Age‐related calcium dysregulation linked with tau pathology and impaired cognition in non‐human primates

Classical complement cascade initiating C1q protein within neurons in the aged rhesus macaque dorsolateral prefrontal cortex

(2020) Dibyadeep Datta et al.   Journal of Neuroinflammation

Cerebrospinal fluid p-tau217 performs better than p-tau181 as a biomarker of Alzheimer’s disease

(2020) Shorena Janelidze et al.   Nature Communications

Cerebrospinal fluid phospho-tau T217 outperforms T181 as a biomarker for the differential diagnosis of Alzheimer’s disease and PET amyloid-positive patient identification

(2020) Nicolas R. Barthélemy et al.   Alzheimers Research & Therapy

Tau molecular diversity contributes to clinical heterogeneity in Alzheimer’s disease

(2020) Simon Dujardin et al.   NATURE MEDICINE

Mapping Phosphodiesterase 4D (PDE4D) in Macaque Dorsolateral Prefrontal Cortex: Postsynaptic Compartmentalization in Layer III Pyramidal Cell Circuits

(2020) Dibyadeep Datta et al.   Frontiers in Neuroanatomy

Tau Phosphorylation Rates Measured by Mass Spectrometry Differ in the Intracellular Brain vs. Extracellular Cerebrospinal Fluid Compartments and Are Differentially Affected by Alzheimer’s Disease

(2019) Nicolas R. Barthélemy et al.   Frontiers in Aging Neuroscience

Understanding PDE4's function in Alzheimer's disease; a target for novel therapeutic approaches

(2019) Amy J. Tibbo et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Alzheimer’s-like pathology in aging rhesus macaques: Unique opportunity to study the etiology and treatment of Alzheimer’s disease

(2019) Amy F. T. Arnsten et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The aged rhesus macaque manifests Braak stage III/IV Alzheimer's-like pathology

(2018) Constantinos D. Paspalas et al.   Alzheimers & Dementia

Striatin-1 is a B subunit of protein phosphatase PP2A that regulates dendritic arborization and spine development in striatal neurons

(2018) Daniel Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tau-targeting therapies for Alzheimer disease

(2018) Erin E. Congdon et al.   Nature Reviews Neurology

Aging-Related Calcium Dysregulation in Rat Entorhinal Neurons Homologous with the Human Entorhinal Neurons in which Alzheimer’s Disease Neurofibrillary Tangles First Appear

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Ultrastructural evidence for impaired mitochondrial fission in the aged rhesus monkey dorsolateral prefrontal cortex

(2017) Yury M. Morozov et al.   NEUROBIOLOGY OF AGING

Familial Alzheimer's Disease Mutations in Presenilins: Effects on Endoplasmic Reticulum Calcium Homeostasis and Correlation with Clinical Phenotypes

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Upregulation of calpain activity precedes tau phosphorylation and loss of synaptic proteins in Alzheimer’s disease brain

(2016) Ksenia Kurbatskaya et al.   Acta Neuropathologica Communications

Altered brain energetics induces mitochondrial fission arrest in Alzheimer’s Disease

(2016) Liang Zhang et al.   Scientific Reports

The preclinical phase of the pathological process underlying sporadic Alzheimer’s disease

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Rapid alteration of protein phosphorylation during postmortem: implication in the study of protein phosphorylation

(2015) Yifan Wang et al.   Scientific Reports

cAMP-PKA phosphorylation of tau confers risk for degeneration in aging association cortex

(2014) Becky C. Carlyle et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Stabilization of the Skeletal Muscle Ryanodine Receptor Ion Channel-FKBP12 Complex by the 1,4-Benzothiazepine Derivative S107

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Neuropathological Alterations in Alzheimer Disease

(2013) A. Serrano-Pozo et al.   Cold Spring Harbor Perspectives in Medicine

Constellation of HCN Channels and cAMP Regulating Proteins in Dendritic Spines of the Primate Prefrontal Cortex: Potential Substrate for Working Memory Deficits in Schizophrenia

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Neuronal basis of age-related working memory decline

(2011) Min Wang et al.   NATURE

The Many Faces of Tau

(2011) Meaghan Morris et al.   NEURON

Calcium Signaling and Amyloid Toxicity in Alzheimer Disease

(2010) Angelo Demuro et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Selective Changes in Thin Spine Density and Morphology in Monkey Prefrontal Cortex Correlate with Aging-Related Cognitive Impairment

(2010) D. Dumitriu et al.   JOURNAL OF NEUROSCIENCE

ER Calcium and Alzheimer's Disease: In a State of Flux

(2010) M. P. Mattson   Science Signaling

Regulation by Ca2+-Signaling Pathways of Adenylyl Cyclases

(2010) M. L. Halls et al.   Cold Spring Harbor Perspectives in Biology

Remodeling of ryanodine receptor complex causes "leaky" channels: A molecular mechanism for decreased exercise capacity

(2008) A. M. Bellinger et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA