Myeloid-Related Proteins 8 and 14 Contribute to Monosodium Urate Monohydrate Crystal-Induced Inflammation in Gout

The Toll-like receptor 4 agonist MRP8/14 protein complex is a sensitive indicator for disease activity and predicts relapses in systemic-onset juvenile idiopathic arthritis

(2012) Dirk Holzinger et al.   ANNALS OF THE RHEUMATIC DISEASES

MRP8 and MRP14, phagocyte-specific danger signals, are sensitive biomarkers of disease activity in cryopyrin-associated periodic syndromes

(2011) H. Wittkowski et al.   ANNALS OF THE RHEUMATIC DISEASES

Canakinumab for the treatment of acute flares in difficult-to-treat gouty arthritis: Results of a multicenter, phase II, dose-ranging study

(2010) Alexander So et al.   ARTHRITIS AND RHEUMATISM

Engagement of fatty acids with toll-like receptor 2 drives interleukin-1β production via the ASC/caspase 1 pathway in monosodium urate monohydrate crystal-induced gouty arthritis

(2010) Leo A. B. Joosten et al.   ARTHRITIS AND RHEUMATISM

Cellular characterization of the gouty tophus: A quantitative analysis

(2010) Nicola Dalbeth et al.   ARTHRITIS AND RHEUMATISM

Methotrexate Withdrawal at 6 vs 12 Months in Juvenile Idiopathic Arthritis in RemissionA Randomized Clinical Trial

(2010) Dirk Foell   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

The Toll-like receptor 4 ligands Mrp8 and Mrp14 are crucial in the development of autoreactive CD8+ T cells

(2010) Karin Loser et al.   NATURE MEDICINE

Update on gout: new therapeutic strategies and options

(2010) Robert Terkeltaub   Nature Reviews Rheumatology

The Inflammasomes: Guardians of the Body

(2009) Fabio Martinon et al.   Annual Review of Immunology

In vivo regulation of interleukin 1β in patients with cryopyrin-associated periodic syndromes

(2009) Helen J. Lachmann et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Crystals of monosodium urate monohydrate enhance lipopolysaccharide-induced release of interleukin 1  by mononuclear cells through a caspase 1-mediated process

(2008) E J Giamarellos-Bourboulis et al.   ANNALS OF THE RHEUMATIC DISEASES

Myeloid-related protein 8/14 and the risk of cardiovascular death or myocardial infarction after an acute coronary syndrome in the Pravastatin or Atorvastatin Evaluation and Infection Theraphy: Thrombolysis in Myocardial Infarction (PROVE IT-TIMI 22) trial

(2007) David A. Morrow et al.   AMERICAN HEART JOURNAL

Myeloid-related proteins S100A8/S100A9 regulate joint inflammation and cartilage destruction during antigen-induced arthritis

(2007) P L E M van Lent et al.   ANNALS OF THE RHEUMATIC DISEASES