Article
Biochemistry & Molecular Biology
Ya-Ning Shi, Le-Ping Liu, Chang-Feng Deng, Tan-Jun Zhao, Zhe Shi, Jian-Ye Yan, Yong-Zhen Gong, Duan-Fang Liao, Li Qin
Summary: The study found that celastrol effectively inhibited intimal hyperplasia and hyperproliferation of VSMCs by inducing autophagy, suggesting it may be a novel drug with great potential to prevent restenosis. The mechanism behind this effect involves lysosomal degradation of c-MYC and the Wnt5a/PKC/mTOR signaling pathway.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Pharmacology & Pharmacy
Mark W. Majesky, Mary C. M. Weiser -Evans
Summary: The adventitia is a complex and dynamic tissue that receives input signals from various sources to regulate the structural and mechanical properties of blood vessels. It plays a crucial role in vascular development, homeostasis, and repair.
BIOCHEMICAL PHARMACOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Jiachong Shi, Bo Zhou, Zhi Tian
Summary: This study aimed to explore the role and mechanism of long non-coding RNA DOCK9 antisense RNA2 (LncRNA DOCK9-AS2) in the proliferation and migration of vascular smooth muscle cells (VSMCs) in atherosclerosis. The results showed that DOCK9-AS2 promoted the proliferation and migration of VSMCs in atherosclerosis through regulating Wnt5a by targeting LIN28B.
Article
Physiology
Michael Schuliga, Amama Kanwal, Jane Read, Kaj E. C. Blokland, Janette K. Burgess, Cecilia M. Prele, Steven E. Mutsaers, Christopher Grainge, Claire Thomson, Allen James, Nathan W. Bartlett, Darryl A. Knight
Summary: The study found that cGAS expression is detected in fibrotic tissue from lungs of patients with idiopathic pulmonary fibrosis (IPF), and cGAS plays an important role in exacerbating AEC senescence. Pharmacological inhibition of cGAS can alleviate IPF-AEC senescence, suggesting cGAS as a potential therapeutic target for IPF.
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Hong-Yu Wu, Jia-Yang Li, Hao Wen, Yi-Qi Li, Ye-Li Li, Guang-Yue Li, Yan Jiang, Jun-Yuan Lv, Dan-li Yang
Summary: This study investigated the effects of Icariside II on vascular smooth muscle cell proliferation and neointimal hyperplasia. The results showed that Icariside II effectively inhibited abnormal vascular remodeling and triggered cell cycle arrest by suppressing the Wnt7b/CCND1 axis.
JOURNAL OF CARDIOVASCULAR PHARMACOLOGY
(2022)
Article
Multidisciplinary Sciences
Xue Liu, Simon C. Rowan, Jiurong Liang, Changfu Yao, Guanling Huang, Nan Deng, Ting Xie, Di Wu, Yizhou Wang, Ankita Burman, Tanyalak Parimon, Zea Borok, Peter Chen, William C. Parks, Cory M. Hogaboam, S. Samuel Weigt, John Belperio, Barry R. Stripp, Paul W. Noble, Dianhua Jiang
Summary: Pulmonary mesenchymal cells play critical roles in lung development and disease states in both mice and humans, showing high heterogeneity and subtype-specific transcriptomic differences which contribute to matrix gene expression in fibrosis. Comparative analysis reveals conserved transcriptomic signatures in orthologous subpopulations of murine and human lung mesenchymal cells, enhancing our understanding of mesenchymal cell diversity in lung development and disease conditions.
Article
Multidisciplinary Sciences
Tasuku Hiroshige, Kei-Ichiro Uemura, Shingo Hirashima, Akinobu Togo, Keisuke Ohta, Kei-Ichiro Nakamura, Tsukasa Igawa
Summary: This study explored the three-dimensional ultrastructure of interstitial cells within the lamina propria of the murine vas deferens, as well as their spatial relationships with surrounding cells. The results revealed the presence of sheet-like interstitial cells with multiple cellular processes, forming a complex three-dimensional network. These cells were in parallel alignment with the epithelium and connected to each other via gap junctions or adherens junctions. The study also observed the presence of extracellular vesicle-like structures around the interstitial cells.
SCIENTIFIC REPORTS
(2022)
Article
Cell Biology
Rachel E. Bell, Tanya J. Shaw
Summary: Research suggests that myofibroblasts are not consistently present in primary keloid lesions, and keloid scars may not necessarily require alpha SMA-positive myofibroblasts. Viewing keloid scars on a quantitative spectrum with normal or hypertrophic scars, using alpha SMA as a biomarker of disease severity, is hindering progress in understanding the disease mechanisms and developing therapies.
