Evidence and perspectives of cell senescence in neurodegenerative diseases

High expression of SMYD3 indicates poor survival outcome and promotes tumour progression through an IGF-1R/AKT/E2F-1 positive feedback loop in bladder cancer

(2020) Guoliang Wang et al.   Aging-US

Senescent Cells: Emerging Targets for Human Aging and Age-Related Diseases

(2020) Shuling Song et al.   TRENDS IN BIOCHEMICAL SCIENCES

Reducing Senescent Cell Burden in Aging and Disease

(2020) Robert J. Pignolo et al.   TRENDS IN MOLECULAR MEDICINE

Mitochondrial phosphatase PGAM5 modulates cellular senescence by regulating mitochondrial dynamics

(2020) Bo Yu et al.   Nature Communications

Cellular senescence and Alzheimer disease: the egg and the chicken scenario

(2020) Sara Saez-Atienzar et al.   NATURE REVIEWS NEUROSCIENCE

Persistent telomere cohesion protects aged cells from premature senescence

(2020) Kameron Azarm et al.   Nature Communications

DNA damage repair response in mesenchymal stromal cells: From cellular senescence and aging to apoptosis and differentiation ability

(2020) Behnaz banimohamad-shotorbani et al.   AGEING RESEARCH REVIEWS

Genome folding and refolding in differentiation and cellular senescence

(2020) Athanasia Mizi et al.   CURRENT OPINION IN CELL BIOLOGY

Ryanodine Receptor Glycation Favors Mitochondrial Damage in the Senescent Heart

(2019) Marisol Ruiz-Meana et al.   CIRCULATION

Mechanisms of Mitochondrial DNA Deletion Formation

(2019) Nadee Nissanka et al.   TRENDS IN GENETICS

Cellular senescence in progenitor cells contributes to diminished remyelination potential in progressive multiple sclerosis

(2019) Alexandra M. Nicaise et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

High Hes1 expression and resultant Ascl1 suppression regulate quiescent vs. active neural stem cells in the adult mouse brain

(2019) Risa Sueda et al.   GENES & DEVELOPMENT

Targeted Elimination of Senescent Beta Cells Prevents Type 1 Diabetes

(2019) Peter J. Thompson et al.   Cell Metabolism

Mitochondrial Permeability Uncouples Elevated Autophagy and Lifespan Extension

(2019) Ben Zhou et al.   CELL

Mitophagy and NAD+ inhibit Alzheimer disease

(2019) Evandro F. Fang   Autophagy

Astrocyte senescence: Evidence and significance

(2019) Justin Cohen et al.   AGING CELL

The NADase CD38 is induced by factors secreted from senescent cells providing a potential link between senescence and age-related cellular NAD+ decline

(2019) Claudia Chini et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Obesity-Induced Cellular Senescence Drives Anxiety and Impairs Neurogenesis

(2019) Mikolaj Ogrodnik et al.   Cell Metabolism

Senolytic therapy alleviates Aβ-associated oligodendrocyte progenitor cell senescence and cognitive deficits in an Alzheimer’s disease model

(2019) Peisu Zhang et al.   NATURE NEUROSCIENCE

Adipose-derived stem cells: Sources, potency, and implications for regenerative therapies

(2019) Zizhen Si et al.   BIOMEDICINE & PHARMACOTHERAPY

The role of telomeres and telomerase in cirrhosis and liver cancer

(2019) Jean-Charles Nault et al.   Nature Reviews Gastroenterology & Hepatology

The innate immune sensor Toll-like receptor 2 controls the senescence-associated secretory phenotype

(2019) Priya Hari et al.   Science Advances

Microglia and the Aging Brain: Are Senescent Microglia the Key to Neurodegeneration?

