Alzheimer’s-like pathology in aging rhesus macaques: Unique opportunity to study the etiology and treatment of Alzheimer’s disease

Tau Phosphorylation Rates Measured by Mass Spectrometry Differ in the Intracellular Brain vs. Extracellular Cerebrospinal Fluid Compartments and Are Differentially Affected by Alzheimer’s Disease

(2019) Nicolas R. Barthélemy et al.   Frontiers in Aging Neuroscience

Atypical behaviour and connectivity in SHANK3-mutant macaques

(2019) Yang Zhou et al.   NATURE

Oligomeric Aβ in the monkey brain impacts synaptic integrity and induces accelerated cortical aging

(2019) Danielle Beckman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Primate optogenetics: Progress and prognosis

(2019) Yasmine El-Shamayleh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The aged rhesus macaque manifests Braak stage III/IV Alzheimer's-like pathology

(2018) Constantinos D. Paspalas et al.   Alzheimers & Dementia

Post-traumatic stress disorder and risk of dementia among members of a health care delivery system

(2018) Jason D. Flatt et al.   Alzheimers & Dementia

Anti-Amyloid-β Monoclonal Antibodies for Alzheimer’s Disease: Pitfalls and Promise

(2018) Christopher H. van Dyck   BIOLOGICAL PSYCHIATRY

Core Differences in Synaptic Signaling Between Primary Visual and Dorsolateral Prefrontal Cortex

(2018) Sheng-Tao Yang et al.   CEREBRAL CORTEX

Aging African green monkeys manifest transcriptional, pathological, and cognitive hallmarks of human Alzheimer's disease

(2018) Paige E. Cramer et al.   NEUROBIOLOGY OF AGING

Mechanisms of Cell-to-Cell Transmission of Pathological Tau

(2018) Garrett S. Gibbons et al.   JAMA Neurology

A nonhuman primate model of early Alzheimer's disease pathologic change: Implications for disease pathogenesis

(2018) Caitlin S. Latimer et al.   Alzheimers & Dementia

Synaptic distributions of pS214-tau in rhesus monkey prefrontal cortex are associated with spine density, but not with cognitive decline

(2018) Johanna L. Crimins et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Tau impairs neural circuits, dominating amyloid-β effects, in Alzheimer models in vivo

(2018) Marc Aurel Busche et al.   NATURE NEUROSCIENCE

Investigational phosphodiesterase inhibitors in phase I and phase II clinical trials for Alzheimer’s disease

(2017) Jos Prickaerts et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Impaired path integration in mice with disrupted grid cell firing

(2017) Mariana Gil et al.   NATURE NEUROSCIENCE

Ultrastructural evidence for impaired mitochondrial fission in the aged rhesus monkey dorsolateral prefrontal cortex

(2017) Yury M. Morozov et al.   NEUROBIOLOGY OF AGING

Aged chimpanzees exhibit pathologic hallmarks of Alzheimer's disease

(2017) Melissa K. Edler et al.   NEUROBIOLOGY OF AGING

Risk factors associated with the onset and progression of Alzheimer’s disease: A systematic review of the evidence

(2017) Mona Hersi et al.   NEUROTOXICOLOGY

Endosomal Traffic Jams Represent a Pathogenic Hub and Therapeutic Target in Alzheimer’s Disease

(2017) Scott A. Small et al.   TRENDS IN NEUROSCIENCES

The Endosomal–Lysosomal Pathway Is Dysregulated by APOE4 Expression in Vivo

(2017) Tal Nuriel et al.   Frontiers in Neuroscience

Why Women Have More Alzheimer's Disease Than Men: Gender and Mitochondrial Toxicity of Amyloid-β Peptide

(2017) Jose Viña et al.   JOURNAL OF ALZHEIMERS DISEASE

Alzheimer’s disease: experimental models and reality

(2016) Eleanor Drummond et al.   ACTA NEUROPATHOLOGICA

Influence of Perceived Stress on Incident Amnestic Mild Cognitive Impairment

(2016) Mindy J. Katz et al.   ALZHEIMER DISEASE & ASSOCIATED DISORDERS

Identification of a multifunctional docking site on the catalytic unit of phosphodiesterase-4 (PDE4) that is utilised by multiple interaction partners

(2016) Kirsty F. Houslay et al.   BIOCHEMICAL JOURNAL

The amyloid hypothesis of Alzheimer's disease at 25 years

(2016) Dennis J Selkoe et al.   EMBO Molecular Medicine

Generation of transgenic marmosets expressing genetically encoded calcium indicators

(2016) Jung Eun Park et al.   Scientific Reports

Evidence of Tau Hyperphosphorylation and Dystrophic Microglia in the Common Marmoset

(2016) Juan D. Rodriguez-Callejas et al.   Frontiers in Aging Neuroscience

Internalized Tau Oligomers Cause Neurodegeneration by Inducing Accumulation of Pathogenic Tau in Human Neurons Derived from Induced Pluripotent Stem Cells

(2015) M. Usenovic et al.   JOURNAL OF NEUROSCIENCE

Altered Regulation of Protein Kinase A Activity in the Medial Prefrontal Cortex of Normal and Brain-Injured Animals Actively Engaged in a Working Memory Task

