(2017) Ye Feng et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Mechanobiology of YAP and TAZ in physiology and disease

(2017) Tito Panciera et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Hepatocyte TAZ/WWTR1 Promotes Inflammation and Fibrosis in Nonalcoholic Steatohepatitis

(2016) Xiaobo Wang et al.   Cell Metabolism

YAP/TAZ Are Mechanoregulators of TGF- -Smad Signaling and Renal Fibrogenesis

(2016) S. G. Szeto et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

PAK proteins and YAP-1 signalling downstream of integrin beta-1 in myofibroblasts promote liver fibrosis

(2016) Katherine Martin et al.   Nature Communications

Mechanosignaling through YAP and TAZ drives fibroblast activation and fibrosis

(2015) Fei Liu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Alternative Wnt Signaling Activates YAP/TAZ

(2015) Hyun Woo Park et al.   CELL

Involvement of the Hippo pathway in regeneration and fibrogenesis after ischaemic acute kidney injury: YAP is the key effector

(2015) J. Xu et al.   CLINICAL SCIENCE

Transcription Factors STAT6 and KLF4 Implement Macrophage Polarization via the Dual Catalytic Powers of MCPIP

(2015) Nidhi Kapoor et al.   JOURNAL OF IMMUNOLOGY

Differential Ly6C Expression after Renal Ischemia-Reperfusion Identifies Unique Macrophage Populations

(2015) M. Clements et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Macrophage Activation and Polarization: Nomenclature and Experimental Guidelines

(2014) Peter J. Murray et al.   IMMUNITY

Wnt5a Promotes Inflammatory Responses via Nuclear Factor κB (NF-κB) and Mitogen-activated Protein Kinase (MAPK) Pathways in Human Dental Pulp Cells

(2014) Yuan Zhao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of YAP by mTOR and autophagy reveals a therapeutic target of tuberous sclerosis complex

(2014) Ning Liang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Wnt5a-Rac1-NF- B Homeostatic Circuitry Sustains Innate Immune Functions in Macrophages

(2014) D. Naskar et al.   JOURNAL OF IMMUNOLOGY

Activation of Wnt5a-Ror2 signaling associated with epithelial-to-mesenchymal transition of tubular epithelial cells during renal fibrosis

(2013) Xin Li et al.   GENES TO CELLS

Yap- and Cdc42-Dependent Nephrogenesis and Morphogenesis during Mouse Kidney Development

(2013) Antoine Reginensi et al.   PLoS Genetics

Wnt/β-Catenin Signaling and Disease

(2012) Hans Clevers et al.   CELL

Macrophage plasticity and polarization: in vivo veritas

(2012) Antonio Sica et al.   JOURNAL OF CLINICAL INVESTIGATION

Wnt5a Induces a Tolerogenic Phenotype of Macrophages in Sepsis and Breast Cancer Patients

(2012) C. Bergenfelz et al.   JOURNAL OF IMMUNOLOGY

Wnt signalling in kidney diseases: dual roles in renal injury and repair

(2012) Takahisa Kawakami et al.   JOURNAL OF PATHOLOGY

Proteomic analysis of extracellular matrix from the hepatic stellate cell line LX-2 identifies CYR61 and Wnt-5a as novel constituents of fibrotic liver

(2012) S. Tamir Rashid et al.   JOURNAL OF PROTEOME RESEARCH

The Wingless homolog Wnt5a stimulates phagocytosis but not bacterial killing

(2012) G. Maiti et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Crumbs Complex Couples Cell Density Sensing to Hippo-Dependent Control of the TGF-β-SMAD Pathway

(2010) Xaralabos Varelas et al.   DEVELOPMENTAL CELL

WNT5A Is a Regulator of Fibroblast Proliferation and Resistance to Apoptosis

(2009) Louis J. Vuga et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Wnt/ -Catenin Signaling Promotes Podocyte Dysfunction and Albuminuria

(2009) C. Dai et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Wnt5A/CaMKII Signaling Contributes to the Inflammatory Response of Macrophages and Is a Target for the Antiinflammatory Action of Activated Protein C and Interleukin-10

(2008) Claudia Pereira et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

TAZ controls Smad nucleocytoplasmic shuttling and regulates human embryonic stem-cell self-renewal

(2008) Xaralabos Varelas et al.   NATURE CELL BIOLOGY