WOUND REPAIR AND REGENERATION
(2021)
Article
Biochemistry & Molecular Biology
Rossana Visigalli, Bianca Maria Rotoli, Francesca Ferrari, Maria Di Lascia, Benedetta Riccardi, Paola Puccini, Valeria Dall'Asta, Amelia Barilli
Summary: In this study, the expression and activity of ABC transporters in human alveoli were analyzed. The results showed that MRP1 was the only transporter expressed and functional at the basolateral side, while the other studied transporters were not expressed on the apical membrane. This suggests the presence of unidentified transporters involved in drug efflux from alveolar epithelium.
Article
Cell Biology
Jian Deng, Shao-Hua Wang, Xue-Mei Zheng, Zan-Mei Tang
Summary: The study showed that CGRP can promote cell viability and inhibit hyperoxia-induced transdifferentiation of AECII, reducing oxidative injury and inflammation. Additionally, CGRP activates the Notch signaling pathway, promoting structural and functional regeneration.
Article
Developmental Biology
Karol Kaiser, Ahram Jang, Petra Kompanikova, Melody P. Lun, Jan Prochazka, Ondrej Machon, Neil Dani, Michaela Prochazkova, Benoit Laurent, Daniel Gyllborg, Renee van Amerongen, Ryann M. Fame, Suhasini Gupta, Feizhen Wu, Roger A. Barker, Ivana Bukova, Radislav Sedlacek, Zbynek Kozmik, Ernest Arenas, Maria K. Lehtinen, Vitezslav Bryja
Summary: The study reveals the dual role of WNT5A in ChP development and identifies MEIS transcription factors as upstream regulators of Wnt5a in the 4V ChP epithelium.
Article
Biochemistry & Molecular Biology
Abid A. Reza, Fatemeh Kohram, Hasan A. Reza, Timothy R. Kalin, Paranthaman S. Kannan, William J. Zacharias, Vladimir V. Kalinichenko
Summary: Mutations in the FOXF1 gene are associated with alveolar capillary dysplasia with misalignment of pulmonary veins (ACDMPV), leading to abnormal lung development. The mutant FOXF1 stimulates WNT/beta-catenin signaling, resulting in increased proliferation and decreased differentiation of alveolar epithelial cells. The activation of Wnt5a gene transcription by FOXF1 is crucial for the abnormal epithelial cell expansion and differentiation.
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
(2023)
Review
Cardiac & Cardiovascular Systems
Mandy O. J. Grootaert, Martin R. Bennett
Summary: Vascular smooth muscle cells play a key role in atherosclerosis by forming a protective fibrous cap and exhibiting various phenotypes that can affect plaque formation and stability. They are a larger proportion of atherosclerotic plaques than previously thought and their plasticity is regulated by various mechanisms.
CARDIOVASCULAR RESEARCH
(2021)
Article
Oncology
Nada Ragab, Julia Bauer, Anja Uhmann, Alexander Marx, Heidi Hahn, Katja Simon-Keller
Summary: Rhabdomyosarcoma (RMS) is an aggressive soft tissue malignancy that mainly affects children. The WNT5A ligand of the non-canonical WNT signaling pathway has been found to have tumor suppressive functions in ERMS and ARMS, decreasing proliferation, migration, self-renewal capacity, and stem cell marker expression of RMS cells. Additionally, WNT5A influences the levels of muscle differentiation markers and destabilizes active beta-Catenin in RMS cells.
INTERNATIONAL JOURNAL OF ONCOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Kaveeta Kaw, Abhijnan Chattopadhyay, Pujun Guan, Jiyuan Chen, Suravi Majumder, Xue-yan Duan, Shuangtao Ma, Chen Zhang, Callie S. Kwartler, Dianna M. Milewicz
Summary: This study investigates how the variant p.Arg149Cys in ACTA2 gene predisposes to atherosclerosis in individuals without cardiovascular risk factors. The variant increases intracellular cholesterol levels in smooth muscle cells, leading to atherosclerotic plaque formation. Treatment with the HMG-CoAR inhibitor pravastatin successfully reverses the increased plaque burden.