(2019) Dafina M. Angelova et al.   JOURNAL OF NEUROCHEMISTRY

Ageing as a risk factor for neurodegenerative disease

(2019) Yujun Hou et al.   Nature Reviews Neurology

CtIP is essential for telomere replication

(2019) Susanna Stroik et al.   NUCLEIC ACIDS RESEARCH

An aging phenotype in the wild

(2019) Jean-Michel Gaillard et al.   SCIENCE

Surviving Telomere Attrition with the MiDAS Touch

(2019) Rachel L. Flynn et al.   TRENDS IN GENETICS

Expression of Clusterin suppresses Cr(VI)-induced premature senescence through activation of PI3K/AKT pathway

(2019) Yujing Zhang et al.   ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY

Polyamines and Aging: A CLEAR Connection?

(2019) Douglas R. Green   MOLECULAR CELL

Premature cell senescence in human skin: Dual face in chronic acquired pigmentary disorders

(2019) Barbara Bellei et al.   AGEING RESEARCH REVIEWS

Telomere length analysis on leukocytes derived from patients with Huntington Disease

(2019) Adriana PerezGrovas-Saltijeral et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Cerebral amyloid angiopathy and Alzheimer disease — one peptide, two pathways

(2019) Steven M. Greenberg et al.   Nature Reviews Neurology

Elevated circulating HtrA4 in preeclampsia may alter endothelial expression of senescence genes

(2019) Yao Wang et al.   PLACENTA

Human iPSC-derived astrocytes from ALS patients with mutated C9ORF72 show increased oxidative stress and neurotoxicity

(2019) Anastasya Birger et al.   EBioMedicine

The role of cellular senescence in aging through the prism of Koch-like criteria

(2018) Hagai Yanai et al.   AGEING RESEARCH REVIEWS

Cellular Senescence, Neurological Function, and Redox State

(2018) Luis Ángel Maciel-Barón et al.   ANTIOXIDANTS & REDOX SIGNALING

Metformin treatment prevents amyloid plaque deposition and memory impairment in APP/PS1 mice

(2018) Zhenri Ou et al.   BRAIN BEHAVIOR AND IMMUNITY

Heme Oxygenase 1 Induces Tau Oligomer Formation and Synapse Aberrations in Hippocampal Neurons

(2018) Zizhen Si et al.   JOURNAL OF ALZHEIMERS DISEASE

Cellular senescence in brain aging and neurodegenerative diseases: evidence and perspectives

(2018) Darren J. Baker et al.   JOURNAL OF CLINICAL INVESTIGATION

Senescence-associated ribosome biogenesis defects contributes to cell cycle arrest through the Rb pathway

(2018) Frédéric Lessard et al.   NATURE CELL BIOLOGY

Hallmarks of Cellular Senescence

(2018) Alejandra Hernandez-Segura et al.   TRENDS IN CELL BIOLOGY

NOTCH-mediated non-cell autonomous regulation of chromatin structure during senescence

(2018) Aled J. Parry et al.   Nature Communications

Cellular Senescence Is Induced by the Environmental Neurotoxin Paraquat and Contributes to Neuropathology Linked to Parkinson’s Disease

(2018) Shankar J. Chinta et al.   Cell Reports

Association of Glycemic Control and Cell Stress With Telomere Attrition in Type 1 Diabetes

(2018) Tine Tesovnik et al.   JAMA Pediatrics

Adjustment of the lysosomal-mitochondrial axis for control of cellular senescence

(2018) Joon Tae Park et al.   AGEING RESEARCH REVIEWS

Tau protein aggregation is associated with cellular senescence in the brain

(2018) Nicolas Musi et al.   AGING CELL

CK2 downregulation induces senescence-associated heterochromatic foci formation through activating SUV39h1 and inactivating G9a

(2018) Jeong-Woo Park et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Telomere Length as Cardiovascular Aging Biomarker

(2018) Tim De Meyer et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Clearance of senescent glial cells prevents tau-dependent pathology and cognitive decline

(2018) Tyler J. Bussian et al.   NATURE

Cellular Senescence: The Sought or the Unwanted?

(2018) Yu Sun et al.   TRENDS IN MOLECULAR MEDICINE

Acute myeloid leukemia induces pro-tumoral p16INK4a driven senescence in the bone marrow microenvironment

(2018) Amina M Abdul-Aziz et al.   BLOOD

VEGF receptor-1 modulates amyloid β 1-42 oligomer-induced senescence in brain endothelial cells

(2018) Ramcharan Singh Angom et al.   FASEB JOURNAL

De novo NAD+ synthesis enhances mitochondrial function and improves health

(2018) Elena Katsyuba et al.   NATURE

Mitochondrial genetic medicine

(2018) Douglas C. Wallace   NATURE GENETICS

Macrophage de novo NAD+ synthesis specifies immune function in aging and inflammation

(2018) Paras S. Minhas et al.   NATURE IMMUNOLOGY

Mitochondria as central regulators of neural stem cell fate and cognitive function

(2018) Mireille Khacho et al.   NATURE REVIEWS NEUROSCIENCE

Getting Too Old Too Quickly for Their Job: Senescent Glial Cells Promote Neurodegeneration

(2018) David Gosselin et al.   NEURON

Noggin rescues age-related stem cell loss in the brain of senescent mice with neurodegenerative pathology

(2018) María Díaz-Moreno et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The DNA Damage Response in Neurons: Die by Apoptosis or Survive in a Senescence-Like State?

(2017) Edward Fielder et al.   JOURNAL OF ALZHEIMERS DISEASE

Epigenetic regulation in cell senescence

(2017) Li-Qin Cheng et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

DNA damage in the oligodendrocyte lineage and its role in brain aging

(2017) Kai-Hei Tse et al.   MECHANISMS OF AGEING AND DEVELOPMENT

A systemic view of Alzheimer disease — insights from amyloid-β metabolism beyond the brain

(2017) Jun Wang et al.   Nature Reviews Neurology

Metformin lowers α-synuclein phosphorylation and upregulates neurotrophic factor in the MPTP mouse model of Parkinson's disease

(2017) Nikita Katila et al.   NEUROPHARMACOLOGY

Replication stress-induced endogenous DNA damage drives cellular senescence induced by a sub-lethal oxidative stress

(2017) Gireedhar Venkatachalam et al.   NUCLEIC ACIDS RESEARCH

Mutations in the promoter of the telomerase geneTERTcontribute to tumorigenesis by a two-step mechanism

(2017) Kunitoshi Chiba et al.   SCIENCE

Spatial and Temporal Control of Senescence

(2017) Yoko Ito et al.   TRENDS IN CELL BIOLOGY

Alternative Lengthening of Telomeres: DNA Repair Pathways Converge

(2017) Alexander P. Sobinoff et al.   TRENDS IN GENETICS

Identification of HSP90 inhibitors as a novel class of senolytics

(2017) Heike Fuhrmann-Stroissnigg et al.   Nature Communications

Parkinson disease

(2017) Werner Poewe et al.   Nature Reviews Disease Primers

Cellular Senescence: A Translational Perspective

(2017) James L. Kirkland et al.   EBioMedicine

Human Neural Stem Cell Aging Is Counteracted by α-Glycerylphosphorylethanolamine

(2016) Simona Daniele et al.   ACS Chemical Neuroscience

Reversal of phenotypes of cellular senescence by pan-mTOR inhibition

(2016) Hannah E. Walters et al.   Aging-US

Discovery of piperlongumine as a potential novel lead for the development of senolytic agents

(2016) Yingying Wang et al.   Aging-US

Mitochondrial Dysfunction Induces Senescence with a Distinct Secretory Phenotype

(2016) Christopher D. Wiley et al.   Cell Metabolism

Mitochondria are required for pro‐ageing features of the senescent phenotype

(2016) Clara Correia‐Melo et al.   EMBO JOURNAL

Accelerated telomere attrition in children and teenagers with α1-antitrypsin deficiency

(2016) Amparo Escribano et al.   EUROPEAN RESPIRATORY JOURNAL

Telomere length in Parkinson's disease: A meta-analysis

(2016) Diego A. Forero et al.   EXPERIMENTAL GERONTOLOGY

Keeping the senescence secretome under control: Molecular reins on the senescence-associated secretory phenotype

(2016) Nicolas Malaquin et al.   EXPERIMENTAL GERONTOLOGY

Age-Associated B Cells with Proinflammatory Characteristics Are Expanded in a Proportion of Multiple Sclerosis Patients