(2015) Nobuhide Kobori et al.   JOURNAL OF NEUROTRAUMA

Stress weakens prefrontal networks: molecular insults to higher cognition

(2015) Amy F T Arnsten   NATURE NEUROSCIENCE

Sex differences and stress across the lifespan

(2015) Tracy L Bale et al.   NATURE NEUROSCIENCE

During Running in Place, Grid Cells Integrate Elapsed Time and Distance Run

(2015) Benjamin J. Kraus et al.   NEURON

Progressive Cognitive Deficit, Motor Impairment and Striatal Pathology in a Transgenic Huntington Disease Monkey Model from Infancy to Adulthood

(2015) Anthony W. S. Chan et al.   PLoS One

Mitochondrial calcium overload is a key determinant in heart failure

(2015) Gaetano Santulli et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Truncation and activation of GSK-3β by calpain I: a molecular mechanism links to tau hyperphosphorylation in Alzheimer's disease

(2015) Nana Jin et al.   Scientific Reports

Early Parkinson's disease symptoms in  -synuclein transgenic monkeys

(2015) Y. Niu et al.   HUMAN MOLECULAR GENETICS

Sex modifies theAPOE-related risk of developing Alzheimer disease

(2014) Andre Altmann et al.   ANNALS OF NEUROLOGY

A two years longitudinal study of a transgenic Huntington disease monkey

(2014) Anthony WS Chan et al.   BMC NEUROSCIENCE

Alzheimer's Disease-Like Pathology Induced by Amyloid-β Oligomers in Nonhuman Primates

(2014) Leticia Forny-Germano et al.   JOURNAL OF NEUROSCIENCE

Crosstalk between mitogen-activated protein kinases and mitochondria in cardiac diseases: Therapeutic perspectives

(2014) Sabzali Javadov et al.   PHARMACOLOGY & THERAPEUTICS

cAMP-PKA phosphorylation of tau confers risk for degeneration in aging association cortex

(2014) Becky C. Carlyle et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Intraneuronal tau aggregation precedes diffuse plaque deposition, but amyloid-β changes occur before increases of tau in cerebrospinal fluid

(2013) Heiko Braak et al.   ACTA NEUROPATHOLOGICA

Ca2+-dependent endoplasmic reticulum stress correlates with astrogliosis in oligomeric amyloid β-treated astrocytes and in a model of Alzheimer's disease

(2013) Elena Alberdi et al.   AGING CELL

Metabotropic Glutamate Receptor 5 Is a Coreceptor for Alzheimer Aβ Oligomer Bound to Cellular Prion Protein

(2013) Ji Won Um et al.   NEURON

NMDA Receptors Subserve Persistent Neuronal Firing during Working Memory in Dorsolateral Prefrontal Cortex

(2013) Min Wang et al.   NEURON

Nicotinic  7 receptors enhance NMDA cognitive circuits in dorsolateral prefrontal cortex

(2013) Y. Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Common psychosocial stressors in middle-aged women related to longstanding distress and increased risk of Alzheimer's disease: a 38-year longitudinal population study

(2013) Lena Johansson et al.   BMJ Open

Role of Leaky Neuronal Ryanodine Receptors in Stress- Induced Cognitive Dysfunction

(2012) Xiaoping Liu et al.   CELL

Constellation of HCN Channels and cAMP Regulating Proteins in Dendritic Spines of the Primate Prefrontal Cortex: Potential Substrate for Working Memory Deficits in Schizophrenia

(2012) Constantinos D. Paspalas et al.   CEREBRAL CORTEX

Neuromodulation of Ih in Layer II Medial Entorhinal Cortex Stellate Cells: A Voltage-Clamp Study

(2012) J. G. Heys et al.   JOURNAL OF NEUROSCIENCE

A map of visual space in the primate entorhinal cortex

(2012) Nathaniel J. Killian et al.   NATURE

The ageing cortical synapse: hallmarks and implications for cognitive decline

(2012) John H. Morrison et al.   NATURE REVIEWS NEUROSCIENCE

Neuromodulation of Thought: Flexibilities and Vulnerabilities in Prefrontal Cortical Network Synapses

(2012) Amy F.T. Arnsten et al.   NEURON

Traumatic brain injury: A risk factor for Alzheimer's disease

(2012) Thamil Mani Sivanandam et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Trans-Synaptic Spread of Tau Pathology In Vivo

(2012) Li Liu et al.   PLoS One

Phosphorylation of cAMP-specific PDE4A5 (phosphodiesterase-4A5) by MK2 (MAPKAPK2) attenuates its activation through protein kinase A phosphorylation

(2011) Kirsty F. MacKenzie et al.   BIOCHEMICAL JOURNAL

Grid Cells Use HCN1 Channels for Spatial Scaling

(2011) Lisa M. Giocomo et al.   CELL

Stages of the Pathologic Process in Alzheimer Disease: Age Categories From 1 to 100 Years

(2011) Heiko Braak et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Neuronal basis of age-related working memory decline

(2011) Min Wang et al.   NATURE

Role of Presenilins in Neuronal Calcium Homeostasis

(2010) H. Zhang et al.   JOURNAL OF NEUROSCIENCE

Mechanisms of tau-induced neurodegeneration

(2009) Khalid Iqbal et al.   ACTA NEUROPATHOLOGICA

Alzheimer's disease-type neuronal tau hyperphosphorylation induced by Aβ oligomers

(2007) Fernanda G. De Felice et al.   NEUROBIOLOGY OF AGING

Altered Calcium Homeostasis and Mitochondrial Dysfunction in Cortical Synaptic Compartments of Presenilin-1 Mutant Mice

(2003) James G. Begley et al.   JOURNAL OF NEUROCHEMISTRY