Oligomerization of Frizzled and LRP5/6 protein initiates intracellular signaling for the canonical WNT/β-catenin pathway

APC Inhibits Ligand-Independent Wnt Signaling by the Clathrin Endocytic Pathway

(2018) Kenyi Saito-Diaz et al.   DEVELOPMENTAL CELL

Deregulation of Frizzled Receptors in Hepatocellular Carcinoma

(2018) Kristy Chan et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Frizzled Receptors as Potential Therapeutic Targets in Human Cancers

(2018) Chui-Mian Zeng et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Frizzled-8 integrates Wnt-11 and transforming growth factor-β signaling in prostate cancer

(2018) Virginia Murillo-Garzón et al.   Nature Communications

Secreted Frizzled-related Protein 2 (sFRP2) Redirects Non-canonical Wnt Signaling from Fz7 to Ror2 during Vertebrate Gastrulation

(2016) Eva-Maria Brinkmann et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Essential role of the Dishevelled DEP domain in a Wnt-dependent human-cell-based complementation assay

(2016) Melissa V. Gammons et al.   JOURNAL OF CELL SCIENCE

Frizzleds and WNT/β-catenin signaling – The black box of ligand–receptor selectivity, complex stoichiometry and activation kinetics

(2015) Gunnar Schulte   EUROPEAN JOURNAL OF PHARMACOLOGY

Keeping Wnt Signalosome in Check by Vesicular Traffic

(2015) Qiang Feng et al.   JOURNAL OF CELLULAR PHYSIOLOGY

LRP5/6 directly bind to Frizzled and prevent Frizzled-regulated tumour metastasis

(2015) Dan-ni Ren et al.   Nature Communications

LRP6 dimerization through its LDLR domain is required for robust canonical Wnt pathway activation

(2014) Jinxiao Chen et al.   CELLULAR SIGNALLING

Disheveled regulates precoupling of heterotrimeric G proteins to Frizzled 6

(2014) Michaela B. C. Kilander et al.   FASEB JOURNAL

Signalosome assembly by domains undergoing dynamic head-to-tail polymerization

(2014) Mariann Bienz   TRENDS IN BIOCHEMICAL SCIENCES

WNT/Frizzled signalling: receptor-ligand selectivity with focus on FZD-G protein signalling and its physiological relevance: IUPHAR Review 3

(2013) J P Dijksterhuis et al.   BRITISH JOURNAL OF PHARMACOLOGY

Secreted Frizzled-related protein potentiation versus inhibition of Wnt3a/β-catenin signaling

(2013) Charles P. Xavier et al.   CELLULAR SIGNALLING

Sfrp1 and Sfrp2 are not involved in Wnt/β-catenin signal silencing during lens induction but are required for maintenance of Wnt/β-catenin signaling in lens epithelial cells

(2013) Yuki Sugiyama et al.   DEVELOPMENTAL BIOLOGY

Targeting Wnt-driven cancer through the inhibition of Porcupine by LGK974

(2013) J. Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural Basis of Wnt Recognition by Frizzled

(2012) C. Y. Janda et al.   SCIENCE

Frizzled and LRP5/6 Receptors for Wnt/ -Catenin Signaling

(2012) B. T. MacDonald et al.   Cold Spring Harbor Perspectives in Biology

Secreted frizzled-related proteins are required for Wnt/ -catenin signalling activation in the vertebrate optic cup

(2011) P. Esteve et al.   DEVELOPMENT

Structural and Functional Studies of LRP6 Ectodomain Reveal a Platform for Wnt Signaling

(2011) Shuo Chen et al.   DEVELOPMENTAL CELL

Wnt/β-catenin Signaling in Embryonic Stem Cell Self-renewal and Somatic Cell Reprogramming

(2011) Toshio Miki et al.   Stem Cell Reviews and Reports

Secreted Frizzled-related protein-2 (sFRP2) augments canonical Wnt3a-induced signaling

(2010) Zofia von Marschall et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Reconstitution of a Frizzled8·Wnt3a·LRP6 Signaling Complex Reveals Multiple Wnt and Dkk1 Binding Sites on LRP6

(2010) Eric Bourhis et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inhibition of tumorigenesis driven by different Wnt proteins requires blockade of distinct ligand-binding regions by LRP6 antibodies

(2010) S. A. Ettenberg et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Secreted Frizzled-related proteins enhance the diffusion of Wnt ligands and expand their signalling range

(2009) Y. Mii et al.   DEVELOPMENT

Wnt/β-Catenin Signaling: Components, Mechanisms, and Diseases

(2009) Bryan T. MacDonald et al.   DEVELOPMENTAL CELL

Wnt-signalling and the Metabolic Syndrome

(2009) S. Schinner   HORMONE AND METABOLIC RESEARCH

Nuclear Dvl, c-Jun, β-catenin, and TCF form a complex leading to stabiLization of β-catenin–TCF interaction

(2008) Xiao-qing Gan et al.   JOURNAL OF CELL BIOLOGY

Frequent epigenetic inactivation of SFRP genes in hepatocellular carcinoma

(2008) Hideyasu Takagi et al.   JOURNAL OF GASTROENTEROLOGY