(2016) Nele Claes et al.   JOURNAL OF IMMUNOLOGY

Meta-analysis of Telomere Length in Alzheimer’s Disease

(2016) Diego A. Forero et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

The cell fate: senescence or quiescence

(2016) Menderes Yusuf Terzi et al.   MOLECULAR BIOLOGY REPORTS

Autophagy maintains stemness by preventing senescence

(2016) Laura García-Prat et al.   NATURE

Non-Cell-Autonomous Regulation of Cellular Senescence in Cancer

(2016) Diletta Di Mitri et al.   TRENDS IN CELL BIOLOGY

Aged and Diseased Neurons Get Lost in Transport

(2016) Anna Tamburrino et al.   TRENDS IN NEUROSCIENCES

Directed elimination of senescent cells by inhibition of BCL-W and BCL-XL

(2016) Reut Yosef et al.   Nature Communications

Adaptation, aging, and genomic information

(2016) Michael R. Rose   Aging-US

The Achilles’ heel of senescent cells: from transcriptome to senolytic drugs

(2015) Yi Zhu et al.   AGING CELL

Cellular senescence and the aging brain

(2015) Shankar J. Chinta et al.   EXPERIMENTAL GERONTOLOGY

Role of the innate and adaptive immune responses in the course of multiple sclerosis

(2015) Bernhard Hemmer et al.   LANCET NEUROLOGY

mTOR regulates MAPKAPK2 translation to control the senescence-associated secretory phenotype

(2015) Nicolás Herranz et al.   NATURE CELL BIOLOGY

MTOR regulates the pro-tumorigenic senescence-associated secretory phenotype by promoting IL1A translation

(2015) Remi-Martin Laberge et al.   NATURE CELL BIOLOGY

Clearance of senescent cells by ABT263 rejuvenates aged hematopoietic stem cells in mice

(2015) Jianhui Chang et al.   NATURE MEDICINE

Selective coexpression of VEGF receptor 2 in EGFRvIII-positive glioblastoma cells prevents cellular senescence and contributes to their aggressive nature

(2015) Karra A. Jones et al.   NEURO-ONCOLOGY

JAK inhibition alleviates the cellular senescence-associated secretory phenotype and frailty in old age

(2015) Ming Xu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The DNA damage response induces inflammation and senescence by inhibiting autophagy of GATA4

(2015) C. Kang et al.   SCIENCE

Aging with ING: a comparative study of different forms of stress induced premature senescence

(2015) Uma Karthika Rajarajacholan et al.   Oncotarget

PIM-1 modulates cellular senescence and links IL-6 signaling to heterochromatin formation

(2015) Bo Jin et al.   AGING CELL

A Model for p38MAPK-Induced Astrocyte Senescence

(2015) José C. M. Mombach et al.   PLoS One

Age-dependent changes on TGFβ1 Smad3 pathway modify the pattern of microglial cell activation

(2014) Juan E. Tichauer et al.   BRAIN BEHAVIOR AND IMMUNITY

Oxidative Glial Cell Damage Associated with White Matter Lesions in the Aging Human Brain

(2014) Sufana Al-Mashhadi et al.   BRAIN PATHOLOGY

Gene expression profiling of replicative and induced senescence

(2014) Maggie Purcell et al.   CELL CYCLE

An Essential Role for Senescent Cells in Optimal Wound Healing through Secretion of PDGF-AA

(2014) Marco Demaria et al.   DEVELOPMENTAL CELL

Cellular senescence and its effector programs

(2014) R. Salama et al.   GENES & DEVELOPMENT

Potential for primary prevention of Alzheimer's disease: an analysis of population-based data

(2014) Sam Norton et al.   LANCET NEUROLOGY

Replication stress is a potent driver of functional decline in ageing haematopoietic stem cells

(2014) Johanna Flach et al.   NATURE

The role of senescent cells in ageing

(2014) Jan M. van Deursen   NATURE

Cellular senescence: from physiology to pathology

(2014) Daniel Muñoz-Espín et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

