Innate immune memory: Implications for host responses to damage-associated molecular patterns

DAMPs, ageing, and cancer: The ‘DAMP Hypothesis’

(2015) Jin Huang et al.   AGEING RESEARCH REVIEWS

DAMPs as mediators of sterile inflammation in aging-related pathologies

(2015) Noa Feldman et al.   AGEING RESEARCH REVIEWS

Soluble uric acid primes TLR-induced proinflammatory cytokine production by human primary cells via inhibition of IL-1Ra

(2015) Tania O Crișan et al.   ANNALS OF THE RHEUMATIC DISEASES

The Role of HMGB1 in Cardiovascular Biology: Danger Signals

(2015) Jingjing Cai et al.   ANTIOXIDANTS & REDOX SIGNALING

Extracellular ATP induces P2X7 receptor activation in mouse Kupffer cells, leading to release of IL-1β, HMGB1, and PGE2, decreased MHC class I expression and necrotic cell death

(2015) Yusuke Toki et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

HMGB1 induces angiogenesis in rheumatoid arthritis via HIF-1α activation

(2015) So Youn Park et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Bone-Marrow-Resident NK Cells Prime Monocytes for Regulatory Function during Infection

(2015) Michael H. Askenase et al.   IMMUNITY

CD36 Binds Oxidized Low Density Lipoprotein (LDL) in a Mechanism Dependent upon Fatty Acid Binding

(2015) Anthony G. Jay et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Human Cytokine-Induced Memory-Like Natural Killer Cells

(2015) Melissa M. Berrien-Elliott et al.   Journal of Innate Immunity

Trained innate immunity as underlying mechanism for the long-term, nonspecific effects of vaccines

(2015) Bastiaan A. Blok et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Innate immune memory: a paradigm shift in understanding host defense

(2015) Mihai G Netea et al.   NATURE IMMUNOLOGY

Innate lymphoid cells in the initiation, regulation and resolution of inflammation

(2015) Gregory F Sonnenberg et al.   NATURE MEDICINE

Trained immunity in newborn infants of HBV-infected mothers

(2015) Michelle Hong et al.   Nature Communications

Extracellular MRP8/14 is a regulator of β2 integrin-dependent neutrophil slow rolling and adhesion

(2015) Monika Pruenster et al.   Nature Communications

Uric Acid Produces an Inflammatory Response through Activation of NF-κB in the Hypothalamus: Implications for the Pathogenesis of Metabolic Disorders

(2015) Wenjie Lu et al.   Scientific Reports

Advanced Glycation End Products Enhance Macrophages Polarization into M1 Phenotype through Activating RAGE/NF-κB Pathway

(2015) Xian Jin et al.   Biomed Research International

Skewed Epigenetics: An Alternative Therapeutic Option for Diabetes Complications

(2015) Gabriele Togliatto et al.   Journal of Diabetes Research

Epigenetic Changes in Endothelial Progenitors as a Possible Cellular Basis for Glycemic Memory in Diabetic Vascular Complications

(2015) Poojitha Rajasekar et al.   Journal of Diabetes Research

Super-low Dose Endotoxin Pre-conditioning Exacerbates Sepsis Mortality

(2015) Keqiang Chen et al.   EBioMedicine

The Effect of Hyperglycaemia on In Vitro Cytokine Production and Macrophage Infection with Mycobacterium tuberculosis

(2015) Ekta Lachmandas et al.   PLoS One

AMP-activated protein kinase suppresses urate crystal-induced inflammation and transduces colchicine effects in macrophages

(2014) Yun Wang et al.   ANNALS OF THE RHEUMATIC DISEASES

Oxidized Low-Density Lipoprotein Induces Long-Term Proinflammatory Cytokine Production and Foam Cell Formation via Epigenetic Reprogramming of Monocytes

(2014) Siroon Bekkering et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Trained Immunity or Tolerance: Opposing Functional Programs Induced in Human Monocytes after Engagement of Various Pattern Recognition Receptors

(2014) Daniela C. Ifrim et al.   Clinical and Vaccine Immunology

BCG-induced trained immunity in NK cells: Role for non-specific protection to infection

(2014) Johanneke Kleinnijenhuis et al.   CLINICAL IMMUNOLOGY

New gout test: enhanced ex vivo cytokine production from PBMCS in common gout patients and a gout patient with Kearns-Sayre syndrome