EUROPEAN HEART JOURNAL
(2023)
Article
Veterinary Sciences
A. L. Ziegler, C. K. Freeman, C. A. Fogle, M. J. Burke, J. L. Davis, V. L. Cook, L. L. Southwood, A. T. Blikslager
EQUINE VETERINARY JOURNAL
(2019)
Letter
Veterinary Sciences
A. L. Ziegler, C. A. Fogle, M. Burke, A. T. Blikslager
EQUINE VETERINARY JOURNAL
(2019)
Article
Veterinary Sciences
A. L. Ziegler, A. T. Blikslager
EQUINE VETERINARY EDUCATION
(2020)
Meeting Abstract
Biochemistry & Molecular Biology
Lindsey Shapiro, Amanda Ziegler, Jack Odle, Laurianne Van Landeghem, Anthony Blikslager
Meeting Abstract
Biochemistry & Molecular Biology
Amanda Ziegler, Anthony Blikslager
Meeting Abstract
Biochemistry & Molecular Biology
Sara Erwin, Melissa Touvron, Jack Odle, Laurianne Van Landeghem, Anthony Blikslager, Amanda Ziegler
Review
Biochemistry & Molecular Biology
Elizabeth C. Rose, Jack Odle, Anthony T. Blikslager, Amanda L. Ziegler
Summary: This review summarizes the effects of probiotics and prebiotics on the intestinal epithelial barrier and non-epithelial barrier constituents, such as the enteric glial cell network, and investigates their potential therapeutic benefits in preventing and treating gastrointestinal diseases associated with impaired intestinal barrier function and dysbiosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Veterinary Sciences
Emily A. Hellstrom, Amanda L. Ziegler, Anthony T. Blikslager
Summary: Postoperative ileus (POI) is a significant issue after surgery, with neurogenic and inflammatory phases being the main components of its pathophysiology. Perioperative care, NSAIDs, and prokinetic therapy are commonly used treatments for POI, but the optimal management remains controversial. Further research on various factors influencing postoperative gastrointestinal motility and the development of POI may provide future treatment strategies.
FRONTIERS IN VETERINARY SCIENCE
(2021)
Article
Agriculture, Dairy & Animal Science
Sara J. Erwin, Anthony T. Blikslager, Amanda L. Ziegler
Summary: Equine colic poses a significant financial burden on horse owners and the equine industry. Research focuses on preventing and improving treatment options for colic. Recent studies have explored intestinal injury mechanisms and highlighted the importance of various intestinal systems in repairing the intestine after colic, with potential impacts on age-dependent outcomes.
Article
Agriculture, Dairy & Animal Science
Sara J. Erwin, Marley E. Clark, Julie E. Dechant, Maia R. Aitken, Diana M. Hassel, Anthony T. Blikslager, Amanda L. Ziegler
Summary: This study compares the survival rates of foals and adults following surgery for colic lesions. The results show that there is no significant difference in short-term survival between foals and adults, possibly due to the impact of decision-making on the farm prior to referral. This suggests that there may be more optimism towards surgical treatment for foals with suspected SISO.
Review
Veterinary Sciences
Elizabeth C. Rose, Anthony T. Blikslager, Amanda L. Ziegler
Summary: Disturbances in the gastrointestinal microbial composition are associated with various diseases, and pigs serve as a powerful translational model due to their similarities with humans in terms of intestinal microbiota, gastrointestinal anatomy, and physiology. The utilization of gnotobiotic pigs has significantly enhanced our understanding of gastrointestinal diseases and holds potential for future research and therapeutics.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Review
Medicine, Research & Experimental
Kasey D. Boger, Ana E. Sheridan, Amanda L. Ziegler, Anthony T. Blikslager
Summary: This article focuses on the use of in vitro injury models and intestinal cell lines to study the mechanisms of intestinal epithelial repair, which is critical for maintaining barrier integrity.
Meeting Abstract
Agriculture, Dairy & Animal Science
Timothy E. Boston, Feng Wang, Lin Xi, Sung Woo Kim, Vivek Fellner, Mark F. Scott, Amanda L. Ziegler, Laurianne Van Landeghem, Anthony T. Blikslager, Jack Odle
JOURNAL OF ANIMAL SCIENCE
(2023)
Article
Gastroenterology & Hepatology
Kristina R. Rivera, R. Jarrett Bilton, Joseph Burclaff, Michael J. Czerwinski, Jintong Liu, Jessica M. Trueblood, Caroline M. Hinesley, Keith A. Breau, Halston E. Deal, Shlok Joshi, Vladimir A. Pozdin, Ming Yao, Amanda L. Ziegler, Anthony T. Blikslager, Michael A. Daniele, Scott T. Magness
Summary: This study investigated the effects of hypoxia on human intestinal stem cells using a micro-physiological system. The results showed that hypoxia induces a dormant state in intestinal stem cells, but they can be reactivated by specific interleukins. These findings are important for understanding the mechanisms of intestinal epithelial regeneration caused by inflammatory hypoxia.
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Medicine, Research & Experimental
Amanda L. Ziegler, Tiffany A. Pridgen, Anthony T. Blikslager