DNA Damage and Its Links to Neurodegeneration

(2014) Ram Madabhushi et al.   NEURON

Ginsenoside Rb1 Prevents H2O2-Induced HUVEC Senescence by Stimulating Sirtuin-1 Pathway

(2014) Zhiming Song et al.   PLoS One

Telomere shortening in neurological disorders: an abundance of unanswered questions

(2014) Erez Eitan et al.   TRENDS IN NEUROSCIENCES

Lysosomal Adaptation: How the Lysosome Responds to External Cues

(2014) C. Settembre et al.   Cold Spring Harbor Perspectives in Biology

Low abundance of the matrix arm of complex I in mitochondria predicts longevity in mice

(2014) Satomi Miwa et al.   Nature Communications

Microglial pathology

(2014) Wolfgang J Streit et al.   Acta Neuropathologica Communications

Metformin inhibits the senescence-associated secretory phenotype by interfering with IKK/NF-κB activation

(2013) Olga Moiseeva et al.   AGING CELL

The Hallmarks of Aging

(2013) Carlos López-Otín et al.   CELL

Programmed Cell Senescence during Mammalian Embryonic Development

(2013) Daniel Muñoz-Espín et al.   CELL

Senescence Is a Developmental Mechanism that Contributes to Embryonic Growth and Patterning

(2013) Mekayla Storer et al.   CELL

Telomere length and Parkinson's disease in men: a nested case−control study

(2013) M. Schürks et al.   EUROPEAN JOURNAL OF NEUROLOGY

The Immune Pathogenesis of Multiple Sclerosis

(2013) Robert Weissert   Journal of Neuroimmune Pharmacology

Tau pathology and neurodegeneration

(2013) Maria Grazia Spillantini et al.   LANCET NEUROLOGY

Reciprocal regulation of p53 and malic enzymes modulates metabolism and senescence

(2013) Peng Jiang et al.   NATURE

A key role for mitochondrial gatekeeper pyruvate dehydrogenase in oncogene-induced senescence

(2013) Joanna Kaplon et al.   NATURE

Senescent cells harbour features of the cancer epigenome

(2013) Hazel A. Cruickshanks et al.   NATURE CELL BIOLOGY

Mitochondrial DNA damage induces apoptosis in senescent cells

(2013) R-M Laberge et al.   Cell Death & Disease

Amyloid-β1–42 oligomer accelerates senescence in adult hippocampal neural stem/progenitor cells via formylpeptide receptor 2

(2013) N He et al.   Cell Death & Disease

Histone Modifications in Senescence-Associated Resistance to Apoptosis by Oxidative Stress

(2013) Yan Y. Sanders et al.   Redox Biology

Astrocytic Control of Biosynthesis and Turnover of the Neurotransmitters Glutamate and GABA

(2013) Arne Schousboe et al.   Frontiers in Endocrinology

Postmitotic neurons develop a p21-dependent senescence-like phenotype driven by a DNA damage response

(2012) Diana Jurk et al.   AGING CELL

Responses of human embryonic stem cells and their differentiated progeny to ionizing radiation

(2012) Ying Zou et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Immune surveillance of senescent cells--biological significance in cancer- and non-cancer pathologies

(2012) L. Hoenicke et al.   CARCINOGENESIS

Repeated Lipopolysaccharide Stimulation Induces Cellular Senescence in BV2 Cells

(2012) Hong-Mei Yu et al.   NEUROIMMUNOMODULATION

Is dementia incidence declining?: Trends in dementia incidence since 1990 in the Rotterdam Study

(2012) E. M. C. Schrijvers et al.   NEUROLOGY

Granule exocytosis mediates immune surveillance of senescent cells

(2012) A Sagiv et al.   ONCOGENE

Testosterone Deficiency Accelerates Neuronal and Vascular Aging of SAMP8 Mice: Protective Role of eNOS and SIRT1

(2012) Hidetaka Ota et al.   PLoS One

Astrocyte Senescence as a Component of Alzheimer’s Disease

(2012) Rekha Bhat et al.   PLoS One

Emerging roles of microglial activation and non-motor symptoms in Parkinson's disease