(2014) Tim L. Jansen et al.   CLINICAL RHEUMATOLOGY

Complement C5a potentiates uric acid crystal-induced IL-1β production

(2014) Ling-Ling An et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Dynamic Modulation of Innate Immune Response by Varying Dosages of Lipopolysaccharide (LPS) in Human Monocytic Cells

(2014) Matthew C. Morris et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

S100A4 and Uric Acid Promote Mesenchymal Stromal Cell Induction of IL-10+/IDO+ Lymphocytes

(2014) J. L. Eisenbacher et al.   JOURNAL OF IMMUNOLOGY

Diet-induced (epigenetic) changes in bone marrow augment atherosclerosis

(2014) Erik van Kampen et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Neutrophils prime a long-lived effector macrophage phenotype that mediates accelerated helminth expulsion

(2014) Fei Chen et al.   NATURE IMMUNOLOGY

The mechanism of action of BCG therapy for bladder cancer—a current perspective

(2014) Gil Redelman-Sidi et al.   Nature Reviews Urology

mTOR- and HIF-1 -mediated aerobic glycolysis as metabolic basis for trained immunity

(2014) S.-C. Cheng et al.   SCIENCE

Epigenetic programming of monocyte-to-macrophage differentiation and trained innate immunity

(2014) S. Saeed et al.   SCIENCE

The Role of High Mobility Group Box 1 in Innate Immunity

(2014) Shin-Ae Lee et al.   YONSEI MEDICAL JOURNAL

Bone Marrow Dendritic Cells from Mice with an Altered Microbiota Provide Interleukin 17A-Dependent Protection against Entamoeba histolytica Colitis

(2014) Stacey L. Burgess et al.   mBio

Autophagy Controls BCG-Induced Trained Immunity and the Response to Intravesical BCG Therapy for Bladder Cancer

(2014) Kathrin Buffen et al.   PLoS Pathogens

Danger signals – damaged-self recognition across the tree of life

(2014) Martin Heil et al.   Frontiers in Plant Science

Myeloid-Related Proteins 8 and 14 Contribute to Monosodium Urate Monohydrate Crystal-Induced Inflammation in Gout

(2014) Dirk Holzinger et al.   Arthritis & Rheumatology

Latent Enhancers Activated by Stimulation in Differentiated Cells

(2013) Renato Ostuni et al.   CELL

Trained innate immunity and atherosclerosis

(2013) Siroon Bekkering et al.   CURRENT OPINION IN LIPIDOLOGY

Detection of a TLR2 agonist by hematopoietic stem and progenitor cells impacts the function of the macrophages they produce

(2013) Alberto Yáñez et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Uric acid, chronic kidney disease and type 2 diabetes: A cluster of vascular risk factors

(2013) Vasilios G. Athyros et al.   JOURNAL OF DIABETES AND ITS COMPLICATIONS

Succinate is an inflammatory signal that induces IL-1β through HIF-1α

(2013) G. M. Tannahill et al.   NATURE

Microtubule-driven spatial arrangement of mitochondria promotes activation of the NLRP3 inflammasome

(2013) Takuma Misawa et al.   NATURE IMMUNOLOGY

High-density lipoprotein mediates anti-inflammatory reprogramming of macrophages via the transcriptional regulator ATF3

(2013) Dominic De Nardo et al.   NATURE IMMUNOLOGY

Innate immune memory: implications for development of pediatric immunomodulatory agents and adjuvanted vaccines

(2013) Ofer Levy et al.   PEDIATRIC RESEARCH

High-Mobility Group Box 1 Mediates Persistent Splenocyte Priming in Sepsis Survivors

(2013) Sergio I. Valdés-Ferrer et al.   SHOCK

A small jab – a big effect: nonspecific immunomodulation by vaccines

(2013) Christine S. Benn et al.   TRENDS IN IMMUNOLOGY

Epigenetics and Bacterial Infections

(2013) H. Bierne et al.   Cold Spring Harbor Perspectives in Medicine

The Interleukin-1α Precursor is Biologically Active and is Likely a Key Alarmin in the IL-1 Family of Cytokines

(2013) Busun Kim et al.   Frontiers in Immunology

Cytokine activation induces human memory-like NK cells

(2012) R. Romee et al.   BLOOD

Candida albicans Infection Affords Protection against Reinfection via Functional Reprogramming of Monocytes

