Mutations in the promoter of the telomerase geneTERTcontribute to tumorigenesis by a two-step mechanism

Whole-genome landscapes of major melanoma subtypes

(2017) Nicholas K. Hayward et al.   NATURE

Telomeres in cancer: tumour suppression and genome instability

(2017) John Maciejowski et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Molecular Profiling Reveals Biologically Discrete Subsets and Pathways of Progression in Diffuse Glioma

(2016) Michele Ceccarelli et al.   CELL

A POT1 mutation implicates defective telomere end fill-in and telomere truncations in Coats plus

(2016) Hiroyuki Takai et al.   GENES & DEVELOPMENT

TERTpromoter mutations in melanoma survival

(2016) Eduardo Nagore et al.   INTERNATIONAL JOURNAL OF CANCER

Long telomeres and cancer risk among 95 568 individuals from the general population

(2016) Line Rode et al.   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

Endogenous Telomerase Reverse Transcriptase N-Terminal Tagging Affects Human Telomerase Function at Telomeres In Vivo

(2016) Kunitoshi Chiba et al.   MOLECULAR AND CELLULAR BIOLOGY

TERT Promoter Mutations Enhance Telomerase Activation by Long-Range Chromatin Interactions

(2016) J. Min et al.   Cancer Discovery

Roles of telomeres and telomerase in cancer, and advances in telomerase-targeted therapies

(2016) Mohammad A. Jafri et al.   Genome Medicine

Genomic Classification of Cutaneous Melanoma

(2015) Rehan Akbani et al.   CELL

The short and long telomere syndromes: paired paradigms for molecular medicine

(2015) Susan E Stanley et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

The Genetic Evolution of Melanoma from Precursor Lesions

(2015) A. Hunter Shain et al.   NEW ENGLAND JOURNAL OF MEDICINE

TERTpromoter mutations and telomerase reactivation in urothelial cancer

(2015) Sumit Borah et al.   SCIENCE

The transcription factor GABP selectively binds and activates the mutant TERT promoter in cancer

(2015) R. J. A. Bell et al.   SCIENCE

Cancer-associated TERT promoter mutations abrogate telomerase silencing

(2015) Kunitoshi Chiba et al.   eLife

Telomere dysfunction accurately predicts clinical outcome in chronic lymphocytic leukaemia, even in patients with early stage disease

(2014) Thet Thet Lin et al.   BRITISH JOURNAL OF HAEMATOLOGY

The Effect on Melanoma Risk of Genes Previously Associated With Telomere Length

(2014) Mark M. Iles et al.   JNCI-Journal of the National Cancer Institute

Multiple independent variants at the TERT locus are associated with telomere length and risks of breast and ovarian cancer

(2013) Stig E Bojesen et al.   NATURE GENETICS

TERT promoter mutations occur frequently in gliomas and a subset of tumors derived from cells with low rates of self-renewal

(2013) P. J. Killela et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TERT Promoter Mutations in Familial and Sporadic Melanoma

(2013) S. Horn et al.   SCIENCE

Highly Recurrent TERT Promoter Mutations in Human Melanoma

(2013) F. W. Huang et al.   SCIENCE

Shorter Telomeres Associate with a Reduced Risk of Melanoma Development

(2011) H. Nan et al.   CANCER RESEARCH

Genetic engineering of human pluripotent cells using TALE nucleases

(2011) Dirk Hockemeyer et al.   NATURE BIOTECHNOLOGY

Derivation of Pre-X Inactivation Human Embryonic Stem Cells under Physiological Oxygen Concentrations

(2010) Christopher J. Lengner et al.   CELL

Measurement of telomere length by the Southern blot analysis of terminal restriction fragment lengths

(2010) Masayuki Kimura et al.   Nature Protocols

Parkinson's Disease Patient-Derived Induced Pluripotent Stem Cells Free of Viral Reprogramming Factors

(2009) Frank Soldner et al.   CELL

Efficient targeting of expressed and silent genes in human ESCs and iPSCs using zinc-finger nucleases

(2009) Dirk Hockemeyer et al.   NATURE BIOTECHNOLOGY

A Prospective Study of Telomere Length and the Risk of Skin Cancer

(2008) Jiali Han et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Dynamic multiple-target tracing to probe spatiotemporal cartography of cell membranes

(2008) Arnauld Sergé et al.   NATURE METHODS