(2012) Karlijn J. Doorn et al.   PROGRESS IN NEUROBIOLOGY

Trends in the incidence and prevalence of Alzheimer’s disease, dementia, and cognitive impairment in the United States

(2011) Walter A. Rocca et al.   Alzheimers & Dementia

The diagnosis of dementia due to Alzheimer’s disease: Recommendations from the National Institute on Aging-Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer's disease

(2011) Guy M. McKhann et al.   Alzheimers & Dementia

p38MAPK is a novel DNA damage response-independent regulator of the senescence-associated secretory phenotype

(2011) Adam Freund et al.   EMBO JOURNAL

Astrocytes in the aging brain express characteristics of senescence-associated secretory phenotype

(2011) Antero Salminen et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Four faces of cellular senescence

(2011) Francis Rodier et al.   JOURNAL OF CELL BIOLOGY

Microglial p38α MAPK is a key regulator of proinflammatory cytokine up-regulation induced by toll-like receptor (TLR) ligands or beta-amyloid (Aβ)

(2011) Adam D Bachstetter et al.   Journal of Neuroinflammation

Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders

(2011) Darren J. Baker et al.   NATURE

The Senescence-Associated Secretory Phenotype: The Dark Side of Tumor Suppression

(2010) Jean-Philippe Coppé et al.   Annual Review of Pathology-Mechanisms of Disease

Senescence-associated beta-galactosidase activity expression in aging hippocampal neurons

(2010) Yi-Qun Geng et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Growth stimulation leads to cellular senescence when the cell cycle is blocked

(2010) Zoya N. Demidenko et al.   CELL CYCLE

Stress-induced senescence in human and rodent astrocytes

(2010) Alessandro Bitto et al.   EXPERIMENTAL CELL RESEARCH

Aβ peptides accelerate the senescence of endothelial cells in vitro and in vivo, impairing angiogenesis

(2010) Sandra Donnini et al.   FASEB JOURNAL

DNA-SCARS: distinct nuclear structures that sustain damage-induced senescence growth arrest and inflammatory cytokine secretion

(2010) F. Rodier et al.   JOURNAL OF CELL SCIENCE

Therapy-Induced Senescence in Cancer

(2010) Jonathan A. Ewald et al.   JNCI-Journal of the National Cancer Institute

Feedback between p21 and reactive oxygen production is necessary for cell senescence

(2010) João F Passos et al.   Molecular Systems Biology

Ex vivo cultures of microglia from young and aged rodent brain reveal age-related changes in microglial function

(2010) eMalick G. Njie et al.   NEUROBIOLOGY OF AGING

Fate Mapping Analysis Reveals That Adult Microglia Derive from Primitive Macrophages

(2010) F. Ginhoux et al.   SCIENCE

Inflammatory networks during cellular senescence: causes and consequences

(2010) Adam Freund et al.   TRENDS IN MOLECULAR MEDICINE

p38MAPK Controls Expression of Multiple Cell Cycle Inhibitors and Islet Proliferation with Advancing Age

(2009) Esther Sook Miin Wong et al.   DEVELOPMENTAL CELL

Tangle-Bearing Neurons Survive Despite Disruption of Membrane Integrity in a Mouse Model of Tauopathy

(2009) Alix de Calignon et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Does neuroinflammation fan the flame in neurodegenerative diseases?

(2009) Tamy C Frank-Cannon et al.   Molecular Neurodegeneration

The Aging Brain

(2008) Bruce A. Yankner et al.   Annual Review of Pathology-Mechanisms of Disease

Cellular Senescence: Molecular Mechanisms, In Vivo Significance, and Redox Considerations

(2008) Michael Muller   ANTIOXIDANTS & REDOX SIGNALING

Both telomeric and non-telomeric DNA damage are determinants of mammalian cellular senescence

(2008) Asako J Nakamura et al.   Epigenetics & Chromatin

Senescence-Associated Secretory Phenotypes Reveal Cell-Nonautonomous Functions of Oncogenic RAS and the p53 Tumor Suppressor

(2008) Jean-Philippe Coppé et al.   PLOS BIOLOGY