(2012) Jessica Quintin et al.   Cell Host & Microbe

A Human Challenge Model for Mycobacterium tuberculosis Using Mycobacterium bovis Bacille Calmette-Guérin

(2012) Angela M. Minassian et al.   JOURNAL OF INFECTIOUS DISEASES

HMGB1: A multifunctional alarmin driving autoimmune and inflammatory disease

(2012) Helena Erlandsson Harris et al.   Nature Reviews Rheumatology

Bacille Calmette-Guerin induces NOD2-dependent nonspecific protection from reinfection via epigenetic reprogramming of monocytes

(2012) J. Kleinnijenhuis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Enhanced interleukin-1β production of PBMCs from patients with gout after stimulation with Toll-like receptor-2 ligands and urate crystals

(2012) Eleni E Mylona et al.   ARTHRITIS RESEARCH & THERAPY

The danger theory: 20 years later

(2012) Thomas Pradeu et al.   Frontiers in Immunology

Prior exposure to oxidized low-density lipoprotein limits apoptosis in subsequent generations of endothelial cells by altering promoter methylation

(2011) Sona Mitra et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Trained Immunity: A Memory for Innate Host Defense

(2011) Mihai G. Netea et al.   Cell Host & Microbe

Atherosclerosis: An Epigenetic Balancing Act that Goes Wrong

(2011) Gertrud Lund et al.   Current Atherosclerosis Reports

IL-1  and IL-1  Recruit Different Myeloid Cells and Promote Different Stages of Sterile Inflammation

(2011) P. Rider et al.   JOURNAL OF IMMUNOLOGY

Randomized Trial of BCG Vaccination at Birth to Low-Birth-Weight Children: Beneficial Nonspecific Effects in the Neonatal Period?

(2011) Peter Aaby et al.   JOURNAL OF INFECTIOUS DISEASES

The immune system in atherosclerosis

(2011) Göran K Hansson et al.   NATURE IMMUNOLOGY

Small Randomized Trial Among Low–birth-weight Children Receiving Bacillus Calmette-Guéerin Vaccination at First Health Center Contact

(2011) Sofie Biering-Sørensen et al.   PEDIATRIC INFECTIOUS DISEASE JOURNAL

The Role of Uric Acid as an Endogenous Danger Signal in Immunity and Inflammation

(2011) Faranak Ghaemi-Oskouie et al.   Current Rheumatology Reports

The non-specific effects of vaccines

(2010) F. Shann   ARCHIVES OF DISEASE IN CHILDHOOD

Engagement of fatty acids with toll-like receptor 2 drives interleukin-1β production via the ASC/caspase 1 pathway in monosodium urate monohydrate crystal-induced gouty arthritis

(2010) Leo A. B. Joosten et al.   ARTHRITIS AND RHEUMATISM

HMGB proteins: Interactions with DNA and chromatin

(2010) Michal Štros   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

HMGB1, a potent proinflammatory cytokine in sepsis

(2010) Wenchang Huang et al.   CYTOKINE

The Anti-Inflammatory Activity of HMGB1 A Box Is Enhanced When Fused with C-Terminal Acidic Tail

(2010) Wei Gong et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

Epigenetics in atherosclerosis and inflammation

(2010) Rutger J. Wierda et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Uric acid promotes an acute inflammatory response to sterile cell death in mice

(2010) Hajime Kono et al.   JOURNAL OF CLINICAL INVESTIGATION

Adaptive immune features of natural killer cells

(2009) Joseph C. Sun et al.   NATURE

Cytokine-induced memory-like natural killer cells

(2009) Megan A. Cooper et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Crystals of monosodium urate monohydrate enhance lipopolysaccharide-induced release of interleukin 1  by mononuclear cells through a caspase 1-mediated process

(2008) E J Giamarellos-Bourboulis et al.   ANNALS OF THE RHEUMATIC DISEASES

Differential requirement for the activation of the inflammasome for processing and release of IL-1  in monocytes and macrophages

(2008) M. G. Netea et al.   BLOOD

Transient high glucose causes persistent epigenetic changes and altered gene expression during subsequent normoglycemia

(2008) Assam El-Osta et al.   JOURNAL OF EXPERIMENTAL MEDICINE

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(2008) John Klune et al.   MOLECULAR MEDICINE